The DOI matches its Crossref record; 97 of the 98 references it cites were found in a registry or an index.
The Impact of Exposure to Cannabinoids in Adolescence: Insights From Animal Models
Abstract
The regular use of cannabis during adolescence is of particular concern because use by this age group seems to be associated with an increased likelihood of deleterious consequences, as reported by several epidemiologic studies. However, despite their unquestionable value, epidemiologic data are inconclusive. Modeling the adolescent phase in animals appears to be a useful approach to investigate the impact of cannabis use on the adolescent brain. In these models, adolescent cannabinoid exposure has been reported to cause long-term impairment in specific components of learning and memory and to have differential effects on anxiety, social behavior, and depressive-like signs. These findings suggest that it may represent, per se or in association with other hits, a risk factor for developing psychotic-like symptoms in adulthood. The neurobiological bases of this association include the induction of alterations in the maturational events of the endocannabinoid system occurring in the adolescent brain. Alterations in the endocannabinoid system may profoundly dysregulate developmental processes in some neurotransmitter systems, such as gamma-aminobutyric acid and glutamate, mainly in the cortex. The resulting picture strongly resembles the one present in schizophrenic patients, highlighting the translational value of this experimental approach.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Some of the detrimental effects of cannabis on behavior seem more pronounced in females in both animals 19 and humans, 15 although this finding remains controversial.”
From Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood (2019) · cites this paper as [19]
In the citing paper
“Additional studies further demonstrate the neurobiological and the pathophysiological depressionlike behavior of adolescent rats when exposed to cannabinoids.19”
From Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood (2019) · cites this paper as [19]
Citations
Cites
Neuronal Oscillations in Cortical Networks
Buzsáki, G., & Draguhn, A. (2004) · Science · doi:10.1126/science.1099745 · Cited by 6,576
Dynamic mapping of human cortical development during childhood through early adulthood
Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., Nugent, T. F., Herman, D. H., Clasen, L. S., Toga, A. W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402680101 · Cited by 5,604 · cited 1×
“N: 0006-3223 SEE COMMENTA more primitive brain regions and later in phylogenetically newer regions, with the most anterior regions of the frontal and temporal lobes being the last to attain adult organization (6,7,9).”
BackgroundBrain development during childhood and adolescence: a longitudinal MRI study
Giedd, J. N., Blumenthal, J., Jeffries, N. O., Castellanos, F. X., Liu, H., Zijdenbos, A., Paus, T., Evans, A. C., & Rapoport, J. L. (1999) · Nature Neuroscience · doi:10.1038/13158 · Cited by 5,552
Abnormal neural oscillations and synchrony in schizophrenia
Uhlhaas, P. J., & Singer, W. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2774 · Cited by 2,120
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition
Wang, X.-J. (2010) · Physiological Reviews · doi:10.1152/physrev.00035.2008 · Cited by 1,939
In vivo evidence for post-adolescent brain maturation in frontal and striatal regions
Sowell, E. R., Thompson, P. M., Holmes, C. J., Jernigan, T. L., & Toga, A. W. (1999) · Nature Neuroscience · doi:10.1038/13154 · Cited by 1,439
Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., Taylor, A., Arseneault, L., Williams, B., Braithwaite, A., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.026 · Cited by 1,409
Morphometric study of human cerebral cortex development
Huttenlocher, P. R. (1990) · Neuropsychologia · doi:10.1016/0028-3932(90)90031-i · Cited by 1,239
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Mei, L., & Xiong, W.-C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2392 · Cited by 1,030
Cannabis use and psychosis: A longitudinal population-based study
van Os, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf043 · Cited by 928
Cited by
Sorted by citations
Gobbi, G., Atkin, T., Zytynski, T., Wang, S., Askari, S., Boruff, J., Ware, M., Marmorstein, N., Cipriani, A., Dendukuri, N., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.4500 · Cited by 914
Ligresti, A., PETROCELLIS, L. D., & Marzo, V. D. (2016) · Physiological Reviews · doi:10.1152/physrev.00002.2016 · Cited by 505
The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development
Meyer, H. C., Lee, F. S., & Gee, D. G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.143 · Cited by 238
Hazekamp, A. (2018) · Medical Cannabis and Cannabinoids · doi:10.1159/000489287 · Cited by 203
Association of Cannabis Use During Adolescence With Neurodevelopment
Albaugh, M. D., Ottino-Gonzalez, J., Sidwell, A., Lepage, C., Juliano, A., Owens, M. M., Chaarani, B., Spechler, P., Fontaine, N., Rioux, P., et al. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.1258 · Cited by 176
Metadata
- Authors
- Rubino, T., & Parolaro, D.
- Affiliations
- University of Insubria (IT)
- Corresponding author
- Rubino, Tiziana
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 79
- Issue
- 7
- Pages
- 578-585
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1068045543
- Cited by
- 183
- References
- 98
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 11 · 2023: 8 · 2022: 16 · 2021: 17 · 2020: 29 · 2019: 24 · 2018: 15 · 2017: 22 · 2016: 15
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- IrInSubria (University of Insubria) (submittedVersion)
- Funders
- Italian Department of Drug Policies (project ADOCANNABIS to DP) (2008.2203)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- adolescent cannabis use, adolescent brain development, learning and memory impairment, anxiety, social behavior, depression-like behavior, psychotic-like symptoms, schizophrenia risk, GABA, glutamate, cortical development
- MeSH terms
- Adolescent, Animals, Brain, Cannabinoids, Marijuana Abuse, Cognition, Disease Models, Animal, gamma-Aminobutyric Acid, Humans, Learning, Memory, Psychoses, Substance-Induced, Mice, Rats, Endocannabinoids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
