Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity, and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway
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Accumulated data from clinical and preclinical studies suggest that, in drug addiction and states of overeating, such as obesity and binge eating disorder (BED), there is an imbalance in circuits that are critical for motivation, reward saliency, executive function, and self-control. Central to these pathologies and the extensive topic of this Review are the aberrations in dopamine (DA) and glutamate (Glu) within the mesolimbic pathway. Group I metabotropic glutamate receptors (mGlus) are highly expressed in the mesolimbic pathway and are poised in key positions to modulate disruptions in synaptic plasticity and neurotransmitter release observed in drug addiction, obesity, and BED. The use of allosteric modulators of group I mGlus has been studied in drug addiction, as they offer several advantages over traditional orthosteric agents. However, they have yet to be studied in obesity or BED. With the substantial overlap between the neurocircuitry involved in drug addiction and eating disorders, group I mGlus may also provide novel targets for obesity and BED.
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The mesolimbic dopaminergic pathway is associated with addictive behaviors, including drug use and binge eating disorders.
“The mesolimbic dopaminergic pathway has been associated with addictive behaviors, including drug use and binge eating disorders [7, 8].”
From The Impact of Social Media & Technology on Child and Adolescent Mental Health (2025) · cites this paper as [8]
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Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340 · see citing works
Dahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,143 · see citing works
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785 · see citing works
Neurobiology of addiction: a neurocircuitry analysis
Koob, G. F., & Volkow, N. D. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)00104-8 · Cited by 3,698 · see citing works
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works
The physiology, signaling, and pharmacology of dopamine receptors
Beaulieu, J.-M., & Gainetdinov, R. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.002642 · Cited by 2,763 · see citing works
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749 · see citing works
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647 · see citing works
Discrete coding of reward probability and uncertainty by dopamine neurons
Fiorillo, C. D., Tobler, P. N., & Schultz, W. (2003) · Science · doi:10.1126/science.1077349 · Cited by 2,085 · see citing works
Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease
Niswender, C. M., & Conn, P. J. (2010) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.011008.145533 · Cited by 1,889 · see citing works
Self-citationImpulsivity, compulsivity, and top-down cognitive control
Dalley, J. W., Everitt, B. J., & Robbins, T. W. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.020 · Cited by 1,589 · see citing works
Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
Johnson, P. M., & Kenny, P. J. (2010) · Nature Neuroscience · doi:10.1038/nn.2519 · Cited by 1,495 · see citing works
The NIMH Research Domain Criteria (RDoC) Project: Precision Medicine for Psychiatry
Insel, T. R. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14020138 · Cited by 1,472 · see citing works
The Neuroscience of Natural Rewards: Relevance to Addictive Drugs
Kelley, A. E., & Berridge, K. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03306.2002 · Cited by 1,465 · see citing works
The mysterious motivational functions of mesolimbic dopamine
Salamone, J. D., & Correa, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.021 · Cited by 1,418 · see citing works
Reward, dopamine and the control of food intake: implications for obesity
Volkow, N. D., Wang, G.-J., & Baler, R. D. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.001 · Cited by 1,400 · see citing works
Preliminary validation of the Yale Food Addiction Scale
Gearhardt, A. N., Corbin, W. R., & Brownell, K. D. (2009) · Appetite · doi:10.1016/j.appet.2008.12.003 · Cited by 1,369 · see citing works
The control of firing pattern in nigral dopamine neurons: burst firing
Grace, A., & Bunney, B. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-11-02877.1984 · Cited by 1,346 · see citing works
Neuron-type-specific signals for reward and punishment in the ventral tegmental area
Cohen, J. Y., Haesler, S., Vong, L., Lowell, B. B., & Uchida, N. (2012) · Nature · doi:10.1038/nature10754 · Cited by 1,318 · see citing works
Molecular and Cellular Basis of Addiction
Nestler, E. J., & Aghajanian, G. K. (1997) · Science · doi:10.1126/science.278.5335.58 · Cited by 1,315 · see citing works
The brain on drugs: from reward to addiction
Volkow, N. D., & Morales, M. (2015) · Cell · doi:10.1016/j.cell.2015.07.046 · Cited by 1,306 · see citing works
Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning
Tsai, H.-C., Zhang, F., Adamantidis, A., Stuber, G. D., Bonci, A., de Lecea, L., & Deisseroth, K. (2009) · Science · doi:10.1126/science.1168878 · Cited by 1,266 · see citing works
Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex
Volkow, N. D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.318 · Cited by 1,240 · see citing works
Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
Volkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Logan, J., Childress, A.-R., Jayne, M., Ma, Y., & Wong, C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1544-06.2006 · Cited by 1,164 · see citing works
Floresco, S. B., West, A. R., Ash, B., Moore, H., & Grace, A. A. (2003) · Nature Neuroscience · doi:10.1038/nn1103 · Cited by 1,106 · see citing works
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling
Lüscher, C., & Malenka, R. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.017 · Cited by 1,105 · see citing works
Dopamine in drug abuse and addiction: results from imaging studies and treatment implications
Volkow, N. D., Fowler, J. S., Wang, G.-J., & Swanson, J. M. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001507 · Cited by 1,101 · see citing works
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
Jeffrey Conn, P., Christopoulos, A., & Lindsley, C. W. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2760 · Cited by 1,063 · see citing works
Self-citationRegulation of firing of dopaminergic neurons and control of goal-directed behaviors
Grace, A. A., Floresco, S. B., Goto, Y., & Lodge, D. J. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.003 · Cited by 1,034 · see citing works
Imaging dopamine's role in drug abuse and addiction
Volkow, N. D., Fowler, J. S., Wang, G. J., Baler, R., & Telang, F. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.022 · Cited by 988 · see citing works
Addiction: Beyond dopamine reward circuitry
Volkow, N. D., Wang, G.-J., Fowler, J. S., Tomasi, D., & Telang, F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010654108 · Cited by 959 · see citing works
The dopamine motive system: implications for drug and food addiction
Volkow, N. D., Wise, R. A., & Baler, R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.130 · Cited by 939 · see citing works
The addicted human brain: insights from imaging studies
Volkow, N. D., Fowler, J. S., & Wang, G.-J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18533 · Cited by 916 · see citing works
The control of firing pattern in nigral dopamine neurons: single spike firing
Grace, A., & Bunney, B. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-11-02866.1984 · Cited by 862 · see citing works
Neve, K. A., Seamans, J. K., & Trantham‐Davidson, H. (2004) · Journal of Receptors and Signal Transduction · doi:10.1081/rrs-200029981 · Cited by 836 · see citing works
Mesolimbic dopamine signals the value of work
Hamid, A., Pettibone, J. R., Mabrouk, O. S., Hetrick, V. L., Schmidt, R., Weele, C. M. V., Kennedy, R. T., Aragona, B. J., & Berke, J. D. (2015) · Nature Neuroscience · doi:10.1038/nn.4173 · Cited by 815 · see citing works
Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology
Volkow, N. D., Wang, G.-J., Fowler, J. S., & Telang, F. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0107 · Cited by 809 · see citing works
The role of impulsive behavior in drug abuse
Perry, J. L., & Carroll, M. E. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1173-0 · Cited by 805 · see citing works
Reward and aversion in a heterogeneous midbrain dopamine system
Lammel, S., Lim, B. K., & Malenka, R. C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.019 · Cited by 804 · see citing works
Obesity and addiction: Neurobiological overlaps
Volkow, N. D., Wang, G. ‐., Tomasi, D., & Baler, R. D. (2013) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01031.x · Cited by 800 · see citing works
Stice, E., Spoor, S., Bohon, C., Veldhuizen, M. G., & Small, D. M. (2008) · Journal of Abnormal Psychology · doi:10.1037/a0013600 · Cited by 779 · see citing works
Metabotropic glutamate receptors: electrophysiological properties and role in plasticity
Anwyl, R. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00050-2 · Cited by 776 · see citing works
Dopaminergic modulation of synaptic transmission in cortex and striatum
Tritsch, N. X., & Sabatini, B. L. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.023 · Cited by 756 · see citing works
Development of the Yale Food Addiction Scale Version 2.0
Gearhardt, A. N., Corbin, W. R., & Brownell, K. D. (2016) · Psychology of Addictive Behaviors · doi:10.1037/adb0000136 · Cited by 740 · see citing works
Impulsivity, frontal lobes and risk for addiction
Crews, F. T., & Boettiger, C. A. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.04.018 · Cited by 679 · see citing works
From the ventral to the dorsal striatum: devolving views of their roles in drug addiction
Everitt, B. J., & Robbins, T. W. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.010 · Cited by 675 · see citing works
Pohjalainen, T., Rinne, J. O., Någren, K., Lehikoinen, P., Anttila, K., Syvälahti, E. K. G., & Hietala, J. A. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000350 · Cited by 672 · see citing works
Should addictive disorders include non-substance-related conditions?
Potenza, M. N. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01591.x · Cited by 663 · see citing works
Noble, E. P. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810310066012 · Cited by 655 · see citing works
Nair‐Roberts, R. G., Chatelain-Badie, S. D., Benson, E. M., White‐Cooper, H., Bolam, J. P., & Ungless, M. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.046 · Cited by 653 · see citing works
Metabotropic glutamate receptors
Ferraguti, F., & Shigemoto, R. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0266-5 · Cited by 647 · see citing works
Drug addiction: the neurobiology of disrupted self-control
Baler, R. D., & Volkow, N. D. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.10.005 · Cited by 640 · see citing works
GABA Neurons of the VTA Drive Conditioned Place Aversion
Tan, K. R., Yvon, C., Turiault, M., Mirzabekov, J. J., Doehner, J., Labouèbe, G., Deisseroth, K. A., Tye, K. M., & Lüscher, C. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.015 · Cited by 635 · see citing works
Lu, Y.-M., Jia, Z., Janus, C., Henderson, J. T., Gerlai, R., Wojtowicz, J. M., & Roder, J. C. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05196.1997 · Cited by 634 · see citing works
Lüscher, C., & Huber, K. M. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.016 · Cited by 627 · see citing works
Activation of VTA GABA Neurons Disrupts Reward Consumption
van Zessen, R., Phillips, J. L., Budygin, E. A., & Stuber, G. D. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.016 · Cited by 609 · see citing works
Fractionating impulsivity: neuropsychiatric implications
Dalley, J. W., & Robbins, T. W. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.8 · Cited by 607 · see citing works
Bertran‐Gonzalez, J., Bosch‐Bouju, C., Maroteaux, M. J., Matamales, M., Hervé, D., Valjent, E., & Girault, J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1039-08.2008 · Cited by 606 · see citing works
Dopamine in Drug Abuse and Addiction: Results of Imaging Studies and Treatment Implications
Volkow, N. D., Fowler, J. S., Wang, G.-J., Swanson, J. M., & Telang, F. (2007) · Archives of Neurology · doi:10.1001/archneur.64.11.1575 · Cited by 605 · see citing works
Roesch, M. R., Calu, D. J., & Schoenbaum, G. (2007) · Nature Neuroscience · doi:10.1038/nn2013 · Cited by 597 · see citing works
The role of D2-autoreceptors in regulating dopamine neuron activity and transmission
Ford, C. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.025 · Cited by 584 · see citing works
Dopaminergic neurons inhibit striatal output through non-canonical release of GABA
Tritsch, N. X., Ding, J. B., & Sabatini, B. L. (2012) · Nature · doi:10.1038/nature11466 · Cited by 576 · see citing works
Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice
Chiamulera, C., Epping-Jordan, M. P., Zocchi, A., Marcon, C., Cottiny, C., Tacconi, S., Corsi, M., Orzi, F., & Conquet, F. (2001) · Nature Neuroscience · doi:10.1038/nn0901-873 · Cited by 554 · see citing works
The Prevalence of Food Addiction as Assessed by the Yale Food Addiction Scale: A Systematic Review
Pursey, K., Stanwell, P., Gearhardt, A. N., Collins, C. E., & Burrows, T. L. (2014) · Nutrients · doi:10.3390/nu6104552 · Cited by 548 · see citing works
Ventral pallidum roles in reward and motivation
Smith, K. S., Tindell, A. J., Aldridge, J. W., & Berridge, K. C. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.038 · Cited by 548 · see citing works
Neurobiologic processes in drug reward and addiction
Adinoff, B. (2004) · Harvard Review of Psychiatry · doi:10.1080/10673220490910844 · Cited by 546 · see citing works
An examination of the food addiction construct in obese patients with binge eating disorder
Gearhardt, A. N., White, M. A., Masheb, R. M., MORGAN, P. T., Crosby, R. D., & Grilo, C. M. (2011) · International Journal of Eating Disorders · doi:10.1002/eat.20957 · Cited by 535 · see citing works
Dopamine Signaling in reward-related behaviors
Baik, J. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00152 · Cited by 534 · see citing works
“Eating addiction”, rather than “food addiction”, better captures addictive-like eating behavior
Hebebrand, J., Albayrak, Ö., Adan, R. A. H., Antel, J., Diéguez, C., de Jong, J. W., Leng, G., Menzies, J. R. W., Mercer, J. G., Murphy, M., et al. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.016 · Cited by 526 · see citing works
Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction
Volkow, N. D., Wang, G. J., Fowler, J. S., Tomasi, D., & Baler, R. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2011_169 · Cited by 525 · see citing works
Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat
Testa, C. M., Standaert, D. G., Young, A. R., & Penney, J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-03005.1994 · Cited by 511 · see citing works
Wang, G.-J., Volkow, N. D., Thanos, P. K., & Fowler, J. S. (2004) · Journal of Addictive Diseases · doi:10.1300/j069v23n03_04 · Cited by 502 · see citing works
Roles for nigrostriatal—not just mesocorticolimbic—dopamine in reward and addiction
Wise, R. A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.06.004 · Cited by 500 · see citing works
The nucleus accumbens: a comprehensive review
Salgado, S., & Kaplitt, M. G. (2015) · Stereotactic and Functional Neurosurgery · doi:10.1159/000368279 · Cited by 489 · see citing works
Firing modes of midbrain dopamine cells in the freely moving rat
Hyland, B. I., Reynolds, J. N. J., HAY, J. G., Perk, C. G., & Miller, R. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00267-1 · Cited by 487 · see citing works
Compulsive overeating as an addiction disorder. A review of theory and evidence
Davis, C. A., & Carter, J. C. (2009) · Appetite · doi:10.1016/j.appet.2009.05.018 · Cited by 479 · see citing works
Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections
Kupchik, Y. M., Brown, R. M., Heinsbroek, J. A., Lobo, M. K., Schwartz, D. J., & Kalivas, P. W. (2015) · Nature Neuroscience · doi:10.1038/nn.4068 · Cited by 459 · see citing works
Groenewegen, H. J., Berendse, H. W., & Haber, S. N. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90115-v · Cited by 456 · see citing works
Heterogeneity and Diversity of Striatal GABAergic Interneurons
Tepper, J. M., Tecuapetla, F., Koós, T. Z., & Ibáñez-Sandoval, O. (2010) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2010.00150 · Cited by 455 · see citing works
Roberts, D. C. S., & Koob, G. F. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90469-5 · Cited by 448 · see citing works
Hedonic Hot Spots in the Brain
Peciña, S., Smith, K. S., & Berridge, K. C. (2006) · The Neuroscientist · doi:10.1177/1073858406293154 · Cited by 441 · see citing works
Role of brain dopamine in food reward and reinforcement
Wise, R. A. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1854 · Cited by 436 · see citing works
Bellone, C., & Lüscher, C. (2006) · Nature Neuroscience · doi:10.1038/nn1682 · Cited by 429 · see citing works
Zweifel, L. S., Parker, J. G., Lobb, C. J., Rainwater, A., Wall, V. Z., Fadok, J. P., Darvas, M., Kim, M. J., Mizumori, S. J. Y., Paladini, C. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813415106 · Cited by 426 · see citing works
Robinson, T. E., & Flagel, S. B. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.006 · Cited by 416 · see citing works
Dopaminergic reward system: a short integrative review
Arias-Carrión, Ó., Stamelou, M., Murillo‐Rodríguez, E., Menéndez‐González, M., & Pöppel, E. (2010) · International Archives of Medicine · doi:10.1186/1755-7682-3-24 · Cited by 413 · see citing works
Role of dopamine in drug reinforcement and addiction in humans: results from imaging studies
Volkow, N. D., Fowler, J. S., & Wang, G.-J. (2002) · Behavioural Pharmacology · doi:10.1097/00008877-200209000-00008 · Cited by 398 · see citing works
The Ventral Pallidum and Hedonic Reward: Neurochemical Maps of Sucrose “Liking” and Food Intake
Smith, K. S., & Berridge, K. C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1902-05.2005 · Cited by 391 · see citing works
Westerink, B. H. C., Kwint, H., & Devries, J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02605.1996 · Cited by 372 · see citing works
Bello, E. P., Mateo, Y., Gelman, D. M., Noaín, D., Shin, J. H., Low, M. J., Alvarez, V. A., Lovinger, D. M., & Rubinstein, M. (2011) · Nature Neuroscience · doi:10.1038/nn.2862 · Cited by 364 · see citing works
The neurobiological basis of binge-eating disorder
KESSLER, R. M., Hutson, P. H., Herman, B. K., & Potenza, M. N. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.01.013 · Cited by 362 · see citing works
The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons
Lodge, D. J., & Grace, A. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510715103 · Cited by 349 · see citing works
Single rodent mesohabenular axons release glutamate and GABA
Root, D. H., Mejias-Aponte, C. A., Zhang, S., Wang, H.-L., Hoffman, A. F., Lupica, C. R., & Morales, M. (2014) · Nature Neuroscience · doi:10.1038/nn.3823 · Cited by 349 · see citing works
Food Craving and Food “Addiction”
Rogers, P. J., & Smit, H. J. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00197-0 · Cited by 347 · see citing works
Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking
Mahler, S. V., Vazey, E. M., Beckley, J. T., Keistler, C., McGlinchey, E. M., Kaufling, J., Wilson, S. P., Deisseroth, K. A., Woodward, J. J., & Aston‐Jones, G. (2014) · Nature Neuroscience · doi:10.1038/nn.3664 · Cited by 344 · see citing works
The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors
Root, D. H., Meléndez, R. I., Záborszky, L., & Napier, T. C. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.03.005 · Cited by 343 · see citing works
Food Addiction: Its Prevalence and Significant Association with Obesity in the General Population
Pedram, P., Wadden, D., Amini, P., Gulliver, W. P., Randell, E. W., Cahill, F., Vasdev, S., Goodridge, A., Carter, J. C., Zhai, G., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074832 · Cited by 338 · see citing works
Critical Involvement of Dopaminergic Neurotransmission in Impulsive Decision Making
van Gaalen, M. M., van Koten, R. C., Schoffelmeer, A. N. M., & Vanderschuren, L. J. M. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.005 · Cited by 338 · see citing works
Is food addiction a valid and useful concept?
Ziauddeen, H., & Fletcher, P. C. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01046.x · Cited by 334 · see citing works
In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward
Calipari, E. S., Bagot, R. C., Purushothaman, I., Davidson, T. J., Yorgason, J. T., Peña, C. J., Walker, D. M., Pirpinias, S. T., Guise, K. G., Ramakrishnan, C., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521238113 · Cited by 317 · see citing works
Self-citationShift from goal-directed to habitual cocaine seeking after prolonged experience in rats
Zapata, A., Minney, V. L., & Shippenberg, T. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4072-10.2010 · Cited by 296 · see citing works
Scholtz, S., Miras, A. D., Chhina, N., Prechtl, C. G., Sleeth, M., Daud, N. M., Ismail, N. A., Durighel, G., Ahmed, A. R., Olbers, T., et al. (2013) · Gut · doi:10.1136/gutjnl-2013-305008 · Cited by 284 · see citing works
Food Addiction in the Light of DSM-5
Meule, A., & Gearhardt, A. N. (2014) · Nutrients · doi:10.3390/nu6093653 · Cited by 277 · see citing works
Nucleus accumbens and impulsivity
Başar, K., Sesia, T., Groenewegen, H. J., Steinbusch, H. W. M., Visser-Vandewalle, V. E. R. M., & Temel, Y. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.08.007 · Cited by 276 · see citing works
Cognitive-motor interactions of the basal ganglia in development
Leisman, G., Benyamin, O. B., & Melillo, R. J. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00016 · Cited by 271 · see citing works
Forster, G. L., & Blaha, C. D. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00250.x · Cited by 271 · see citing works
Issues for DSM-V: Should obesity be included as a brain disorder?
Volkow, N. D., & O’Brien, C. P. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.5.708 · Cited by 271 · see citing works
Glutamatergic mechanisms in addiction
Tzschentke, T., & Schmidt, W. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001269 · Cited by 265 · see citing works
Cooper, S., Robison, A. J., & Mazei‐Robison, M. S. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0525-z · Cited by 264 · see citing works
Marinelli, M., & White, F. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08876.2000 · Cited by 254 · see citing works
mGluR5 Antagonist MPEP Reduces Ethanol-Seeking and Relapse Behavior
Bäckström, P., Bachteler, D., Koch, S., Hyytiä, P., & Spanagel, R. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300381 · Cited by 249 · see citing works
Food addiction and associations with mental health symptoms: A systematic review with meta-analysis
Burrows, T., Kay‐Lambkin, F., Pursey, K., Skinner, J., & Dayas, C. (2018) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12532 · Cited by 245 · see citing works
Ventral pallidum firing codes hedonic reward: when a bad taste turns good
Tindell, A. J., Smith, K. S., Peciña, S., Berridge, K. C., & Aldridge, J. W. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00576.2006 · Cited by 241 · see citing works
Mogenson, G. J., & Yang, C. R. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-0145-6_14 · Cited by 238 · see citing works
Kawano, M., Kawasaki, A., Sakata‐Haga, H., Fukui, Y., Kawano, H., Nogami, H., & Hisano, S. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21054 · Cited by 230 · see citing works
Dopamine and glucose, obesity, and reward deficiency syndrome
Blum, K., Thanos, P. K., & Gold, M. S. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00919 · Cited by 230 · see citing works
Development of allosteric modulators of GPCRs for treatment of CNS disorders
Nickols, H. H., & Conn, P. J. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.09.013 · Cited by 227 · see citing works
Self-citationFoster, D. J., & Conn, P. J. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.016 · Cited by 227 · see citing works
Self-citationMicroglia Play an Active Role in Obesity-Associated Cognitive Decline
Cope, E. C., LaMarca, E. A., Monari, P. K., Olson, L. B., Martinez, S., Zych, A. D., Katchur, N. J., & Gould, E. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0789-18.2018 · Cited by 225 · see citing works
Food addiction: a valid concept?
Fletcher, P. C., & Kenny, P. J. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0203-9 · Cited by 224 · see citing works
The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice
Paterson, N. E., Semenova, S., Gasparini, F., & Markou, A. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1432-z · Cited by 220 · see citing works
Cromwell, H. C., & Berridge, K. C. (1993) · Brain Research · doi:10.1016/0006-8993(93)90053-p · Cited by 220 · see citing works
Root, D. H., Mejías-Aponte, C. A., Qi, J., & Morales, M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2029-14.2014 · Cited by 213 · see citing works
Alterations of Central Dopamine Receptors Before and After Gastric Bypass Surgery
Steele, K. E., Prokopowicz, G. P., Schweitzer, M. A., Magunsuon, T. H., Lidor, A. O., Kuwabawa, H., Kumar, A., Brasic, J., & Wong, D. F. (2010) · Obesity Surgery · doi:10.1007/s11695-009-0015-4 · Cited by 213 · see citing works
Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement
Yoo, J. H., Zell, V., Gutierrez-Reed, N. A., Wu, J., Ressler, R. L., Shenasa, M. A., Johnson, A. B., Fife, K. H., Faget, L. C., & Hnasko, T. S. (2016) · Nature Communications · doi:10.1038/ncomms13697 · Cited by 210 · see citing works
Gagnon, D., Petryszyn, S., Sánchez, M. G., Bories, C., Beaulieu, J., Koninck, Y. D., Parent, A., & Parent, M. (2017) · Scientific Reports · doi:10.1038/srep41432 · Cited by 209 · see citing works
Fourgeaud, L., Mato, S., Bouchet, D., Hémar, A., Worley, P. F., & Manzoni, O. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0671-04.2004 · Cited by 207 · see citing works
Urwyler, S. (2011) · Pharmacological Reviews · doi:10.1124/pr.109.002501 · Cited by 207 · see citing works
Impulsivity in Binge Eating Disorder: Food Cues Elicit Increased Reward Responses and Disinhibition
Schag, K., Teufel, M., Junne, F., Preissl, H. T., Hautzinger, M., Zipfel, S., & Giel, K. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076542 · Cited by 203 · see citing works
VTA glutamatergic inputs to nucleus accumbens drive aversion by acting on GABAergic interneurons
Qi, J., Zhang, S., Wang, H., Barker, D. J., Miranda-Barrientos, J. A., & Morales, M. (2016) · Nature Neuroscience · doi:10.1038/nn.4281 · Cited by 203 · see citing works
Identification of Rat Ventral Tegmental Area GABAergic Neurons
Margolis, E. B., Toy, B. C., Himmels, P., Morales, M., & Fields, H. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042365 · Cited by 202 · see citing works
Reward sensitivity and the D2 dopamine receptor gene: A case-control study of binge eating disorder
Davis, C., Levitan, R. D., Kaplan, A. S., Carter, J., Reid, C., Curtis, C., Patte, K., Hwang, R., & Kennedy, J. L. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.024 · Cited by 200 · see citing works
Wolf, M. E., & Tseng, K. Y. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00072 · Cited by 199 · see citing works
The role of reward circuitry and food addiction in the obesity epidemic: An update
Leigh, S.-J., & Morris, M. J. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2016.12.013 · Cited by 191 · see citing works
Frascella, J., Potenza, M. N., Brown, L. L., & Childress, A. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05420.x · Cited by 191 · see citing works
Reappraising striatal D1- and D2-neurons in reward and aversion
Soares‐Cunha, C., Coimbra, B., Sousa, N., & Rodrigues, A. J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.021 · Cited by 190 · see citing works
Impulsivity predicts the escalation of cocaine self-administration in rats
Anker, J. J., Perry, J. L., Gliddon, L. A., & Carroll, M. E. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.05.013 · Cited by 188 · see citing works
The neural basis of delay discounting: A review and preliminary model
Frost, R., & McNaughton, N. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.022 · Cited by 180 · see citing works
Arce, E., & Santisteban, C. (2006) · PubMed · Cited by 177 · see citing works
Mameli, M., Bellone, C., Brown, M. T. C., & Lüscher, C. (2011) · Nature Neuroscience · doi:10.1038/nn.2763 · Cited by 177 · see citing works
Altered Dopamine Release and Uptake Kinetics in Mice Lacking D2Receptors
Schmitz, Y., Schmauss, C., & Sulzer, D. L. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-08002.2002 · Cited by 176 · see citing works
Convergence of Reinforcing and Anhedonic Cocaine Effects in the Ventral Pallidum
Creed, M. C., Ntamati, N. R., Chandra, R., Lobo, M. K., & Lüscher, C. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.001 · Cited by 176 · see citing works
Mapping brain circuits of reward and motivation: In the footsteps of Ann Kelley
Richard, J. M., Castro, D. C., DiFeliceantonio, A. G., Robinson, M. J. F., & Berridge, K. C. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.008 · Cited by 175 · see citing works
Substance use and addictive disorders in DSM-5 and ICD 10 and the draft ICD 11
Saunders, J. B. (2017) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000332 · Cited by 171 · see citing works
Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity
Trifilieff, P., & Martinez, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.031 · Cited by 171 · see citing works
Oleson, E. B., Beckert, M., Morra, J. T., Lansink, C. S., Cachope, R., Abdullah, R. A., Loriaux, A. L., Schetters, D., Pattij, T., Roitman, M. F., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.018 · Cited by 168 · see citing works
Tessari, M., Pilla, M. A., Andreoli, M., Hutcheson, D. M., & Heidbreder, C. A. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.056 · Cited by 168 · see citing works
Gonzales, K. K., & Smith, Y. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12762 · Cited by 164 · see citing works
Food addiction A common neurobiological mechanism with drug abuse
Wang, G. (2017) · Frontiers in bioscience · doi:10.2741/4618 · Cited by 163 · see citing works
Potent Regulation of Midbrain Dopamine Neurons by the Bed Nucleus of the Stria Terminalis
Georges, F., & Aston-Jones, G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-j0003.2001 · Cited by 163 · see citing works
Miras, A. D., Jackson, R. N., Jackson, S. N., Goldstone, A. P., Olbers, T., Hackenberg, T., Spector, A. C., & le Roux, C. W. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.036921 · Cited by 162 · see citing works
Schroeder, J. P., Overstreet, D. H., & Hodge, C. W. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2175-9 · Cited by 161 · see citing works
Bo, G. D., St-Gelais, F., Danik, M., Williams, S., Cotton, M., & Trudeau, L. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02277.x · Cited by 159 · see citing works
Dong, Y., Saal, D., Thomas, M., Faust, R., Bonci, A., Robinson, T., & Malenka, R. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401553101 · Cited by 158 · see citing works
Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving
Loweth, J. A., Scheyer, A. F., Milovanovic, M., LaCrosse, A. L., Flores-Barrera, E., Werner, C. T., Li, X., Ford, K. A., Le, T., Olive, M. F., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3590 · Cited by 157 · see citing works
Paterson, N. E., & Markou, A. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2070-9 · Cited by 155 · see citing works
Pelchat, M. L. (2009) · Journal of Nutrition · doi:10.3945/jn.108.097816 · Cited by 154 · see citing works
THE BEHAVIORAL PHARMACOLOGY OF EFFORT‐RELATED CHOICE BEHAVIOR: DOPAMINE, ADENOSINE AND BEYOND
Salamone, J. D., Correa, M., Nunes, E. J., Randall, P. A., & Pardo, M. (2012) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.2012.97-125 · Cited by 151 · see citing works
Nunes-Neto, P. R., Köhler, C. A., Schuch, F. B., Solmi, M., Quevedo, J., Maes, M., Murru, A., Vieta, E., McIntyre, R. S., McElroy, S. L., et al. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.10.003 · Cited by 150 · see citing works
Voon, V., Irvine, M. A., Derbyshire, K. L., Worbe, Y., Lange, I., Abbott, S., Morein‐Zamir, S., Dudley, R., Caprioli, D., Harrison, N. A., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.013 · Cited by 150 · see citing works
Mechanisms of synaptic depression triggered by metabotropic glutamate receptors
Bellone, C., Lüscher, C., & Mameli, M. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8263-3 · Cited by 150 · see citing works
Tang, X., McFarland, K., Cagle, S., & Kalivas, P. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0685-05.2005 · Cited by 148 · see citing works
Group II metabotropic glutamate receptors (mGlu2/3) in drug addiction
Moussawi, K., & Kalivas, P. W. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.01.030 · Cited by 146 · see citing works
Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction
van Huijstee, A. N., & Mansvelder, H. D. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00466 · Cited by 144 · see citing works
Glutamatergic transmission in drug reward: implications for drug addiction
D’Souza, M. S. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00404 · Cited by 141 · see citing works
The Regulation of Dopamine Transmission by Metabotropic Glutamate Receptors
Hu, G., Duffy, P., Swanson, C. J., Ghasemzadeh, M. B., & Kalivas, P. W. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38151-0 · Cited by 140 · see citing works
Glutamatergic and dopaminergic neurons in the mouse ventral tegmental area
Yamaguchi, T., Qi, J., Wang, H., Zhang, S. S., & Morales, M. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.12818 · Cited by 139 · see citing works
Impulsivity and emotion dysregulation as predictors of food addiction
Pivarunas, B., & Conner, B. T. (2015) · Eating Behaviors · doi:10.1016/j.eatbeh.2015.06.007 · Cited by 139 · see citing works
Steward, T., Mestre‐Bach, G., Vintró‐Alcaraz, C., Agüera, Z., Jiménez‐Múrcia, S., Granero, R., & Fernández‐Aranda, F. (2017) · European Eating Disorders Review · doi:10.1002/erv.2543 · Cited by 139 · see citing works
Reward, interrupted: Inhibitory control and its relevance to addictions
Jentsch, J. D., & Pennington, Z. T. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.022 · Cited by 134 · see citing works
Rook, J. M., Xiang, Z., Lv, X., Ghoshal, A., Dickerson, J. W., Bridges, T. M., Johnson, K. A., Foster, D. J., Gregory, K. J., Vinson, P. N., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.063 · Cited by 130 · see citing works
Self-citationEating Disorders, Physical Fitness and Sport Performance: A Systematic Review
Ghoch, M. E., Soave, F., Calugi, S., & Grave, R. D. (2013) · Nutrients · doi:10.3390/nu5125140 · Cited by 130 · see citing works
Impaired goal-directed behavioural control in human impulsivity
Hogarth, L., Chase, H. W., & Baess, K. (2012) · Quarterly Journal of Experimental Psychology · doi:10.1080/17470218.2010.518242 · Cited by 129 · see citing works
Olive, M. F., McGeehan, A., Kinder, J. R., McMahon, T., Hodge, C. W., Janak, P. H., & Messing, R. O. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.003319 · Cited by 128 · see citing works
Ventral Pallidal Representation of Pavlovian Cues and Reward: Population and Rate Codes
Tindell, A. J., Berridge, K. C., & Aldridge, J. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1437-03.2004 · Cited by 128 · see citing works
Omelchenko, N., & Sesack, S. R. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20852 · Cited by 127 · see citing works
Impulsivity in disorders of food and drug misuse
Mole, T. B., Irvine, M. A., Worbe, Y., Collins, P., Mitchell, S., Bolton, S., Harrison, N. A., Robbins, T. W., & Voon, V. (2014) · Psychological Medicine · doi:10.1017/s0033291714001834 · Cited by 127 · see citing works
Gallo, E. F., Mészáros, J., Sherman, J. D., Chohan, M. O., Teboul, E., Choi, C. S., Moore, H. M., Javitch, J. A., & Kellendonk, C. (2018) · Nature Communications · doi:10.1038/s41467-018-03272-2 · Cited by 125 · see citing works
Rewarding Effects of Optical Stimulation of Ventral Tegmental Area Glutamatergic Neurons
Wang, H., Qi, J., Zhang, S. S., Wang, H., & Morales, M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3428-15.2015 · Cited by 119 · see citing works
WINSTANLEY, C. A. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.024 · Cited by 119 · see citing works
The DRD4 exon 3 VNTR polymorphism and addiction-related phenotypes: A review
McGeary, J. E. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.03.010 · Cited by 117 · see citing works
The pharmacology of effort-related choice behavior: Dopamine, depression, and individual differences
Salamone, J. D., Correa, M., Yohn, S. E., López‐Cruz, L., Miguel, N. S., & Alatorre, L. F. (2016) · Behavioural Processes · doi:10.1016/j.beproc.2016.02.008 · Cited by 117 · see citing works
Self-citationHypothalamic Microglial Activation in Obesity: A Mini-Review
Mendes, N. F., Kim, Y., Velloso, L. A., & ARAUJO, E. P. D. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00846 · Cited by 117 · see citing works
The overlap between binge eating disorder and substance use disorders: Diagnosis and neurobiology
Schreiber, L. R. N., Odlaug, B. L., & Grant, J. E. (2013) · Journal of Behavioral Addictions · doi:10.1556/jba.2.2013.015 · Cited by 112 · see citing works
Opioid Modulation of Ventral Pallidal Inputs
Napier, T. C., & Mitrovic, I. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09268.x · Cited by 106 · see citing works
Overlapping Neural Endophenotypes in Addiction and Obesity
Michaud, A., Vainik, U., García‐García, I., & Dagher, A. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00127 · Cited by 103 · see citing works
Neurochemical modulation of ingestive behavior in the ventral pallidum
Shimura, T., Imaoka, H., & Yamamoto, T. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04689.x · Cited by 102 · see citing works
Diversity and Homogeneity in Responses of Midbrain Dopamine Neurons
Fiorillo, C. D., Yun, S. R., & Song, M. R. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3886-12.2013 · Cited by 99 · see citing works
Multiplexed neurochemical signaling by neurons of the ventral tegmental area
Barker, D. J., Root, D. H., Zhang, S., & Morales, M. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2015.12.016 · Cited by 99 · see citing works
Regulation of Motivation to Self‐Administer Ethanol by mGluR5 in Alcohol‐Preferring (P) Rats
Besheer, J., Faccidomo, S., Grondin, J. J. M., & Hodge, C. W. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00570.x · Cited by 97 · see citing works
Wang, L., Martin, B., Brenneman, R., Luttrell, L. M., & Maudsley, S. R. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.156380 · Cited by 97 · see citing works
Dopamine D2 receptors and striatopallidal transmission in addiction and obesity
Kenny, P. J., Voren, G., & Johnson, P. M. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.04.012 · Cited by 96 · see citing works
Addiction-like Synaptic Impairments in Diet-Induced Obesity
Brown, R. M., Kupchik, Y. M., Spencer, S. M., García‐Keller, C., Spanswick, D. C., Lawrence, A. J., Simonds, S. E., Schwartz, D., Jordan, K. A., Jhou, T. C., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.019 · Cited by 96 · see citing works
Benton, D., & Young, H. A. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.9 · Cited by 94 · see citing works
Драволина, О. А., Захарова, Е. С., Шекунова, Е. В., Zvartau, E. E., Danysz, W., & Bespalov, A. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.023 · Cited by 93 · see citing works
Garvey, M. A., Avenevoli, S., & Anderson, K. C. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.11.002 · Cited by 93 · see citing works
Chase, H. W., Fournier, J. C. J., Bertocci, M. A., Greenberg, T., Aslam, H. A., Stiffler, R. S., Lockovich, J., Graur, S., Bebko, G. M., Forbes, E. E., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.60 · Cited by 92 · see citing works
The Reinforcing Properties of Alcohol are Mediated by GABAA1 Receptors in the Ventral Pallidum
June, H. L., Foster, K. L., McKay, P. F., Seyoum, R., Woods, J. E., Harvey, S. C., Eiler, W. J. A., Grey, C., Carroll, M. R., McCane, S., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300239 · Cited by 91 · see citing works
Olive, M. F., Antón, B., Micevych, P. E., Evans, C. J., & Maidment, N. T. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07471.1997 · Cited by 89 · see citing works
Ménard, C., & Quirion, R. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00182 · Cited by 88 · see citing works
Flagged first, then by citations
1 of the 337 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
- [9]Baler RD; and Volkow ND (2006) Drug addiction: the neurobiology of disrupted selfcontrol, Trends Mol Med 12, 559– 566. 17070107
- [25]Baumgartner G; and Soyka M (2013) [DSM-5--what has changed in therapy for and research on substance-related and addictive disorders?], Fortschr Neurol Psychiatr 648– 654. 24194058
- [53]Cleva RM; and Olive MF (2012) mGlu receptors and drug addiction, Wiley Interdiscip Rev Membr Transp Signal 1, 281– 295. 22662312 PMC3364533
- [131]Fourgeaud L; Mato S; Bouchet D; Hemar A; Worley PF; and Manzoni OJ (2004) A single in vivo exposure to cocaine abolishes endocannabinoid-mediated longterm depression in the nucleus accumbens, J Neurosci 24, 6939– 6945. 15295029 PMC6729592
- [295]Derman RC; and Ferrario CR (2018) Enhanced incentive motivation in obesity-prone rats is mediated by NAc core CP-AMPARs, Neuropharmacology 131, 326– 336. 29291424 PMC6010194
Cited by
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Latif, S., Jahangeer, M., Razia, D. E. M., Ashiq, M., Ghaffar, A., Akram, M., Allam, A. E., Bouyahya, A., Garipova, L., Shariati, M. A., et al. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.08.009 · Cited by 360 · see citing works
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Feng, B. C., Harms, J., Chen, E., Gao, P., Xu, P., & He, Y. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20146325 · Cited by 59 · see citing works
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Swale, D. R. (2019) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2019.07.001 · Cited by 45 · see citing works
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Masri-zada, T., Martirosyan, S., Abdou, A., Barbar, R., Kades, S., Makki, H., Haley, G., & K Agrawal, D. (2025) · Journal of Psychiatry and Psychiatric Disorders · doi:10.26502/jppd.2572-519x0242 · Cited by 45 · see citing works
Kearney, P. J., Bolden, N. C., Kahuno, E. W., Conklin, T. L., Martin, G. E., Lübec, G., & Melikian, H. E. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.102900 · Cited by 16 · see citing works
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Maqsood, S., Ahmed, F., Arshad, M. T., Ikram, A., & Abdullahi, M. A. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70799 · Cited by 15 · see citing works
Sommer, L. M., Halbeisen, G., Erim, Y., & Paslakis, G. (2021) · Nutrients · doi:10.3390/nu13113813 · Cited by 14 · see citing works
Golden, A. K., & Davis, J. M. (2025) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s509971 · Cited by 10 · see citing works
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Hámor, P. U., & Schwendt, M. (2021) · Brain Plasticity · doi:10.3233/bpl-210120 · Cited by 10 · see citing works
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Heidinger, B. A., Cameron, J. D., Vaillancourt, R., Lisio, M. D., Ngu, M., Tasca, G. A., Chyurlia, L., Doucet, É., Doucette, S. P., Rivas, A. M. O., et al. (2021) · Gene · doi:10.1016/j.gene.2021.145538 · Cited by 8 · see citing works
Abdullah, M., Lin, S., Huang, L.-C., Chen, P. S., Tseng, H., & Yang, Y. K. (2024) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2024.04.004 · Cited by 8 · see citing works
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Malone, S. G., Davis, C. N., Piserchia, Z., Setzer, M. R., Toikumo, S., Zhou, H., Winterlind, E. L., Gelernter, J. E., Justice, A. C., Leggio, L., et al. (2025) · Nature Human Behaviour · doi:10.1038/s41562-025-02148-y · Cited by 8 · see citing works
Carr, M. M., Serowik, K. L., Na, P. J., Potenza, M. N., Martino, S., Masheb, R. M., & Pietrzak, R. H. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.03.039 · Cited by 8 · see citing works
Mihov, Y., Meyer, A. H., Kakebeeke, T. H., Stülb, K., Arhab, A., Zysset, A. E., Leeger‐Aschmann, C. S., Schmutz, E. A., Kriemler, S., Jenni, O. G., et al. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1292939 · Cited by 6 · see citing works
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Pak, E. S., & Murashov, A. K. (2021) · Journal of Visualized Experiments · doi:10.3791/63163 · Cited by 4 · see citing works
Huh, E., Agosto, M. A., Wensel, T. G., & Lichtarge, O. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.103030 · Cited by 4 · see citing works
Fasakin, O. W., Oboh, G., & Ademosun, A. O. (2024) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2024.12.006 · Cited by 3 · see citing works
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Aggarwal, D., Naik, J., & Lindquist, D. H. (2025) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-025-00314-0 · Cited by 3 · see citing works
Lan, Y., Ding, C.-Z., Xia, J.-X., Yang, Y.-Z., & Zhao, Y. (2024) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000001119 · Cited by 3 · see citing works
Elibol, R., & Şengör, N. S. (2020) · Journal of Computational Neuroscience · doi:10.1007/s10827-020-00769-y · Cited by 3 · see citing works
Weight Categories among Male Adolescents Linked to Risky Behaviors: High or Low BMI, Which Is Worse?
Denoth, F., Biagioni, S., Baldini, F., Baroni, M., Franchini, M., & Molinaro, S. (2022) · Adolescents · doi:10.3390/adolescents2010012 · Cited by 2 · see citing works
Keeler, J. L., Treasure, J. L., Juruena, M. F., Kan, C., & Himmerich, H. (2022) · Nutrients · doi:10.3390/nu14102119 · Cited by 2 · see citing works
Linking the Features of Food Addiction and Drug Addiction
Brasiel, P. G. D. A., & Luquetti, S. C. P. D. (2022) · Springer eBooks · doi:10.1007/978-3-030-92392-1_26 · Cited by 1 · see citing works
Lista, S., Ballerio, M., López‐Ortiz, S., Khoramipour, K., Imbimbo, B. P., Santos‐Lozano, A., Minoretti, P., & Emanuele, E. (2026) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2026.174217 · Cited by 1 · see citing works
Keyvanlo, S., Aghajani, S., & Sheykhzadeh, G. R. (2023) · فصلنامه علمی و پژوهشی اعتیادپژوهی · doi:10.61186/etiadpajohi.17.69.323 · Cited by 1 · see citing works
Adipose in Candyland: Diet and exercise in a pill
Greener, M. (2022) · Independent Nurse · doi:10.12968/indn.2022.9.24 · Cited by 1 · see citing works
Phenylpiracetam: molecular mechanisms of effects in obesity
Громова, О. А., Torshin, I. Y., & Лазебник, Л. Б. (2024) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2024-204 · Cited by 1 · see citing works
Громова, О. А., & Torshin, I. Y. (2024) · FARMAKOEKONOMIKA Modern Pharmacoeconomics and Pharmacoepidemiology · doi:10.17749/2070-4909/farmakoekonomika.2024.260 · Cited by 1 · see citing works
Linking the Features of Food Addiction and Drug Addiction
Brasiel, P. G. D. A., & Luquetti, S. C. P. D. (2022) · Springer eBooks · doi:10.1007/978-3-030-67928-6_26-1
Mathews, A. M., Riley, I. L., Henderson, R. J., Holbrook, J. T., Lang, J. E., Dixon, A. E., Wise, R. A., & Que, L. G. (2022) · Journal of Asthma and Allergy · doi:10.2147/jaa.s336945
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Hirsch, J. A., Mandel, S., Hegmann, K. T., Stratyner, A. G., Gitlow, S., Talmage, J. B., & Brigham, C. R. (2023) · AMA guides newsletter · doi:10.1001/amaguidesnewsletters.2023.marapr01
Torshin, I. Y., Громова, О. А., & Лазебник, Л. Б. (2024) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-225-5-12-25
Oyerinde, T. O., Asuku, A. O., Olajide, T. S., Afolabi, H. O., Kehinde, A., Saliu, S. B., & Arinde, E. S. (2025) · IGI Global eBooks · doi:10.4018/979-8-3693-5464-3.ch011
Avanesyan, H., Parsadanyan, M. A., Shahinyan, M. A., Багдасарович, Л. А., Mikaelyan, M. S., Grigoryan, S. V., & Vardevanyan, P. O. (2025) · Neurophysiology · doi:10.1007/s11062-026-10001-9
Longo‐Silva, G., Ayón, S. T., Rodríguez‐Martín, M., & Garaulet, M. (2026) · Appetite · doi:10.1016/j.appet.2026.108750
The biphasic model of addiction: integration, application, and limitations
Lindquist, D. H. (2026) · Addiction and substance abuse · doi:10.46439/addiction.4.012
Aranda, H., Jones, N., Haroon, H., & Choi, D. (2026) · Addiction Biology · doi:10.1111/adb.70195
- Authors
- Yohn, S. E., Galbraith, J., Calipari, E. S., & Conn, P. J.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Yohn, Samantha E.
- Conn, P. Jeffrey
- Venue
- ACS Chemical Neuroscience
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-04-01
- Volume
- 10
- Issue
- 5
- Pages
- 2125-2143
- ISSN
- 1948-7193 (ISSN-L)
- PMC
- PMC7898461
- OpenAlex
- W2933700335
- Cited by
- 36
- References
- 337
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 1 · 2019: 1
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- ACS Chemical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS031373)
- Whitehall Foundation
- Brain and Behavior Research Foundation
- National Institute on Drug Abuse (DA042111)
- National Institute of Mental Health (MH062646)
- Edward Mallinckrodt, Jr. Foundation
- Department of Pharmacology, Vanderbilt University
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- group I metabotropic glutamate receptors, mesolimbic dopamine system, drug addiction, obesity, binge eating disorder, allosteric modulators, dopamine-glutamate interaction, synaptic plasticity, neurotransmitter release, self-control, eating disorders
- MeSH terms
- Animals, Dopamine, Humans, Nerve Net, Obesity, Reward, Receptors, Metabotropic Glutamate, Substance-Related Disorders, Binge-Eating Disorder, Dopaminergic Neurons
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