Cited by 96Suicide and Self-Harm StudiesNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

Higher Postmortem Prefrontal 5-HT2A Receptor Binding Correlates with Lifetime Aggression in Suicide

Oquendo, Maria A., Russo, Stefani A., Underwood, Mark D., Kassir, Suham A., Ellis, Steven P., Mann, J. John, Arango, Victoria·2006·Biological Psychiatry

Abstract

Background In vivo studies find altered serotonin function associated with aggressive and suicidal behaviors. Postmortem studies also reveal serotonergic alterations in suicide subjects but have not reported on the relationship between aggression and the serotonin system. We measured 5-hydroxytryptamine 2A (5-HT(2A)) receptor binding in prefrontal cortex of suicide and nonsuicide subjects and explored the relationship between 5-HT(2A) receptor binding, lifetime aggression, and suicide.Methods The 5-HT(2A) receptor binding in coronal sections of prefrontal cortex was quantified by autoradiography with [(3)H] ketanserin in 37 suicide subjects and 73 nonsuicide subjects. The relationship between [(3)H] ketanserin binding and lifetime aggression, rated on the Brown-Goodwin Aggression History Scale, was assessed controlling for age and sex.Results In suicide subjects, lifetime aggression scores correlated positively with [(3)H] ketanserin binding in all prefrontal Brodmann areas examined, after adjusting for age and sex. This was not the case in nonsuicide subjects. We found no significant differences in aggression scores or [(3)H] ketanserin binding between the suicide subjects and nonsuicide subjects.Conclusions The relationship between aggression and 5-HT(2A) receptor binding in suicide subjects, but not in nonsuicide subjects, may reflect differences in the regulation of the 5-HT(2A) receptor related to suicidal behavior and perhaps other proaggressive changes in brains of suicide subjects.

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Crossref · 10.1016/j.biopsych.2005.06.037

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  • Up-regulated postsynaptic cortical serotonin 2A receptors correlate with lifetime aggression severity.

    “Other studies report up-regulated postsynaptic cortical serotonin 2A receptors that correlate with lifetime aggression severity (114).”

    From A brain-centric model of suicidal behavior (2020) · cites this paper as [114]

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Authors
Oquendo, M. A., Russo, S. A., Underwood, M. D., Kassir, S. A., Ellis, S. P., Mann, J. J., & Arango, V.
Affiliations
New York State Psychiatric Institute (US)
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2006-02
Volume
59
Issue
3
Pages
235-243
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2068475798
Cited by
96
References
50
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 7
FWCI
5.78
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (AA11293, R01AA011293, AA09004, R01AA009004)
  • National Institute of Mental Health (MH 62185, MH-40210, R01MH040210, P50MH062185)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
suicide, 5-HT2A receptor, serotonin, prefrontal cortex, postmortem brain, ketanserin binding, aggression, serotonergic system
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Aggression, Major Depressive Disorder, Female, Humans, Ketanserin, Male, Middle Aged, Radioligand Assay, Statistics as Topic, Suicide, Prefrontal Cortex, Receptor, Serotonin, 5-HT2A

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