Stress reverses plasticity in the pathway projecting from the ventromedial prefrontal cortex to the basolateral amygdala

Maroun, Mouna

doi:10.1111/j.1460-9568.2006.05169.x

Cited by 82Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchStress Responses and Cortisol

Stress reverses plasticity in the pathway projecting from the ventromedial prefrontal cortex to the basolateral amygdala

Maroun, Mouna·2006·European Journal of Neuroscience

DOI 10.1111/j.1460-9568.2006.05169.x

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Abstract

We have previously shown that high‐frequency stimulation to the basolateral amygdala (BLA) induces long‐term potentiation (LTP) in the ventromedial prefrontal cortex (vmPFC) and that prior exposure to inescapable stress inhibits the induction of LTP in this pathway [Maroun & Richter‐Levin (2003)J. Neurosci., 23, 4406–4409]. Here, we show that the reciprocal pathway projecting from the vmPFC to the BLA is resistant to the induction of LTP. Conversely, long‐term depression (LTD) is robustly induced in the BLA in response to low‐frequency stimulation to the vmPFC. Furthermore, prior exposure to inescapable stress reverses plasticity in this pathway, resulting in the promotion of LTP and the inhibition of LTD. Our findings suggest that, under normal and safe conditions, the vmPFC is unable to exert excitatory synaptic plasticity over the BLA; rather, LTD, which encodes memory of safety in the BLA, is favoured. Following stressful experiences, LTP in the BLA is promoted to encode memory of fear.

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Previous animal studies have shown that stress can modulate the nature of interactions among brain regions.
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Authors: Maroun, M.
Affiliations: University of Haifa (IL)
Corresponding author: Maroun, Mouna
ORCID: Maroun, Mouna
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 2006-11
Volume: 24
Issue: 10
Pages: 2917-2922
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1111/j.1460-9568.2006.05169.x
OpenAlex: W2166892356
Cited by: 82
References: 68
Citations by year: 2026: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 4 · 2018: 1 · 2017: 6 · 2016: 2 · 2015: 7 · 2014: 8 · 2013: 9 · 2012: 10
FWCI: 2.27
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 16 d)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Zeit-Stiftung Ebelin und Gerd Bucerius
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: ventromedial prefrontal cortex, basolateral amygdala, synaptic plasticity, long-term potentiation, long-term depression, inescapable stress, fear memory
MeSH terms: Amygdala, Animals, Dose-Response Relationship, Radiation, Efferent Pathways, Electric Stimulation, Male, Neuronal Plasticity, Stress, Physiological, Rats, Sprague-Dawley, Prefrontal Cortex, Rats

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Stress reverses plasticity in the pathway projecting from the ventromedial prefrontal cortex to the basolateral amygdala

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