Cited by 139Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsGenetic Associations and Epidemiology

APOE ε4 is not associated with Alzheimer's disease in elderly Nigerians

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Gureje, Oye, Ogunniyi, Adesola, Baiyewu, Olusegun, Price, Brandon, Unverzagt, Frederick W., Evans, Rebecca M., Smith‐Gamble, Valerie, Lane, Kathleen A. +4 more·2006·Annals of Neurology

Abstract

Since 1992, research teams from Indiana University and the University of Ibadan have been collecting and comparing data from two diverse, elderly populations to identify risk factors for dementia and Alzheimer's disease. Apolipoprotein E (APOE) was genotyped in 2,245 Nigerian samples. Of these, 830 had a diagnosis: 459 were normal, and 140 had dementia including 123 diagnosed with Alzheimer's disease. In contrast with other populations, the APOE ε4 allele was not significantly associated with Alzheimer's disease or dementia. This lack of association in the Yoruba might reflect genetic variation, environmental factors, as well as genetic/environmental interactions. Ann neurol 2006

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  • The association between APOEε4 and Alzheimer's disease is weaker among African-American and Hispanic individuals and nonexistent among Nigerian individuals.

    “the association between ε4 and disease is reported to be weaker among African-American and Hispanic individuals [58, 61, 62] and nonexistent among Nigerian individuals [63].”

    From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [63]

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Authors
Gureje, O., Ogunniyi, A., Baiyewu, O., Price, B., Unverzagt, F. W., Evans, R. M., Smith‐Gamble, V., Lane, K. A., Gao, S., Hall, K. S., Hendrie, H. C., & Murrell, J. R.
Affiliations
  • University of Ibadan (NG)
  • Indiana University Indianapolis (US)
  • Indiana University School of Medicine (US)
Corresponding author
Murrell, Jill R.
Venue
Annals of Neurology
Publisher
Wiley
Published
2005-12-22
Volume
59
Issue
1
Pages
182-185
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2160403558
Cited by
139
References
16
Citations by year
2026: 6 · 2025: 7 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 10 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 7 · 2013: 2 · 2012: 6
FWCI
4.63
Type
journal article
Language
en
Open access
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • IUScholarWorks (Indiana University) (submittedVersion)
Funders
National Institute on Aging (P30AG010133, R01AG09956, P30 AG-10133, R01AG009956)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
APOE ε4, Alzheimer's disease, dementia, apolipoprotein E, genetic association, Yoruba, genetic variation, gene-environment interaction, risk factors
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Ethnicity, Female, Genotype, Humans, Male, Mass Screening, Nigeria, Risk Factors, Protein Isoforms

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