Interactions Among Polymorphisms of Susceptibility Loci for Alzheimer’s Disease or Depressive Disorder
Open accessAbstract
BACKGROUND Several genetic susceptibility loci for major depressive disorder (MDD) or Alzheimer's disease (AD) have been described. Interactions among polymorphisms are thought to explain the differences between low- and high-risk groups. We tested for the contribution of interactions between multiple functional polymorphisms in the risk of MDD or AD. MATERIAL AND METHODS A genetic association case-control study was performed in 68 MDD cases, 84 AD cases (35 of them with comorbid depression), and 90 controls. The contribution of 7 polymorphisms from 5 genes (APOE, HSPA1A, SLC6A4, HTR2A, and BDNF) related to risk of MDD or AD development was analyzed. RESULTS Significant associations were found between MDD and interactions among polymorphisms in HSPA1A, SLC6A4, and BDNF or HSPA1A, BDNF, and APOE genes. For polymorphisms in the APOE gene in AD, significant differences were confirmed on the distributions of alleles and genotype rates compared to the control or MDD. Increased probability of comorbid depression was found in patients with AD who do not carry the ε4 allele of APOE. CONCLUSIONS Assessment of the interactions among polymorphisms of susceptibility loci in both MDD and AD confirmed a synergistic effect of genetic factors influencing inflammatory, serotonergic, and neurotrophic pathways at these heterogenous complex diseases. The effect of interactions was greater in MDD than in AD. A presence of the ε4 allele was confirmed as a genetic susceptibility factor in AD. Our findings indicate a role of APOE genotype in onset of comorbid depression in a subgroup of patients with AD who are not carriers of the APOE ε4 allele.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Research has shown associations between depression and BDNF, candidate SNPs of the BDNF gene, polymorphisms of the BDNF gene, and the interaction of these polymorphisms with other determinants such as stress.
“Research has shown associations between depression and BDNF (as well as candidate SNPs of the BDNF gene, polymorphisms of the BDNF gene, and the interaction of these polymorphisms with other determinants, such as stress) [129,144,145].”
From Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature (2021) · cites this paper as [129]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
A simple salting out procedure for extracting DNA from human nucleated cells
Miller, S. A., Dykes, D. D., & Polesky, H. F. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.3.1215 · Cited by 20,341 · see citing works
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
Vos, T., Flaxman, A. D., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., Aboyans, V., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61729-2 · Cited by 8,291 · see citing works
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162 · see citing works
2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069 · see citing works
Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028 · see citing works
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works
Pathways towards and Away from Alzheimer’s Disease
Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052 · see citing works
Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.
Hixson, J., & Vernier, D. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43176-1 · Cited by 2,933 · see citing works
Shi, Y., & He, L. (2005) · Cell Research · doi:10.1038/sj.cr.7290272 · Cited by 2,224 · see citing works
Allelic Variation of Human Serotonin Transporter Gene Expression
Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062621.x · Cited by 2,221 · see citing works
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129 · see citing works
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
Bertram, L., McQueen, M. B., Mullin, K., Blacker, D., & Tanzi, R. E. (2007) · Nature Genetics · doi:10.1038/ng1934 · Cited by 1,857 · see citing works
Wacholder, S., Chanock, S. J., García‐Closas, M., ghormli, L. K. E., & Rothman, N. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh075 · Cited by 1,743 · see citing works
Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J., & Merikangas, K. R. (2009) · JAMA · doi:10.1001/jama.2009.878 · Cited by 1,655 · see citing works
Ownby, R. L., Crocco, E., Acevedo, A., John, V., & Loewenstein, D. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.5.530 · Cited by 1,493 · see citing works
Sen, S., Duman, R., & Sanacora, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.005 · Cited by 1,232 · see citing works
Brain-derived neurotrophic factor in neurodegenerative diseases
Zuccato, C., & Cattaneo, E. (2009) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.54 · Cited by 947 · see citing works
The Genetics of Alzheimer's Disease
Bertram, L., & Tanzi, R. E. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385883-2.00008-4 · Cited by 784 · see citing works
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses
Bertram, L., & Tanzi, R. E. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2494 · Cited by 747 · see citing works
The Genetics of Major Depression
Flint, J., & Kendler, K. S. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.027 · Cited by 724 · see citing works
The Ubiquitous Nature of Epistasis in Determining Susceptibility to Common Human Diseases
Moore, J. H. (2003) · Human Heredity · doi:10.1159/000073735 · Cited by 715 · see citing works
Monoamine neurocircuitry in depression and strategies for new treatments
Hamon, M., & Blier, P. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.04.009 · Cited by 643 · see citing works
The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants
Nakamura, M., Ueno, S., Sano, A., & Tanabe, H. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000698 · Cited by 627 · see citing works
Age, APOE and sex: triad of risk of Alzheimer’s disease.
Riedel, B. C., Thompson, P. M., & Brinton, R. D. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.012 · Cited by 627 · see citing works
ApoE genotype accounts for the vast majority of AD risk and AD pathology
Raber, J., Huang, Y., & Ashford, J. W. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.023 · Cited by 599 · see citing works
Gene×environment interactions at the serotonin transporter locus
Munafò, M. R., Durrant, C., Lewis, G., & Flint, J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.009 · Cited by 576 · see citing works
New insights into brain BDNF function in normal aging and Alzheimer disease
Tapia‐Arancibia, L., Aliaga, E., Silhol, M., & Arancibia, S. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.07.007 · Cited by 571 · see citing works
Sklar, P. B., Gabriel, S., McInnis, M. G., Bennett, P., Lim, Y.-M., Tsan, G., Schaffner, S. F., Kirov, G., Jones, I. R., Owen, M. J., et al. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001058 · Cited by 563 · see citing works
Depression as a Risk Factor for Alzheimer Disease: The MIRAGE Study
Green, R. C., Cupples, L. A., Kurz, A., Auerbach, S., Go, R., Sadovnick, D., Duara, R., Kukull, W. A., Chui, H., Edeki, T., et al. (2003) · Archives of Neurology · doi:10.1001/archneur.60.5.753 · Cited by 551 · see citing works
Hock, C., Heese, K., Hulette, C., Rosenberg, C., & Otten, U. (2000) · Archives of Neurology · doi:10.1001/archneur.57.6.846 · Cited by 523 · see citing works
Psychiatric genetics: progress amid controversy
Burmeister, M., McInnis, M. G., & Zöllner, S. K. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2381 · Cited by 522 · see citing works
Schinka, J. A., Busch, R. M., & Robichaux-Keene, N. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001405 · Cited by 521 · see citing works
How might circadian rhythms control mood? Let me count the ways
McClung, C. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.019 · Cited by 507 · see citing works
Meta-analyses of genetic studies on major depressive disorder
López‐León, S., Janssens, A. C. J. W., Ladd, A. M. G., Del‐Favero, J., Claes, S. J., Oostra, B. A., & van Duijn, C. M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002088 · Cited by 484 · see citing works
Targeting the murine serotonin transporter: insights into human neurobiology
Murphy, D. L., & Lesch, K.-P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2284 · Cited by 478 · see citing works
Apolipoprotein E4 allele in a population–based study of early–onset Alzheimer's disease
van Duijn, C. M., de Knijff, P., Cruts, M., Wehnert, A., Havekes, L., Hofman, A., & van Broeckhoven, C. (1994) · Nature Genetics · doi:10.1038/ng0594-74 · Cited by 472 · see citing works
Verhagen, M., van der Meij, A., van Deurzen, P. A. M., Janzing, J. G. E., Arias-Vásquez, A., Buitelaar, J. K., & Franke, B. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.109 · Cited by 470 · see citing works
Anguelova, M., Benkelfat, C., & Turecki, G. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001336 · Cited by 421 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 396 · see citing works
Apolipoprotein E in Alzheimer's Disease: An Update
Yu, J.-T., Tan, L., & Hardy, J. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014300 · Cited by 394 · see citing works
The role of serotonin 5-HT2A receptors in memory and cognition
Zhang, G., & Stackman, R. W. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00225 · Cited by 386 · see citing works
Duman, R. S., & Li, N. (2012) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2011.0357 · Cited by 362 · see citing works
Mackinnon, A. J. (2000) · Computers in Biology and Medicine · doi:10.1016/s0010-4825(00)00006-8 · Cited by 360 · see citing works
Porcelli, S., Fabbri, C., & Serretti, A. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.10.003 · Cited by 331 · see citing works
Maes, M., Fišar, Z., Medina, M., Scapagnini, G., Nowak, G., & Berk, M. (2012) · Inflammopharmacology · doi:10.1007/s10787-011-0111-7 · Cited by 325 · see citing works
Self-citationProtective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats
Arancibia, S., Silhol, M., Mouliere, F. C., Meffre, J., Höllinger, I., Maurice, T., & Tapia‐Arancibia, L. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.012 · Cited by 318 · see citing works
Enache, D., Winblad, B. G., & Aarsland, D. (2011) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32834bb9d4 · Cited by 315 · see citing works
Gatt, J. M., Burton, K., Williams, L. M., & Schofield, P. R. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.09.014 · Cited by 281 · see citing works
Anguelova, M., Benkelfat, C., & Turecki, G. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001328 · Cited by 276 · see citing works
The anti-inflammatory mechanisms of Hsp70
Borges, T. J., Wieten, L., van Herwijnen, M. J. C., Broere, F., van der Zee, R., Bonorino, C., & van Eden, W. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00095 · Cited by 276 · see citing works
The serotonergic system in ageing and Alzheimer's disease
Rodriguez, J. J., Noristani, H. N., & Verkhratsky, A. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.06.010 · Cited by 266 · see citing works
Duman, R. S. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.1/rduman · Cited by 249 · see citing works
Protective effects of hsp70 in inflammation
Jacquier‐Sarlin, M. R., Fuller, K., Dinh‐Xuan, A. T., Richard, M., & Polla, B. S. (1994) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923458 · Cited by 239 · see citing works
Brain-Derived Neurotrophic Factor in Alzheimer’s Disease: Risk, Mechanisms, and Therapy
Song, J., Yu, J., & Tan, L. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8958-4 · Cited by 237 · see citing works
Pratt, W. B., Gestwicki, J. E., Osawa, Y., & Lieberman, A. P. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010814-124332 · Cited by 237 · see citing works
Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease
Ventriglia, M., Bocchio‐Chiavetto, L., Benussi, L., Binetti, G. G., Zanetti, O. O., Riva, M. A., & Gennarelli, M. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000952 · Cited by 234 · see citing works
Introduction to Genetic Association StudiesPreprint
Lewis, C. M., & Knight, J. (2012) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top068163 · Cited by 210 · see citing works
Genetics of Alzheimer’s Disease
Chouraki, V. A., & Seshadri, S. S. (2014) · Advances in genetics · doi:10.1016/b978-0-12-800149-3.00005-6 · Cited by 208 · see citing works
Partial Response and Nonresponse to Antidepressant Therapy
Hirschfeld, R. M. A., Montgomery, S., Aguglia, E., Amore, M., Delgado, P. L., Gastpar, M., Hawley, C. J., Kasper, S. F., Linden, M., Massana, J., et al. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n0913 · Cited by 193 · see citing works
Feinstein, D. L., Kalinin, S., & Braun, D. J. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13447 · Cited by 178 · see citing works
The genetics of Alzheimer's disease
Bagyinszky, E., Youn, Y. C., An, S. S. A., & Kim, S. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s51571 · Cited by 173 · see citing works
The expanding role of BDNF: a therapeutic target for Alzheimer's disease?
Fumagalli, F., Racagni, G., & Riva, M. A. (2005) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500337 · Cited by 173 · see citing works
Drago, A., & Ronchi, D. D. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707781368450 · Cited by 162 · see citing works
Fernandes, B. S., Berk, M., Turck, C. W., Steiner, J. H., & Gonçalves, C.-A. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.172 · Cited by 159 · see citing works
GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression
Plátenı́k, J., Fišar, Z., Buchal, R., Jirák, R., Kitzlerová, E., Zvěřová, M., & Raboch, J. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.12.001 · Cited by 159 · see citing works
Self-citationGenetic Determinants of Depression: Recent Findings and Future Directions
Dunn, E. C., Brown, R. C., Dai, Y., Rosand, J., Nugent, N. R., Amstadter, A. B., & Smoller, J. W. (2015) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000054 · Cited by 158 · see citing works
Gene environment interaction studies in depression and suicidal behavior: An update
Mandelli, L., & Serretti, A. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.011 · Cited by 157 · see citing works
Role of Serotonin in the Behavioral and Psychological Symptoms of Dementia
Lanctôt, K. L., Herrmann, N., & Mazzotta, P. (2001) · Journal of Neuropsychiatry · doi:10.1176/jnp.13.1.5 · Cited by 153 · see citing works
Neurotrophins and Psychiatric Disorders
Castrén, E. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-45106-5_17 · Cited by 150 · see citing works
Serotonergic genes and suicide: A systematic review
Antypa, N., Serretti, A., & Rujescu, D. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.03.013 · Cited by 150 · see citing works
Herbert, J., & Lucassen, P. J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.12.001 · Cited by 150 · see citing works
Assal, F., Alarcón, M., Solomon, E., Masterman, D. L., Geschwind, D. H., & Cummings, J. L. (2004) · Archives of Neurology · doi:10.1001/archneur.61.8.1249 · Cited by 142 · see citing works
Imaging Alzheimer Pathology in Late-Life Depression With PET and Pittsburgh Compound-B
Butters, M. A., Klunk, W. E., Mathis, C. A., Price, J. C., Ziolko, S. K., Hoge, J. A., Tsopelas, N. D., Lopresti, B. J., Reynolds, C. F., DeKosky, S. T., et al. (2008) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31816c92bf · Cited by 139 · see citing works
Harrisberger, F., Smieskova, R., Schmidt, A., Lenz, C., Walter, A., Wittfeld, K., Grabe, H. J., Lang, U. E., Fusar-Poli, P., & Borgwardt, S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.017 · Cited by 138 · see citing works
Chen, C., Alder, J. T., Bowen, D. M., Esiri, M. M., McDonald, B., Hope, T., Jobst, K. A., & Francis, P. T. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66041592.x · Cited by 136 · see citing works
Myers, R. L., Airey, D. C., Manier, D. H., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.018 · Cited by 136 · see citing works
Qin, X.-Y., Cao, C., Cawley, N. X., Liu, T.-T., Yuan, J., Loh, Y. P., & Cheng, Y. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.62 · Cited by 135 · see citing works
Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link?
Guiard, B. P., & Giovanni, G. D. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00046 · Cited by 132 · see citing works
Fan, J., & Sklar, P. B. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001690 · Cited by 130 · see citing works
The Genetics of the Human APOE Polymorphism
Seripa, D., D’Onofrio, G., Panza, F., Cascavilla, L., Masullo, C., & Pilotto, A. (2011) · Rejuvenation Research · doi:10.1089/rej.2011.1169 · Cited by 128 · see citing works
Serotonin transporter gene polymorphisms and hyperserotonemia in autistic disorder
Betancur, C., Corbex, M. A., Spielewoy, C., Philippe, A., Laplanche, J., Launay, J., Gillberg, C., Mouren-Siméoni, M., Hamon, M., Bruno Giros, A., et al. (2002) · Molecular Psychiatry · doi:10.1038/sj/mp/4000923 · Cited by 125 · see citing works
Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms
Lee, J. E., Fukumoto, H., Orne, J. D., Klucken, J., Raju, S., Vanderburg, C. R., Irizarry, M. C., Hyman, B. T., & Ingelsson, M. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.01.026 · Cited by 124 · see citing works
Farrer, L. A. (1997) · JAMA · doi:10.1001/jama.1997.03550160069041 · Cited by 124 · see citing works
SHEsisPlus, a toolset for genetic studies on polyploid species
Shen, J., Li, Z., Chen, J., Song, Z., Zhou, Z., & Shi, Y. (2016) · Scientific Reports · doi:10.1038/srep24095 · Cited by 118 · see citing works
APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer’s disease
Vélez, J. I., Lopera, F., Sepulveda-Falla, D., Patel, H. R., Johar, A. S., Chuah, A., Tobón, C., Rivera, D., Villegas, A., Cai, Y., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.177 · Cited by 111 · see citing works
Lai, M. K. P., Tsang, S. W., Alder, J. T., Keene, J., Hope, T., Esiri, M. M., Francis, P. T., & Chen, C. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2077-2 · Cited by 110 · see citing works
A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism
Zhong, L., Xie, Y.-Z., Cao, T.-T., Wang, Z., Wang, T., Li, X., Shen, R.-C., Xu, H., Bu, G., & Chen, X. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0069-4 · Cited by 108 · see citing works
Heat Shock Protein 70 in Alzheimer’s Disease
Lu, R.-C., Tan, M., Wang, H., Xie, A., Yu, J., & Tan, L. (2014) · BioMed Research International · doi:10.1155/2014/435203 · Cited by 100 · see citing works
Murphy, D. L., & Moya, P. R. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.02.008 · Cited by 97 · see citing works
Apolipoprotein E. Structure, Function, and Possible Roles in Alzheimer's Diseasea
Mahley, R. W., Nathan, B. P., & Pitas, R. E. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34412.x · Cited by 92 · see citing works
Mechanisms Underlying Neurocognitive Dysfunctions in Recurrent Major Depression
Maes, M. H. J. (2015) · Medical Science Monitor · doi:10.12659/msm.893176 · Cited by 91 · see citing works
Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.189 · Cited by 87 · see citing works
Skoog, I., Waern, M., Duberstein, P., Blennow, K., Zetterberg, H., Börjesson-Hanson, A., Östling, S., Guo, X., Kern, J., Gustafson, D., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.01.006 · Cited by 85 · see citing works
ApoE4 Allele Is Associated With Late-Life Depression: A Population-Based Study
Yen, Y.-C., Rebok, G. W., Gallo, J. J., Yang, M.-J., Lung, F.-W., & Shih, C.-H. (2007) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3180f63373 · Cited by 73 · see citing works
Lin, J., Jiang, M., Kan, Z., & Chu, Y. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.06.012 · Cited by 72 · see citing works
Bízik, G., Picard, M., Nijjar, R., Tourjman, V., McEwen, B., Lupien, S., & Juster, R. (2013) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000012 · Cited by 70 · see citing works
Are there depression and anxiety genetic markers and mutations? A systematic review
Lacerda-Pinheiro, S. D. F., Pinheiro, R. F. F., de Lima, M. A. P., da Silva, C. G. L., dos Santos, M. D. S. V., Júnior, A. G. T., de Oliveira, P. N. L., Ribeiro, K. D. B., Neto, M. L. R., & Bianco, B. A. V. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.07.016 · Cited by 69 · see citing works
BDNF Genetic Variations Increase the Risk of Alzheimer's Disease-Related Depression
Borroni, B., Grassi, M., Archetti, S., Costanzi, C., Bianchi, M., Caimi, L., Caltagirone, C., Luca, M. D., & Padovani, A. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1191 · Cited by 68 · see citing works
Anti-inflammatory properties and pharmacological induction of Hsp70 after brain injury
Kim, N., Kim, J. Y., & Yenari, M. A. (2012) · Inflammopharmacology · doi:10.1007/s10787-011-0115-3 · Cited by 68 · see citing works
Sapkota, Y., Mackey, J. R., Lai, R. L., Franco‐Villalobos, C., Lupichuk, S., Robson, P. J., Kopciuk, K. A., Cass, C. E., Yasui, Y., & Damaraju, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064896 · Cited by 61 · see citing works
Desai, P. P., Nebes, R. D., DeKosky, S. T., & Kamboh, M. I. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.01.008 · Cited by 60 · see citing works
Engedal, K., Barca, M. L., Laks, J., & Selbæk, G. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2631 · Cited by 60 · see citing works
HTR2A is Associated with SSRI Response in Major Depressive Disorder in a Japanese Cohort
Kishi, T., Yoshimura, R., Kitajima, T., Okochi, T., Okumura, T., Tsunoka, T., Yamanouchi, Y., Kinoshita, Y., Kawashima, K., Naitoh, H., et al. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8105-y · Cited by 56 · see citing works
Heat-shock protein-70 genes and response to antidepressants in major depression
Pae, C., Mandelli, L., Serretti, A., Patkar, A. A., Kim, J.-J., Lee, C., Lee, S.-J., Lee, C., Ronchi, D. D., & Paik, I. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.02.011 · Cited by 52 · see citing works
Plasma cortisol in Alzheimer’s disease with or without depressive symptoms
Raboch, J. (2013) · Medical Science Monitor · doi:10.12659/msm.889110 · Cited by 52 · see citing works
Self-citationTielbeek, J. J., Linnér, R. K., Beers, K., Danielle Posthuma, B., Popma, A., & Polderman, T. J. C. (2016) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32442 · Cited by 52 · see citing works
Chen, S., Lee, S.-Y., Chang, Y.-H., Chen, S., Chu, C., Wang, T.-Y., Chen, P.-S., Lee, I., Yang, Y.-K., Hong, J.-S., et al. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.01.012 · Cited by 51 · see citing works
Association between apolipoprotein E gene polymorphism and depression
Feng, F., Lu, S.-S., Hu, C.-Y., Gong, F.-F., Qian, Z.-Z., Yang, H.-Y., Wu, Y.-L., Zhao, Y.-Y., Bi, P., & Sun, Y.-H. (2015) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2015.02.012 · Cited by 51 · see citing works
Celi, M., Vazzana, M., Sanfratello, M. A., et al. (2011) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2011.11.037 · Cited by 50 · see citing works
Zhang, L., Fang, Y., Zeng, Z., Lian, Y., Wei, J., Zhu, H., Jia, Y., Zhao, X., & Xu, Y. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110113 · Cited by 47 · see citing works
Li, P., Hsiao, I., Liu, C.-Y., Chen, C., Huang, S., Yen, T., Wu, K.-Y., & Lin, K. (2017) · EJNMMI Research · doi:10.1186/s13550-017-0273-4 · Cited by 46 · see citing works
Niti, M., Yap, K. B., Kua, E. H., & Ng, T. P. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln013 · Cited by 42 · see citing works
Distinguishing true from false positives in genomic studies: p values
Broer, L., Lill, C. M., Schuur, M., Amin, N., Roehr, J. T., Bertram, L., Ioannidis, J. P. A., & van Duijn, C. M. (2013) · European Journal of Epidemiology · doi:10.1007/s10654-012-9755-x · Cited by 41 · see citing works
Jin, C., Xu, W., Yuan, J., Wang, G., & Cheng, Z. (2013) · Neurological Research · doi:10.1179/1743132812y.0000000111 · Cited by 41 · see citing works
Serotonin Transporter Gene Polymorphism and BPSD in Mild Alzheimer's Disease
Ueki, A., Ueno, H., Sato, N., et al. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-12306 · Cited by 40 · see citing works
Imaging genetics studies on monoaminergic genes in major depressive disorder
Won, E., & Ham, B. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.03.014 · Cited by 39 · see citing works
Ricca, V., Nacmias, B., Boldrini, M., Cellini, E., Bernardo, M. D., Ravaldi, C., Tedde, A., Bagnoli, S., Placidi, G. F., Rotella, C. M., et al. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.04.057 · Cited by 38 · see citing works
Genetics of Serotonin Receptors and Depression: State of the Art
Fabbri, C., Marsano, A., & Serretti, A. (2013) · Current Drug Targets · doi:10.2174/1389450111314050004 · Cited by 35 · see citing works
Serotonergic System Genes in Psychosis of Alzheimer Dementia: Meta-Analysis
Ramanathan, S., & Glatt, S. J. (2009) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181ab8c3f · Cited by 33 · see citing works
5HTTLPR: White Knight or Dark Blight?
Murphy, D. L., Maile, M. S., & Vogt, N. M. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn3002224 · Cited by 32 · see citing works
Micheli, D., Bonvicini, C., Rocchi, A., et al. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-10405 · Cited by 31 · see citing works
Sáiz, P. A., García‐Portilla, M. P., Paredes, B., Arango, C., Morales, B., Álvarez, V., Coto, E., Bobes-Bascarán, T., Bousoño, M., & Bobes, J. (2008) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3283050ada · Cited by 30 · see citing works
Wilkosz, P. A., Kodavali, C. V., Weamer, E. A., Miyahara, S., López, O. L., Nimgaonkar, V. L., DeKosky, S. T., & Sweet, R. A. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30549 · Cited by 30 · see citing works
Chronobiological Approaches to Alzheimers Disease
Stranahan, A. M. (2012) · Current Alzheimer Research · doi:10.2174/156720512799015028 · Cited by 26 · see citing works
Marner, L., Knudsen, G. M., Madsen, K., Holm, S., Baaré, W. F. C., & Hasselbalch, S. G. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100903 · Cited by 25 · see citing works
Shared Genetic Risk Factors for Late-Life Depression and Alzheimer’s Disease
Ye, Q., Bai, F., & Zhang, Z. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151129 · Cited by 25 · see citing works
Biomarkers of aggression in dementia
Gotovac, K., Perković, M. N., Pivac, N., & Borovečki, F. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.03.002 · Cited by 24 · see citing works
The algorithm for Alzheimer risk assessment based on APOE promoter polymorphisms
Limon-Sztencel, A., Lipska-Ziętkiewicz, B. S., Chmara, M., Wasąg, B., Bidzan, L., Godlewska, B. R., & Limon, J. (2016) · Alzheimer s Research & Therapy · doi:10.1186/s13195-016-0187-9 · Cited by 24 · see citing works
Zhang, Z., Mu, J., Li, J., Li, W., & Song, J. (2012) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2012.0253 · Cited by 23 · see citing works
Genetics of Depression: An Overview of the Current Science
Elder, B. L., & Mosack, V. (2011) · Issues in Mental Health Nursing · doi:10.3109/01612840.2010.541588 · Cited by 19 · see citing works
Boiocchi, C., Maggioli, E., Zorzetto, M., Sinforiani, E., Cereda, C., Ricevuti, G., & Cuccia, M. (2012) · Rejuvenation Research · doi:10.1089/rej.2012.1381 · Cited by 17 · see citing works
Plasma homocysteine in Alzheimer's disease with or without co-morbid depressive symptoms.
Kitzlerová, E., Fišar, Z., Jirák, R., Zvěřová, M., Hroudová, J., Benaková, H., & Raboch, J. (2014) · PubMed · Cited by 17 · see citing works
Self-citationBrain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in febrile seizures
Chou, I., Tsai, C., Lee, C.-C., et al. (2004) · Epilepsy Research · doi:10.1016/j.eplepsyres.2004.05.001 · Cited by 16 · see citing works
Serotonin transporter and serotonin receptor 2A gene polymorphisms in Alzheimer's disease
Fehér, Á., Juhász, A., László, A., et al. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.12.020 · Cited by 15 · see citing works
Weitkunat, R., Kaelin, E., Vuillaume, G., et al. (2010) · BMC Medical Research Methodology · doi:10.1186/1471-2288-10-47 · Cited by 10 · see citing works
Pathophysiology of Mood Disorders and Mechanisms of Action of Antidepressants and Mood Stabilizers
Fišar, Z. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7940-6_6 · Cited by 7 · see citing works
Self-citationLin, S., Lee, I. H., Chen, K. C., Chen, P. S., Chiu, N.-T., Yao, W. J., & Yang, Y. K. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.03.009 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [32]Ye Q Bai F Zhang Z Shared genetic risk factors for late-life depression and Alzheimer’s disease J Alzheimers Dis 2016 52 1 15 27060956
Cited by
Sorted by citations
Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature
Remes, O., Mendes, J. F., & Templeton, P. (2021) · Brain Sciences · doi:10.3390/brainsci11121633 · Cited by 482 · see citing works
- Authors
- Kitzlerová, E., Fišar, Z., Lelková, P., Jirák, R., Zvěřová, M., Hroudová, J., Manukyan, A., Martásek, P., & Raboch, J.
- Affiliations
- Charles University (CZ)
- Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
- Corresponding author
- Fišar, Zdeněk
- Venue
- Medical Science Monitor
- Published
- 2018-04-28
- Volume
- 24
- Pages
- 2599-2619
- ISSN
- 1234-1010 (ISSN-L)
- 1643-3750
- PMC
- PMC5944403
- OpenAlex
- W2802909891
- Cited by
- 21
- References
- 140
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 5
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Medical Science Monitor (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- Alzheimer's disease, major depressive disorder, genetic susceptibility loci, gene-gene interaction, polymorphism, APOE ε4, HSPA1A, serotonin transporter, HTR2A, brain-derived neurotrophic factor, comorbid depression, serotonergic pathways, inflammatory signaling
- MeSH terms
- Aged, Alleles, Alzheimer Disease, Demography, Depressive Disorder, Major, Major Depressive Disorder, Epistasis, Genetic, Female, Gene Frequency, Humans, Male, Middle Aged, Polymorphism, Genetic, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genetic Loci, Genetic Association Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review