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Cited by 1,509Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

Addiction

Robinson, Terry E., Berridge, Kent C.·2003·Annual Review of Psychology
DOI 10.1146/annurev.psych.54.101601.145237
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Abstract

The development of addiction involves a transition from casual to compulsive patterns of drug use. This transition to addiction is accompanied by many drug-induced changes in the brain and associated changes in psychological functions. In this article we present a critical analysis of the major theoretical explanations of how drug-induced alterations in psychological function might cause a transition to addiction. These include: (a) the traditional hedonic view that drug pleasure and subsequent unpleasant withdrawal symptoms are the chief causes of addiction; (b) the view that addiction is due to aberrant learning, especially the development of strong stimulus-response habits; (c) our incentive-sensitization view, which suggests that sensitization of a neural system that attributes incentive salience causes compulsive motivation or “wanting” to take addictive drugs; and (d) the idea that dysfunction of frontal cortical systems, which normally regulate decision making and inhibitory control over behavior, leads to impaired judgment and impulsivity in addicts.

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Crossref · 10.1146/annurev.psych.54.101601.145237

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119 of 119 references verified0 citation errors · 0 not checkable

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  • The mesolimbic DA system represents only one component of a complex integrated set of circuits, and non-DA systems also modulate reward responsivity.

    “The mesolimbic DA system represents only one component of a very complex and integrated set of circuits, and although DA is clearly a crucial neurotransmitter in the reward-processing system, non-DA systems clearly also modulate reward responsibility [19,735].”

    From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [735]

  • Neural sensitization produces strong impulsive reactions to conditioned cues that signal alcohol or drugs.

    “neural sensitization leads to strong impulsive reactions (e.g., attentional biases and approach tendencies) to classically conditioned cues that signal alcohol or drugs”

    From Addiction, adolescence, and the integration of control and motivation (2011) · cites this paper as Robinson and Berridge, 2003

  • Repeated alcohol and drug use produces two broad types of neuro-adaptations.

    “Current neurobiological research has identified two broad types of neuro-adaptations that result from repeated alcohol and drug use.”

    From Addiction, adolescence, and the integration of control and motivation (2011) · cites this paper as Robinson and Berridge, 2003

  • The human imaging distinction between reward anticipation and reward receipt resembles the anticipatory wanting versus consummatory liking distinction.

    “The distinction between reward anticipation vs. reward receipt in the imaging literature in humans is reminiscent of the anticipatory/”wanting” vs. consummatory/”liking” distinctions drawn by Robinson & Berridge (2003).”

    From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Robinson & Berridge, 2003

  • In laboratory animal studies using sign-tracking to index wanting, adolescents often show less anticipatory responding than adults.

    “In these studies as well, there are clear indications that, at least when using tests of sign-tracking to index “wanting” (Robinson & Berridge, 2003), adolescents frequently exhibit less anticipatory responding than do adults.”

    From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Robinson & Berridge, 2003

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Authors
Robinson, T. E., & Berridge, K. C.
Affiliations
University of Michigan (US)
ORCID
Venue
Annual Review of Psychology
Publisher
Annual Reviews
Published
2003-02
Volume
54
Issue
1
Pages
25-53
ISSN
  • 0066-4308 (ISSN-L)
  • 1545-2085
DOI
10.1146/annurev.psych.54.101601.145237
OpenAlex
W4213265599
Cited by
1,509
References
118
Citations by year
2026: 15 · 2025: 29 · 2024: 35 · 2023: 33 · 2022: 26 · 2021: 36 · 2020: 75 · 2019: 49 · 2018: 58 · 2017: 58 · 2016: 71 · 2015: 59 · 2014: 89 · 2013: 118 · 2012: 81
FWCI
3.99
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Psychology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • National Institute on Drug Abuse
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
addiction, compulsive drug use, withdrawal symptoms, incentive-sensitization theory, incentive salience, stimulus-response learning, impulsivity, decision-making, inhibitory control
MeSH terms
Animals, Brain, Conditioning, Psychological, Decision Making, Humans, Motivation, Neuronal Plasticity, Pleasure-Pain Principle, Illicit Drugs, Substance Withdrawal Syndrome, Substance-Related Disorders

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