The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Epigenetic Regulation in Human Brain—Focus on Histone Lysine Methylation
Open accessAbstract
Alterations in RNA levels are frequently reported in brain of subjects diagnosed with autism, schizophrenia, depression and other psychiatric diseases, but it remains unclear whether the underlying molecular pathology involves changes in gene expression, as opposed to alterations in mRNA processing. Pre-clinical studies have revealed that stress, drugs, and a variety of other environmental factors lead to changes in RNA levels in brain via epigenetic mechanisms, including modification of histone proteins. A number of site-specific modifications of the nucleosome core histones—including the trimethylated forms of histone H3 lysines K4, K9, and K27—are of particular interest for postmortem research, because these marks differentiate between active and inactive chromatin, and appear to remain relatively stable during tissue autolysis. Therefore, histone methylation profiling at promoter regions could provide important clues about mechanisms of gene expression in human brain during development and in disease. Intriguingly, mutations within the genes encoding the H3K9-specific methyltransferase, EHMT1, and the H3K4-specific histone demethylase, JARID1C/SMCX, have been linked to mental retardation and autism, respectively. In addition, the H3K4-specific methyltransferase, MLL1, is essential for hippocampal synaptic plasticity and may be involved in cortical dysfunction of some cases of schizophrenia. Together, these findings emphasize the potential significance of histone lysine methylation for orderly brain development and also as a molecular toolbox to study chromatin function in postmortem tissue.
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Cites
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Cited by
Epigenetics and the biological definition of gene×environment interactions
Meaney, M. J. (2010) · Child Development · doi:10.1111/j.1467-8624.2009.01381.x · Cited by 1,239
Davydov, D. M., Stewart, R., Ritchie, K., & Chaudieu, I. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.03.003 · Cited by 1,189
Epigenetics and the environmental regulation of the genome and its function
Zhang, T.-Y., & Meaney, M. J. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163625 · Cited by 565
Histone Methylation Regulates Memory Formation
Gupta, S., Kim, S. Y., Artis, S., Molfese, D. L., Schumacher, A., Sweatt, J. D., Paylor, R. E., & Lubin, F. D. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3732-09.2010 · Cited by 561
Redox dysregulation, neurodevelopment, and schizophrenia
Do, K. Q., Cabungcal, J. H., Frank, A., Steullet, P., & Cuenod, M. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.05.001 · Cited by 384
Metadata
- Authors
- Akbarian, S., & Huang, H.-S.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 65
- Issue
- 3
- Pages
- 198-203
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1998442739
- Cited by
- 214
- References
- 20
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- green
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