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Cited by 288Alzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

The DOI matches its Crossref record; 91 of the 93 references it cites were found in a registry or an index.

Cognitive and Physical Activity Differently Modulate Disease Progression in the Amyloid Precursor Protein (APP)-23 Model of Alzheimer’s Disease

Wolf, Susanne A., Kronenberg, Golo, Lehmann, Kathrin, Blankenship, Aaron, Overall, Rupert, Staufenbiel, Matthias, Kempermann, Gerd·2006·Biological Psychiatry
DOI 10.1016/j.biopsych.2006.04.004
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Abstract

Background In aging mice, activity maintains hippocampal plasticity and adult hippocampal neurogenesis at a level corresponding to a younger age. Here we studied whether physical exercise and environmental enrichment would also affect brain plasticity in a mouse model of Alzheimer's disease (AD). Methods Amyloid precursor protein (APP)-23 mice were housed under standard or enriched conditions or in cages equipped with a running wheel. We assessed beta-amyloid plaque load, adult hippocampal neurogenesis, spatial learning, and mRNA levels of trophic factors in the brain. Results Despite stable beta-amyloid plaque load, enriched-living mice showed improved water maze performance, an up-regulation of hippocampal neurotrophin (NT-3) and brain-derived neurotrophic factor (BDNF) and increased hippocampal neurogenesis. In contrast, despite increased bodily fitness, wheel-running APP23 mice showed no change in spatial learning and no change in adult hippocampal neurogenesis but a down-regulation of hippocampal and cortical growth factors. Conclusions We conclude that structural and molecular prerequisites for activity-dependent plasticity are preserved in mutant mice with an AD-like pathology. Our study might help explain benefits of activity for the aging brain but also demonstrates differences between physical and more cognitive activity. It also suggests a possible cellular correlate for the dissociation between structural and functional pathology often found in AD.

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Metadata

Authors
Wolf, S. A., Kronenberg, G., Lehmann, K., Blankenship, A., Overall, R., Staufenbiel, M., & Kempermann, G.
Affiliations
  • Max Delbrück Center (DE)
  • Novartis (Switzerland) (CH)
Corresponding author
Kempermann, Gerd
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2006-12
Volume
60
Issue
12
Pages
1314-1323
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2006.04.004
OpenAlex
W2020895118
Cited by
288
References
93
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 14 · 2019: 13 · 2018: 19 · 2017: 19 · 2016: 14 · 2015: 15 · 2014: 9 · 2013: 22 · 2012: 17
FWCI
13.07
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
Alzheimer's disease, APP23 mice, physical activity, wheel running, environmental enrichment, adult hippocampal neurogenesis, hippocampal plasticity, amyloid plaques, spatial learning, brain-derived neurotrophic factor, neurotrophin-3, growth factors, cognitive activity, brain aging
MeSH terms
Alzheimer Disease, Animals, Brain, Cell Count, Cerebral Cortex, Cognition, Environment, Female, Hippocampus, Insulin-Like Growth Factor I, Mice, Transgenic, Motor Activity, RNA, Messenger, Fibroblast Growth Factor 2, Amyloid beta-Protein Precursor, Disease Progression, Maze Learning, Brain-Derived Neurotrophic Factor, Reverse Transcriptase Polymerase Chain Reaction, Nerve Growth Factor, Neurotrophin 3, Vascular Endothelial Growth Factor A, Mice

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