A 9-Year Prospective Population-Based Study on the Association Between the APOE*E4 Allele and Late-Life Depression in Sweden
Abstract
Background It is well established that there is an association between the apolipoprotein E (APOE) ε4 allele (APOE*E4) and Alzheimer's disease. It is less clear whether there is also an association with geriatric depression. We examined the relationship between APOE*E4 and 5-year incidence of depression in a Swedish population-based sample of older adults without dementia and excluding older adults who developed dementia within 4 years after the diagnosis of depression. Methods In 2000-2001, 839 women and men (age range, 70-92 years; mean age, 73.8 years) free from dementia and depression underwent neuropsychiatric and neuropsychological examinations and genotyping of the APOE*E4 allele. Follow-up evaluations were conducted in 2005 and 2009.The association between APOE*E4 allele and 5-year incidence of depression was examined, while avoiding possible confounding effects of clinical or preclinical dementia by excluding participants who had dementia at study entry, subsequently developed dementia during the 9-year follow-up period, or had a decline in Mini-Mental State Examination score of ≥5 points. Results Among subjects without depression at study entry and without dementia or significant cognitive decline during the subsequent 9 years, APOE*E4 was prospectively associated with more severe depressive symptoms (b = 1.56, p = .007), incident minor depression (odds ratio = 1.99 [confidence interval = 1.11-3.55], p = .020), and any depression (odds ratio = 1.75 [confidence inter…
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The current study provides substantial evidence for the clinical relationship between APOE ε4 allele and late life depression.
“which provides substantial evidence for the clinical relationship between APOE ε4 allele and late life depression (LLD) [35].”
From APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline (2021) · cites this paper as [35]
Cites
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Steffens, D. C., Otey, E., Alexopoulos, G. S., Butters, M. A., Cuthbert, B., Ganguli, M., Geda, Y. E., Hendrie, H. C., Krishnan, R. R., Kumar, A., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.2.130 · Cited by 274 · see citing works
Cerebrovascular Effects of Apolipoprotein E: Implications for Alzheimer Disease
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<i>APOE</i> ε4 is not associated with Alzheimer's disease in elderly Nigerians
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Peters, R., Xu, Y., Antikainen, R., Beckett, N., Gussekloo, J., Jagger, C., Jukema, J. W., Keinanen-Kiukaanniemi, S., Rydén, L., Skoog, I., et al. (2021) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000519452 · Cited by 51 · see citing works
Self-citationAPOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline
Fang, W., Xiao, N., Zeng, G., Bi, D., Dai, X., Mi, X., Ye, Q., Chen, X., & Zhang, J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01631-0 · Cited by 42 · see citing works
Kitzlerová, E., Fišar, Z., Lelková, P., Jirák, R., Zvěřová, M., Hroudová, J., Manukyan, A., Martásek, P., & Raboch, J. (2018) · Medical Science Monitor · doi:10.12659/msm.907202 · Cited by 21 · see citing works
Wu, J., Hasselgren, C., Zettergren, A., Zetterberg, H., Blennow, K., Skoog, I., & Halleröd, B. (2020) · Aging & Mental Health · doi:10.1080/13607863.2018.1531368 · Cited by 18 · see citing works
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- Authors
- Skoog, I., Waern, M., Duberstein, P., Blennow, K., Zetterberg, H., Börjesson-Hanson, A., Östling, S., Guo, X., Kern, J., Gustafson, D., Gudmundsson, P., Marlow, T., & Kern, S.
- Affiliations
- University of Rochester Medicine (US)
- University of Gothenburg (SE)
- UCL Queen Square Institute of Neurology (GB)
- Corresponding author
- Kern, Silke
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 78
- Issue
- 10
- Pages
- 730-736
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2082405652
- Cited by
- 85
- References
- 8
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 12 · 2019: 6 · 2018: 13 · 2017: 7 · 2016: 12 · 2015: 5
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- APOE ε4, apolipoprotein E, geriatric depression, depression incidence, older adults, genetic risk factors, dementia, cognitive decline, depressive symptoms
- MeSH terms
- Late Onset Disorders, Aged, Aged, 80 and over, Major Depressive Disorder, Depressive Disorder, Female, Follow-Up Studies, Humans, Male, Prospective Studies, Sweden, Apolipoprotein E4
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