The DOI matches its Crossref record; 292 of the 292 references it cites were found in a registry or an index.
Mood Disorders in the Medically Ill: Scientific Review and Recommendations
Abstract
Objective The purpose of this review is to assess the relationship between mood disorders and development, course, and associated morbidity and mortality of selected medical illnesses, review evidence for treatment, and determine needs in clinical practice and research.Data sources Data were culled from the 2002 Depression and Bipolar Support Alliance Conference proceedings and a literature review addressing prevalence, risk factors, diagnosis, and treatment. This review also considered the experience of primary and specialty care providers, policy analysts, and patient advocates. The review and recommendations reflect the expert opinion of the authors.Study selection/data extraction Reviews of epidemiology and mechanistic studies were included, as were open-label and randomized, controlled trials on treatment of depression in patients with medical comorbidities. Data on study design, population, and results were extracted for review of evidence that includes tables of prevalence and pharmacological treatment. The effect of depression and bipolar disorder on selected medical comorbidities was assessed, and recommendations for practice, research, and policy were developed.Conclusions A growing body of evidence suggests that biological mechanisms underlie a bidirectional link between mood disorders and many medical illnesses. In addition, there is evidence to suggest that mood disorders affect the course of medical illnesses. Further prospective studies are warranted.
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“Notably, the causal relationship between medical and psychiatric conditions may well be bidirectional; and their comorbidity adversely impacts quality of life and prognosis and is associated with shortened life expectancy [5].”
From One-day acceptance and commitment training workshops in medical populations (2015) · cites this paper as [5]
In the citing paper
“Notably, the causal relationship between medical and psychiatric conditions may well be bidirectional; and their comorbidity adversely impacts quality of life and prognosis and is associated with shortened life expectancy [5].”
From One-day acceptance and commitment training workshops in medical populations (2015) · cites this paper as [5]
In the citing paper
“Additionally, depression heightens risks for morbidity and mortality from chronic diseases associated with aging, including autoimmune, metabolic, and cardiovascular conditions (2).”
From Clustering of depression and inflammation in adolescents previously exposed to childhood adversity (2012) · cites this paper as [2]
In the citing paper
“The particular medical illnesses that are more frequent in these psychiatric conditions are those that are more commonly seen with advanced age, e.g., cardiovascular disease (CVD), stroke, dementia, cancer, obesity, type II diabetes mellitus, osteoporosis (Evans et al., 2005).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Evans et al., 2005
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Cited by
Sorted by citations
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009
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Metadata
- Authors
- Evans, D. L., Charney, D. S., Lewis, L., Golden, R. N., Gorman, J. M., Krishnan, K. R. R., Nemeroff, C. B., Bremner, J. D., Carney, R. M., Coyne, J. C., Delong, M. R., Frasure-Smith, N., Glassman, A. H., Gold, P. W., Grant, I., Gwyther, L., Ironson, G., Johnson, R. L., Kanner, A. M., Katon, W. J., Kaufmann, P. G., Keefe, F. J., Ketter, T., Laughren, T. P., Leserman, J., Lyketsos, C. G., McDonald, W. M., McEwen, B. S., Miller, A. H., Musselman, D., O’Connor, C., Petitto, J. M., Pollock, B. G., Robinson, R. G., Roose, S. P., Rowland, J., Sheline, Y., Sheps, D. S., Simon, G., Spiegel, D., Stunkard, A., Sunderland, T., Tibbits, P., & Valvo, W. J.
- Affiliations
- University of Pennsylvania (US)
- Washington University in St. Louis (US)
- University of North Carolina at Chapel Hill (US)
- Icahn School of Medicine at Mount Sinai (US)
- Duke University (US)
- Emory University (US)
- Columbia University (US)
- National Institutes of Health (US)
- University of California San Diego (US)
- University of Miami (US)
- Rutgers, The State University of New Jersey (US)
- Rush University Medical Center (US)
- University of Washington (US)
- Stanford University (US)
- United States Food and Drug Administration (US)
- Johns Hopkins University (US)
- Rockefeller University (US)
- University of Florida (US)
- University of Pittsburgh (US)
- University of Iowa (US)
- Group Health Cooperative (US)
- American Diabetes Association (US)
- Corresponding author
- Evans, Dwight L.
- ORCID
- Charney, Dennis S.
- Lewis, Lydia
- Gorman, Jack M.
- Krishnan, K. Ranga Rama
- Nemeroff, Charles B.
- Bremner, J. Douglas
- Carney, Robert M.
- Delong, Mahlon R.
- Gold, Philip W.
- Ironson, Gail
- Johnson, Robert L.
- Kanner, Andres M.
- Keefe, Francis J.
- Ketter, Terence
- Lyketsos, Constantine G.
- McDonald, William M.
- McEwen, Bruce S.
- Miller, Andrew H.
- Pollock, Bruce G.
- Rowland, Julia
- Sheline, Yvette
- Simon, Gregory
- Spiegel, David
- Sunderland, Trey
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 58
- Issue
- 3
- Pages
- 175-189
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2033028677
- Cited by
- 1,071
- References
- 292
- Citations by year
- 2026: 18 · 2025: 25 · 2024: 30 · 2023: 32 · 2022: 36 · 2021: 41 · 2020: 44 · 2019: 37 · 2018: 51 · 2017: 42 · 2016: 62 · 2015: 72 · 2014: 63 · 2013: 71 · 2012: 64
- FWCI
- 36.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- mood disorders, depression, bipolar disorder, comorbidities, morbidity and mortality, prevalence, risk factors, diagnosis, pharmacotherapy, primary care, health policy
- MeSH terms
- Acquired Immunodeficiency Syndrome, Brain Diseases, Cerebrovascular Disorders, Delivery of Health Care, Humans, Neoplasms, Obesity, Osteoporosis, Pain, Comorbidity, Prevalence, Practice Guidelines as Topic, Mood Disorders, Diabetes Complications
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