The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Meta-Analysis of the Cognitive Effects of the Catechol-O-Methyltransferase Gene Val158/108Met Polymorphism
Abstract
Background Cognitive endophenotypes may further our understanding of the genetic basis of psychiatric disorders, and the catechol-O-methyltransferase (COMT) gene is a promising candidate gene for both cognitive function and disorder. We conducted a meta-analysis of reported associations between the COMT Val158/108Met polymorphism and measures of memory and executive function.Methods The PubMed database was searched for studies relating cognitive functions and the COMT Val158/108Met polymorphism. This enabled meta-analyses of six cognitive phenotypes (Trail Making task, verbal recall, verbal fluency, IQ score, n-back task, and Wisconsin Card Sorting Test). Data were extracted by two reviewers and included cognitive scores by COMT genotype, publication year, diagnostic status, ancestry, proportion of male participants, and whether genotype frequencies were consistent with Hardy-Weinberg equilibrium.Results We found no association between COMT genotype and the majority of phenotypes. There was evidence of association with IQ score (d = .06), which did not differ significantly by ancestry, sex, average sample age, or patient status. For the n-back task, there was no robust evidence for genetic association, but the effect size was significantly larger in patient (d = .40) than nonpatient (d = -.27) populations, larger in both samples with fewer male subjects, and those of greater average age. There was also evidence of publication bias and decreasing effect sizes with later publication.Conclusions Despite initially promising results, the COMT Val158/108Met polymorphism appears to have little if any association with cognitive function. Publication bias may hamper attempts to understand the genetic basis of psychological functions and psychiatric disorders.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Better working memory (WM) performance (e.g. in N-back tasks), fewer perseverative errors, and higher IQ tend to be associated with the Met allele in healthy individuals (9-11), although some studies have failed to replicate these effects (see 10).”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [10]
In the citing paper
“Better working memory (WM) performance (e.g. in N-back tasks), fewer perseverative errors, and higher IQ tend to be associated with the Met allele in healthy individuals (9-11), although some studies have failed to replicate these effects (see 10).”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [10]
In the citing paper
“Better working memory (WM) performance (e.g. in N-back tasks), fewer perseverative errors, and higher IQ tend to be associated with the Met allele in healthy individuals (9-11), although some studies have failed to replicate these effects (see 10).”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [10]
Citations
Cites
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615
J Neuropsychiatry Clin Neurosci
Yudofsky, S. C., & Hales, R. E. (1992) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.4.4.359 · Cited by 3,818
Publication bias in clinical research
Easterbrook, P. J., Gopalan, R., Berlin, J. A., & Matthews, D. R. (1991) · The Lancet · doi:10.1016/0140-6736(91)90201-y · Cited by 3,109
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,416
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020
Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Kolachana, B. S., Hyde, T. M., Herman, M. M., Apud, J., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/425589 · Cited by 1,675
Structural magnetic resonance imaging of the adolescent brain
GIEDD, J. N. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1308.009 · Cited by 1,610
Structural and functional brain development and its relation to cognitive development
Casey, B. J., Giedd, J. N., & Thomas, K. M. (2000) · Biological Psychology · doi:10.1016/s0301-0511(00)00058-2 · Cited by 1,506
In vivo evidence for post-adolescent brain maturation in frontal and striatal regions
Sowell, E. R., Thompson, P. M., Holmes, C. J., Jernigan, T. L., & Toga, A. W. (1999) · Nature Neuroscience · doi:10.1038/13154 · Cited by 1,439
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 411
The Influence of Genetic and Environmental Factors among MDMA Users in Cognitive Performance
Cuyàs, E., Verdejo‐García, A., Fagundo, A. B., Khymenets, O., Rodríguez, J. C., Cuenca‐Royo, A., Llopis, S. D. S., Langohr, K., Peña‐Casanova, J., Torrens, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027206 · Cited by 49
Rasch, B., Spalek, K., Buholzer, S., Luechinger, R., Boesiger, P., de Quervain, D. J. ‐., & Papassotiropoulos, A. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.05.054 · Cited by 47
Blanchard, M. M., Chamberlain, S. R., Roiser, J. P., Robbins, T. W., & Müller, U. (2010) · Psychological Medicine · doi:10.1017/s003329171000098x · Cited by 51
Effects of age, genes, and pulse pressure on executive functions in healthy adults
Raz, N., Dahle, C. L., Rodrigue, K. M., Kennedy, K. M., & Land, S. J. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.05.015 · Cited by 48
Green, A. E., Kraemer, D. J. M., DeYoung, C. G., Fossella, J., & Gray, J. R. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs035 · Cited by 48
Zilles‐Wegner, D., Meyer, J., Schneider-Axmann, T., Ekawardhani, S., Gruber, E., Falkai, P., & Gruber, O. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0312-0 · Cited by 45
COMT val158met modulates association between brain white matter architecture and IQ
Li, J., Yu, C., Li, Y., Liu, B., Liu, Y., Shu, N., Song, M., Zhou, Y., Zhu, W., Li, K., et al. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30825 · Cited by 44
A review of cognitive neuropsychiatry in the taxonomy of eating disorders: State, trait, or genetic?
Kanakam, N., & Treasure, J. L. (2012) · Cognitive Neuropsychiatry · doi:10.1080/13546805.2012.682362 · Cited by 45
Simons, C. J. P., van Winkel, R., & GROUP (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs067 · Cited by 43
Wirgenes, K. V., Djurovic, S., Sundet, K. S., Agartz, I., Mattingsdal, M., Athanasiu, L., Melle, I. S., & Andreassen, O. A. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.05.007 · Cited by 42
Potential Moderators of Physical Activity on Brain Health
Leckie, R. L., Weinstein, A. M., Hodzic, J. C., & Erickson, K. I. (2012) · Journal of Aging Research · doi:10.1155/2012/948981 · Cited by 47
Generation and Characterization of Humanized Mice Carrying COMT158 Met/Val Alleles
Risbrough, V. B., Ji, B., Hauger, R., & Zhou, X. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.29 · Cited by 41
Genetic Polymorphisms Influence Recovery from Traumatic Brain Injury
Weaver, S. M., Chau, A., Tremont, J. N. P., & Grafman, J. H. (2012) · The Neuroscientist · doi:10.1177/1073858411435706 · Cited by 40
Genetics and Functional Imaging: Effects of APOE, BDNF, COMT, and KIBRA in Aging
Papenberg, G., Salami, A., Persson, J., Lindenberger, U., & Bäckman, L. (2015) · Neuropsychology Review · doi:10.1007/s11065-015-9279-8 · Cited by 39
COMT polymorphism and memory dedifferentiation in old age.
Papenberg, G., Bäckman, L., Nagel, I. E., Nietfeld, W., Schröder, J., Bertram, L., Heekeren, H. R., Lindenberger, U., & Li, S. (2013) · Psychology and Aging · doi:10.1037/a0033225 · Cited by 41
Bolton, J. L., Marioni, R. E., Deary, I. J., Harris, S. E., Stewart, M. C. W., Murray, G. D., Fowkes, F. G. R., & Price, J. F. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9372-y · Cited by 39
Dixon, R. A., DeCarlo, C. A., MacDonald, S. W. S., Vergote, D., Jhamandas, J. H., & Westaway, D. A. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00236 · Cited by 41
Shaw, P., Wallace, G. L., Addington, A., Evans, A., Rapoport, J., & Giedd, J. N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.121 · Cited by 38
Klaus, K., Butler, K., Curtis, F., Bridle, C., & Pennington, K. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.01.021 · Cited by 40
Common neurobiological and psychological underpinnings of gambling and substance-use disorders
Balodis, I. M., & Potenza, M. N. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109847 · Cited by 41
Tunbridge, E. M., Dunn, G., Murray, R. M., Evans, N., Lister, R., Stumpenhorst, K., Harrison, P. J., Morrison, P. D., & Freeman, D. H. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115609073 · Cited by 37
Variation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment
Bernhard, R. M., Chaponis, J., Siburian, R., Gallagher, P., Ransohoff, K. J., Wikler, D. I., Perlis, R. H., & Greene, J. D. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw103 · Cited by 41
Matsuzaka, C. T., Christofolini, D. M., Ota, V., Gadelha, A., Berberian, A. D. A., Noto, C. D. S., Mazzotti, D. R., Spíndola, L., Moretti, P. N. S., Smith, M. D. A. C., et al. (2017) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2016-1987 · Cited by 39
Herrmann, M. J., Würflein, H., Schreppel, T., Koehler, S., Mühlberger, A., Reif, A., Canli, T., Romanos, M., Jacob, C., Lesch, K., et al. (2009) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.9.2.168 · Cited by 37
Klaus, K., Butler, K., Durrant, S. J., Ali, M., Inglehearn, C. F., Hodgson, T. L., Gutiérrez, H., & Pennington, K. (2017) · Brain and Behavior · doi:10.1002/brb3.695 · Cited by 35
Zhu, X., Gu, H., Liu, Z., Xu, Z., Chen, X., Sun, X., Zhai, J., Zhang, Q.-M., Chen, M., Wang, K., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.234 · Cited by 35
Kirby, B. P., Waddington, J. L., & O’Tuathaigh, C. M. P. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.09.010 · Cited by 36
Landi, N., Frost, S. J., Mencl, W. E., Preston, J. L., Jacobsen, L. K., Lee, M., Yrigollen, C. M., Pugh, K. R., & Grigorenko, E. L. (2012) · Developmental Science · doi:10.1111/j.1467-7687.2012.01180.x · Cited by 34
Gurvich, C., & Rossell, S. L. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.11.045 · Cited by 33
Weaver, S. M., Tremont, J. N. P., Chau, A., Cristofori, I., Moretti, L., & Grafman, J. H. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-012-9197-9 · Cited by 35
Onur, O. A., Piefke, M., Lie, C., Thiel, C. M., & Fink, G. R. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2011.21603 · Cited by 33
Robinson, R., Smith, S. M., Wolkenberg, S. E., Kandebo, M., Yao, L., Gibson, C. R., Harrison, S. T., Polsky-Fisher, S. L., Barrow, J. C., Manley, P. J., et al. (2011) · ACS Chemical Neuroscience · doi:10.1021/cn200109w · Cited by 34
Laatikainen, L. M., Sharp, T., Bannerman, D. M., Harrison, P. J., & Tunbridge, E. M. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112454228 · Cited by 33
Lin, S., Liu, C., Hwang, T., Hsieh, M. H., Hsiao, P., Faraone, S. V., Tsuang, M. T., Hwu, H., & Chen, W. J. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs141 · Cited by 34
Ben‐Eliyahu, A., & Zeidner, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.041 · Cited by 33
Anokhin, A. P., Golosheykin, S., Grant, J. D., & Heath, A. C. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.01.067 · Cited by 32
Shehzad, Z. E., DeYoung, C. G., Kang, Y., Grigorenko, E. L., & Gray, J. R. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.097 · Cited by 32
Impact of COMT genotype on cognition in schizophrenia spectrum patients and their relatives
López-García, P., Espinoza, L. Y., Molero, P., Marin, J., & Pedreño, F. O. S. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.09.043 · Cited by 32
Pomarol‐Clotet, E., Fatjó‐Vilas, M., McKenna, P. J., Monté, G. C., Sarró, S., Ortiz‐Gil, J., Aguirre, C., Gomar, J. J., Guerrero, A., Landín, R., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.04.018 · Cited by 32
Genetic differences in emotionally enhanced memory
Todd, R. M., Palombo, D. J., Levine, B., & Anderson, A. K. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.11.010 · Cited by 34
The gene in its natural habitat: The importance of gene–trait interactions
DeYoung, C. G., & Clark, R. (2012) · Development and Psychopathology · doi:10.1017/s0954579412000727 · Cited by 31
Unraveling the genetic underpinnings of sleep deprivation-induced impairments in human cognition
Satterfield, B. C., Stucky, B., Landolt, H., & Dongen, H. P. A. V. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.03.026 · Cited by 34
Jaspar, M., Genon, S., Muto, V., Meyer, C., Manard, M., Dideberg, V., Bours, V., Salmon, É., Maquet, P., & Collette, F. (2013) · Cortex · doi:10.1016/j.cortex.2013.06.003 · Cited by 30
Liu, B., Li, J., Yu, C., Li, Y., Liu, Y., Song, M., Fan, M., Li, K., & Jiang, T. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.020 · Cited by 30
Does COMT genotype influence the effects of d‐amphetamine on executive functioning?
Wardle, M. C., Hart, A. B., Palmer, A. A., & de Wit, H. (2013) · Genes, Brain and Behavior · doi:10.1111/gbb.12012 · Cited by 29
Parkin, G. M., Udawela, M., Gibbons, A. S., Scarr, E., & Dean, B. (2018) · Journal of Human Genetics · doi:10.1038/s10038-018-0511-2 · Cited by 29
DeYoung, C. G., & Blain, S. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.026 · Cited by 34
Solís-Ortiz, S., Pérez-Luque, E., Morado-Crespo, L., & Gutiérrez-Muñoz, M. (2010) · Behavioral and Brain Functions · doi:10.1186/1744-9081-6-67 · Cited by 28
CACNA1C risk variant affects reward responsiveness in healthy individuals
Lancaster, T. M., Heerey, E. A., Mantripragada, K. K., & Linden, D. E. J. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.100 · Cited by 29
Behavioural genetics of Alzheimer's disease: a comprehensive review
Flirski, M., Sobów, T., & Kłoszewska, I. (2011) · Archives of Medical Science · doi:10.5114/aoms.2011.22068 · Cited by 28
Carmel, M., Zarchi, O., Michaelovsky, E., Frisch, A., Patya, M., Green, T., Gothelf, D., & Weizman, A. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.04.019 · Cited by 28
The effect of interactions between genetics and cannabis use on neurocognition. A review
Cosker, E., Schwitzer, T., Ramoz, N., Ligier, F., Lalanne, L., Gorwood, P. A. P. M., Schwan, R., & Laprévote, V. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.11.024 · Cited by 29
C957T polymorphism of the dopamine D2 receptor gene is associated with motor learning and heart rate
Huertas, E., Bühler, K., Echeverry‐Alzate, V., Giménez, T., & López‐Moreno, J. A. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00793.x · Cited by 27
Parasuraman, R., de Visser, E. J., Lin, M., & Greenwood, P. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039675 · Cited by 31
The effect of the COMT val158met polymorphism on neural correlates of semantic verbal fluency
Krug, A., Markov, V., Sheldrick, A. J., Krach, S., Jansen, A., Zerres, K., Eggermann, T., Stöcker, T., Shah, N. J., & Kircher, T. T. J. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-009-0010-8 · Cited by 27
Chou, L., Kuo, P., Lin, C. C. H., & Chen, W. J. (2009) · Behavior Genetics · doi:10.1007/s10519-009-9299-3 · Cited by 25
Ceaser, A. E., Csernansky, J. G., & Barch, D. M. (2012) · Cognitive Neuropsychiatry · doi:10.1080/13546805.2012.698100 · Cited by 26
Acute effects of cocaine and cannabis on reversal learning as a function of COMT and DRD2 genotype
Spronk, D. B., van der Schaaf, M. E., Cools, R., de Bruijn, E. R. A., Franke, B., van Wel, J. H. P., Ramaekers, J. G., & Verkes, R. J. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4141-5 · Cited by 28
Walsh, J., Tighe, O., Lai, D., Harvey, R. P., Karayiorgou, M., Gogos, J. A., Waddington, J. L., & O’Tuathaigh, C. M. P. (2010) · Brain Research · doi:10.1016/j.brainres.2010.06.027 · Cited by 26
Perspective: Does COMT val158met Affect Behavioral Phenotypes: Yes, No, Maybe?
Lachman, H. M. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.189 · Cited by 26
Neural and Behavioral Endophenotypes in ADHD
del Campo, N., Müller, U., & Sahakian, B. J. (2012) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_200 · Cited by 26
Boku, S., Izumi, T., Abe, S., Takahashi, T., Nishi, A., Nomaru, H., Naka, Y., Kang, G., Nagashima, M., Hishimoto, A., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.158 · Cited by 25
Weiss, E. M., Schulter, G., Fink, A., Reiser, E. M., Mittenecker, E., Niederstätter, H., Nagl, S., Parson, W., & Papousek, I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085506 · Cited by 27
Goldberg, X., Fatjó‐Vilas, M., Alemany, S., Nenadić, I., Gastó, C., & Fañanás, L. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.02.002 · Cited by 24
Geller, S., Wilhelm, O., Wacker, J., Hamm, A. O., & Hildebrandt, A. (2017) · Intelligence · doi:10.1016/j.intell.2017.09.002 · Cited by 25
Dopamine in socioecological and evolutionary perspectives: implications for psychiatric disorders
Yamaguchi, Y., Lee, Y., & Goto, Y. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00219 · Cited by 26
Saville, C. W. N., Lancaster, T. M., Stefanou, M. E., Salunkhe, G., Lourmpa, I., Nadkarni, A., Boehm, S. G., Bender, S., Smyrnis, N., Ettinger, U., et al. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.06.006 · Cited by 22
Reisenzein, R., Hildebrandt, A., & Weber, H. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.009 · Cited by 26
Functional polymorphism ( C ‐ 824T ) of the tyrosine hydroxylase gene affects IQ in schizophrenia
Horiguchi, M., Ohi, K., Hashimoto, R., Hao, Q., Yasuda, Y., Yamamori, H., Fujimoto, M., Umeda‐Yano, S., Takeda, M., & Ichinose, H. (2014) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12157 · Cited by 23
Tian, T., Qin, W., Liu, B., Wang, D., Wang, J., Jiang, T., & Yu, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078697 · Cited by 24
Das, D., Tan, X., Bielak, A. A. M., Cherbuin, N., Easteal, S., & Anstey, K. J. (2014) · Psychology and Aging · doi:10.1037/a0035702 · Cited by 23
Nieratschker, V., Frank, J., Mühleisen, T. W., Strohmaier, J., Wendland, J. R., Schumacher, J. H., Treutlein, J., Breuer, R., Jamra, R. A., Mattheisen, M., et al. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.06.018 · Cited by 22
A frontal dopamine system for reflective exploratory behavior
Blanco, N. J., Love, B. C., Cooper, J. A., McGeary, J. E., Knopik, V. S., & Maddox, W. T. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.05.004 · Cited by 22
Gender effects of the COMT Val158Met genotype on verbal fluency in healthy adults
Soeiro‐de‐Souza, M. G., Bio, D. S., David, D. P., Missio, G., LIMA, B., Fernandes, F. D. S., Machado‐Vieira, R., & Moreno, R. A. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1564 · Cited by 22
The genetics of episodic memory
Koppel, J. L., & Goldberg, T. E. (2009) · Cognitive Neuropsychiatry · doi:10.1080/13546800902990438 · Cited by 24
Vrijsen, J. N., van Oostrom, I., Vásquez, A. A., Franke, B., Becker, E. S., & Speckens, A. E. M. (2014) · Genes Brain & Behavior · doi:10.1111/gbb.12129 · Cited by 23
Lehto, K., Akkermann, K., Parik, J., Veidebaum, T., & Harro, J. (2013) · European Psychiatry · doi:10.1016/j.eurpsy.2013.06.008 · Cited by 23
Willmott, C., Ponsford, J. L., McAllister, T. W., & Burke, R. (2013) · Brain Injury · doi:10.3109/02699052.2013.809553 · Cited by 21
Genome-Wide Analyses of Working-Memory Ability: A Review
Knowles, E. E. M., Mathias, S. R., McKay, D., Sprooten, E., Blangero, J., Almasy, L. A., & Glahn, D. C. (2014) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-014-0028-8 · Cited by 22
No Association of COMT (Val158Met) Genotype with Brain Structure Differences between Men and Women
Barnes, A., Isohanni, M. K., Barnett, J. H., Pietiläinen, O. P. H., Veijola, J. M., Miettunen, J., Paunio, T., Tanskanen, P., Ridler, K., Suckling, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033964 · Cited by 22
Gustavsson, J., Papenberg, G., Falahati, F., Laukka, E. J., & Kalpouzos, G. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.838228 · Cited by 21
Gaysina, D., Xu, M. K., Barnett, J. H., Croudace, T. J., Wong, A., Richards, M., & Jones, P. B. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.11.007 · Cited by 20
The influence of 5-HTT and COMT genotypes on verbal fluency in ecstasy users
Fagundo, A. B., Cuyàs, E., Verdejo‐García, A., Khymenets, O., Langohr, K., Martín‐Santos, R., Farré, M., & de la Torre, R. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881109354926 · Cited by 22
Healthy aging increases the cognitive effects of two genes that influence extracellular dopamine.
Greenwood, P. M., Lin, M., Sundararajan, R., Fryxell, K. J., & Parasuraman, R. (2014) · Psychology and Aging · doi:10.1037/a0036109 · Cited by 21
Xie, W., Cappiello, M., Meng, M., Rosenthal, R., & Zhang, W. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.010 · Cited by 23
González‐Giraldo, Y., Rojas, J., Novoa, P., Mueller, S. T., Piper, B. J., Adán, A., & Forero, D. A. (2014) · Neuropsychobiology · doi:10.1159/000366483 · Cited by 19
Blair, C., Sulik, M. J., Willoughby, M. T., Mills-Koonce, R., Petrill, S. A., Bartlett, C. W., Greenberg, M. T., & the Family Life Project Investigators (2015) · Developmental Psychobiology · doi:10.1002/dev.21332 · Cited by 20
COMT Val158Met Polymorphism Modulates Cognitive Effects of Dietary Intervention
Witte, A. V., Jansen, S., Schirmacher, A., Young, P., & Flöel, A. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00146 · Cited by 19
Corbo, R. M., Gambina, G., Broggio, E., Scarabino, D., & Scacchi, R. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.06.045 · Cited by 19
Association of COMT Val108/158Met Genotype and Cigarette Smoking in Pregnant Women
Munafo, M. R., Freathy, R. M., Ring, S. M., Pourcain, B. S., & Smith, G. D. (2010) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntq209 · Cited by 20
Interactive effects of age and multi-gene profile on motor learning and sensorimotor adaptation
Noohi, F., Boyden, N. B., Kwak, Y., Humfleet, J., Müller, M. L. T. M., Bohnen, N. I., & Seidler, R. D. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.02.021 · Cited by 21
Dopamine and Working Memory: Genetic Variation, Stress and Implications for Mental Health
Klaus, K., & Pennington, K. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2019_113 · Cited by 20
Animal models of neuropsychiatric
Hyman, S. E. (2010) · Cited by 18
Gao, S., Hu, Z., Cheng, J. R., Zhou, W., Xu, Y., Xie, S., Liu, S., ZaiZhong, L., Guo, J., Dong, J., et al. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.04.016 · Cited by 18
The influence of COMT rs4680 on functional connectivity in healthy adults: A systematic review
Morris, K. A., Grace, S., Woods, W., Dean, B., & Rossell, S. L. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14748 · Cited by 18
Ashare, R. L., Valdez, J. N., Ruparel, K., Albelda, B., Hopson, R. D., Keefe, J. R., Loughead, J., & Lerman, C. E. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3197-3 · Cited by 17
Donges, B., Haupt, L. M., Lea, R. A., Chan, R. C. K., Shum, D., & Griffiths, L. R. (2012) · Gene · doi:10.1016/j.gene.2012.06.067 · Cited by 17
Stuart, K. E., Summers, M. J., Valenzuela, M., & Vickers, J. C. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.01.013 · Cited by 17
Persson, J., & Stenfors, C. U. D. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201837 · Cited by 16
Genetics of cognitive control: Implications for Nimh's research domain criteria initiative
Glahn, D. C., Knowles, E. E. M., & Pearlson, G. D. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32345 · Cited by 16
Metadata
- Authors
- Barnett, J. H., Scoriels, L., & Munafò, M. R.
- Affiliations
- University of Cambridge (GB)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 64
- Issue
- 2
- Pages
- 137-144
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2133169656
- Cited by
- 412
- References
- 90
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 10 · 2022: 10 · 2021: 7 · 2020: 51 · 2019: 13 · 2018: 10 · 2017: 12 · 2016: 25 · 2015: 28 · 2014: 32 · 2013: 35 · 2012: 47
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- catechol-O-methyltransferase, cognitive function, executive function, memory, IQ, n-back task, Trail Making Test, Wisconsin Card Sorting Test, verbal fluency, word recall, publication bias, genetic association, mental illness, endophenotypes
- MeSH terms
- Adult, Aged, Alleles, Catechol O-Methyltransferase, Cognition Disorders, Female, Humans, Intelligence, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Phenotype, Polymorphism, Genetic, Problem Solving, Sex Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
