The complex language of chromatin regulation during transcription
Abstract
An important development in understanding the influence of chromatin on gene regulation has been the finding that DNA methylation and histone post-translational modifications lead to the recruitment of protein complexes that regulate transcription. Early interpretations of this phenomenon involved gene regulation reflecting predictive activating or repressing types of modification. However, further exploration reveals that transcription occurs against a backdrop of mixtures of complex modifications, which probably have several roles. Although such modifications were initially thought to be a simple code, a more likely model is of a sophisticated, nuanced chromatin 'language' in which different combinations of basic building blocks yield dynamic functional outcomes.
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These findings point to the potential for a bidirectional relation between transcription factor binding and transcriptional activity and DNA methylation.
“These findings also point to the potential for bidirectional relation between transcription factor binding and transcriptional activity and that of DNA methylation.104,122”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [104]
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- Authors
- Berger, S. L.
- Affiliations
- The Wistar Institute (US)
- Corresponding author
- Berger, Shelley L.
- ORCID
- Berger, Shelley L.
- Venue
- Nature
- Published
- 2007-05
- Volume
- 447
- Issue
- 7143
- Pages
- 407-412
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2089689396
- Cited by
- 2,768
- References
- 1
- Citations by year
- 2026: 45 · 2025: 60 · 2024: 70 · 2023: 82 · 2022: 110 · 2021: 117 · 2020: 106 · 2019: 130 · 2018: 123 · 2017: 150 · 2016: 156 · 2015: 167 · 2014: 198 · 2013: 194 · 2012: 195
- FWCI
- 16.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- chromatin regulation, transcription, DNA methylation, histone modifications, gene expression regulation, epigenetic code
- MeSH terms
- Chromatin, Gene Expression Regulation, Histones, Methylation, RNA, Messenger, Transcription, Genetic
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