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Neural and Behavioral Plasticity Associated with the Transition from Controlled to Escalated Cocaine Use
Open accessAbstract
Background Rats given extended access to cocaine develop several symptoms of addiction, including a gradual escalation of drug intake, whereas rats given limited access do not. We asked here whether extended access to cocaine also produces drug-induced sensitization, a form of neurobehavioral plasticity implicated in addiction.Methods Rats were given limited (1 hour/session) or extended access (6 hours/session) to self-administered cocaine. Following a period of abstinence, rats were selected at random for assessment of their psychomotor response to cocaine or drug-seeking during extinction or for anatomic studies.Results When re-exposed to cocaine, rats allowed extended drug access showed greater drug-seeking behavior and were hypersensitive (sensitized) to the psychomotor activating effects of cocaine compared with rats given limited access. Extended access to cocaine was also associated with a greater increase in the density of dendritic spines on neurons specifically in the core of the nucleus accumbens (and not in the shell or medial or orbital frontal cortex).Conclusions The transition from stable to escalated cocaine use, a hallmark of addiction, is associated with especially robust behavioral sensitization and synaptic reorganization in the core of the nucleus accumbens.
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“This increased urge for the drug is due to a sensitization of the neural pathways responsible for ‘wanting’ (Ferrario & Robinson, 2007; Ferrario et al., 2005).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Ferrario et al., 2005
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“Sensitization can also be seen as a greater behavioral response to the drug or enhanced acquisition and escalation of drug self-administration, that accompany brain neural adaptations that underlie amplified ‘wanting’ for the reward (Ferrario et al., 2005; Ferrario & Robinson, 2007; Vezina, 2004; Vezina et al., 2002).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Ferrario et al., 2005
Citations
Cites
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Self-citationJ Neuropsychiatry Clin Neurosci
Yudofsky, S. C., & Hales, R. E. (1992) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.4.4.359 · Cited by 3,818
A psychomotor stimulant theory of addiction.
Wise, R. A., & Bozarth, M. A. (1987) · Psychological Review · doi:10.1037/0033-295x.94.4.469 · Cited by 2,747
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00007-6 · Cited by 2,129
Robinson, T. G., & BECKER, J. (1986) · Brain Research · doi:10.1016/s0006-8993(86)80193-7 · Cited by 2,108
Self-citationRobinson, T. E., & Becker, J. B. (1986) · Brain Research Reviews · doi:10.1016/0165-0173(86)90002-0 · Cited by 1,796
Self-citationJentsch, J. D., & Taylor, J. R. (1999) · Psychopharmacology · doi:10.1007/pl00005483 · Cited by 1,545
Gueorguieva, R., & Krystal, J. H. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.3.310 · Cited by 1,529
Robinson, T. E., & Berridge, K. C. (2003) · Annual Review of Psychology · doi:10.1146/annurev.psych.54.101601.145237 · Cited by 1,509
Self-citationVanderschuren, L. J. M. J., & Kalivas, P. W. (2000) · Psychopharmacology · doi:10.1007/s002130000493 · Cited by 1,360
Factors That Predict Individual Vulnerability to Amphetamine Self-Administration
Piazza, P. V., Deminière, J.-M., Moal, M. L., & Simon, H. (1989) · Science · doi:10.1126/science.2781295 · Cited by 1,355
Transition from Moderate to Excessive Drug Intake: Change in Hedonic Set Point
Ahmed, S. H., & Koob, G. F. (1998) · Science · doi:10.1126/science.282.5387.298 · Cited by 1,186
Evidence for Addiction-like Behavior in the Rat
Deroche-Gamonet, V., Belin, D., & Piazza, P. V. (2004) · Science · doi:10.1126/science.1099020 · Cited by 1,135
Structural plasticity associated with exposure to drugs of abuse
Robinson, T. E., & Kolb, B. E. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.025 · Cited by 1,130
Self-citationRogers, R. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00091-8 · Cited by 1,101
Zilles, K. (1985) · Springer eBooks · doi:10.1007/978-3-642-70573-1 · Cited by 1,066
Nucleus accumbens shell and core dopamine: differential role in behavior and addiction
Di Chiara, G. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00286-3 · Cited by 996
Wise, R. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00965-0 · Cited by 881
Self-administration of psychoactive substances by the monkey
Deneau, G. A., Yanagita, T., & Seevers, M. H. (1969) · Psychopharmacology · doi:10.1007/bf00405254 · Cited by 808
Drug Seeking Becomes Compulsive After Prolonged Cocaine Self-Administration
Vanderschuren, L. J. M. J., & Everitt, B. J. (2004) · Science · doi:10.1126/science.1098975 · Cited by 733
Robinson, T. E., & Kolb, B. E. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00576.x · Cited by 726
Self-citationMethods of Assessing the Reinforcing Properties of Abused Drugs
Bozarth, M. A. (1987) · Springer eBooks · doi:10.1007/978-1-4612-4812-5 · Cited by 693
Pierce, R. C., Bell, K., Duffy, P., & Kalivas, P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01550.1996 · Cited by 624
Vezina, P. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.001 · Cited by 515
Lett, B. T. (1989) · Psychopharmacology · doi:10.1007/bf00451687 · Cited by 479
Increasing effects of repetitive cocaine administration in the rat
Post, R. M., & Rose, H. H. R. M. (1976) · Nature · doi:10.1038/260731a0 · Cited by 442
Wyvell, C. L., & Berridge, K. C. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07831.2001 · Cited by 436
Robinson, T. E., Gorny, G., Mitton, E., & Kolb, B. E. (2001) · Synapse · doi:10.1002/1098-2396(20010301)39:3 · Cited by 411
Vries, T. J. D., Schoffelmeer, A. N. M., Binnekade, R., Mulder, A. H., & Vanderschuren, L. J. M. J. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00368.x · Cited by 332
Current Developments in Psychopharmacology
Essman, W. B., & Valzelli, L. (1981) · Springer eBooks · doi:10.1007/978-94-011-8123-5 · Cited by 290
Preexposure sensitizes rats to the rewarding effects of cocaine
Horger, B. A., Shelton, K. L., & Schenk, S. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90552-s · Cited by 271
Toxicity Associated With Long-term Intravenous Heroin and Cocaine Self-administration in the Rat
Bozarth, M. A. (1985) · JAMA · doi:10.1001/jama.1985.03360010087032 · Cited by 262
Pierce, R. C., & Kalivas, P. W. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12090-9 · Cited by 249
Robinson, T. E., Gorny, G., Savage, V. R., & Kolb, B. E. (2002) · Synapse · doi:10.1002/syn.10146 · Cited by 224
Self-citationIncreased motivation for self-administered cocaine after escalated cocaine intake
Paterson, N. E., & Markou, A. (2003) · Neuroreport · doi:10.1097/00001756-200312020-00019 · Cited by 203
Vries, T. J. D. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00293-7 · Cited by 200
Li, Y., Acerbo, M. J., & Robinson, T. E. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03612.x · Cited by 180
Self-citationCrombag, H. S. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh136 · Cited by 178
Self-citationCocaine self‐administration increases the incentive motivational properties of the drug in rats
Deroche‐Gamonet, V., Moal, M. L., & Piazza, P. V. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00696.x · Cited by 178
Mendrek, A., Blaha, C. D., & Phillips, A. G. (1998) · Psychopharmacology · doi:10.1007/s002130050530 · Cited by 176
The Neuropsychiatry of Chronic Cocaine Abuse
Bolla, K. I., Cadet, J. L., & London, E. D. (1998) · Journal of Neuropsychiatry · doi:10.1176/jnp.10.3.280 · Cited by 175
Psychostimulant sensitization: differential changes in accumbal shell and core dopamine
Cadoni, C., Solinas, M., & Chiara, G. D. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00824-9 · Cited by 171
Li, Y., Kolb, B. E., & Robinson, T. E. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300115 · Cited by 164
Self-citationSchoenbaum, G. M., & Setlow, B. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh216 · Cited by 161
Yokel, R. A. (1987) · Springer eBooks · doi:10.1007/978-1-4612-4812-5_1 · Cited by 143
Behavioral and neurochemical correlates of repeated d-amphetamine administration.
Ds, S. (1975) · PubMed · Cited by 140
Behavioral and neurochemical sensitization following cocaine self-administration
Hooks, M. S., Duffy, P., Striplin, C. D., & Kalivas, P. W. (1994) · Psychopharmacology · doi:10.1007/bf02244782 · Cited by 134
Enhanced appetitive conditioning following repeated pretreatment with d-amphetamine
Harmer, C. J., & Phillips, G. D. (1998) · Behavioural Pharmacology · doi:10.1097/00008877-199807000-00001 · Cited by 107
The transition from controlled to compulsive drug use is associated with a loss of sensitization
Ben‐Shahar, O., Ahmed, S. H., Koob, G. F., & Ettenberg, A. (2003) · Brain Research · doi:10.1016/j.brainres.2003.09.053 · Cited by 104
Sensitization to the reinforcing effects of cocaine following binge-abstinent self-administration
Morgan, D., & Roberts, D. C. S. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.004 · Cited by 89
Heyne, A., & Wolffgramm, J. (1998) · Psychopharmacology · doi:10.1007/s002130050796 · Cited by 71
Behavioral sensitization is induced by intravenous self-administration of cocaine by rats
Phillips, A. G., & Ciano, P. D. (1996) · Psychopharmacology · doi:10.1007/bf02246669 · Cited by 65
Robinson, T. E. (2004) · Science · doi:10.1126/science.1102496 · Cited by 56
Self-citationZapata, A. G., Chefer, V. I., Ator, R., Shippenberg, T. S., & Rocha, B. A. G. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02491.x · Cited by 56
Parkinson, B., & Colman, B. (1995) · Longman eBooks · Cited by 47
Uslaner, J. M., Crombag, H. S., Ferguson, S. M., & Robinson, T. E. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02638.x · Cited by 32
Self-citationLONG-TERM INTRAVENOUS INFUSIONS
Bethell, H. J. N. (1972) · The Lancet · doi:10.1016/s0140-6736(72)91835-1 · Cited by 30
Research works printed but not linked: 1
- Lyon, 1975, The action of central nervous system stimulant drugs, Vol. 2, 80
Cited by
Sorted by citations
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340
The incentive sensitization theory of addiction: some current issues
Robinson, T. E., & Berridge, K. C. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0093 · Cited by 1,717
Self-citationEveritt, B. J., Belin, D., Economidou, D., Pelloux, Y., Dalley, J. W., & Robbins, T. W. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0089 · Cited by 974
From the ventral to the dorsal striatum: devolving views of their roles in drug addiction
Everitt, B. J., & Robbins, T. W. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.010 · Cited by 675
Drug Wanting: Behavioral Sensitization and Relapse to Drug-Seeking Behavior
Steketee, J. D., & Kalivas, P. W. (2011) · Pharmacological Reviews · doi:10.1124/pr.109.001933 · Cited by 671
Metadata
- Authors
- Ferrario, C. R., Gorny, G., Crombag, H. S., Li, Y., Kolb, B., & Robinson, T. E.
- Affiliations
- University of Michigan (US)
- University of Lethbridge (CA)
- Corresponding author
- Robinson, Terry E.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 58
- Issue
- 9
- Pages
- 751-759
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2022992863
- Cited by
- 283
- References
- 58
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 4 · 2023: 10 · 2022: 4 · 2021: 19 · 2020: 12 · 2019: 12 · 2018: 8 · 2017: 8 · 2016: 13 · 2015: 14 · 2014: 14 · 2013: 26 · 2012: 19
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- cocaine, extended access, restricted access, drug-seeking behavior, behavioral sensitization, nucleus accumbens core, dendritic spines, synaptic plasticity, addiction, locomotor sensitization, self-administration, extinction
- MeSH terms
- Animals, Behavior, Animal, Cocaine, Conditioning, Operant, Dendrites, Dose-Response Relationship, Drug, Male, Motor Activity, Neuronal Plasticity, Nucleus Accumbens, Reinforcement, Psychology, Self Administration, Stereotyped Behavior, Rats, Wistar, Prefrontal Cortex, Head Movements, Cocaine-Related Disorders, Rats
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