Cited by 1,071Treatment of Major DepressionBipolar Disorder and TreatmentMental Health Treatment and Access

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Mood Disorders in the Medically Ill: Scientific Review and Recommendations

Evans, Dwight L., Charney, Dennis S., Lewis, Lydia, Golden, Robert N., Gorman, Jack M., Krishnan, K. Ranga Rama, Nemeroff, Charles B., Bremner, J. Douglas, Carney, Robert M., Coyne, James C., Delong, Mahlon R., Frasure-Smith, Nancy, Glassman, Alexander H., Gold, Philip W., Grant, Igor, Gwyther, Lisa, Ironson, Gail, Johnson, Robert L., Kanner, Andres M., Katon, Wayne J., Kaufmann, Peter G., Keefe, Francis J., Ketter, Terence, Laughren, Thomas P., Leserman, Jane, Lyketsos, Constantine G., McDonald, William M., McEwen, Bruce S., Miller, Andrew H., Musselman, Dominique, O’Connor, Christopher, Petitto, John M., Pollock, Bruce G., Robinson, Robert G., Roose, Steven P., Rowland, Julia, Sheline, Yvette, Sheps, David S., Simon, Gregory, Spiegel, David, Stunkard, Albert, Sunderland, Trey, Tibbits, Paul, Valvo, William J.·2005·Biological Psychiatry

DOI 10.1016/j.biopsych.2005.05.001

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Abstract

Objective The purpose of this review is to assess the relationship between mood disorders and development, course, and associated morbidity and mortality of selected medical illnesses, review evidence for treatment, and determine needs in clinical practice and research.Data sources Data were culled from the 2002 Depression and Bipolar Support Alliance Conference proceedings and a literature review addressing prevalence, risk factors, diagnosis, and treatment. This review also considered the experience of primary and specialty care providers, policy analysts, and patient advocates. The review and recommendations reflect the expert opinion of the authors.Study selection/data extraction Reviews of epidemiology and mechanistic studies were included, as were open-label and randomized, controlled trials on treatment of depression in patients with medical comorbidities. Data on study design, population, and results were extracted for review of evidence that includes tables of prevalence and pharmacological treatment. The effect of depression and bipolar disorder on selected medical comorbidities was assessed, and recommendations for practice, research, and policy were developed.Conclusions A growing body of evidence suggests that biological mechanisms underlie a bidirectional link between mood disorders and many medical illnesses. In addition, there is evidence to suggest that mood disorders affect the course of medical illnesses. Further prospective studies are warranted.

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Authors: Evans, D. L., Charney, D. S., Lewis, L., Golden, R. N., Gorman, J. M., Krishnan, K. R. R., Nemeroff, C. B., Bremner, J. D., Carney, R. M., Coyne, J. C., Delong, M. R., Frasure-Smith, N., Glassman, A. H., Gold, P. W., Grant, I., Gwyther, L., Ironson, G., Johnson, R. L., Kanner, A. M., Katon, W. J., Kaufmann, P. G., Keefe, F. J., Ketter, T., Laughren, T. P., Leserman, J., Lyketsos, C. G., McDonald, W. M., McEwen, B. S., Miller, A. H., Musselman, D., O’Connor, C., Petitto, J. M., Pollock, B. G., Robinson, R. G., Roose, S. P., Rowland, J., Sheline, Y., Sheps, D. S., Simon, G., Spiegel, D., Stunkard, A., Sunderland, T., Tibbits, P., & Valvo, W. J.
Affiliations: University of Pennsylvania (US)
Washington University in St. Louis (US)
University of North Carolina at Chapel Hill (US)
Icahn School of Medicine at Mount Sinai (US)
Duke University (US)
Emory University (US)
Columbia University (US)
National Institutes of Health (US)
University of California San Diego (US)
University of Miami (US)
Rutgers, The State University of New Jersey (US)
Rush University Medical Center (US)
University of Washington (US)
Stanford University (US)
United States Food and Drug Administration (US)
Johns Hopkins University (US)
Rockefeller University (US)
University of Florida (US)
University of Pittsburgh (US)
University of Iowa (US)
Group Health Cooperative (US)
American Diabetes Association (US)
Corresponding author: Evans, Dwight L.
ORCID: Charney, Dennis S.
Lewis, Lydia
Gorman, Jack M.
Krishnan, K. Ranga Rama
Nemeroff, Charles B.
Bremner, J. Douglas
Carney, Robert M.
Delong, Mahlon R.
Gold, Philip W.
Ironson, Gail
Johnson, Robert L.
Kanner, Andres M.
Keefe, Francis J.
Ketter, Terence
Lyketsos, Constantine G.
McDonald, William M.
McEwen, Bruce S.
Miller, Andrew H.
Pollock, Bruce G.
Rowland, Julia
Sheline, Yvette
Simon, Gregory
Spiegel, David
Sunderland, Trey
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2005-08
Volume: 58
Issue: 3
Pages: 175-189
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2005.05.001
OpenAlex: W2033028677
Cited by: 1,071
References: 292
Citations by year: 2026: 18 · 2025: 25 · 2024: 30 · 2023: 32 · 2022: 36 · 2021: 41 · 2020: 44 · 2019: 37 · 2018: 51 · 2017: 42 · 2016: 62 · 2015: 72 · 2014: 63 · 2013: 71 · 2012: 64
FWCI: 36.71
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords: mood disorders, depression, bipolar disorder, comorbidities, morbidity and mortality, prevalence, risk factors, diagnosis, pharmacotherapy, primary care, health policy
MeSH terms: Acquired Immunodeficiency Syndrome, Brain Diseases, Cerebrovascular Disorders, Delivery of Health Care, Humans, Neoplasms, Obesity, Osteoporosis, Pain, Comorbidity, Prevalence, Practice Guidelines as Topic, Mood Disorders, Diabetes Complications

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Mood Disorders in the Medically Ill: Scientific Review and Recommendations

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