Cited by 231Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Glutamate Dysfunction in People with Prodromal Symptoms of Psychosis: Relationship to Gray Matter Volume

Open access

Stone, James M., Day, Fern, Tsagaraki, Helen, Valli, Isabel, McLean, Mary A., Lythgoe, David J., O'Gorman, Ruth L., Barker, Gareth J., McGuire, Philip K.·2009·Biological Psychiatry

DOI 10.1016/j.biopsych.2009.05.006

Open this paper in CoChat — free account Open PDF

Abstract

Background The glutamate model of schizophrenia proposes that altered glutamatergic neurotransmission is fundamental to the development of the disorder. In addition, its potential to mediate neurotoxicity raises the possibility that glutamate dysfunction could underlie neuroanatomic changes in schizophrenia. Here we determine whether changes in brain glutamate are present in subjects at ultra high risk of developing psychosis and whether these changes are related to reductions in cortical gray matter volume.Methods Twenty-seven individuals with an at-risk mental state and a group of 27 healthy volunteers underwent proton magnetic resonance spectroscopy and volumetric proton magnetic resonance imaging using a 3-Tesla scanner. Glutamate and glutamine levels were measured in anterior cingulate, left hippocampus, and left thalamus. These measures were then related to cortical gray matter volume.Results At-risk mental state (ARMS) subjects had significantly lower levels of glutamate than control subjects in the thalamus (p < .05) but higher glutamine in the anterior cingulate (p < .05). Within the ARMS group, the level of thalamic glutamate was directly correlated with gray matter volume in the medial temporal cortex and insula (p < .01).Conclusions This study provides the first evidence that brain glutamate function is perturbed in people with prodromal signs of schizophrenia and that glutamatergic dysfunction is associated with a reduction in gray matter volume in brain regions thought to be critical to the pathogenesis of the disorder. These findings support the hypothesis that drugs affecting the glutamate system may be of benefit in the early stages of psychotic illness.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2009.05.006

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences
Faul, F., Erdfelder, E., Lang, A.-G., & Buchner, A. (2007) · Behavior Research Methods · doi:10.3758/bf03193146 · Cited by 65,971
A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455
Estimation of metabolite concentrations from localized in vivo proton NMR spectra
Provencher, S. W. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910300604 · Cited by 3,659
Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793
Glutamate receptor dysfunction and schizophrenia
Olney, J. W. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240016004 · Cited by 1,685
Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison
Pantelis, C., Velakoulis, D., McGorry, P. D., Wood, S. J., John Suckling, A., Phillips, L., Yung, A. R., Bullmore, E. T., Brewer, W. J., Soulsby, B., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12323-9 · Cited by 1,309
Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group
Yung, A. R., Phillips, L. J., Yuen, H. P., Francey, S. M., McFarlane, C. A., Hallgren, M., & McGorry, P. D. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00167-6 · Cited by 1,136
Global, voxel, and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain
Bullmore, E. T., Suckling, J., Overmeyer, S., Rabe-Hesketh, S., Taylor, E., & Brammer, M. J. (1999) · IEEE Transactions on Medical Imaging · doi:10.1109/42.750253 · Cited by 1,088

Show all 45 references

Sorted by citations

Items 101–200 of 231

Genetic Association of ErbB4 and Human Cortical GABA LevelsIn Vivo
Marenco, S., Geramita, M. A., van der Veen, J. W. C., Barnett, A. S., Kolachana, B. S., Shen, J., Weinberger, D. R., & Law, A. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1529-11.2011 · Cited by 40
The interaction of working memory and emotion in persons clinically at risk for psychosis: An fMRI pilot study
Pauly, K. D., Romanczuk‐Seiferth, N., Kellermann, T., Ruhrmann, S., Daumann, B., Backes, V., Klosterkötter, J., Shah, N. J., Schneider, F. W., Kircher, T. T. J., et al. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2009.12.008 · Cited by 39
The Relationship of Developmental Changes in White Matter to the Onset of Psychosis
Karlsgodt, K. H., Jacobson, S. C., Seal, M. L., & Fusar‐Poli, P. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799316073 · Cited by 35
Evidence that reduced gray matter volume in psychotic disorder is associated with exposure to environmental risk factors
Frissen, A., van Os, J., Peeters, S. C. T., Gronenschild, E. H. B. M., & Marcelis, M. C. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.11.004 · Cited by 40
Glutamate and Psychosis Risk
Egerton, A., Fusar-Poli, P., & M. Stone, J. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799316244 · Cited by 36
Glutamatergic and dopaminergic function and the relationship to outcome in people at clinical high risk of psychosis: a multi-modal PET-magnetic resonance brain imaging study
Howes, O. D., Bonoldi, I., McCutcheon, R. A., Azis, M., Antoniades, M., Bossong, M. G., Modinos, G., Pérez, J., Stone, J. M., Santangelo, B., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0541-2 · Cited by 36
Dopamine and glutamate in individuals at high risk for psychosis: a meta‐analysis of in vivo imaging findings and their variability compared to controls
McCutcheon, R. A., Merritt, K., & Howes, O. D. (2021) · World Psychiatry · doi:10.1002/wps.20893 · Cited by 36
Corticolimbic hyper-response to emotion and glutamatergic function in people with high schizotypy: a multimodal fMRI-MRS study
Modinos, G., McLaughlin, A. P., Egerton, A., McMullen, K., Kumari, V., Barker, G. J., Keysers, C., & Williams, S. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.53 · Cited by 36
Neural circuitry of novelty salience processing in psychosis risk: Association with clinical outcome
Modinos, G., Allen, P., Zugman, A., Dima, D., Azis, M., Samson, C., Bonoldi, I., Quinn, B., Gifford, G. W. G., Smart, S. E., et al. (2020) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz089 · Cited by 31
Third-generation neuroimaging in early schizophrenia: Translating research evidence into clinical utility
Borgwardt, S., & Fusar‐Poli, P. (2012) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.111.103234 · Cited by 35
Psychiatric Disorders - Trends and Developments
Uehara, T. (2011) · InTech eBooks · doi:10.5772/2330 · Cited by 36
Glutamate, N-acetyl aspartate and psychotic symptoms in chronic ketamine users
Stone, J. M., Pepper, F., Fam, J., Furby, H., Hughes, E., Morgan, C. J. A., & Howes, O. D. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3354-8 · Cited by 34
Apoptotic markers in cultured fibroblasts correlate with brain metabolites and regional brain volume in antipsychotic-naive first-episode schizophrenia and healthy controls
Batalla, A., Bargalló, N., Gassó, P., Molina-Andreu, O., Pareto, D., Mas, S., de la Roca, J. M., Bernardo, M., Lafuente, A., & Parellada, E. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.122 · Cited by 33
NMDA Receptor Model of Antipsychotic Drug-Induced Hypofrontality
Krzystanek, M., & Pałasz, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061442 · Cited by 34
Candidate metabolic biomarkers for schizophrenia in CNS and periphery: Do any possible associations exist?
Cao, T., Li, N., & Cai, H. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.03.009 · Cited by 30
Heritability of cerebral glutamate levels and their association with schizophrenia spectrum disorders: a 1[H]-spectroscopy twin study
Legind, C. S., Broberg, B. V., Mandl, R. C. W., Brouwer, R. M., Anhøj, S. J., Hilker, R. W., Jensen, M. H., McGuire, P. K., Pol, H. E. H., Fagerlund, B., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0236-0 · Cited by 29
Functional magnetic resonance spectroscopy in patients with schizophrenia and bipolar affective disorder: Glutamate dynamics in the anterior cingulate cortex during a working memory task
Jelen, L. A., King, S., Horne, C. M., Lythgoe, D. J., Young, A. H., & Stone, J. M. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.12.005 · Cited by 29
Salience network glutamate and brain connectivity in medication-naïve first episode patients – A multimodal magnetic resonance spectroscopy and resting state functional connectivity MRI study
Maximo, J. O., Briend, F., Armstrong, W. P., Kraguljac, N. V., & Lahti, A. C. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102845 · Cited by 29
Study of retinal structure and function in patients with major depressive disorder, bipolar disorder or schizophrenia: A review of the literature
Adeline, T. A. N., Schwitzer, T., Conart, J., & Angioï-Duprez, K. (2020) · Journal Français d Ophtalmologie · doi:10.1016/j.jfo.2020.04.004 · Cited by 29
Reduced GABA/glutamate in the thalamus of individuals at clinical high risk for psychosis
Quiñones, G. M., Mayeli, A., Yushmanov, V. E., Hetherington, H. P., & Ferrarelli, F. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00920-4 · Cited by 28
Antipsychotic Interventions in Prodromal Psychosis
Liu, C., & Demjaha, A. (2013) · CNS Drugs · doi:10.1007/s40263-013-0046-1 · Cited by 28
Metabolic gray matter changes of adolescents with anorexia nervosa in combined MR proton and phosphorus spectroscopy
Blasel, S., Pilatus, U., Magerkurth, J., von Stauffenberg, M., Vronski, D., Mueller, M., Wöckel, L., & Hattingen, E. (2012) · Neuroradiology · doi:10.1007/s00234-011-1001-9 · Cited by 28
Preclinical 1 H-Mrs Neurochemical Profiling in Neurological And Psychiatric Disorders
Lee, M. R., Đenić, A., Hinton, D. J., Mishra, P. K., Choi, D., Pirko, I., Rodriguez, M., & Macura, S. I. (2012) · Bioanalysis · doi:10.4155/bio.12.129 · Cited by 27
Neuroanatomical changes in people with high schizotypy: relationship to glutamate levels
Modinos, G., Egerton, A., McLaughlin, A. P., McMullen, K., Kumari, V., Lythgoe, D. J., Barker, G. J., Aleman, A., & Williams, S. (2017) · Psychological Medicine · doi:10.1017/s0033291717003403 · Cited by 30
Are there glutamate abnormalities in subjects at high risk mental state for psychosis? A review of the evidence
Treen, D., Vila, S., Mollà, L., Forcadell, E., Chamorro, J., Bulbena, A., & Pérez, V. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.01.005 · Cited by 29
Cortical gray matter reduction precedes transition to psychosis in individuals at clinical high-risk for psychosis: A voxel-based meta-analysis
Fortea, A., Batalla, A., Raduà, J., van Eijndhoven, P., Baeza, I., Albajes‐Eizagirre, A., Fusar‐Poli, P., Castro‐Fornieles, J., de la Serna, E., Luna, L., et al. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.05.008 · Cited by 27
Thalamic neurochemical abnormalities in individuals with prodromal symptoms of schizophrenia — Relationship to auditory event-related potentials
Stone, J. M., Bramon, E., Pauls, A. M., Sumich, A. L., & McGuire, P. K. (2010) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.05.004 · Cited by 26
Sense of agency and its disturbances: A systematic review targeting the intentional binding effect in neuropsychiatric disorders
Moccia, L., Luzio, M. D., Conte, E., Modica, M., Ambrosecchia, M., Ardizzi, M., Lanzotti, P., Kotzalidis, G. D., Janiri, D., Nicola, M. D., et al. (2023) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13601 · Cited by 27
Substance use and regional gray matter volume in individuals at high risk of psychosis
Stone, J. M., Bhattacharyya, S., Barker, G. J., & McGuire, P. K. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.06.004 · Cited by 25
Investigating Cortical Inhibition in First-Degree Relatives and Probands in Schizophrenia
Radhu, N., Dominguez, L. G., Greenwood, T. A., Farzan, F., Semeralul, M. O., Richter, M. A., Kennedy, J. L., Blumberger, D. M., Chen, R. E., Fitzgerald, P. B., et al. (2017) · Scientific Reports · doi:10.1038/srep43629 · Cited by 26
Cerebral Glutamate and Gamma-Aminobutyric Acid Levels in Individuals at Ultra-high Risk for Psychosis and the Association With Clinical Symptoms and Cognition.
Wenneberg, C., Nordentoft, M., Rostrup, E., Glenthøj, L., Bojesen, K., Fagerlund, B., Hjorthøj, C., Krakauer, K., Kristensen, T. D., Schwartz, C., et al. (2019) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.12.005 · Cited by 28
Hippocampal Glutamate Levels and Striatal Dopamine D2/3 Receptor Occupancy in Subjects at Ultra High Risk of Psychosis
Bloemen, O., Gleich, T., de Koning, M. B., Alvis, F. D. S., de Haan, L., LINSZEN, D. H., Booij, J., & van Amelsvoort, T. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.11.030 · Cited by 24
Deconstructing Schizophrenia: Advances in Preclinical Models for Biomarker Identification
Pratt, J. A., MORRIS, B. J., & Dawson, N. (2018) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_48 · Cited by 23
Differential effects of DAAO on regional activation and functional connectivity in schizophrenia, bipolar disorder and controls
Papagni, S. A., Mechelli, A., Prata, D. P., Kambeitz, J. P., Fu, C. H. Y., Picchioni, M., Walshe, M., Toulopoulou, T., Bramon, E., Murray, R. M., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.03.037 · Cited by 22
Effect of D ‐amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency
Prata, D. P., Papagni, S. A., Mechelli, A., Fu, C. H. Y., Kambeitz, J. P., Picchioni, M., Kane, F., Kalidindi, S., McDonald, C., Kravariti, E., et al. (2011) · Human Brain Mapping · doi:10.1002/hbm.21198 · Cited by 22
Investigation of the effects of cannabidiol on vacuous chewing movements, locomotion, oxidative stress and blood glucose in rats treated with oral haloperidol
Kajero, J. A., Seedat, S., OHAERI, J. U., Akindele, A. J., & Aina, O. O. (2020) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2020.1752934 · Cited by 22
Molecular and micro-architectural mapping of gray matter alterations in psychosis
García-San-Martín, N., Bethlehem, R. A. I., Mihalik, Á., Seidlitz, J., Sebenius, I., Alemán-Morillo, C., Dorfschmidt, L., Shafiei, G., de la Foz, V. O., Merritt, K., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02724-0 · Cited by 21
Adolescent‐onset heavy cannabis use associated with significantly reduced glial but not neuronal markers and glutamate levels in the hippocampus
Blest‐Hopley, G., O’Neill, A., Wilson, R. P., Giampietro, V., Lythgoe, D. J., Egerton, A., & Bhattacharyya, S. (2019) · Addiction Biology · doi:10.1111/adb.12827 · Cited by 22
Sodium nitroprusside treatment for psychotic symptoms and cognitive deficits of schizophrenia: A randomized, double-blind, placebo-controlled trial
Wang, X., Zhao, J., Hu, Y., Jiao, Z., Lu, Y., Ding, M., Kou, Y., Li, B., Meng, F., Zhao, H., et al. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.08.079 · Cited by 21
Evidence-based psychotherapy for the prevention and treatment of first-episode psychosis
Müller, H., Laier, S., & Bechdolf, A. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0538-0 · Cited by 20
Clinical and Cerebral Volumetric Effects of Sodium Benzoate, a d-Amino Acid Oxidase Inhibitor, in a Drug-Naïve Patient with Major Depression
Lai, C., Lane, H., & Tsai, G. E. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.034 · Cited by 21
A Neurophysiological Perspective on a Preventive Treatment against Schizophrenia Using Transcranial Electric Stimulation of the Corticothalamic Pathway
Pinault, D. (2017) · Brain Sciences · doi:10.3390/brainsci7040034 · Cited by 23
T2 relaxation effects on apparent N-acetylaspartate concentration in proton magnetic resonance studies of schizophrenia
Bracken, B. K., Rouse, E. D., Renshaw, P. F., & Olson, D. P. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.03.005 · Cited by 20
The prodromal phase of psychosis
Modinos, G., & McGuire, P. K. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.11.003 · Cited by 20
Human Striatal Response to Reward Anticipation Linked to Hippocampal Glutamate Levels
Bossong, M. G., Wilson, R. P., Appiah‐Kusi, E., McGuire, P. K., & Bhattacharyya, S. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy011 · Cited by 19
Magnetic resonance spectroscopy studies in subjects with high risk for psychosis: A meta-analysis and review
Roméo, B., Petillion, A., Martelli, C., & Benyamina, A. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.03.006 · Cited by 19
No Evidence of Association between Childhood Urban Environment and Cortical Thinning in Psychotic Disorder
Frissen, A., van Os, J., Lieverse, R., Habets, P., Gronenschild, E. H. B. M., Marcelis, M. C., & (G.R.O.U.P.), G. R. A. O. I. P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0166651 · Cited by 19
Beyond NMDA Receptors: Homeostasis at the Glutamate Tripartite Synapse and Its Contributions to Cognitive Dysfunction in Schizophrenia
Bauminger, H., & Gaisler‐Salomon, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158617 · Cited by 16
Recent Updates on Predicting Conversion in Youth at Clinical High Risk for Psychosis
Caballero, N., Machiraju, S. N., Diomino, A., Kennedy, L., Kadivar, A., & Cadenhead, K. S. (2023) · Current Psychiatry Reports · doi:10.1007/s11920-023-01456-2 · Cited by 17
Metabolite abnormalities in psychosis risk: A meta-analysis of proton magnetic resonance spectroscopy studies
Wang, Y.-M., Xiao, Y., & Xie, W.-L. (2020) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2020.102220 · Cited by 15
Reward Processing in Mood Disorders and Schizophrenia: A Neurodevelopmental Framework
Nusslock, R., Mittal, V. A., & Alloy, L. B. (2025) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-080822-041621 · Cited by 16
An imaging-based risk calculator for prediction of conversion to psychosis in clinical high-risk individuals using glutamate 1H MRS
Kegeles, L. S., Ciarleglio, A., León-Ortíz, P., Reyes-Madrigal, F., Lieberman, J. A., Brucato, G., Girgis, R. R., & de la Fuente‐Sandoval, C. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.09.004 · Cited by 14
Early Detection and Prevention of Schizophrenic Psychosis—A Review
Westhoff, M. S., Ladwig, J., Heck, J., Schülke, R., Groh, A., Deest, M., Bleich, S., Frieling, H., & Jahn, K. (2021) · Brain Sciences · doi:10.3390/brainsci12010011 · Cited by 14
Acute oxytocin effects in inferring others’ beliefs and social emotions in people at clinical high risk for psychosis
Schmidt, A., Davies, C., Paloyelis, Y., Meyer, N., Micheli, A. D., Ramella‐Cravaro, V., Provenzani, U., Aoki, Y. Y., Rutigliano, G., Cappucciati, M., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00885-4 · Cited by 14
White matter alterations and the conversion to psychosis: A combined diffusion tensor imaging and glutamate 1H MRS study
León-Ortíz, P., Reyes-Madrigal, F., Kochunov, P., Gómez-Cruz, G., Moncada-Habib, T., Malacara, M., Mora-Durán, R., Rowland, L. M., & de la Fuente‐Sandoval, C. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.06.006 · Cited by 14
Neurodegenerative Aspects in Vulnerability to Schizophrenia Spectrum Disorders
Archer, T., Ricci, S., Garcia, D., & Ricciardi, M. R. (2014) · Neurotoxicity Research · doi:10.1007/s12640-014-9473-0 · Cited by 14
Reduced cortical GABA and glutamate in high schizotypy
Kozhuharova, P., Diaconescu, A. O., & Allen, P. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05867-y · Cited by 12
Magnetic resonance spectroscopic evidence of increased choline in the dorsolateral prefrontal and visual cortices in recent onset schizophrenia
Smucny, J., Carter, C. S., & Maddock, R. J. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136410 · Cited by 12
Glutamatergic function in a genetic high-risk group for psychosis: A proton magnetic resonance spectroscopy study in individuals with 22q11.2 deletion
Rogdaki, M., Hathway, P., Gudbrandsen, M., McCutcheon, R. A., Jauhar, S., Daly, E., & Howes, O. D. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.09.005 · Cited by 13
Automatic auditory processing features in distinct subtypes of patients at clinical high risk for psychosis: Forecasting remission with mismatch negativity
Wu, G., Tang, X., Gan, R., Zeng, J., Hu, Y., Xu, L., Wei, Y., Tang, Y., Chen, T., Liu, H., et al. (2022) · Human Brain Mapping · doi:10.1002/hbm.26021 · Cited by 11
Ethical Implications for Clinical Practice and Future Research in “At Risk” Individuals
Singh, F., Mirzakhanian, H., Fusar‐Poli, P., de la Fuente‐Sandoval, C., & Cadenhead, K. S. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799316262 · Cited by 10
Contributions of Experimental Psychiatry to Research on the Psychosis Prodrome
Bodatsch, M., Klosterkötter, J., & Daumann, J. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00170 · Cited by 10
Long term antipsychotic treatment does not alter metabolite concentrations in rat striatum: An in vivo magnetic resonance spectroscopy study
Lindquist, D. M., Dunn, R. S., & Cecil, K. M. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.02.019 · Cited by 10
Cortical Development and Glutamatergic Dysregulation in Schizophrenia
Sawa, A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.07.016 · Cited by 10
Differential cortical gray matter changes in early- and late-onset patients with amyotrophic lateral sclerosis
Ai, Y., Li, F. Y., Hou, Y., Li, X., Li, W., Qin, K., Suo, X., Lei, D., Shang, H., & Gong, Q. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad426 · Cited by 9
Biological embedding of early trauma: the role of higher prefrontal synaptic strength
Tamman, A. J. F., Jiang, L., Averill, C. L., Mason, G. F., Averill, L. A., & Abdallah, C. G. (2023) · European Journal of Psychotraumatology · doi:10.1080/20008066.2023.2246338 · Cited by 9
Neurochemical effects of oxytocin in people at clinical high risk for psychosis
Davies, C., Rutigliano, G., Micheli, A. D., Stone, J. M., Ramella‐Cravaro, V., Provenzani, U., Cappucciati, M., Scutt, E., Paloyelis, Y., Oliver, D., et al. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.03.008 · Cited by 8
Molecular Mechanisms Provide a Landscape for Biomarker Selection for Schizophrenia and Schizoaffective Psychosis
Fryar-Williams, S., Strobel, J. E., & Clements, P. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015296 · Cited by 8
An overview of functional, structural and neurochemical imaging studies in individuals with a clinical high risk for psychosis
Egerton, A., Borgwardt, S., Tognin, S., Howes, O. D., McGuire, P. K., & Allen, P. (2011) · Neuropsychiatry · doi:10.2217/npy.11.51 · Cited by 8
Alterations of neurometabolism in the dorsolateral prefrontal cortex and thalamus in transition to psychosis patients change under treatment as usual – A two years follow-up 1H/31P-MR-spectroscopy study
Smesny, S., Berberich, D., Gussew, A., Schönfeld, N., Langbein, K., Walther, M., & Reichenbach, J. R. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2020.11.063 · Cited by 7
Is clinical intervention in the ultra high risk phase effective?
McGuire, P. K., Selvaraj, S., & Howes, O. D. (2011) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462011000600004 · Cited by 7
Correction: Proton Magnetic Resonance Spectroscopy in 22q11 Deletion Syndrome
Alves, F. D. S., Boot, E., Schmitz, N., Nederveen, A. J., Vorstman, J. A. S., Lavini, C., Pouwels, P. J. W., de Haan, L., LINSZEN, D. H., & van Amelsvoort, T. (2011) · PLoS ONE · doi:10.1371/annotation/805ba3f5-0fd7-41f9-bc2c-31ebf507f05b · Cited by 7
Abnormal thalamic glutamate and liability to psychosis: State or trait marker?
Stone, J. M., & Fusar‐Poli, P. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.08.004 · Cited by 7
Association of cannabis with glutamatergic levels in patients with early psychosis: Evidence for altered volume striatal glutamate relationships in patients with a history of cannabis use in early psychosis
Sami, M. B., Worker, A., Colizzi, M., Annibale, L., Das, D., Kelbrick, M., Eranti, S. V., Collier, T., Onyejiaka, C., O’Neill, A., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0790-1 · Cited by 6
Baseline measures of cerebral glutamate and GABA levels in individuals at ultrahigh risk for psychosis: Implications for clinical outcome after 12 months
Wenneberg, C., Glenthøj, B., Glenthøj, L., Fagerlund, B., Krakauer, K., Kristensen, T. D., Hjorthøj, C., Edden, R., Broberg, B., Bojesen, K., et al. (2020) · European psychiatry · doi:10.1192/j.eurpsy.2020.77 · Cited by 7
Glutamate correlates negatively with cognitive theory of mind in schizotypy
Chen, S.-Y., Wang, L., Li, G., Wang, Y., Chu, M., Yan, C., Lui, S. S. Y., Li, J., & Chan, R. C. K. (2021) · PsyCh Journal · doi:10.1002/pchj.503 · Cited by 6
The Relationships between Dopaminergic, Glutamatergic, and Cognitive Functioning in 22q11.2 Deletion Syndrome: A Cross-Sectional, Multimodal 1H-MRS and 18F-Fallypride PET Study
van Hooijdonk, C. F. M., Tse, D. H. Y., Roosenschoon, J., Ceccarini, J., Booij, J., van Amelsvoort, T., & Vingerhoets, C. (2022) · Genes · doi:10.3390/genes13091672 · Cited by 6
Hippocampal Glutamate, Resting Perfusion and the Effects of Cannabidiol in Psychosis Risk
Davies, C., Bossong, M. G., Martins, D., Wilson, R. P., Appiah‐Kusi, E., Blest‐Hopley, G., Allen, P., Zelaya, F. O., Lythgoe, D. J., Brammer, M. J., et al. (2023) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgad022 · Cited by 6
Ex vivo 1H-MRS brain metabolic profiling in a two-hit model of neurodevelopmental disorders: Prenatal immune activation and peripubertal stress
Capellán, R., Moreno, M. G., Orihuel, J., Roura‐Martínez, D., Ucha, M., Ambrosio, E., & Higuera‐Matas, A. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.11.007 · Cited by 6
Personalisierte Medizin in der Psychiatrie und Psychotherapie
Koutsouleris, N., Ruhrmann, S., Falkai, P., & Maier, W. (2013) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-013-1840-0 · Cited by 5
A study of long-term GABA and high-energy phosphate alterations in the primary motor cortex using anodal tDCS and 1H/31P MR spectroscopy
Patel, H., Stollberg, L.-S., Choi, C., Nitsche, M. A., Shah, N. J., & Binkofski, F. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2024.1461417 · Cited by 4
Putative Structural Neuroimaging Endophenotypes In Schizophrenia: A Comprehensive Review of the Current Evidence
Waters, S., & Toulopoulou, T. (2011) · Future Neurology · doi:10.2217/fnl.11.35 · Cited by 4
Mapping Prodromal Psychosis
Fusar‐Poli, P., Borgwardt, S., & McGuire, P. K. (2011) · Springer eBooks · doi:10.1007/978-94-007-0837-2_20 · Cited by 3
Neurobiologie und Psychopathologie – wie passt das zusammen?
Borgwardt, S., Retz, W., & Reischies, F. M. (2012) · Zeitschrift für Psychiatrie Psychologie und Psychotherapie · doi:10.1024/1661-4747/a000126 · Cited by 3
MRS of Psychiatric Disorders
Taylor, M. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-401688-0.00016-1 · Cited by 3
Long-term adaptation of prefrontal circuits in a mouse model of NMDAR hypofunction
Ponserre, M., Ionescu, T. M., Franz, A. A., Deiana, S., Schuelert, N., Lamla, T., Williams, R. H., Wotjak, C. T., Hobson, S., Dine, J., et al. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109970 · Cited by 4
Glutamate Concentration in the Superior Temporal Sulcus Relates to Neuroticism in Schizophrenia
Balz, J., Romero, Y. R., Keil, J., Schubert, F., Ittermann, B., Ralf Mekle, A., Montag, C., Gallinat, J., & Senkowski, D. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00578 · Cited by 3
Neurocognitive Expression of Hypofrontality in Long Term Schizophrenia
Krzystanek, M., Krupka-Matuszczyk, I., & Klasik, A. (2011) · InTech eBooks · doi:10.5772/25762 · Cited by 3
Neurotoxic Vulnerability Underlying Schizophrenia Spectrum Disorders
Archer, T., Karilampi, U., Ricci, S., & Rapp‐Ricciardi, M. (2014) · Springer eBooks · doi:10.1007/978-1-4614-5836-4_119 · Cited by 3
THALAMIC GLUTAMATE LEVELS AS A PREDICTOR OF CORTICAL RESPONSE DURING EXECUTIVE FUNCTIONING IN SUBJECTS AT HIGH RISK FOR PSYCHOSIS
Fusar-Poli, P. (2012) · Schizophrenia Research · doi:10.1016/s0920-9964(12)70123-8 · Cited by 9
Spectral editing in proton magnetic resonance spectroscopy. Determination of GABA level in the brains of humans with ultra-high risk for schizophrenia
Menshchikov, P. E., Семенова, Н. А., Ublinskiy, M. V., Akhadov, T. A., Keshishian, R. A., Лебедева, И. С., Omelchenko, M. A., Каледа, В. Г., & Varfolomeev, S. D. (2015) · Russian Chemical Bulletin · doi:10.1007/s11172-015-1144-7 · Cited by 3
Neurodevelopmental Theories of Schizophrenia: Twenty‐First Century Perspectives
Haut, K. M., Schvarcz, A., Cannon, T. D., & Bearden, C. E. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy223 · Cited by 3
Aging in Schizophrenia: Perspectives on Molecular Mechanisms and a Mini-review
Weerasekera, A., Dost, Ö., & Fei, D. (2025) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaf099 · Cited by 2
Structural and Functional Neuroimaging Biomarkers as Predictors of Psychosis Conversion in Ultra-High Risk Individuals: A Systematic Review
Martinotti, G., Piro, T., Ciraselli, N., Persico, L., Inserra, A., Pettorruso, M., Maina, G., & Ricci, V. (2026) · Brain Science · doi:10.3390/brainsci16010112 · Cited by 4
Neurotransmitter visualization in schizophrenia
Brašić, J. R. (2013) · Journal of Biomedical Graphics and Computing · doi:10.5430/jbgc.v3n2p30 · Cited by 3
Neuroimaging and the At-Risk Mental State
Lin, Y.-S., Fusar‐Poli, P., & Borgwardt, S. (2019) · Springer eBooks · doi:10.1007/978-3-319-97307-4_6 · Cited by 2
Étude de la structure et de la fonction rétinienne chez les patients atteints de trouble dépressif sévère, de trouble bipolaire ou de schizophrénie : une revue de la littérature
Adeline, T. A. N., Schwitzer, T., Conart, J., & Angioï-Duprez, K. (2020) · Journal Français d Ophtalmologie · doi:10.1016/j.jfo.2019.10.029 · Cited by 2
Frontoparietal anodal tDCS reduces ketamine-induced oscillopathies
Lahogue, C., & Pinault, D. (2021) · Translational Neuroscience · doi:10.1515/tnsci-2020-0157 · Cited by 2
N-Acetylaspartate and Choline Metabolites in Cortical and Subcortical Regions in Clinical High Risk Relative to Healthy Control Subjects: An Exploratory 7T MRSI Study
Mayeli, A., Janssen, S. A., Huston, C. A., Rupp, J. S., Sharma, K., Moon, C., Keihani, A., Hetherington, H. P., & Ferrarelli, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097682 · Cited by 2
Do cognitive and neuropsychological functioning deficits coincide with hippocampal alteration during first-psychotic episode?
Kadriu, B., Gu, W., Korenis, P., & Levine, J. M. (2018) · CNS Spectrums · doi:10.1017/s1092852918001293 · Cited by 2

Authors: Stone, J. M., Day, F., Tsagaraki, H., Valli, I., McLean, M. A., Lythgoe, D. J., O'Gorman, R. L., Barker, G. J., & McGuire, P. K.
Affiliations: University of London (GB)
UCL Queen Square Institute of Neurology (GB)
Corresponding author: Stone, James M.
ORCID: Stone, James M.
Day, Fern
Valli, Isabel
McLean, Mary A.
Lythgoe, David J.
Barker, Gareth J.
McGuire, Philip K.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2009-09
Volume: 66
Issue: 6
Pages: 533-539
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2009.05.006
OpenAlex: W1994737820
Cited by: 231
References: 45
Citations by year: 2026: 4 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 3 · 2021: 13 · 2020: 16 · 2019: 17 · 2018: 11 · 2017: 11 · 2016: 10 · 2015: 20 · 2014: 21 · 2013: 20 · 2012: 21
FWCI: 14.60
Type: journal article
Language: en
Open access: green
kclpure.kcl.ac.uk
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: glutamate dysfunction, glutamatergic neurotransmission, schizophrenia, clinical high risk for psychosis, prodromal psychosis, gray matter volume, glutamine, thalamus, anterior cingulate cortex, hippocampus, insula, neurotoxicity, 1H NMR
MeSH terms: Adult, Mental Disorders, Brain Mapping, Female, Glutamine, Humans, Magnetic Resonance Imaging, Male, Magnetic Resonance Spectroscopy, Protons, Psychiatric Status Rating Scales, Risk, Temporal Lobe, Thalamus, Glutamic Acid, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Glutamate Dysfunction in People with Prodromal Symptoms of Psychosis: Relationship to Gray Matter Volume

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks