Effects of early or late prenatal immune activation in mice on behavioral and neuroanatomical abnormalities relevant to schizophrenia in the adulthood
Abstract
Maternal immune activation (MIA) during pregnancy in rodents increases the risk of the offspring to develop schizophrenia-related behaviors, suggesting a relationship between the immune system and the brain development. Here we tested the hypothesis that MIA induced by the viral mimetic polyinosinic-polycytidylic acid (poly I:C) in early or late gestation of mice leads to behavioral and neuroanatomical disorders in the adulthood. On gestational days (GDs) 9 or 17 pregnant dams were treated with poly I:C or saline via intravenous route and the offspring behaviors were measured during adulthood. Considering the progressive structural neuroanatomical alterations in the brain of individuals with schizophrenia, we used magnetic resonance imaging (MRI) to perform brain morphometric analysis of the offspring aged one year. MIA on GD9 or GD17 led to increased basal locomotor activity, enhanced motor responses to ketamine, a psychotomimetic drug, and reduced time spent in the center of the arena, suggesting an increased anxiety-like behavior. In addition, MIA on GD17 reduced glucose preference in the offspring. None of the treatments altered the relative volume of the lateral ventricles. However, a decrease in brain volume, especially for posterior structures, was observed for one-year-old animals treated with poly I:C compared with control groups. Thus, activation of the maternal immune system at different GDs lead to neuroanatomical and behavioral alterations possibly related to the positive and negative symptoms of schizophrenia. These results provide insights on neuroimmunonological and neurodevelopmental aspects of certain psychopathologies, such as schizophrenia.
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Prenatal poly(I:C) exposure decreased overall brain volume in adult mice.
“Decreased overall brain volume was reported with prenatal exposure to poly(I:C) in adult mice (da Silveira et al., 2017).”
From Neuroinflammation as a risk factor for attention deficit hyperactivity disorder (2019) · cites this paper as da Silveira et al., 2017
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- Authors
- da Silveira, V. T., de Castro Medeiros, D., Ropke, J., Guidine, P. A., Rezende, G. H., Moraes, M. F. D., Mendes, E. M. A. M., Macedo, D., Moreira, F. A., & de Oliveira, A. C. P.
- Affiliations
- Department of Pharmacology Institute of Biological Sciences, Universidade Federal de Minas Gerais Brazil
- Center for Technology and Research in Magneto‐Resonance (CTPMAG), Graduate Program in Electrical Engineering – Universidade Federal de Minas Gerais Brazil
- Universidade Federal de Minas Gerais (BR)
- Drug Research and Development Center Department of Physiology and Pharmacology Medical School, Universidade Federal do Ceará Brazil
- Venue
- International Journal of Developmental Neuroscience
- Publisher
- Wiley
- Published
- 2017-01-22
- Volume
- 58
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0736-5748 (ISSN-L)
- 1873-474X
- OpenAlex
- W2581631145
- Cited by
- 51
- References
- 70
- Citations by year
- 2025: 3 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 9 · 2019: 9 · 2018: 4 · 2017: 4
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Developmental Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (479254/2013‐3, 466724/2014‐4)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- maternal immune activation, schizophrenia, poly(I:C), pregnancy timing, prenatal immune activation, brain morphometry, anxiety-like behavior, locomotor activity, brain volume, brain development, neuroimmunology, positive and negative symptoms
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Animals, Newborn, Mental Disorders, Brain, Disease Models, Animal, Embryo, Mammalian, Female, Food Preferences, Interferon Inducers, Ketamine, Locomotion, Magnetic Resonance Imaging, Mice, Inbred C57BL, Poly I-C, Pregnancy, Prenatal Exposure Delayed Effects, Schizophrenia, Sucrose, Mice
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