The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.
The Neural Basis of Drug Stimulus Processing and Craving: An Activation Likelihood Estimation Meta-Analysis
Open accessAbstract
Background The capacity of drug cues to elicit drug-seeking behavior is believed to play a fundamental role in drug dependence; yet the neurofunctional basis of human drug cue-reactivity is not fully understood. We performed a meta-analysis to identify brain regions that are consistently activated by presentation of drug cues. Studies involving treatment-seeking and nontreatment-seeking substance users were contrasted to determine whether there were consistent differences in the neural response to drug cues between these populations. Finally, to assess the neural basis of craving, consistency across studies in brain regions that show correlated activation with craving was assessed. Methods Appropriate studies, assessing the effect of drug-related cues or manipulations of drug craving in drug-user populations across the whole brain, were obtained via the PubMed database and literature search. Activation likelihood estimation, a method of quantitative meta-analysis that estimates convergence across experiments by modeling the spatial uncertainty of neuroimaging data, was used to identify consistent regions of activation. Results Cue-related activation was observed in the ventral striatum (across both subgroups), amygdala (in the treatment-seeking subgroup and overall), and orbitofrontal cortex (in the nontreatment-seeking subgroup and overall) but not insula cortex. Although a different pattern of frontal and temporal lobe activation between the subgroups was observed, these differences were not significant. Finally, right amygdala and left middle frontal gyrus activity were positively associated with craving. Conclusions These results substantiate the key neural substrates underlying reactivity to drug cues and drug craving.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Surprisingly, a 2011 meta-analysis did not support the role of the insula in drug cue activity- or craving-related activity.”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Chase et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(1994) · DigitalGeorgetown (Georgetown University Library) · Cited by 10,542
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388
DESCARTES' ERROR: Emotion, Reason, and the Human Brain
Marg, E. (1995) · Optometry and Vision Science · doi:10.1002/j.1538-9235.1995.tb03988.x · Cited by 8,178
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data
Eickhoff, S. B., Stephan, K. E., Mohlberg, H., Grefkes, C., Fink, G. R., Amunts, K., & Zilles, K. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.12.034 · Cited by 4,033
Self-citationStatistical Parametric Mapping: The Analysis of Functional Brain Images
Penny, W. D., Friston, K. J., Ashburner, J., Kiebel, S. J., & Thomas, N. (2007) · UCL Discovery (University College London) · Cited by 3,339
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229
Inhibition and the right inferior frontal cortex
Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.02.010 · Cited by 3,197
The human orbitofrontal cortex: linking reward to hedonic experience
Kringelbach, M. L. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1747 · Cited by 2,180
Research works printed but not linked: 2
- Hogarth, 2010, The associative basis of cue-elicited drug taking in humans, Psychopharmacology (Berl), 208, 337, 10.1007/s00213-009-1735-9 · DOI
- Garavan, 2010, Insula and drug cravings, Brain Struct Funct, 214, 593, 10.1007/s00429-010-0259-8 · DOI · Paper page
Cited by
Sorted by citations
Neural network of cognitive emotion regulation—an ALE meta-analysis and MACM analysis
Kohn, N., Eickhoff, S. B., Scheller, M., Laird, A. R., Fox, P. T., & Habel, U. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.11.001 · Cited by 956
Self-citationNeural correlates of action: Comparing meta-analyses of imagery, observation, and execution
Hardwick, R. M., Caspers, S., Eickhoff, S. B., & Swinnen, S. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.08.003 · Cited by 948
Self-citationFood cue reactivity and craving predict eating and weight gain: A meta-analytic review
Boswell, R. G., & Kober, H. (2016) · Obesity Reviews · doi:10.1111/obr.12354 · Cited by 703
Strang, J., Volkow, N. D., Degenhardt, L., Hickman, M., Johnson, K., Koob, G. F., Marshall, B. D. L., Tyndall, M., & Walsh, S. L. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0137-5 · Cited by 639
A quantitative meta-analysis and review of motor learning in the human brain
Hardwick, R. M., Rottschy, C., Miall, R. C., & Eickhoff, S. B. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.11.020 · Cited by 607
Self-citation
Metadata
- Authors
- Chase, H. W., Eickhoff, S. B., Laird, A. R., & Hogarth, L.
- Affiliations
- University of Nottingham (GB)
- Forschungszentrum Jülich (DE)
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Chase, Henry W.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 70
- Issue
- 8
- Pages
- 785-793
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC4827617
- OpenAlex
- W2019447274
- Cited by
- 316
- References
- 132
- Citations by year
- 2026: 11 · 2025: 8 · 2024: 15 · 2023: 24 · 2022: 17 · 2021: 29 · 2020: 31 · 2019: 21 · 2018: 25 · 2017: 19 · 2016: 29 · 2015: 21 · 2014: 25 · 2013: 27 · 2012: 13
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Update notices
- erratum (2021-03-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- JuSER (Forschungszentrum Jülich) (submittedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Funders
- Medical Research Council (G0701456, R01-MH074457-01A1)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- drug cue reactivity, drug craving, drug addiction, ventral striatum, amygdala, orbitofrontal cortex, insula cortex, middle frontal gyrus
- MeSH terms
- Algorithms, Brain, Brain Mapping, Cues, Humans, Patient Acceptance of Health Care, Behavior, Addictive, Drug-Seeking Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
