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Cognitive and Physical Activity Differently Modulate Disease Progression in the Amyloid Precursor Protein (APP)-23 Model of Alzheimer’s Disease
Abstract
Background In aging mice, activity maintains hippocampal plasticity and adult hippocampal neurogenesis at a level corresponding to a younger age. Here we studied whether physical exercise and environmental enrichment would also affect brain plasticity in a mouse model of Alzheimer's disease (AD). Methods Amyloid precursor protein (APP)-23 mice were housed under standard or enriched conditions or in cages equipped with a running wheel. We assessed beta-amyloid plaque load, adult hippocampal neurogenesis, spatial learning, and mRNA levels of trophic factors in the brain. Results Despite stable beta-amyloid plaque load, enriched-living mice showed improved water maze performance, an up-regulation of hippocampal neurotrophin (NT-3) and brain-derived neurotrophic factor (BDNF) and increased hippocampal neurogenesis. In contrast, despite increased bodily fitness, wheel-running APP23 mice showed no change in spatial learning and no change in adult hippocampal neurogenesis but a down-regulation of hippocampal and cortical growth factors. Conclusions We conclude that structural and molecular prerequisites for activity-dependent plasticity are preserved in mutant mice with an AD-like pathology. Our study might help explain benefits of activity for the aging brain but also demonstrates differences between physical and more cognitive activity. It also suggests a possible cellular correlate for the dissociation between structural and functional pathology often found in AD.
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“although the extant literature provides some clues concerning the molecular and cellular pathways that support the interactive effects of different factors, much remains to be discovered in further research on multimodal interventions”
From Enrichment Effects on Adult Cognitive Development: Can the Functional Capacity of Older Adults Be Preserved and Enhanced? (2008) · cites this paper as Wolf et al., 2006
Citations
Cites
Primer3 on the WWW for General Users and for Biologist Programmers
Rozen, S., & Skaletsky, H. (2003) · Humana Press eBooks · doi:10.1385/1-59259-192-2:365 · Cited by 15,068
Developments of a water-maze procedure for studying spatial learning in the rat
Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Self-citationMore hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,586
Self-citationLearning enhances adult neurogenesis in the hippocampal formation
Gould, E., Beylin, A., Tanapat, P., Reeves, A., & Shors, T. J. (1999) · Nature Neuroscience · doi:10.1038/6365 · Cited by 2,157
An active and socially integrated lifestyle in late life might protect against dementia
Fratiglioni, L., Paillard-Borg, S., & Winblad, B. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00767-7 · Cited by 2,135
Exercise enhances learning and hippocampal neurogenesis in aged mice
van Praag, H., Shubert, T., Zhao, C., & Gage, F. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-05.2005 · Cited by 2,078
Cardiovascular fitness, cortical plasticity, and aging
Colcombe, S. J., Kramer, A. F., Erickson, K. I., Scalf, P., McAuley, E., Cohen, N. J., Webb, A., Jerome, G. J., Marquez, D. X., & Elavsky, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400266101 · Cited by 1,648
Transient expression of doublecortin during adult neurogenesis
Brown, J. P., Couillard‐Després, S., Cooper‐Kuhn, C. M., Winkler, J., Aigner, L., & Kuhn, H. G. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10874 · Cited by 1,540
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507
Self-citationMilestones of neuronal development in the adult hippocampus
Kempermann, G., Jessberger, S., Steiner, B., & Kronenberg, G. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.05.013 · Cited by 1,460
Self-citationParticipation in Cognitively Stimulating Activities and Risk of Incident Alzheimer Disease
Wilson, R. S. (2002) · JAMA · doi:10.1001/jama.287.6.742 · Cited by 1,352
Education and the prevalence of dementia and Alzheimer's disease
Katzman, R. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.13 · Cited by 1,186
Experience-Induced Neurogenesis in the Senescent Dentate Gyrus
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03206.1998 · Cited by 1,150
Self-citationExercise and brain neurotrophins
Neeper, S. A., Góauctemez-Pinilla, F., Choi, J., & Cotman, C. (1995) · Nature · doi:10.1038/373109a0 · Cited by 1,066
Borchelt, D. R., Ratovitski, T., van Lare, J., Lee, M. K., Gonzales, V., Jenkins, N. A., Copeland, N. G., Price, D. L., & Sisodia, S. S. (1997) · Neuron · doi:10.1016/s0896-6273(00)80974-5 · Cited by 1,023
Trejo, J. L., Carro, E., & Torres-Alemán, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01628.2001 · Cited by 1,017
Doublecortin expression levels in adult brain reflect neurogenesis
Couillard‐Després, S., Winner, B., Schaubeck, S., Aigner, R., Vroemen, M., Weidner, N., Bogdahn, U., Winkler, J., Kuhn, H. G., & Aigner, L. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03813.x · Cited by 990
Increased hippocampal neurogenesis in Alzheimer's disease
Jin, K., Peel, A. L., Mao, X. O., Xie, L., Cottrell, B. A., Henshall, D. C., & Greenberg, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2634794100 · Cited by 971
Kempermann, G., Gast, D., & Gage, F. H. (2002) · Annals of Neurology · doi:10.1002/ana.10262 · Cited by 889
Self-citationEnvironmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
Lazarov, O., Robinson, J., Tang, Y.-P., Hairston, I. S., Korade-Mirnics, Z., Lee, V. M.-Y., Hersh, L. B., Sapolsky, R. M., Mirnics, K., & Sisodia, S. S. (2005) · Cell · doi:10.1016/j.cell.2005.01.015 · Cited by 885
VEGF is necessary for exercise‐induced adult hippocampal neurogenesis
Fabel, K., Fabel, K., Tam, B., Kaufer, D., Baiker, A., Simmons, N., Kuo, C. J., & Palmer, T. D. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03041.x · Cited by 861
VEGF links hippocampal activity with neurogenesis, learning and memory
Cao, L., Jiao, X., Zuzga, D. S., Liu, Y., Fong, D. M., Young, D., & During, M. J. (2004) · Nature Genetics · doi:10.1038/ng1395 · Cited by 850
Farmer, J., Zhao, X., van Praag, H., Wodtke, K., Gage, F. H., & Christie, B. R. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.09.029 · Cited by 836
Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease
Adlard, P. A., Perreau, V. M., Pop, V., & Cotman, C. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0496-05.2005 · Cited by 829
Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective
Young, D., Lawlor, P. A., Leone, P., Dragunow, M., & During, M. J. (1999) · Nature Medicine · doi:10.1038/7449 · Cited by 745
Snowdon, D. A. (1996) · JAMA · doi:10.1001/jama.1996.03530310034029 · Cited by 696
Rao, M. S. R., & Shetty, A. K. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2003.03123.x · Cited by 665
Kronenberg, G., Reuter, K., Steiner, B., Brandt, M. D., Jessberger, S., Yamaguchi, M., & Kempermann, G. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10945 · Cited by 640
Self-citationCarro, E., Trejo, J. L., Busiguina, S., & Torres-Aleman, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05678.2001 · Cited by 601
Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat Brain
Ickes, B. R., Pham, T. M., Sanders, L., Albeck, D. S., Mohammed, A. H. S., & Granholm, A. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7415 · Cited by 541
Benraiss, A., Chmielnicki, E., Lerner, K., Roh, D., & Goldman, S. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06718.2001 · Cited by 540
Brandt, M., Jessberger, S., Steiner, B., Kronenberg, G., Reuter, K., Bick‐Sander, A., von der Behrens, W., & Kempermann, G. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00207-0 · Cited by 510
Self-citationNeuron loss in APP transgenic mice
Calhoun, M. E., Wiederhold, K.-H., Abramowski, D., Phinney, A. L., Probst, A., Sturchler-Pierrat, C., Staufenbiel, M., Sommer, B., & Jucker, M. (1998) · Nature · doi:10.1038/27351 · Cited by 502
Self-citationGriesbach, G. S., Hovda, D. A., Molteni, R., Wu, A., & Gómez‐Pinilla, F. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.01.030 · Cited by 488
Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus
Kronenberg, G., Bick-Sander, A., Bunk, E., Wolf, C., Ehninger, D., & Kempermann, G. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.016 · Cited by 477
Self-citationHaughey, N. J., Nath, A., Chan, S. L., Borchard, A. C., Rao, M. S., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01267.x · Cited by 466
Friedland, R. P., Fritsch, T., Smyth, K. A., Koss, E., Lerner, A. J., Chen, C. H., Petot, G. J., & Debanne, S. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061002998 · Cited by 445
Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APP Sw,Ind ) mice
Jin, K., Galván, V., Xie, L., Mao, X. O., Gorostiza, O. F., Bredesen, D. E., & Greenberg, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403678101 · Cited by 444
Lichtenwalner, R. J., Forbes, M. E., Bennett, S. A., Lynch, C. D., Sonntag, W. E., & Riddle, D. R. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00378-5 · Cited by 428
Caillé, I., Allinquant, B., Dupont, E., Bouillot, C., Langer, A., Müller, U., & Prochiantz, A. (2004) · Development · doi:10.1242/dev.01103 · Cited by 422
Letenneur, L., Gilleron, V, Commenges, D., Helmer, C., Orgogozo, J. M., & Dartigues, J. F. (1999) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.66.2.177 · Cited by 406
ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models
Price, D. L., Tanzi, R. E., Borchelt, D. R., & Sisodia, S. S. (1998) · Annual Review of Genetics · doi:10.1146/annurev.genet.32.1.461 · Cited by 406
Falkenberg, T., Mohammed, A. K., Henriksson, B. G., Persson, H., Winblad, B. G., & Lindefors, N. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90494-r · Cited by 388
Schänzer, A., Wachs, F., Wilhelm, D., Acker, T., Cooper‐Kuhn, C. M., Beck, H., Winkler, J., Aigner, L., Plate, K. H., & Kuhn, H. G. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00060.x · Cited by 379
(1994) · Choice Reviews Online · doi:10.5860/choice.31-2688 · Cited by 372
Differential regulation of gliogenesis in the context of adult hippocampal neurogenesis in mice
Steiner, B., Kronenberg, G., Jessberger, S., Brandt, M., Reuter, K., & Kempermann, G. (2004) · Glia · doi:10.1002/glia.10337 · Cited by 337
Self-citationEhninger, D. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.8.845 · Cited by 321
Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic mice
Wang, J., Tanila, H., Puoliväli, J., Kadish, I., & Groen, T. V. (2003) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.08.009 · Cited by 316
Seizures induce proliferation and dispersion of doublecortin-positive hippocampal progenitor cells
Jessberger, S., Römer, B., Babu, H., & Kempermann, G. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.08.010 · Cited by 305
Self-citationAge‐dependent cognitive decline in the APP23 model precedes amyloid deposition
Dam, D. V., D’Hooge, R., Staufenbiel, M., Ginneken, C. J. V., Meir, F. V., & Deyn, P. P. D. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02444.x · Cited by 300
Self-citationPhysical exercise induces FGF-2 and its mRNA in the hippocampus
Gómez‐Pinilla, F., Dao, L., & So, V. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00375-2 · Cited by 292
What provides cerebral reserve?
Staff, R. T., Murray, A. D., Deary, I. J., & Whalley, L. J. (2004) · Brain · doi:10.1093/brain/awh144 · Cited by 285
Döbrössy, M. D., Drapeau, E., Aurousseau, C., Moal, M. L., Piazza, P. V., & Abrous, D. N. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001419 · Cited by 266
Pham, T. M., Ickes, B. R., Albeck, D. S., Söderström, S., Granholm, A.-C., & Mohammed, A. H. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00316-4 · Cited by 265
Carro, E., & Torres‐Alemán, I. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.050 · Cited by 262
The exercise-induced expression of BDNF within the hippocampus varies across life-span
Adlard, P. A., Perreau, V. M., & Cotman, C. W. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.05.006 · Cited by 260
Effects of Stress on Neurotrophic Factor Expression in the Rat Brain
SMITH, M. A., Makino, S., Květňanský, R., & Post, R. M. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44684.x · Cited by 258
Jankowsky, J. L., Xu, G. M., Fromholt, D., Gonzales, V., & Borchelt, D. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.12.1220 · Cited by 238
Arendash, G. W., Garcia, M. F., Costa, D. A., Cracchiolo, J. R., Wefes, I., & Potter, H. (2004) · Neuroreport · doi:10.1097/01.wnr.0000137183.68847.4e · Cited by 237
Neurocognitive aging and cardiovascular fitness: recent findings and future directions
Colcombe, S. J., Kramer, A. F., McAuley, E., Erickson, K. I., & Scalf, P. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:24:1:009 · Cited by 214
Bondolfi, L., Calhoun, M., Ermini, F., Kuhn, H. G., Wiederhold, K.-H., Walker, L., Staufenbiel, M., & Jucker, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00515.2002 · Cited by 213
Self-citationWang, R., Dineley, K. T., Sweatt, J. D., & Zheng, H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.03.048 · Cited by 207
Haughey, N. J., Liu, D., Nath, A., Borchard, A. C., & Mattson, M. P. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:1:2:125 · Cited by 203
Exercise Level and Cognitive Decline: The MoVIES Project
Lytle, M. E., Vander Bilt, J., Pandav, R. S., Dodge, H. H., & Ganguli, M. (2004) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000126614.87955.79 · Cited by 200
Progressive age-related impairment of cognitive behavior in APP23 transgenic mice
Kelly, P. H., Bondolfi, L., Hunziker, D., Schlecht, H. P., Carver, K., Maguire, E., Abramowski, D., Wiederhold, K., Sturchler, C., Jucker, M., et al. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00098-2 · Cited by 196
Self-citationWen, P. H., Hof, P. R., Chen, X., Gluck, K., Austin, G., Younkin, S. G., Younkin, L. H., DeGasperi, R., Sosa, M. A. G., Robakis, N. K. R. K., et al. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.04.002 · Cited by 193
Early-life risk factors and the development of Alzheimer’s disease
Moceri, V. M., Kukull, W. A., Emanuel, I., van Belle, G., & Larson, E. B. (2000) · Neurology · doi:10.1212/wnl.54.2.415 · Cited by 185
Torasdotter, M., METSIS, M. L., Henriksson, B. G., Winblad, B. G., & Mohammed, A. H. S. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00142-3 · Cited by 182
Yang, S., Bae, D., Kang, H. J., Gwag, B. J., Gho, Y. S., & Chae, C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00111-8 · Cited by 178
Will, B. E., Rosenzweig, M. R., Bennett, E. L., Hébert, M., & Morimoto, H. (1977) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077306 · Cited by 165
An autopsy-verified study of the effect of education on degenerative dementia
del Ser, T., Hachinski, V., Merskey, H., & Muñoz, D. G. (1999) · Brain · doi:10.1093/brain/122.12.2309 · Cited by 165
Pham, T. M., Söderström, S., Winblad, B., & Mohammed, A. H. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00019-4 · Cited by 162
Problems in the study of rodent aggression
Blanchard, R. J., Wall, P. M., & Blanchard, D. C. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(03)00127-2 · Cited by 160
THE GENETICS AND MOLECULAR PATHOLOGY OF ALZHEIMER'S DISEASE
Selkoe, D. J. (2000) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70232-2 · Cited by 146
Lalonde, R., Dumont, M., Staufenbiel, M., Sturchler, C., & Strazielle, C. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03476-5 · Cited by 135
Self-citationBrain reserve and the clinical expression of Alzheimer's disease.
Mortimer, J. A. (1997) · PubMed · Cited by 133
Larsson, E., Nanobashvili, A., Kokaia, Z., & Lindvall, O. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199911000-00006 · Cited by 127
Ehninger, D., & Kempermann, G. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00129.x · Cited by 111
Self-citationNiikura, T., Hashimoto, Y., Okamoto, T., Abe, Y., Yasukawa, T., Kawasumi, M., Hiraki, T., Kita, Y. A., Terashita, K., Kouyama, K., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01902.2001 · Cited by 76
Teather, L. A., Magnusson, J. E., Chow, C. M., & Wurtman, R. J. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02416.x · Cited by 60
Krucker, T., Schuler, A., Meyer, E. P., Staufenbiel, M., & Beckmann, N. (2004) · Neurological Research · doi:10.1179/016164104225016281 · Cited by 58
Self-citationTransgenic mouse models of neurodegenerative disease: Opportunities for therapeutic development
Jankowsky, J. L., Savonenko, A. V., Schilling, G., Wang, J., Xu, G. M., & Borchelt, D. (2002) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-002-0073-7 · Cited by 57
Dumont, M., Strazielle, C., Staufenbiel, M., & Lalonde, R. (2004) · Brain Research · doi:10.1016/j.brainres.2004.07.052 · Cited by 55
Self-citationNormal brain development in PS1 hypomorphic mice with markedly reduced γ-secretase cleavage of βAPP
Rozmahel, R. F., Huang, J., Chen, F., Liang, Y., Nguyen, V., Ikeda, M., Lévesque, G., Yu, G., Nishimura, M., Mathews, P. M., et al. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00267-6 · Cited by 49
Aguado‐Llera, D., Arilla, E., Campos‐Barros, Á., Puebla‐Jiménez, L., & Barrios, V. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02889.x · Cited by 47
Solerte, S. B., Ferrari, E., Cuzzoni, G., Locatelli, E., Giustina, A., Zamboni, M. M., Schifino, N., Rondanelli, M., Gazzaruso, C., & Fioravanti, M. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000080963 · Cited by 41
Actions and interactions of the IGF system in Alzheimer’s disease: review and hypotheses
Lackey, B. R., Gray, S. L., & Henricks, D. M. (2000) · Growth Hormone & IGF Research · doi:10.1054/ghir.1999.0129 · Cited by 37
Clinical Trials in Alzheimer Disease: Debate on the Use of Placebo Controls
Kawas, C. H., Clark, C. M., Farlow, M. R., Knopman, D. S., Marson, D. C., Morris, J. C., Thai, L. J., & Whitehouse, P. J. (1999) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199907000-00002 · Cited by 36
Zubenko, G. S., Stiffler, J. S., Hughes, H. B., Hurtt, M. R., & Kaplan, B. B. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980207)81:1 · Cited by 29
Controlling neural stem cell division within the adult subventricular zone: an APPealing job
Conti, L., & Cattaneo, E. F. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.11.005 · Cited by 25
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Hertzog, C., Kramer, A. F., Wilson, R. S., & Lindenberger, U. (2008) · Psychological Science in the Public Interest · doi:10.1111/j.1539-6053.2009.01034.x · Cited by 1,495
Miranda, M., Morici, J. F., Zanoni, M. B., & Bekinschtein, P. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00363 · Cited by 1,416
Alzheimer’s Disease: The Challenge of the Second Century
Holtzman, D. M., Morris, J. C., & Goate, A. M. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002369 · Cited by 1,424
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Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
Bezprozvanny, I., & Mattson, M. P. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.005 · Cited by 938
Metadata
- Authors
- Wolf, S. A., Kronenberg, G., Lehmann, K., Blankenship, A., Overall, R., Staufenbiel, M., & Kempermann, G.
- Affiliations
- Max Delbrück Center (DE)
- Novartis (Switzerland) (CH)
- Corresponding author
- Kempermann, Gerd
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 60
- Issue
- 12
- Pages
- 1314-1323
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2020895118
- Cited by
- 288
- References
- 93
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 14 · 2019: 13 · 2018: 19 · 2017: 19 · 2016: 14 · 2015: 15 · 2014: 9 · 2013: 22 · 2012: 17
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Alzheimer's disease, APP23 mice, physical activity, wheel running, environmental enrichment, adult hippocampal neurogenesis, hippocampal plasticity, amyloid plaques, spatial learning, brain-derived neurotrophic factor, neurotrophin-3, growth factors, cognitive activity, brain aging
- MeSH terms
- Alzheimer Disease, Animals, Brain, Cell Count, Cerebral Cortex, Cognition, Environment, Female, Hippocampus, Insulin-Like Growth Factor I, Mice, Transgenic, Motor Activity, RNA, Messenger, Fibroblast Growth Factor 2, Amyloid beta-Protein Precursor, Disease Progression, Maze Learning, Brain-Derived Neurotrophic Factor, Reverse Transcriptase Polymerase Chain Reaction, Nerve Growth Factor, Neurotrophin 3, Vascular Endothelial Growth Factor A, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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