Tau accelerates α-synuclein aggregation and spreading in Parkinson’s disease
Abstract
The aggregation and prion-like propagation of α-synuclein are involved in the pathogenesis of Parkinson's disease. However, the underlying mechanisms regulating the assembly and spreading of α-synuclein fibrils remain poorly understood. Tau co-deposits with α-synuclein in the brains of Parkinson's disease patients, suggesting a pathological interplay between them. Here we show that tau interacts with α-synuclein and accelerates its aggregation. Compared with pure α-synuclein fibrils, the tau-modified α-synuclein fibrils show enhanced seeding activity, inducing mitochondrial dysfunction, synaptic impairment and neurotoxicity in vitro. Injection of the tau-modified α-synuclein fibrils into the striatum of mice induces more severe α-synuclein pathology, motor dysfunction and cognitive impairment when compared with the mice injected with pure α-synuclein fibrils. Knockout of tau attenuates the propagation of α-synuclein pathology and Parkinson's disease-like symptoms both in mice injected with α-syn fibrils and α-syn A53T transgenic mice. In conclusion, tau facilitates α-synuclein aggregation and propagation in Parkinson's disease.
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Tau protein promotes the aggregation and spread of α-synuclein in Parkinson's disease.
“and that tau protein promotes the aggregation and spread of α-Syn in PD [48].”
From Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review (2024) · cites this paper as [48]
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“…α -Syn and accelerate its aggregation; that tau-modified α -Syn protofibrils have a stronger spreading activity than pure α -Syn protofibrils and induce mitochondrial dysfunction, synaptic dysfunction, and neurotoxicity; and that tau protein promotes the aggregation and spread of α -Syn in PD [48].”
BackgroundTau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease
Chimal-Juárez, E., Patel, H., Jury-Garfe, N., Dabin, L. C., Vidal, R., Kim, J., & Lasagna-Reeves, C. A. (2026) · bioRxiv · doi:10.64898/2026.05.12.724684
- Authors
- Pan, L., Li, C., Meng, L., Tian, Y., He, M., Yuan, X., Zhang, G., Zhang, Z., Xiong, J., Chen, G., & Zhang, Z.
- Affiliations
- Renmin Hospital of Wuhan University (CN)
- Hubei Provincial Institute for Food Supervision and Test , Wuhan 430070 , China
- Emory University (US)
- Corresponding author
- Zhang, Zhentao
- ORCID
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2022-05-13
- Volume
- 145
- Issue
- 10
- Pages
- 3454-3471
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W4280555112
- Cited by
- 154
- References
- 83
- Citations by year
- 2026: 41 · 2025: 48 · 2024: 36 · 2023: 28 · 2022: 1
- FWCI
- 14.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Basic Research Program of China (2019YFE0115900)
- National Natural Science Foundation of China (81771382, 81822016, 81901090, 81901291)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- tau protein, alpha-synuclein, Parkinson's disease, protein aggregation, prion-like propagation, seeding activity, mitochondrial dysfunction, synaptic dysfunction, neurotoxicity, A53T alpha-synuclein, motor impairment, cognitive impairment
- MeSH terms
- Synucleinopathies, Animals, Mice, Transgenic, Parkinson Disease, Prions, Mice, Knockout, Mice, alpha-Synuclein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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