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Prenatal Interaction of Mutant DISC1 and Immune Activation Produces Adult Psychopathology
Open accessAbstract
Background Gene-environment interactions (GEI) are involved in the pathogenesis of mental diseases. We evaluated interaction between mutant human disrupted-in-schizophrenia 1 (mhDISC1) and maternal immune activation implicated in schizophrenia and mood disorders.Methods Pregnant mice were treated with saline or polyinosinic:polycytidylic acid at gestation day 9. Levels of inflammatory cytokines were measured in fetal and adult brains; expression of mhDISC1, endogenous DISC1, lissencephaly type 1, nuclear distribution protein nudE-like 1, glycoprotein 130, growth factor receptor-bound protein 2, and glycogen synthase kinase-3beta were assessed in cortical samples of newborn mice. Tissue content of monoamines, volumetric brain abnormalities, dendritic spine density in the hippocampus, and various domains of the mouse behavior repertoire were evaluated in adult male mice.Results Prenatal interaction produced anxiety, depression-like responses, and altered social behavior that were accompanied by decreased reactivity of the hypothalamic-pituitary-adrenal axis, attenuated serotonin neurotransmission in the hippocampus, reduced enlargement of lateral ventricles, decreased volumes of amygdala and periaqueductal gray matter and density of spines on dendrites of granule cells of the hippocampus. Prenatal interaction modulated secretion of inflammatory cytokines in fetal brains, levels of mhDISC1, endogenous mouse DISC1, and glycogen synthase kinase-3beta. The behavioral effects of GEI were observed only if mhDISC1 was expressed throughout the life span.Conclusions Prenatal immune activation interacted with mhDISC1 to produce the neurobehavioral phenotypes that were not seen in untreated mhDISC1 mice and that resemble aspects of major mental illnesses. Our DISC1 mouse model is a valuable system to study GEI relevant to mental illnesses.
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“In contrast, one study found that prenatal poly(I:C) exposure increased 5-HT levels in the hippocampus (Abazyan et al., 2010).”
From Neuroinflammation as a risk factor for attention deficit hyperactivity disorder (2019) · cites this paper as Abazyan et al., 2010
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“prenatal maternal immune activation and expression of a mutant DISC1 protein interacted to produce an altered pattern of sociability.”
From Autism risk factors: genes, environment, and gene-environment interactions (2012) · cites this paper as [107]
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“This neurobehavioral profile was absent in untreated mice expressing the mutant.”
From Autism risk factors: genes, environment, and gene-environment interactions (2012) · cites this paper as [107]
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“In addition, elevated levels and decreased turnover of 5-HT in the hippocampus in mhDISC1 mice treated with Poly I:C are reminiscent of serotonin abnormalities associated with affective states (64,81,82).”
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Metadata
- Authors
- Abazyan, B., Nomura, J., Kannan, G., Ishizuka, K., Tamashiro, K. L., Nucifora, F., Pogorelov, V., Ladenheim, B., Yang, C., Krasnova, I. N., Cadet, J. L., Pardo, C., Mori, S., Kamiya, A., Vogel, M. W., Sawa, A., Ross, C. A., & Pletnikov, M. V.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Pletnikov, Mikhail V.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 68
- Issue
- 12
- Pages
- 1172-1181
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC3026608
- OpenAlex
- W2068766837
- Cited by
- 255
- References
- 83
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 11 · 2023: 9 · 2022: 15 · 2021: 11 · 2020: 11 · 2019: 15 · 2018: 18 · 2017: 13 · 2016: 24 · 2015: 24 · 2014: 16 · 2013: 24 · 2012: 32
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health
- Cell Science Research Foundation
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- DISC1, gene-environment interaction, maternal immune activation, polyinosinic-polycytidylic acid, prenatal immune activation, schizophrenia, mood disorders, anxiety, depression-like behavior, social behavior, hypothalamic-pituitary-adrenal axis, serotonergic neurotransmission, lateral ventricle enlargement, amygdala, periaqueductal gray, glycogen synthase kinase-3β, inflammatory cytokines
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Animals, Animals, Newborn, Atrophy, Behavior, Animal, Brain, Carrier Proteins, Corticosterone, Disease Models, Animal, Female, Male, Mice, Mutant Strains, Mice, Transgenic, Microtubule-Associated Proteins, Nerve Tissue Proteins, Poly I-C, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological, Biogenic Monoamines, Cytokines, Mood Disorders, Glycogen Synthase Kinase 3, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Dendritic Spines, Cytokine Receptor gp130, Mice, GRB2 Adaptor Protein
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