Cited by 718Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsDiabetes, Cardiovascular Risks, and Lipoproteins

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Meta-analysis of Alzheimer’s disease risk with obesity, diabetes, and related disorders

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Profenno, Louis A., Porsteinsson, Anton P., Faraone, Stephen V.·2010·Biological Psychiatry

DOI 10.1016/j.biopsych.2009.02.013

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Abstract

Background Late-onset Alzheimer's disease (AD) is a multifactorial and heterogeneous disorder with major risk factors including advanced age, presence of an apolipoprotein E epsilon4 (APOE4) allele, and family history of AD. Other risk factors may be obesity and diabetes and related disorders, which are highly prevalent.Methods We reviewed longitudinal epidemiological studies of body mass, diabetes, metabolic syndrome, and glucose and insulin levels on risk for AD. We conducted meta-analyses of the results from these studies.Results For obesity assessed by body mass index, the pooled effect size for AD was 1.59 (95% confidence interval [CI] 1.02-2.5; z = 2.0; p = .042), and for diabetes, the pooled effect size for AD was 1.54 (95% CI 1.33-1.79; z = 5.7; p < .001). Egger's test did not find significant evidence for publication bias in the meta-analysis for obesity (t = -1.4, p = .21) or for diabetes (t = -.86, p = .42). Since these disorders are highly comorbid, we conducted a meta-analysis combining all studies of obesity, diabetes, and abnormal glucose or insulin levels, which yielded a highly significant pooled effect size for AD of 1.63 (95% CI 1.39-1.92; z = 5.9; p < .001).Conclusions Obesity and diabetes significantly and independently increase risk for AD. Though the level of risk is less than that with the APOE4 allele, the high prevalence of these disorders may result in substantial increases in future incidence of AD. Physiological changes common to obesity and diabetes plausibly promote AD.

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Authors: Profenno, L. A., Porsteinsson, A. P., & Faraone, S. V.
Affiliations: SUNY Upstate Medical University (US)
University of Rochester Medicine (US)
Corresponding author: Profenno, Louis A.
ORCID: Porsteinsson, Anton P.
Faraone, Stephen V.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2010-03
Volume: 67
Issue: 6
Pages: 505-512
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2009.02.013
OpenAlex: W2032605307
Cited by: 718
References: 45
Citations by year: 2026: 19 · 2025: 41 · 2024: 55 · 2023: 51 · 2022: 44 · 2021: 47 · 2020: 55 · 2019: 65 · 2018: 39 · 2017: 43 · 2016: 41 · 2015: 52 · 2014: 50 · 2013: 46 · 2012: 44
FWCI: 2.84
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
SUNY Digital Repository Support (State University of New York System) (submittedVersion, cc-by-nc-nd)
Funders: U.S. Department of Veterans Affairs
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: Alzheimer's disease, obesity, diabetes mellitus, metabolic syndrome, body mass index, glucose concentration, insulin levels, disease risk factors, APOE ε4, comorbidities
MeSH terms: Aged, Alzheimer Disease, Female, Glucose, Humans, Insulin, Longitudinal Studies, Male, Mental Status Schedule, Middle Aged, Obesity, Retrospective Studies, Risk Factors, Body Mass Index, Proportional Hazards Models, PubMed, Diabetes Complications, Overweight, Apolipoprotein E4

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Meta-analysis of Alzheimer’s disease risk with obesity, diabetes, and related disorders

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