The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Altered function and connectivity of the medial frontal cortex in pediatric obsessive compulsive disorder
Open accessAbstract
Background Exaggerated concern for correct performance has been linked to hyperactivity of the medial frontal cortex (MFC) in adult obsessive-compulsive disorder (OCD), but the role of the MFC during the early course of illness remains poorly understood. We tested whether hyperactive MFC-based performance monitoring function relates to altered MFC connectivity within task control and default mode networks in pediatric patients.Methods Eighteen pairs of OCD and matched healthy youth underwent functional magnetic resonance imaging during performance monitoring and at rest. Task-related hyperactivations in the posterior and ventral MFC were used as seeds for connectivity analyses during task and resting state.Results In posterior MFC, patients showed greater activation of dorsal anterior cingulate cortex (dACC) than control subjects, with greater activation predicting worse performance. In ventral MFC, control subjects exhibited deactivation, whereas patients activated this region. Compared with control subjects, patients showed increased dACC-ventral MFC connectivity during task and decreased dACC-right anterior operculum and ventral MFC-posterior cingulate connectivity during rest.Conclusions Excessive activation and increased interactions of posterior and ventral MFC during performance monitoring may combine with reduced resting state connectivity of these regions within networks for task control and default mode to reflect early markers of OCD. Alteration of reciprocal interactions between these networks could potentiate the intrusion of ventral MFC-based affectively laden, self-referential thoughts, while disrupting posterior MFC-based performance-monitoring function in young patients.
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“regions of the “default-mode” network (DMN) including VMPFC and posterior cingulate cortex deactivate with increases in externally-directed cognition (31-33) including that associated with error detection (34, 35).”
From Hyperactive error responses and altered connectivity in ventromedial and frontoinsular cortices in obsessive-compulsive disorder (2011) · cites this paper as [34]
In the citing paper
“In OCD, enlarged volume and hyperactive function of the ACC associate with deficits of cognitive control2,3,9, while vMFC alterations – especially hyperactivity in the orbitofrontal cortex – has been linked to excessive valuation of consequences from actions3.”
From Developmental alterations of frontal-striatal-thalamic connectivity in obsessive-compulsive disorder (2011) · cites this paper as [9]
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“Alteration of ACC recruitment by these functions has been repeatedly demonstrated in neuroimaging studies of OCD3, including in child patients9.”
From Developmental alterations of frontal-striatal-thalamic connectivity in obsessive-compulsive disorder (2011) · cites this paper as [9]
In the citing paper
“However, the development of ACC cognitive control function depends not only on the maturation of its connections within FSTC, but also on its role within other brain networks (e.g., cingulopercular network for task control13) implicated in both pediatric9 and adult28 OCD.”
From Developmental alterations of frontal-striatal-thalamic connectivity in obsessive-compulsive disorder (2011) · cites this paper as [9]
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Milad, M. R., Furtak, S. C., Greenberg, J. L., Keshaviah, A., Im, J. J., Falkenstein, M. J., Jenike, M., Rauch, S. L., & Wilhelm, S. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.914 · Cited by 308
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Metadata
- Authors
- Fitzgerald, K. D., Stern, E. R., Angstadt, M., Nicholson-Muth, K. C., Maynor, M. R., Welsh, R. C., Hanna, G. L., & Taylor, S. F.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Fitzgerald, Kate Dimond
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 68
- Issue
- 11
- Pages
- 1039-1047
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC2988474
- OpenAlex
- W2069603286
- Cited by
- 152
- References
- 68
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 8 · 2018: 8 · 2017: 21 · 2016: 9 · 2015: 18 · 2014: 12 · 2013: 16 · 2012: 11
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Update notices
- erratum (2012-03-15)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Dana Foundation
- National Alliance for Research on Schizophrenia and Depression
- Todd Ouida Clinical Scholars Award
- National Institute of Mental Health (K23-MH082176, R01-MH071821)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- pediatric obsessive-compulsive disorder, medial frontal cortex, performance monitoring, dorsal anterior cingulate cortex, ventromedial prefrontal cortex, default mode network, resting-state functional connectivity, posterior cingulate cortex, self-referential processing
- MeSH terms
- Adolescent, Brain Mapping, Child, Female, Frontal Lobe, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Net, Neural Pathways, Obsessive-Compulsive Disorder, Psychiatric Status Rating Scales, Psychomotor Performance, Reaction Time, Cluster Analysis
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