The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Meta-Analysis of the Cognitive Effects of the Catechol-O-Methyltransferase Gene Val158/108Met Polymorphism
Abstract
Background Cognitive endophenotypes may further our understanding of the genetic basis of psychiatric disorders, and the catechol-O-methyltransferase (COMT) gene is a promising candidate gene for both cognitive function and disorder. We conducted a meta-analysis of reported associations between the COMT Val158/108Met polymorphism and measures of memory and executive function.Methods The PubMed database was searched for studies relating cognitive functions and the COMT Val158/108Met polymorphism. This enabled meta-analyses of six cognitive phenotypes (Trail Making task, verbal recall, verbal fluency, IQ score, n-back task, and Wisconsin Card Sorting Test). Data were extracted by two reviewers and included cognitive scores by COMT genotype, publication year, diagnostic status, ancestry, proportion of male participants, and whether genotype frequencies were consistent with Hardy-Weinberg equilibrium.Results We found no association between COMT genotype and the majority of phenotypes. There was evidence of association with IQ score (d = .06), which did not differ significantly by ancestry, sex, average sample age, or patient status. For the n-back task, there was no robust evidence for genetic association, but the effect size was significantly larger in patient (d = .40) than nonpatient (d = -.27) populations, larger in both samples with fewer male subjects, and those of greater average age. There was also evidence of publication bias and decreasing effect sizes with later publication.Conclusions Despite initially promising results, the COMT Val158/108Met polymorphism appears to have little if any association with cognitive function. Publication bias may hamper attempts to understand the genetic basis of psychological functions and psychiatric disorders.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Better working memory (WM) performance (e.g. in N-back tasks), fewer perseverative errors, and higher IQ tend to be associated with the Met allele in healthy individuals (9-11), although some studies have failed to replicate these effects (see 10).”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [10]
In the citing paper
“Better working memory (WM) performance (e.g. in N-back tasks), fewer perseverative errors, and higher IQ tend to be associated with the Met allele in healthy individuals (9-11), although some studies have failed to replicate these effects (see 10).”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [10]
In the citing paper
“Better working memory (WM) performance (e.g. in N-back tasks), fewer perseverative errors, and higher IQ tend to be associated with the Met allele in healthy individuals (9-11), although some studies have failed to replicate these effects (see 10).”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [10]
Citations
Cites
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615
J Neuropsychiatry Clin Neurosci
Yudofsky, S. C., & Hales, R. E. (1992) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.4.4.359 · Cited by 3,818
Publication bias in clinical research
Easterbrook, P. J., Gopalan, R., Berlin, J. A., & Matthews, D. R. (1991) · The Lancet · doi:10.1016/0140-6736(91)90201-y · Cited by 3,109
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,416
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020
Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Kolachana, B. S., Hyde, T. M., Herman, M. M., Apud, J., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/425589 · Cited by 1,675
Structural magnetic resonance imaging of the adolescent brain
GIEDD, J. N. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1308.009 · Cited by 1,610
Structural and functional brain development and its relation to cognitive development
Casey, B. J., Giedd, J. N., & Thomas, K. M. (2000) · Biological Psychology · doi:10.1016/s0301-0511(00)00058-2 · Cited by 1,506
In vivo evidence for post-adolescent brain maturation in frontal and striatal regions
Sowell, E. R., Thompson, P. M., Holmes, C. J., Jernigan, T. L., & Toga, A. W. (1999) · Nature Neuroscience · doi:10.1038/13154 · Cited by 1,439
Cited by
Sorted by citations
Items 301–400 of 411
Mental Function as Genetic Expression: Emerging Insights From Cognitive Neurogenetics
Green, A. E., & Dunbar, K. N. (2012) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780199734689.013.0007 · Cited by 5
Juárez‐Cedillo, T., González–Figueroa, E., Martínez‐Rodríguez, N., Fragosos, J. M., Garrido-Acosta, O., & Vargas‐Alarcón, G. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00740-5 · Cited by 4
Sanwald, S., Montag, C., & Kiefer, M. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02019-5 · Cited by 4
Liu, D., Schwieter, J. W., Liu, W., Mu, L., & Liu, H. (2022) · Cognitive Neurodynamics · doi:10.1007/s11571-022-09867-2 · Cited by 4
Schizophrénie, génétique et cognition
Belzeaux-R, R., Ibrahim, E. C., Fakra, É., Adida, M., Cermolacce, M., & Azorin, J. (2011) · L Encéphale · doi:10.1016/s0013-7006(11)70039-2 · Cited by 4
Functional Gene Group Analysis Indicates No Role for Heterotrimeric G Proteins in Cognitive Ability
Hill, W. D., de Leeuw, C., Davies, G., Liewald, D. C. M., Payton, A., Craig, L. C. A., Whalley, L. J., Horan, M. A., Ollier, W., Starr, J. M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091690 · Cited by 4
López-García, P., Young, L., Marín, J., Molero, P., & Ortuño, F. (2015) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2015.10.002 · Cited by 3
COMT Val158Met Polymorphism Is Associated with Verbal Working Memory in Neurofibromatosis Type 1
Costa, D. D. S., de Paula, J. J., Alvim-Soares, A., Pereira, P. A., Malloy‐Diniz, L. F., Rodrigues, L. O. C., Romano‐Silva, M. A., & de Miranda, D. M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00334 · Cited by 3
El‐Hage, W., Cléry, H., Andersson, F., Filipiak, I., de Schotten, M. T., Gohier, B., & Surguladze, S. (2017) · Brain and Behavior · doi:10.1002/brb3.786 · Cited by 3
Personality Traits and Mental Disorders
Hakulinen, C. A., Jokela, M. M., Mika Kivimaki, B., & Elovainio, M. J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.018 · Cited by 4
Anxiety, Depression and Cognitive Dysfunction
Eysenck, M. W., & Holmes, A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.033 · Cited by 3
Salgado, J. F., Anderson, N. R., & Moscoso, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.040 · Cited by 4
Apa, Z. L., Gilsoul, J., Dideberg, V., & Collette, F. (2024) · PLoS ONE · doi:10.1371/journal.pone.0303343 · Cited by 3
Niarchou, M., Zammit, S., Escott‐Price, V., Owen, M. J., & van den Bree, M. B. M. (2014) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32245 · Cited by 3
Devrimci-Özgüven, H., Alıcı, Y. H., Öz, M. D., Suzen, H. S., Kale, E. H., & Başkak, B. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135310 · Cited by 3
Models of Personality Structure
Raad, B. D., & Barelds, D. P. H. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.012 · Cited by 4
Cognitive Processes and Models
Matthews, G. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.028 · Cited by 5
Basic Needs, Goals and Motivation
Szalma, J. L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.030 · Cited by 3
Personality in Cross-Cultural Perspective
Dragūns, J. G., & Tanaka‐Matsumi, J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.037 · Cited by 4
Conceptual issues and empirical challenges in the disruptive behavior disorders
Hill, J., & Maughan, B. (2015) · Wiley eBooks · doi:10.1002/9781118381953.ch4 · Cited by 3
Plichta, M. M. (2009) · Online Publication Service of Würzburg University (Würzburg University) · Cited by 3
Interaction between Genotype and Environment: A Tale of Two Concepts
Mayo, O. (2011) · Transactions of the Royal Society of South Australia · doi:10.1080/03721426.2011.10887151 · Cited by 2
Gene polymorphisms associated with temperament in Merino sheep
Qiu, X. (2015) · Cited by 2
Narrative Identity in the Social World
McLean, K. C., Syed, M., Haraldsson, K. G., & Lowe, L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.035 · Cited by 2
Lynam, D. R., Vize, C. E., & Miller, J. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.043 · Cited by 2
Jayawickreme, E., & Zachry, C. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.032 · Cited by 2
Does COMT Play a Role in Parkinson's Disease Susceptibility across Diverse Ancestral Populations?
Martín‐Bórnez, M., Shar, N. A., Nour, M. A., Murphy, D. P., Elsayed, I., Nanjundaswamy, M. S., Nwaokorie, F. O., Olusanya, A. W., Kuznetsov, N., Bandrés‐Ciga, S., et al. (2025) · Movement Disorders · doi:10.1002/mds.70040 · Cited by 2
Kaczorowski, J. A. (2012) · NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro) · Cited by 2
Alazizi, A. (2011) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 2
Intermediate Phenotype Approach for Neuropsychiatric Disorders
Ohi, K., Hashimoto, R., Yamamori, H., Yasuda, Y., Fujimoto, M., Umeda‐Yano, S., & Takeda, M. (2015) · Springer eBooks · doi:10.1007/978-4-431-54541-5_7 · Cited by 2
Tõugu, P., Vaht, M., Tulviste, T., Veidebaum, T., & Harro, J. (2016) · Cognitive Development · doi:10.1016/j.cogdev.2016.06.002 · Cited by 4
Billino, J., Hennig, J., & Gegenfurtner, K. R. (2016) · Vision Research · doi:10.1016/j.visres.2016.10.001 · Cited by 2
Molecular Genetics and Human Behavior☆
Forero, D. A., Pereira‐Morales, A. J., & González‐Giraldo, Y. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.06489-0 · Cited by 2
Progress in the studies on endophenotypes of schizophrenia
Huang, J., & Chan, R. C. K. (2017) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972015-01383 · Cited by 2
Molecular Genetic Research on Temperament in Infancy and Early Childhood
Sheese, B. E. (2020) · Springer eBooks · doi:10.1007/978-1-0716-0933-0_3 · Cited by 2
Mikulincer, M., & Shaver, P. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.020 · Cited by 4
Pizzonia, K. L., Suhr, J. A., Clark, L. A., & Clark, B. C. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1206473 · Cited by 3
Heitzer, A. M., Rashkin, S. R., Trpchevska, A., Longoria, J. N., Rampersaud, E., Olufadi, Y., Wang, W. C., Raches, D., Potter, B., Steinberg, M. H., et al. (2023) · Current Research in Translational Medicine · doi:10.1016/j.retram.2023.103433 · Cited by 2
Grigorenko, E. L., & Burenkova, O. V. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108770422.007 · Cited by 2
Models of Physical Health and Personality
Heilmayr, D., & Friedman, H. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.019 · Cited by 2
Barnett, J. H., Scoriels, L., & Munafo, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.020 · Cited by 2
Genetics and Antipsychotic Response in Schizophrenia: an Update
Foster, A. E., Nisar, A., Sanchez, G., & Trieu, M. (2017) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-017-0119-4 · Cited by 1
Kostrzewa‐Nowak, D., Nowak, R., Kubaszewska, J., & Gos, W. (2022) · Brain Sciences · doi:10.3390/brainsci12020236 · Cited by 3
Massaroni, V., Donne, V. D., Arcangeli, V., Moriconi, F., & Chieffo, D. P. R. (2026) · Journal of Neurolinguistics · doi:10.1016/j.jneuroling.2026.101314 · Cited by 1
Monoamin rendszerek érintettsége gyermekkori neuropszichiátriai zavarokban
Nemoda, Z., & Tárnok, Z. (2009) · Pszichológia · doi:10.1556/pszicho.29.2009.1.4 · Cited by 1
(2015) · Neurotransmitter · doi:10.14800/nt.483 · Cited by 1
Auswirkungen des Polymorphismus rs3176921 im CRH-Gen auf kognitive Phänotypen
Möller, H. (2011) · Cited by 1
Association Between Paternal Schizophrenia and Low Birthweight: A Nationwide Population-Based Study
(2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr014 · Cited by 1
Akiyama, K., Saito, A., Saitô, S., Ozeki, Y., Watanabe, T., Fujii, K., & Shimoda, K. (2019) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2019.100134 · Cited by 1
Sallis, H., Smith, G. D., & Munafo, M. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.024 · Cited by 1
Self-Regulation and Control in Personality Functioning
Carver, C. S., & Scheier, M. F. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.029 · Cited by 1
López-García, P., Young, L., Marín, J., Molero, P., & Ortuño, F. (2015) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2015.05.004 · Cited by 1
Using Genetics to Improve Addiction Treatment Outcomes
Allenby, C. E., & Falcone, M. (2017) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-017-0106-9 · Cited by 1
Personality in Nonhuman Animals
Bell, A. M., & Bensky, M. K. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.023 · Cited by 1
Weiß, A., & Deary, I. J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.005 · Cited by 2
Personality and the Unconscious
Perugini, M., Richetin, J., & Costantini, G. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.008 · Cited by 2
New drug targets in psychiatry: Neurobiological considerations in the genomics era
Harrison, P. J., Mould, A. W., & Tunbridge, E. M. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104763 · Cited by 1
Pharmacogenomics of chemotherapy induced cognitive dysfunction
AlEjielat, R. (2013) · doi:10.17077/etd.n7km95tr · Cited by 1
Catecol O-metiltransferase e o transtorno obsessivo-compulsivo: revisão sistemática com meta-análise
Sampaio, A. S. (2012) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2012.tde-27112012-105200 · Cited by 2
Genetic Variation in Neurotransmitter Receptors Generates Behavioral Diversity
Bendesky, A. (2025) · Digital Commons - RU (Rockefeller University) · doi:10.48496/3y0n-tx90 · Cited by 1
Corr, P. J., & Matthews, G. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.001 · Cited by 1
Addendum: Statistical Analyses and Computer Programming in Personality
Corr, P. J., & Matthews, G. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.045 · Cited by 1
Intermediate Phenotypes in Genetic Studies of Schizophrenia
Egan, M. F., & Cannon, T. D. (2010) · Wiley eBooks · doi:10.1002/9781444327298.ch14 · Cited by 1
Milioni, A. L. V. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2023.tde-01082023-122323 · Cited by 1
An investigation of eating disorder neurocognitive and behavioural endophenotypes in twins
Kanakam, N. (2012) · UPT. Syiah Kuala University Library (Syiah Kuala University) · Cited by 1
Genetic Factors in the Regulation of Striatal and Extrastriatal Dopamine D2 Receptor Expression
Hirvonen, M. (2009) · UTUPub (University of Turku) · Cited by 1
COMT Genotype, sex steroids, and bone phenotype in mice and men
Eriksson, A. (2009) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Niarchou, M. (2013) · ORCA Online Research @Cardiff (Cardiff University)
Beyond the GWAS in schizophrenia
Malhotra, A. K. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100137
Villemonteix, T. (2015) · theses.fr (ABES) · doi:10.70675/84304c2az6a4fz488czbda7z8935968796d4 · Cited by 1
Bipolar disorder and cognitive functioning : a two-year naturalistic study
Arts, B. M. G. (2012) · Research Publications (Maastricht University) · doi:10.26481/dis.20120511ba
Common and rare genetic risk factors for schizophrenia and their associations with cognition
Hubbard, L. (2014) · ORCA Online Research @Cardiff (Cardiff University)
Schellekens, A., Hoppenreijs, S., Ellenbroek, B. A., de Jong, C., Franke, B., Buitelaar, J. K., Cools, L., & Verkes, R. (2009) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(09)70105-1
Lonsdorf, T. B. (2010) · Figshare
WM + deficit APOE Neuropsychologia 2010
Reinvang, I., Winjevoll, I. L., & Rootwelt, H. (2010)
Genetic approaches to treating and preventing symptoms in patients with cancer
Shi, Q., & Cleeland, C. S. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511780868.022
Mutant and Transgenic Tools in Modeling Schizophrenia
Desbonnet, L., Tomiyama, K., Koshikawa, N., O’Tuathaigh, C. M. P., & Waddington, J. L. (2009) · Neuromethods · doi:10.1007/978-1-60761-474-6_12
Smith, C. T. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/k27y-rp17
Farmacogenetica en schizofrene psychose
Mertens, C., Bleeker, E. D., Hert, M. D., Hulselmans, J., Janssen, F., Vandendriessche, F., Lecompte, D., Peuskens, J., & Wampers, M. (2009)
Met on 15 Years Episodic Memory Trajectories
Persson, N., Lavebratt, C., Sundström, A. E., & Fischer, H. (2016)
Clinical and Molecular Characterization of Psychosis in 22q11 Deletion Syndrome
Stachon, A. C. (2010) · TSpace (University of Toronto)
«Vanishing heritability» – a new paradox in the context of an old problem
Марютина, Т. М. (2016) · Journal of Modern Foreign Psychology · doi:10.17759/jmfp.2016050401
Soeiro‐de‐Souza, M. G. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2016.tde-11042013-181243
Gołyszny, M. J. (2019) · Kwartalnik Pedagogiczny · doi:10.5604/01.3001.0013.3616 · Cited by 1
Bonetti, L., Sedghi, N. A., Bruzzone, S. E. P., Haumann, N. T., Paunio, T., Kantojärvi, K., Kliuchko, M., Vuust, P., & Brattico, E. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.26.314732
The relation among aging, dopamine-regulating genes, and neurocognition
Li, X. (2020) · Figshare
Personality Assessment Methods
Boyle, G. J., & Helmes, E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.011 · Cited by 1
Schermer, J. A., & Saklofske, D. H. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.014
Social Relations and Social Support
Austin, E. Q., Knack, J. M., Jensen‐Campbell, L. A., & Rex‐Lear, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.036
Zmigrod, L., & Robbins, T. (2021) · doi:10.31234/osf.io/2wqgm
The Role of the Dopamine D1 Receptor in Cognition
Arola, A. (2013) · doi:10.26686/wgtn.17004805
Corr, P. J., & Matthews, G. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.002
Eggers, C., & Röpcke, B. (2011) · Springer eBooks · doi:10.1007/978-3-642-19846-5_16
Ferrera, D., Gómez-Equer, F., Peláez, I., Barjola, P., Fernandes-Magalhaes, R., Carpio, A., Lahoz, M. E. D., Martín-Buro, M. C., & Mercado, F. (2022) · Research Square · doi:10.21203/rs.3.rs-1572830/v1
Investigação das bases biológicas da cognição na esquizofrenia com Imagiologia Genética
Prata, D. P. (2015) · Imprensa da Universidade de Coimbra eBooks · doi:10.14195/978-989-26-0852-5_8
Corr, P. J., & Matthews, G. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.046
Ferrera, D., Gómez-Equer, F., Peláez, I., Barjola, P., Fernandes-Magalhaes, R., Carpio, A., Lahoz, M. E. D., Martín-Buro, M. C., & Mercado, F. (2022) · Research Square · doi:10.21203/rs.3.rs-1572830/v2
Ferrera, D., Gómez-Es, F., Peláez, I., Barjola, P., Fernandes-Magalhaes, R., Carpio, A., Lahoz, M. E. D., Martín-Buro, M. C., & Mercado, F. (2022) · Research Square · doi:10.21203/rs.3.rs-1572830/v3
Metadata
- Authors
- Barnett, J. H., Scoriels, L., & Munafò, M. R.
- Affiliations
- University of Cambridge (GB)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 64
- Issue
- 2
- Pages
- 137-144
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2133169656
- Cited by
- 412
- References
- 90
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 10 · 2022: 10 · 2021: 7 · 2020: 51 · 2019: 13 · 2018: 10 · 2017: 12 · 2016: 25 · 2015: 28 · 2014: 32 · 2013: 35 · 2012: 47
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- catechol-O-methyltransferase, cognitive function, executive function, memory, IQ, n-back task, Trail Making Test, Wisconsin Card Sorting Test, verbal fluency, word recall, publication bias, genetic association, mental illness, endophenotypes
- MeSH terms
- Adult, Aged, Alleles, Catechol O-Methyltransferase, Cognition Disorders, Female, Humans, Intelligence, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Phenotype, Polymorphism, Genetic, Problem Solving, Sex Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
