Cited by 37Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchEating Disorders and Behaviors

Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity, and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway

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Yohn, Samantha E., Galbraith, Jordan, Calipari, Erin S., Conn, P. Jeffrey·2019·ACS Chemical Neuroscience

Abstract

Accumulated data from clinical and preclinical studies suggest that, in drug addiction and states of overeating, such as obesity and binge eating disorder (BED), there is an imbalance in circuits that are critical for motivation, reward saliency, executive function, and self-control. Central to these pathologies and the extensive topic of this Review are the aberrations in dopamine (DA) and glutamate (Glu) within the mesolimbic pathway. Group I metabotropic glutamate receptors (mGlus) are highly expressed in the mesolimbic pathway and are poised in key positions to modulate disruptions in synaptic plasticity and neurotransmitter release observed in drug addiction, obesity, and BED. The use of allosteric modulators of group I mGlus has been studied in drug addiction, as they offer several advantages over traditional orthosteric agents. However, they have yet to be studied in obesity or BED. With the substantial overlap between the neurocircuitry involved in drug addiction and eating disorders, group I mGlus may also provide novel targets for obesity and BED.

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Authors
Yohn, S. E., Galbraith, J., Calipari, E. S., & Conn, P. J.
Affiliations
Vanderbilt University (US)
Corresponding author
  • Yohn, Samantha E.
  • Conn, P. Jeffrey
Venue
ACS Chemical Neuroscience
Published
2019-04-01
Volume
10
Issue
5
Pages
2125-2143
ISSN
1948-7193 (ISSN-L)
OpenAlex
W2933700335
Cited by
36
References
337
Citations by year
2026: 4 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 1 · 2019: 1
FWCI
0.47
Type
journal article
Language
en
Open access
Locations
  • ACS Chemical Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke (NS031373)
  • Whitehall Foundation
  • Brain and Behavior Research Foundation
  • National Institute on Drug Abuse (DA042111)
  • National Institute of Mental Health (MH062646)
  • Edward Mallinckrodt, Jr. Foundation
  • Department of Pharmacology, Vanderbilt University
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords
group I metabotropic glutamate receptors, mesolimbic dopamine system, drug addiction, obesity, binge eating disorder, allosteric modulators, dopamine-glutamate interaction, synaptic plasticity, neurotransmitter release, self-control, eating disorders
MeSH terms
Animals, Dopamine, Humans, Nerve Net, Obesity, Reward, Receptors, Metabotropic Glutamate, Substance-Related Disorders, Binge-Eating Disorder, Dopaminergic Neurons

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