Subgenual Prefrontal Cortex Activity Predicts Individual Differences in Hypothalamic-Pituitary-Adrenal Activity Across Different Contexts

Jahn, Allison L.; Fox, Andrew S.; Abercrombie, Heather C.; Shelton, Steven E.; Oakes, Terrence R.; Davidson, Richard J.; Kalin, Ned H.

doi:10.1016/j.biopsych.2009.07.039

Cited by 61Stress Responses and CortisolNeural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on Behavior

Subgenual Prefrontal Cortex Activity Predicts Individual Differences in Hypothalamic-Pituitary-Adrenal Activity Across Different Contexts

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Jahn, Allison L., Fox, Andrew S., Abercrombie, Heather C., Shelton, Steven E., Oakes, Terrence R., Davidson, Richard J., Kalin, Ned H.·2010·Biological Psychiatry

DOI 10.1016/j.biopsych.2009.07.039PMC PMC2804442

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Abstract

Background Hypothalamic-pituitary-adrenal (HPA) system activation is adaptive in response to stress, and HPA dysregulation occurs in stress-related psychopathology. It is important to understand the mechanisms that modulate HPA output, yet few studies have addressed the neural circuitry associated with HPA regulation in primates and humans. Using high-resolution F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) in rhesus monkeys, we assessed the relation between individual differences in brain activity and HPA function across multiple contexts that varied in stressfulness.Methods Using a logical AND conjunctions analysis, we assessed cortisol and brain metabolic activity with FDG-PET in 35 adolescent rhesus monkeys exposed to two threat and two home-cage conditions. To test the robustness of our findings, we used similar methods in an archival data set. In this data set, brain metabolic activity and cortisol were assessed in 17 adolescent male rhesus monkeys that were exposed to three stress-related contexts.Results Results from the two studies revealed that subgenual prefrontal cortex (PFC) metabolism (Brodmann's area 25/24) consistently predicted individual differences in plasma cortisol concentrations regardless of the context in which brain activity and cortisol were assessed.Conclusions These findings suggest that activation in subgenual PFC may be related to HPA output across a variety of contexts (including familiar settings and novel or threatening situations). Individuals prone to elevated subgenual PFC activity across multiple contexts may be individuals who consistently show heightened cortisol and may be at risk for stress-related HPA dysregulation.

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Area 25 activity positively correlates with cortisol levels during anxiety-provoking contexts in macaques.
“Consistent with the latter is the finding that area 25 activity positively correlates with cortisol levels during anxiety-provoking contexts in macaques [143].”
From Prefrontal cortex and depression (2022) · cites this paper as [143]

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Authors: Jahn, A. L., Fox, A. S., Abercrombie, H. C., Shelton, S. E., Oakes, T. R., Davidson, R. J., & Kalin, N. H.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Kalin, Ned H.
ORCID: Fox, Andrew S.
Abercrombie, Heather C.
Davidson, Richard J.
Kalin, Ned H.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2010-01
Volume: 67
Issue: 2
Pages: 175-181
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2009.07.039
PMC: PMC2804442
OpenAlex: W2067411830
Cited by: 61
References: 52
Citations by year: 2026: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 9 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 7
FWCI: 2.29
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Wisconsin National Primate Research Center (RR000167)
HealthEmotions Research Institute (MH46729,, MH69315,, MH84051,)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: subgenual prefrontal cortex, hypothalamic-pituitary-adrenal axis, cortisol, individual differences, rhesus monkeys, brain glucose metabolism, stress response, threats, home cage, stress-related psychopathology
MeSH terms: Animals, Brain, Brain Mapping, Disease Models, Animal, Female, Hydrocortisone, Hypothalamo-Hypophyseal System, Immunoassay, Individuality, Macaca mulatta, Magnetic Resonance Imaging, Male, Pituitary-Adrenal System, Predictive Value of Tests, Probability, Social Isolation, Stress, Psychological, Logistic Models, Prefrontal Cortex, Fluorodeoxyglucose F18, Positron-Emission Tomography

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Subgenual Prefrontal Cortex Activity Predicts Individual Differences in Hypothalamic-Pituitary-Adrenal Activity Across Different Contexts

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