Cited by 416Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesMemory and Neural Mechanisms

The DOI matches its Crossref record; 18 of the 19 references it cites were found in a registry or an index.

Dissociating the Predictive and Incentive Motivational Properties of Reward-Related Cues Through the Study of Individual Differences

Open access

Robinson, Terry E., Flagel, Shelly B.·2009·Biological Psychiatry

DOI 10.1016/j.biopsych.2008.09.006PMC PMC2737368

Open this paper in CoChat — free account

Abstract

Background If presentation of a stimulus (conditional stimulus, CS) reliably predicts delivery of a reward, the CS will come to evoke a conditional response (CR) through Pavlovian learning, and the CS may also acquire incentive motivational properties. Thus, CSs can have both predictive and incentive properties. We ask here whether it is possible to dissociate the predictive versus incentive properties of a CS in rats by considering individual differences in the nature of the CR.Methods We used Pavlovian procedures to study the ability of a localizable CS (an illuminated lever) to acquire two properties of an incentive stimulus-the ability to attract and the ability to act as a conditional reinforcer.Results For some rats, the CS evoked a "sign-tracking" CR, consisting of approach toward and engagement with the CS itself. For other rats, the CS instead produced a "goal-tracking" CR: approach was directed away from the CS toward the site of food delivery. For sign-trackers (but not goal-trackers) the CS also acted as an effective conditional reinforcer.Conclusions The predictive and incentive properties of a CS can be dissociated by considering individual differences in the CR. In a given animal, a cue that is predictive of reward, supporting Pavlovian learning, may or may not be attributed with incentive salience. This procedure may provide a powerful means to test hypotheses regarding the role of neural systems in learning versus incentive motivational functions and to study individual variation in the extent to which reward-associated stimuli act as incentive stimuli.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2008.09.006

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Self-citation
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Self-citation
The debate over dopamine’s role in reward: the case for incentive salience
Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00007-6 · Cited by 2,129
Pavlovian conditioning: it's not what you think it is
Rescorla, R. A. (1988) · American Psychologist · doi:10.1037/0003-066x.43.3.151 · Cited by 1,542
Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.
Stewart, J., de Wit, H., & Eikelboom, R. (1984) · Psychological Review · doi:10.1037/0033-295x.91.2.251 · Cited by 1,261
Reinforcement, expectancy, and learning.
Bolles, R. C. (1972) · Psychological Review · doi:10.1037/h0033120 · Cited by 1,091
Sign-tracking : the stimulus-reinforcer relation and directed action
Hearst, E. S., & Jenkins, H. M. (1974) · Medical Entomology and Zoology · Cited by 812
How adaptive behavior is produced: a perceptual-motivational alternative to response reinforcements
Bindra, D. (1978) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00059380 · Cited by 732

Show all 19 references

Research works printed but not linked: 2

Phillips, 2008, Transfer of phasic dopamine release from unconditioned to conditioned stimuli requires the attribution of incentive salience, Soc Neurosci Abstracts
Flagel, 2006, An animal model of individual differences in “conditionability”: Relevance to psychopathology, Neuropsychopharmacology, 31, S262

Sorted by citations

Items 101–200 of 416

Neurobiological Foundations of Behavioral Addictions
Vaccaro, A. G., & Potenza, M. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.016 · Cited by 45
Neurobiology of Substance Addictions
Christie, N. C., & Bechara, A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.015 · Cited by 44
Sensitization of Incentive Salience and the Transition to Addiction
Warlow, S. M., Baumgartner, H. M., Freeland, C. M., Naffziger, E. E., Olney, J. J., Berridge, K. C., & Robinson, M. J. F. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.006 · Cited by 46
‘Hot’ vs. ‘cold’ behavioural‐cognitive styles: motivational‐dopaminergic vs. cognitive‐cholinergic processing of a Pavlovian cocaine cue in sign‐ and goal‐tracking rats
Pitchers, K. K., Kane, L. F., Kim, Y., Robinson, T. E., & Sarter, M. F. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13741 · Cited by 56
Self-citation
Neural correlates and determinants of approach–avoidance conflict in the prelimbic prefrontal cortex
Fernández-León, J. A., Engelke, D. S., Aquino-Miranda, G., Goodson, A., Rasheed, M. N., & Monte, F. H. D. (2021) · eLife · doi:10.7554/elife.74950 · Cited by 39
Mindfulness-Based Interventions Applied to Addiction Treatments
Kechter, A., & Black, D. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.040 · Cited by 43
Multiple Memory Systems, Addiction, and Health Habits: New Routes for Translational Science
Stacy, A. W., Pike, J. R., & Lee, A. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.017 · Cited by 43
Tanning as an Addiction: The State of the Research and Implications for Intervention
Miller, K. A., & Mays, D. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.037 · Cited by 43
Food versus Eating Addictions
Schulte, E. M., Schiestl, E. T., & Gearhardt, A. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.035 · Cited by 43
Ventral pallidal encoding of reward-seeking behavior depends on the underlying associative structure
Richard, J. M., Stout, N., Acs, D., & Janak, P. H. (2018) · eLife · doi:10.7554/elife.33107 · Cited by 46
HeiDI: A model for Pavlovian learning and performance with reciprocal associations.
Honey, R. C., Dwyer, D. M., & Iliescu, A. F. (2020) · Psychological Review · doi:10.1037/rev0000196 · Cited by 46
Behavioral Economics and Addictive Disorders
Jarmolowicz, D. P., & Schneider, T. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.005 · Cited by 42
Prevention and Treatment of Compulsive Buying Disorder
Galimov, A., & Black, D. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.027 · Cited by 42
Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis
Blum, K., Roy, A. K., Podesta, A., Modestino, E. J., Steinberg, B., Gondré-Lewis, M. C., Baron, D. A., Thanos, P. K., Lott, L., Badgaiyan, S., et al. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.031 · Cited by 42
Prevention and Treatment of “Food Addiction”
Davis, C., & Mason, A. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.023 · Cited by 42
Human Neurobiological Approaches to Hedonically Motivated Behaviors
Burger, K. S., Shearrer, G. E., & Sadler, J. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.009 · Cited by 42
Feedback Models for Gambling Control: The Use and Efficacy of Online Responsible Gambling Tools
Griffiths, M. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.034 · Cited by 42
Individual variation in incentive salience attribution and accumbens dopamine transporter expression and function
Singer, B. F., Guptaroy, B., Austin, C. J., Wohl, I., Lovic, V., Seiler, J. L., Vaughan, R. A., Gnegy, M. E., Robinson, T. E., & Aragona, B. J. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13134 · Cited by 43
Self-citation
From sign-tracking to attentional bias: Implications for gambling and substance use disorders
Anselme, P., & Robinson, M. J. F. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109861 · Cited by 48
Variation within the serotonin (5-HT) 5-HT2C receptor system aligns with vulnerability to cocaine cue reactivity
Anastasio, N. C., Liu, S., Maili, L., Swinford-Jackson, S. E., Lane, S. D., Fox, R. G., Hamon, S., Nielsen, D. A., Cunningham, K. A., & Moeller, F. G. (2014) · Translational Psychiatry · doi:10.1038/tp.2013.131 · Cited by 42
Individual differences in anticipatory activity to food rewards predict cue-induced appetitive 50-kHz calls in rats
Brenes, J. C., & Schwarting, R. K. W. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.012 · Cited by 45
Rats classified as low or high cocaine locomotor responders: A unique model involving striatal dopamine transporters that predicts cocaine addiction-like behaviors
Yamamoto, D. J., Nelson, A. M., Mandt, B. H., Larson, G. A., Rorabaugh, J. M., Ng, C. M. C., Barcomb, K., Richards, T. L., Allen, R. M., & Zahniser, N. R. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.002 · Cited by 39
Dopamine D2 Modulation of Sign and Goal Tracking in Rats
López, J. C., Karlsson, R., & O’Donnell, P. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.68 · Cited by 40
Continuous, but not Intermittent, Antipsychotic Drug Delivery Intensifies the Pursuit of Reward Cues
Bédard, A.-M., Maheux, J., Lévesque, D., & Samaha, A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.10 · Cited by 41
Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior
Deroche‐Gamonet, V., Revest, J., Fiancette, J.-F., Balado, É., Koehl, M., Grosjean, N., Abrous, D. N., & Piazza, P. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0038-0 · Cited by 45
Effects of Limited and Extended Pavlovian Training on Devaluation Sensitivity of Sign- and Goal-Tracking Rats
Keefer, S. E., Bacharach, S. Z., Kochli, D. E., Chabot, J. M., & Calu, D. J. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00003 · Cited by 40
Contemporary approaches to neural circuit manipulation and mapping: focus on reward and addiction
Saunders, B. T., Richard, J. M., & Janak, P. H. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0210 · Cited by 40
The role of conditioning history and reinforcer strength in the reinforcement enhancing effects of nicotine in rats
Palmatier, M. I., O’Brien, L. C., & Hall, M. J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2439-5 · Cited by 38
Premature responding is associated with approach to a food cue in male and female heterogeneous stock rats
King, C. P., Palmer, A. A., Woods, L. C. S., Hawk, L. W., Richards, J. B., & Meyer, P. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4306-x · Cited by 37
Autoshaping in adolescence enhances sign-tracking behavior in adulthood: Impact on ethanol consumption
Anderson, R. I., & SPEAR, L. P. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.01.004 · Cited by 38
Manipulating the revision of reward value during the intertrial interval increases sign tracking and dopamine release
Lee, B., Gentry, R. N., Bissonette, G. B., Herman, R. J., Mallon, J. J., Bryden, D. W., Calu, D. J., Schoenbaum, G. M., Coutureau, É., Marchand, A. R., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2004015 · Cited by 38
Blocking in autoshaped lever-pressing procedures with rats
Holland, P. C., Asem, J. S. A., Galvin, C. P., Keeney, C. M. H., Hsu, M., Miller, A., & Zhou, V. (2013) · Learning & Behavior · doi:10.3758/s13420-013-0120-z · Cited by 37
Detailed mapping of behavior reveals the formation of prelimbic neural ensembles across operant learning
Zhang, Y., Denman, A. J., Liang, B., Werner, C. T., Beacher, N. J., Chen, R., Li, Y., Shaham, Y., Barbera, G., & Lin, D. (2021) · Neuron · doi:10.1016/j.neuron.2021.11.022 · Cited by 37
Sign-tracking behavior is sensitive to outcome devaluation in a devaluation context-dependent manner: implications for analyzing habitual behaviorPreprint
Amaya, K. A., Stott, J. J., & Smith, K. S. (2020) · Learning & Memory · doi:10.1101/lm.051144.119 · Cited by 35
Examining the role of dopamine D2 and D3 receptors in Pavlovian conditioned approach behaviors
Fraser, K. M., Haight, J. L., Gardner, E. L., & Flagel, S. B. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.02.022 · Cited by 37
Self-citation
Toward isolating the role of dopamine in the acquisition of incentive salience attribution
Chow, J. J., Nickell, J. R., Darna, M., & Beckmann, J. S. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.06.028 · Cited by 38
Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity, and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway
Yohn, S. E., Galbraith, J., Calipari, E. S., & Conn, P. J. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00601 · Cited by 36
Roux-en-Y Gastric Bypass Alters Brain Activity in Regions that Underlie Reward and Taste Perception
Thanos, P. K., Michaelides, M., Subrize, M., Miller, M. L., Bellezza, R., Cooney, R. N., Leggio, L., Wang, G., Rogers, A. M., Volkow, N. D., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125570 · Cited by 37
Individual Differences in the Attribution of Incentive Salience to a Pavlovian Alcohol Cue
Villaruel, F. R., & Chaudhri, N. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00238 · Cited by 35
Unresponsive Choline Transporter as a Trait Neuromarker and a Causal Mediator of Bottom-Up Attentional Biases
Cherian, A. K., Kucinski, A. J., Pitchers, K. K., Yegla, B., Parikh, V., Kim, Y., Valuskova, P., Gurnani, S. D., Lindsley, C. W., Blakely, R., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3499-16.2017 · Cited by 36
Sign-tracking behavior is difficult to extinguish and resistant to multiple cognitive enhancers
Fitzpatrick, C. J., Geary, T. N., Creeden, J. F., & Morrow, J. D. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.107045 · Cited by 34
The contributions of value‐based decision‐making and attentional bias to alcohol‐seeking following devaluation
Rose, A. K., Brown, K. G., Field, M., & Hogarth, L. (2013) · Addiction · doi:10.1111/add.12152 · Cited by 36
Individual variation in the motivational properties of a nicotine cue: sign-trackers vs. goal-trackers
Yager, L. M., & Robinson, T. E. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3962-6 · Cited by 34
Self-citation
Development of anticipatory 50kHz USV production to a social stimuli in adolescent and adult male Sprague-Dawley rats
Willey, A. R., & SPEAR, L. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.001 · Cited by 34
High Locomotor Reactivity to Novelty Is Associated with an Increased Propensity to Choose Saccharin Over Cocaine: New Insights into the Vulnerability to Addiction
Vanhille, N., Belin‐Rauscent, A., Mar, A. C., Ducret, E., & Belin, D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.204 · Cited by 33
Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats
King, C. P., Tripi, J. A., Netzley, A. H., Horvath, A. P., Lamparelli, A. C., Holl, K. L., Chitre, A. S., Polesskaya, O., Ishiwari, K., Woods, L. C. S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-80798-w · Cited by 32
Self-citation
Separating desire from prediction of outcome value
Berridge, K. C. (2023) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2023.07.007 · Cited by 37
Naltrexone moderates the relationship between cue-induced craving and subjective response to methamphetamine in individuals with methamphetamine use disorder
Roche, D. J. O., Worley, M. J., Courtney, K. E., Bujarski, S., London, E. D., SHOPTAW, S. J., & Ray, L. A. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4607-8 · Cited by 32
Sign Tracking and Goal Tracking Are Characterized by Distinct Patterns of Nucleus Accumbens Activity
Gillis, Z. S., & Morrison, S. E. (2019) · eNeuro · doi:10.1523/eneuro.0414-18.2019 · Cited by 35
The hot ‘n’ cold of cue-induced drug relapsePreprint
Pitchers, K. K., Sarter, M. F., & Robinson, T. E. (2018) · Learning & Memory · doi:10.1101/lm.046995.117 · Cited by 36
Self-citation
Effects of nucleus accumbens core and shell lesions on autoshaped lever-pressing
Chang, S. E., & Holland, P. C. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.07.046 · Cited by 31
Transient inactivation of the paraventricular nucleus of the thalamus enhances cue-induced reinstatement in goal-trackers, but not sign-trackers
Kuhn, B. N., Klumpner, M. S., Covelo, I. R., Campus, P., & Flagel, S. B. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4816-1 · Cited by 35
Self-citation
The sensory features of a food cue influence its ability to act as an incentive stimulus and evoke dopamine release in the nucleus accumbens corePreprint
Singer, B. F., Bryan, M. A., Popov, P., Scarff, R., Carter, C., Wright, E., Aragona, B. J., & Robinson, T. E. (2016) · Learning & Memory · doi:10.1101/lm.043026.116 · Cited by 30
Self-citation
The mGluR5 Antagonist MTEP Dissociates the Acquisition of Predictive and Incentive Motivational Properties of Reward-Paired Stimuli in Mice
O’Connor, E. C., Crombag, H. S., Mead, A. N., & Stephens, D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.48 · Cited by 30
Skewed by Cues? The Motivational Role of Audiovisual Stimuli in Modelling Substance Use and Gambling Disorders
Barrus, M. M., Cherkasova, M. V., & Winstanley, C. A. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_393 · Cited by 30
The propensity to sign-track is associated with externalizing behavior and distinct patterns of reward-related brain activation in youth
Colaizzi, J. M., Flagel, S. B., Gearhardt, A. N., Borowitz, M. A., Kuplicki, R., Zotev, V. S., Clark, G., Coronado, J., Abbott, T., & Paulus, M. P. (2023) · Scientific Reports · doi:10.1038/s41598-023-30906-3 · Cited by 45
Self-citation
Animal Models of Maladaptive Traits: Disorders in Sensorimotor Gating and Attentional Quantifiable Responses as Possible Endophenotypes
Vargas, J. P., Díaz, E., Portavella, M., & López, J. C. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.00206 · Cited by 28
Reward-related attentional capture predicts non-abstinence during a one-month abstinence challenge
Albertella, L., Hooven, J. V., Bovens, R. H. L. M., & Wiers, R. W. H. J. (2020) · Addictive Behaviors · doi:10.1016/j.addbeh.2020.106745 · Cited by 32
Disrupting reconsolidation: memory erasure or blunting of emotional/motivational value?
Cogan, E. S., Shapses, M. A., Robinson, T. E., & Tronson, N. C. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0082-0 · Cited by 25
Neural correlates of attentional bias for smoking cues: modulation by variance in the dopamine transporter gene
Wetherill, R. R., Jagannathan, K., Lohoff, F. W., Ehrman, R. N., O’Brien, C. P., Childress, A. R., & Franklin, T. R. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00507.x · Cited by 27
Conditioned place preferences in humans using secondary reinforcers
Astur, R. S., Palmisano, A. N., Carew, A. W., Deaton, B. E., Kuhney, F. S., Niezrecki, R. N., Hudd, E. C., Mendicino, K. L., & Ritter, C. J. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.09.042 · Cited by 28
Dynamic Encoding of Incentive Salience in the Ventral Pallidum: Dependence on the Form of the Reward Cue
Ahrens, A. M., Ferguson, L. M., Robinson, T. E., & Aldridge, J. W. (2018) · eNeuro · doi:10.1523/eneuro.0328-17.2018 · Cited by 25
Self-citation
Choose your path: Divergent basolateral amygdala efferents differentially mediate incentive motivation, flexibility and decision-making
Keefer, S. E., Gyawali, U., & Calu, D. J. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113306 · Cited by 27
Reinforcer predictability and stimulus salience promote discriminated habit learning.
Thrailkill, E. A., Michaud, N. L., & Bouton, M. E. (2021) · Journal of Experimental Psychology Animal Learning and Cognition · doi:10.1037/xan0000285 · Cited by 30
Dimensions of Temperament Modulate Cue-Controlled Behavior: A Study on Pavlovian to Instrumental Transfer in Horses (Equus Caballus)
Lansade, L., Coutureau, É., Marchand, A. R., Baranger, G., Valenchon, M., & Calandreau, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064853 · Cited by 27
Estradiol and progesterone in female reward-learning, addiction, and therapeutic interventions
Hilz, E. N., & Lee, H. J. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.101043 · Cited by 29
Basolateral amygdala and orbitofrontal cortex, but not dorsal hippocampus, are necessary for the control of reward-seeking by occasion setters
Fraser, K. M., & Janak, P. H. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06227-0 · Cited by 26
Inhibition of Dopamine Neurons Prevents Incentive Value Encoding of a Reward Cue: With Revelations from Deep Phenotyping
Iglesias, A. G., Chiu, A. S., Wong, J. W. H., Campus, P., Li, F. R., Liu, Z., Bhatti, J. K., Patel, S. A., Deisseroth, K. A., Akil, H., et al. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0848-23.2023 · Cited by 32
Self-citation
Cues Paired with either Rapid or Slower Self-Administered Cocaine Injections Acquire Similar Conditioned Rewarding Properties
Samaha, A., Minogianis, E.-A., & Nachar, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026481 · Cited by 29
Neural circuits linking sleep and addiction: Animal models to understand why select individuals are more vulnerable to substance use disorders after sleep deprivation
Ahrens, A. M., & Ahmed, O. J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.11.007 · Cited by 25
Multistability, perceptual value, and internal foraging
Safavi, S., & Dayan, P. (2022) · Neuron · doi:10.1016/j.neuron.2022.07.024 · Cited by 29
Pavlovian learning and conditioned reinforcement
Madden, G. J., Mahmoudi, S., & Brown, K. R. (2023) · Journal of Applied Behavior Analysis · doi:10.1002/jaba.1004 · Cited by 45
Role of prefrontal 5-HT in the strain-dependent variation in sign-tracking behavior of C57BL/6 and DBA/2 mice
Campus, P., Accoto, A., Maiolati, M., Latagliata, E. C., & Orsini, C. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4192-7 · Cited by 27
Considering sex differences in the cognitive controls of feeding
Sample, C. H., & Davidson, T. (2017) · Physiology and Behavior · doi:10.1016/j.physbeh.2017.11.023 · Cited by 22
Low Impulsive Action, but not Impulsive Choice, Predicts Greater Conditioned Reinforcer Salience and Augmented Nucleus Accumbens Dopamine Release
Zeeb, F. D., Soko, A. D., Ji, X., & Fletcher, P. J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.9 · Cited by 23
The lateral hypothalamus and orexinergic transmission in the paraventricular thalamus promote the attribution of incentive salience to reward-associated cues
Haight, J. L., Campus, P., Maria-Rios, C. E., Johnson, A., Klumpner, M. S., Kuhn, B. N., Covelo, I. R., Morrow, J. D., & Flagel, S. B. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05651-4 · Cited by 23
Self-citation
Individual differences in food cue responsivity are associated with acute and repeated cocaine-induced vocalizations, but not cue-induced vocalizations
Tripi, J. A., Dent, M. L., & Meyer, P. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4476-6 · Cited by 23
Future Directions in “Food Addiction”: Next Steps and Treatment Implications
LaFata, E. M., Joyner, M. A., Schiestl, E. T., & Gearhardt, A. N. (2017) · Current Addiction Reports · doi:10.1007/s40429-017-0140-4 · Cited by 25
Instrumental and Pavlovian Mechanisms in Alcohol Use Disorder
Doñamayor, N., Ebrahimi, C., Garbusow, M., Wedemeyer, F., Schlagenhauf, F., & Heinz, A. (2020) · Current Addiction Reports · doi:10.1007/s40429-020-00333-9 · Cited by 24
Sign tracking predicts suboptimal behavior in a rodent gambling task
Swintosky, M., Brennan, J. T., Koziel, C., Paulus, J. P., & Morrison, S. E. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05887-8 · Cited by 22
Experimental predictions drawn from a computational model of sign-trackers and goal-trackers
Lesaint, F., Sigaud, O., Clark, J. J., Flagel, S. B., & Khamassi, M. (2014) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2014.06.001 · Cited by 22
Self-citation
Individual differences in incentive salience attribution are not related to suboptimal choice in rats
López, P., Alba, R., & Orduña, V. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.028 · Cited by 22
Subanesthetic ketamine decreases the incentive-motivational value of reward-related cues
Fitzpatrick, C. J., & Morrow, J. D. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116667709 · Cited by 21
Human Motives
Carruthers, P. (2024) · doi:10.1093/oso/9780198906131.001.0001 · Cited by 22
Reward-Related Attentional Capture Moderates the Association between Fear-Driven Motives and Heavy Drinking
Liu, C., Yücel, M., Suo, C., Pelley, M. E. L., Tiego, J., Rotaru, K., Fontenelle, L. F., & Albertella, L. (2021) · European Addiction Research · doi:10.1159/000513470 · Cited by 23
Single prolonged stress decreases sign-tracking and cue-induced reinstatement of cocaine-seeking
Fitzpatrick, C. J., Jagannathan, L., Lowenstein, E. D., Robinson, T. E., Becker, J. B., & Morrow, J. D. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.07.026 · Cited by 20
Self-citation
Distinguishing between predictive and incentive value of uncertain gambling-like cues in a Pavlovian autoshaping task
Robinson, M. J. F., Clibanoff, C., Freeland, C. M., Knes, A. S., Cote, J. R., & Russell, T. I. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111971 · Cited by 20
Interactive Effects of Naturalistic Drinking Context and Alcohol Sensitivity on Neural Alcohol Cue‐Reactivity Responses
Martins, J. S., Bartholow, B. D., Cooper, M. L., Irvin, K., & Piasecki, T. M. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14134 · Cited by 22
Cannabinoid receptor-1 signaling contributions to sign-tracking and conditioned reinforcement in rats
Bacharach, S. Z., Nasser, H. M., Zlebnik, N. E., Dantrassy, H. M., Kochli, D. E., Gyawali, U., Cheer, J. F., & Calu, D. J. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4993-6 · Cited by 19
Transfer of incentive salience from a first‐order alcohol cue to a novel second‐order alcohol cue among individuals at risk for alcohol use disorder: electrophysiological evidence
Fleming, K. A., Cofresí, R. U., & Bartholow, B. D. (2020) · Addiction · doi:10.1111/add.15380 · Cited by 21
Distinct effects of ventral tegmental area NMDA and acetylcholine receptor blockade on conditioned reinforcement produced by food-associated cues
Wickham, R. J., Solecki, W., Nunes, E. J., & Addy, N. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.06.021 · Cited by 21
Lesions of the ventral hippocampus attenuate the acquisition but not expression of sign-tracking behavior in rats
Fitzpatrick, C. J., Creeden, J. F., Perrine, S. A., & Morrow, J. D. (2016) · Hippocampus · doi:10.1002/hipo.22619 · Cited by 18
Ultrasonic vocalizations and individual differences in rats performing a Pavlovian conditioned approach task
Sangarapillai, N., Ellenberger, M., Wöhr, M., & Schwarting, R. K. W. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112926 · Cited by 17
The impact of a junk-food diet during development on ‘wanting’ and ‘liking’
Lesser, E. N., Arroyo-Ramirez, A., Mi, S. J., & Robinson, M. J. F. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.09.041 · Cited by 17
Associative mechanisms involved in specific Pavlovian-to-instrumental transfer in human learning tasks
Alarcón, D. E., Bonardi, C., & Delamater, A. (2018) · Quarterly Journal of Experimental Psychology · doi:10.1080/17470218.2017.1342671 · Cited by 14
Basolateral Amygdala to Nucleus Accumbens Communication Differentially Mediates Devaluation Sensitivity of Sign- and Goal-Tracking Rats
Kochli, D. E., Keefer, S. E., Gyawali, U., & Calu, D. J. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.593645 · Cited by 15
Inhibition of a cortico-thalamic circuit attenuates cue-induced reinstatement of drug-seeking behavior in “relapse prone” male rats
Kuhn, B. N., Campus, P., Klumpner, M. S., Chang, S. E., Iglesias, A. G., & Flagel, S. B. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05894-9 · Cited by 18
Self-citation
Effects of nicotine exposure and anxiety on motivation for reward and gambling-like cues under reward uncertainty.
Russell, T. I., & Robinson, M. J. F. (2019) · Behavioral Neuroscience · doi:10.1037/bne0000311 · Cited by 17
Beyond simple tests of value: measuring addiction as a heterogeneous disease of computation-specific valuation processesPreprint
Sweis, B. M., Thomas, M. J., & Redish, A. D. (2018) · Learning & Memory · doi:10.1101/lm.047795.118 · Cited by 17
From skinner box to daily life: Sign-tracker phenotype co-segregates with impulsivity, compulsivity, and addiction tendencies in humans
Schettino, M., Ceccarelli, I., Tarvainen, M. P., Martelli, M., Orsini, C., & Ottaviani, C. (2022) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-022-01014-y · Cited by 20

Authors: Robinson, T. E., & Flagel, S. B.
Affiliations: University of Michigan (US)
Corresponding author: Robinson, Terry E.
ORCID: Robinson, Terry E.
Flagel, Shelly B.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2009-05
Volume: 65
Issue: 10
Pages: 869-873
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2008.09.006
PMC: PMC2737368
OpenAlex: W2005718472
Cited by: 416
References: 19
Citations by year: 2026: 17 · 2025: 20 · 2024: 34 · 2023: 17 · 2022: 20 · 2021: 20 · 2020: 67 · 2019: 28 · 2018: 27 · 2017: 22 · 2016: 28 · 2015: 29 · 2014: 22 · 2013: 21 · 2012: 10
FWCI: 4.76
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (P01DA021633, R37DA004294, R37 DA04294)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: classical conditioning, incentive salience, sign-tracking, goal tracking, individual differences, approach behavior, incentive motivation, rats
MeSH terms: Animals, Conditioning, Classical, Cues, Individuality, Motivation, Reinforcement, Psychology, Reward, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dissociating the Predictive and Incentive Motivational Properties of Reward-Related Cues Through the Study of Individual Differences

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks