Sawa, Akira

Schizophrenia

Owen, M. J., Sawa, A., & Mortensen, P. B. (2016) · The Lancet

Schizophrenia research and treatmentMental Health and Psychiatry

Cited by 1,870

Improving polygenic prediction in ancestrally diverse populations

Ruan, Y., Lin, Y.-F., Feng, Y.-C. A., Chen, C.-Y., Lam, M., Guo, Z., Initiatives, S. G. A., Ahn, Y. M., Akiyama, K., Arai, M., et al. (2022) · Nature Genetics

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 707

The diverse functions of GAPDH: Views from different subcellular compartments

Tristan, C., Shahani, N., Sedlak, T. W., & Sawa, A. (2011) · Cellular Signalling

Redox biology and oxidative stressCell death mechanisms and regulation

Cited by 663

Altering the course of schizophrenia: progress and perspectives

Millan, M. J., Andrieux, A., Bartzokis, G., Cadenhead, K., Dazzan, P., Fusar-Poli, P., Gallinat, J., Giedd, J., Grayson, D. R., Heinrichs, M., et al. (2016) · Nature Reviews Drug Discovery

Schizophrenia research and treatmentMental Health and Psychiatry

Cited by 516

The insula: an underestimated brain area in clinical neuroscience, psychiatry, and neurology

Namkung, H., Kim, S.-H., & Sawa, A. (2017) · Trends in Neurosciences

Psychosomatic Disorders and Their TreatmentsNeural and Behavioral Psychology Studies

Cited by 462

KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant

Golzio, C., Willer, J., Talkowski, M. E., Oh, E. C., Taniguchi, Y., Jacquemont, S., Reymond, A., Sun, M., Sawa, A., Gusella, J. F., et al. (2012) · Nature

Genomic variations and chromosomal abnormalitiesGenetics and Neurodevelopmental Disorders

Cited by 410

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

Hayashi-Takagi, A., Takaki, M., Graziane, N., Seshadri, S., Murdoch, H., Dunlop, A. J., Makino, Y., Seshadri, A. J., Ishizuka, K., Srivastava, D. P., et al. (2010) · Nature Neuroscience

Neuroscience and Neuropharmacology ResearchSchizophrenia research and treatment

Cited by 399

Adolescent Stress–Induced Epigenetic Control of Dopaminergic Neurons via Glucocorticoids

Niwa, M., Jaaro-Peled, H., Tankou, S., Seshadri, S., Hikida, T., Matsumoto, Y., Cascella, N. G., Kano, S.-I., Ozaki, N., Nabeshima, T., et al. (2013) · Science

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 318

Towards a youth mental health paradigm: a perspective and roadmap

Uhlhaas, P. J., Davey, C. G., Mehta, U. M., Shah, J., Torous, J., Allen, N. B., Avenevoli, S., Bella-Awusah, T., Chanen, A., Chen, E. Y. H., et al. (2023) · Molecular Psychiatry

Child and Adolescent Psychosocial and Emotional DevelopmentPsychology and Mental Health

Cited by 318

Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy

Watkins, C. C., Sawa, A., Jaffrey, S., Blackshaw, S., Barrow, R. K., Snyder, S. H., & Ferris, C. D. (2000) · Journal of Clinical Investigation

Gastrointestinal motility and disordersNitric Oxide and Endothelin Effects

Cited by 268

Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology

Abazyan, B., Nomura, J., Kannan, G., Ishizuka, K., Tamashiro, K. L., Nucifora, F., Pogorelov, V., Ladenheim, B., Yang, C., Krasnova, I. N., et al. (2010) · Biological Psychiatry

Tryptophan and brain disordersSchizophrenia research and treatment

Cited by 255

Understanding the Role of DISC1 in Psychiatric Disease and during Normal Development

Brandon, N. J., Millar, J. K., Korth, C., Sive, H., Singh, K. K., & Sawa, A. (2009) · The Journal of Neuroscience

Schizophrenia research and treatmentMental Health and Psychiatry

Cited by 198

A Review of Disrupted-in-Schizophrenia-1 (disc1): Neurodevelopment, Cognition, and Mental Conditions

Ishizuka, K., Paek, M., Kamiya, A., & Sawa, A. (2006) · Biological Psychiatry

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 190

Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs

Lipska, B. K., Peters, T., Hyde, T. M., Halim, N., Horowitz, C., Mitkus, S., Weickert, C. S., Matsumoto, M., Sawa, A., Straub, R. E., et al. (2006) · Human Molecular Genetics

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 168

Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders

Ayhan, Y., Abazyan, B., Nomura, J., Kim, R., Ladenheim, B., Krasnova, I. N., Sawa, A., Margolis, R. L., Cadet, J. L., Mori, S., et al. (2011) · Molecular Psychiatry

Schizophrenia research and treatmentGenetics and Neurodevelopmental Disorders

Cited by 148

Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate

Saiardi, A., Nagata, E., Luo, H. R., Sawa, A., Luo, X., Snowman, A. M., & Snyder, S. H. (2001) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingCalcium signaling and nucleotide metabolism

Cited by 110

DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex

Kirkpatrick, B., Xu, L., Cascella, N., Ozeki, Y., Sawa, A., & Roberts, R. C. (2006) · Journal of Comparative Neurology

Schizophrenia research and treatmentNeuroscience and Neuropharmacology Research

Cited by 104

PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence

Hayashi-Takagi, A., Araki, Y., Nakamura, M., Vollrath, B., Duron, S. G., Yan, Z., Kasai, H., Huganir, R. L., Campbell, D. A., & Sawa, A. (2014) · Proceedings of the National Academy of Sciences

Schizophrenia research and treatmentNeuroscience and Neuropharmacology Research

Cited by 101

Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application

Watkins, C. C., Sawa, A., & Pomper, M. G. (2014) · Translational Psychiatry

Bipolar Disorder and TreatmentNeuroinflammation and Neurodegeneration Mechanisms

Cited by 100

Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness

Johnson, A. W., Jaaro-Peled, H., Shahani, N., Sedlak, T. W., Zoubovsky, S., Burruss, D., Emiliani, F., Sawa, A., & Gallagher, M. (2013) · Proceedings of the National Academy of Sciences

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 96

Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1

Nucifora, F. C., Nucifora, L. G., Ng, C.-H., Arbez, N., Guo, Y., Roby, E., Shani, V., Engelender, S., Wei, D., Wang, X.-F., et al. (2016) · Nature Communications

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 82

Glutathione is a physiologic reservoir of neuronal glutamate

Koga, M., Serritella, A. V., Messmer, M. M., Hayashi-Takagi, A., Hester, L. D., Snyder, S. H., Sawa, A., & Sedlak, T. W. (2011) · Biochemical and Biophysical Research Communications

Sulfur Compounds in BiologyNeuroscience and Neuropharmacology Research

Cited by 73

Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits

Bader, V., Tomppo, L., Trossbach, S. V., Bradshaw, N. J., Prikulis, I., Leliveld, S. R., Lin, C.-Y., Ishizuka, K., Sawa, A., Ramos, A., et al. (2012) · Human Molecular Genetics

Schizophrenia research and treatmentMental Health and Psychiatry

Cited by 70

Marked reduction of soluble superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with recent-onset schizophrenia

Coughlin, J. M., Ishizuka, K., Kano, S. I., Edwards, J. A., Seifuddin, F. T., Shimano, M. A., Daley, E. L., Zandi, P. P., Leweke, F. M., Cascella, N. G., et al. (2013) · Molecular Psychiatry

Schizophrenia research and treatmentTryptophan and brain disorders

Cited by 66