Cited by 2,768Genomics and Chromatin DynamicsEpigenetics and DNA MethylationChromatin Remodeling and Cancer

The complex language of chromatin regulation during transcription

Berger, Shelley L.·2007·Nature

Abstract

An important development in understanding the influence of chromatin on gene regulation has been the finding that DNA methylation and histone post-translational modifications lead to the recruitment of protein complexes that regulate transcription. Early interpretations of this phenomenon involved gene regulation reflecting predictive activating or repressing types of modification. However, further exploration reveals that transcription occurs against a backdrop of mixtures of complex modifications, which probably have several roles. Although such modifications were initially thought to be a simple code, a more likely model is of a sophisticated, nuanced chromatin 'language' in which different combinations of basic building blocks yield dynamic functional outcomes.

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Crossref · 10.1038/nature05915

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  • These findings point to the potential for a bidirectional relation between transcription factor binding and transcriptional activity and DNA methylation.

    “These findings also point to the potential for bidirectional relation between transcription factor binding and transcriptional activity and that of DNA methylation.104,122”

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Authors
Berger, S. L.
Affiliations
The Wistar Institute (US)
Corresponding author
Berger, Shelley L.
Venue
Nature
Published
2007-05
Volume
447
Issue
7143
Pages
407-412
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2089689396
Cited by
2,768
References
1
Citations by year
2026: 45 · 2025: 60 · 2024: 70 · 2023: 82 · 2022: 110 · 2021: 117 · 2020: 106 · 2019: 130 · 2018: 123 · 2017: 150 · 2016: 156 · 2015: 167 · 2014: 198 · 2013: 194 · 2012: 195
FWCI
16.02
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
chromatin regulation, transcription, DNA methylation, histone modifications, gene expression regulation, epigenetic code
MeSH terms
Chromatin, Gene Expression Regulation, Histones, Methylation, RNA, Messenger, Transcription, Genetic

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