Adolescent Alcohol Exposure Epigenetically Suppresses Amygdala Arc Enhancer RNA Expression to Confer Adult Anxiety Susceptibility
Open accessAbstract
BACKGROUND: Adolescent intermittent ethanol (AIE) exposure is an emerging risk factor for adult psychopathology such as anxiety disorders. Enhancer RNAs (eRNAs) are short non-coding RNAs transcribed from enhancer regions that regulate synaptic plasticity-associated gene expression including activity-regulated cytoskeleton-associated protein (Arc), but their role in AIE-induced anxiety susceptibility in adulthood is unknown. METHODS: Rats were exposed to ethanol (2 days on/off; AIE) or intermittent n-saline (AIS) during postnatal days (PND) 28–41 and allowed to grow to adulthood for analysis of behavior and biochemical measures. Some AIE and AIS rats were exposed to an acute challenge with ethanol in adulthood. Cohorts of alcohol-naïve adult rats were cannulated in the central nucleus of amygdala (CeA) and infused with either lysine demethylase 6B(Kdm6b) small interfering RNA (siRNA) or an antisense locked nucleic acid (LNA) oligonucleotide specific to Arc eRNA prior to behavioral and biochemical analysis. RESULTS: AIE adult rats display heightened anxiety and decreased Arc eRNA expression, which is regulated epigenetically through decreased KDM6B expression. This triggers condensed chromatin at the synaptic activity response element (SARE) site and promoter of the Arc gene, facilitating increased negative elongation factor (NELF) binding to the Arc promoter and decreasing Arc expression in the amygdala. Knockdown of Kdm6b or Arc eRNA expression in the CeA provokes anxiety in naïve adult rats and recapitulates the molecular and epigenetic phenotypes of AIE. CONCLUSION: These data suggest that eRNA regulation via epigenetic reprogramming in the amygdala, particularly at the Arc SARE site, contributes to adult anxiety after adolescent alcohol exposure.
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Adolescent alcohol exposure-induced epigenetic repression of the synaptic activity response element within the immediate-early gene Arc in the central amygdala is a critical mediator for anxiety-like behavior.
“Recent evidence points to AAE-induced epigenetic repression of the synaptic activity response element (SARE) within the immediate-early gene activity-regulated cytoskeleton-associated protein (Arc) in the central amygdala (CeA) [51, 52] as a critical mediator for anxiety-like behavior.”
From Consequences of adolescent drug use (2023) · cites this paper as [51]
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Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate
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“Interestingly, the deficits in BDNF and Arc in the adult amygdala in the AIE model (Pandey et al., 2015; Kyzar et al., 2019) used here are similar to molecular findings in human postmortem amygdala of AUD patients who started drinking before the age of 21 when compared with control subjects (Bohnsack et al.”
BackgroundMethodResultInfluentialSelf-citationAdolescent Ethanol Exposure: Anxiety-Like Behavioral Alterations, Ethanol Intake, and Sensitivity
Towner, T. T., & Varlinskaya, E. I. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00045 · Cited by 31 · see citing works
Galaj, E., Guo, C., Huang, D., Ranaldi, R., & Ma, Y. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.108309 · Cited by 31 · see citing works
“The behavioral consequences, especially the prolonged effects of adolescent/young adult alcohol exposure in the clinic cause substantial morbidity, but available treatments are limited (Kyzar et al., 2019; Sakharkar et al., 2019; Viner and Taylor, 2007).”
BackgroundHistone modifications, DNA methylation, and the epigenetic code of alcohol use disorder
Bohnsack, J. P., & Pandey, S. C. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.08.005 · Cited by 32 · see citing works
Self-citationCurrent and Future Perspectives of Noncoding RNAs in Brain Function and Neuropsychiatric Disease
Kyzar, E. J., Bohnsack, J. P., & Pandey, S. C. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.08.013 · Cited by 27 · see citing works
Self-citationChandler, L. J., Vaughan, D. T., & Gass, J. T. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.837657 · Cited by 24 · see citing works
Chen, Y., Wang, X., Xiao, B., Luo, Z., & Long, H. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03442-4 · Cited by 25 · see citing works
“In addition, Pol II promoter-proximal stalling is associated with chromatin modifications such as H3K4me3, H3K9ac, and H3K14ac, which contribute to the formation of an active chromatin structure [11].”
BackgroundInfluentialHealey, K. L., Kibble, S., Bell, A., Kramer, G. F., Maldonado‐Devincci, A. M., & Swartzwelder, H. S. (2021) · Alcohol · doi:10.1016/j.alcohol.2021.11.002 · Cited by 20 · see citing works
Unraveling the epigenomic and transcriptomic interplay during alcohol-induced anxiolysis
Krishnan, H. R., Zhang, H., Chen, Y., Bohnsack, J. P., Shieh, A. W., Kusumo, H., Drnevich, J. M., Liu, C., Grayson, D. R., Maienschein‐Cline, M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01732-2 · Cited by 20 · see citing works
“ab10134, Abcam, Waltham, MA) was evaluated at specific sites of genes using chromatin immunoprecipitation (ChIP) assay in the amygdala followed by qPCR and relative fold changes were determined, as described previously [20, 21].”
MethodSelf-citationShentu, Y., Tian, Q., Yang, J., Liu, X., Han, Y., Yang, D., Zhang, N., Fan, X., Wang, P., Ma, J., et al. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113305 · Cited by 21 · see citing works
Kipp, B. T., Nunes, P. T., Galaj, E., Hitchcock, B., Nasra, T., Poynor, K. R., Heide, S., Reitz, N. L., & Savage, L. M. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.08.014 · Cited by 18 · see citing works
Arc controls alcohol cue relapse by a central amygdala mechanism
Pagano, R., Salamian, A., Zielinski, J., Beroun, A., Nalberczak‐Skóra, M., Skonieczna, E., Cały, A., Tay, N., Banaschewski, T., Desrivières, S., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01849-4 · Cited by 18 · see citing works
“Decreased Arc expression in the amygdala was implicated in increased early life stress-induced alcohol consumption in animal models [55, 57, 62].”
BackgroundWaeiss, R. A., Knight, C. P., Carvajal, G. B., Bell, R. L., Engleman, E. A., McBride, W. J., Hauser, S. R., & Rodd, Z. A. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112190 · Cited by 16 · see citing works
“Lasting alterations found within the mesolimbic system of the adult brain resulting from adolescent EtOH exposure involves (i) reduced cholinergic regulation, (ii) elevated DA stimulation and release, as well as (iii) epigenetic reprogramming (Vetreno et al. 2014; Sahr et al. 2004; Toalston et al. 2014; Kyzar et al. 2…”
BackgroundBrancato, A., Castelli, V., Cannizzaro, C., & Tringali, G. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110699 · Cited by 14 · see citing works
Early life adversity: Epigenetic regulation underlying drug addiction susceptibility
Winter, J. J., Rodríguez-Acevedo, K. L., Dittrich, M., & Heller, E. A. (2023) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2023.103825 · Cited by 15 · see citing works
Targeting Epigenetic Mechanisms to Treat Alcohol Use Disorders (AUD)
Rodriguez, F. D. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210203142539 · Cited by 15 · see citing works
Amodeo, L. R., Jennings, S. D., Mulholland, P. J., & Ehlers, C. L. (2021) · Alcohol · doi:10.1016/j.alcohol.2021.09.032 · Cited by 14 · see citing works
Mostafi, H. E., Elhessni, A., Touil, T., Ouichou, A., Abderrahim, L., Doumar, H., & Mesfioui, A. (2020) · Alcohol · doi:10.1016/j.alcohol.2020.04.007 · Cited by 13 · see citing works
Yao, Y., Du, J., Wang, D., Li, N., Tao, Z., Wu, D., Peng, F., Shi, J., Zhou, W., Zhao, T., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.06.006 · Cited by 12 · see citing works
“A recent study reported that decreased KDM6B expression contributes to anxiety in adult rats after adolescent alcohol exposure (Kyzar, Zhang, & Pandey, 2019).”
BackgroundTowner, T. T., Applegate, D. T., Varlinskaya, E. I., & Werner, D. F. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.841657 · Cited by 13 · see citing works
“, 2020), and dysregulated epigenetic regulators (Kokare et al., 2017; Kyzar et al., 2017; Kyzar et al., 2019).”
BackgroundGamble, M. E., & Diaz, M. R. (2020) · Brain Sciences · doi:10.3390/brainsci10110829 · Cited by 12 · see citing works
“These results contrast previous work that has shown either increased [13,14,16,48] or decreased [21,22,49] anxiety-like behavior in adult males following exposures to much higher levels of ethanol during adolescence, which in and of itself suggests that there are many factors that influence the alterations in anxiety-…”
ResultCruise, T. M., Kumar, K. U., Malovic, E., & Pandey, S. C. (2023) · Advances in Drug and Alcohol Research · doi:10.3389/adar.2023.10871 · Cited by 12 · see citing works
“AIE decreases lysine demethylase 6b (KDM6b) occupancy at the Arc promoter and SARE, which permits increased H3K27me3 at the Arc promoter and SARE site (45).”
BackgroundSelf-citationAdolescent intermittent ethanol exposure enhances adult stress effects in male rats
Healey, K. L., Kibble, S., Dubester, K., Bell, A., & Swartzwelder, H. S. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173513 · Cited by 12 · see citing works
Adolescent alcohol exposure alters threat avoidance in adulthood
Landin, J. D., & Chandler, L. J. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.1098343 · Cited by 11 · see citing works
“For example, adult male Sprague-Dawley rats that had been subjected to AIE exhibited increased time in the closed arms of the elevated plus maze (EPM; Pandey et al., 2015; Kyzar et al., 2019), whereas adult male Wistar and Long-Evans rats that had undergone AIE exposure displayed increased time in the open arms of the…”
Przybysz, K. R., Gamble, M. E., & Diaz, M. R. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108512 · Cited by 11 · see citing works
Neuroepigenetic consequences of adolescent ethanol exposure
Brocato, E. R., & Wolstenholme, J. T. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2021.06.008 · Cited by 11 · see citing works
Zhou, Y., Tian, Q., Zheng, C., Yang, J., Fan, J., & Shentu, Y. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.08.023 · Cited by 10 · see citing works
It is not just about transcription: involvement of brain RNA splicing in substance use disorders
de Carvalho, L. M., & Lasek, A. W. (2024) · Journal of Neural Transmission · doi:10.1007/s00702-024-02740-y · Cited by 9 · see citing works
“Therefore, another way in which drugs of abuse can potentially impact splicing is through the changes in epigenetic modifications at specific genes (Xu et al. 2021; Kyzar et al. 2019).”
Alcohol: Epigenome alteration and inter/transgenerational effect
Heidari, N., Hajikarim‐Hamedani, A., Heidari, A., Ghane, Y., Ashabi, G., Zarrindast, M., & Sadat‐Shirazi, M. (2024) · Alcohol · doi:10.1016/j.alcohol.2024.03.008 · Cited by 9 · see citing works
Matrisciano, F., Locci, V., Dong, E., Nicoletti, F., Guidotti, A., & Grayson, D. R. (2022) · Current Neuropharmacology · doi:10.2174/1567202619999220209112609 · Cited by 9 · see citing works
“In CA1 hippocampal neurons, activation of mGlu5 receptors promotes synapse elimination and long-term depression by stimulating the translation of Mef-2-induced Arc mRNA [65-70].”
Insights into Enhancer RNAs: Biogenesis and Emerging Role in Brain Diseases
Shen, Y., Huang, Z., Yang, R., Chen, Y., Wang, Q., & Gao, L. (2021) · The Neuroscientist · doi:10.1177/10738584211046889 · Cited by 10 · see citing works
Lodha, J., Brocato, E. R., Nash, M., Marcus, M. M., Pais, A. C., Pais, A. B., Miles, M. F., & Wolstenholme, J. T. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1287584 · Cited by 8 · see citing works
“Arc is an immediate early transcription factor and is epigenetically reduced in adolescent drinking mice (Kyzar et al., 2019).”
BackgroundRoles of super enhancers and enhancer RNAs in skeletal muscle development and disease
Lei, S., Li, C., She, Y., Zhou, S., Shi, H., & Chen, R. (2022) · Cell Cycle · doi:10.1080/15384101.2022.2129240 · Cited by 8 · see citing works
“eRNAs are useful for “mapping” anxiety disorders [95], cardiac hypertrophy [96], lymphoblast proliferation [97], neurological disorders [98], recurrent pregnancy loss [99,100], and cancer [101–104].”
BackgroundNarendra, S., Klengel, C., Hamzeh, B., Patel, D., Otten, J., Lardenoije, R., Newman, E. L., Miczek, K. A., Klengel, T., Ressler, K. J., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02231-2 · Cited by 8 · see citing works
“In addition, few studies investigated gene networks in the amygdala that are targeted by voluntary alcohol drinking, where molecular processes may underlie the development and maintenance of alcohol-drinking and seeking behaviors [24, 25].”
BackgroundAn Emerging Role for Enhancer RNAs in Brain Disorders
Patel, A., & Dharap, A. A. (2024) · NeuroMolecular Medicine · doi:10.1007/s12017-024-08776-3 · Cited by 8 · see citing works
“The first study investigating eRNAs in addiction was conducted in an adolescent intermittent ethanol (AIE) exposure model in rats (Kyzar et al., 2019).”
Fesser, E. A., Gianatiempo, O., Berardino, B. G., Ferroni, N. M., Cambiasso, M. Y., Fontana, V. A., Calvo, J. C., Sonzogni, S. V., & Cánepa, E. T. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.05.041 · Cited by 8 · see citing works
Epigenetic Mechanisms Underlying Pathobiology of Alcohol Use Disorder
Dulman, R. S., Wandling, G. M., & Pandey, S. C. (2020) · Current Pathobiology Reports · doi:10.1007/s40139-020-00210-0 · Cited by 9 · see citing works
Self-citationTowner, T. T., Goyden, M. A., Coleman, H. J., Drumm, M. K., Ritchie, I. P., Lieb, K. R., Varlinskaya, E. I., & Werner, D. F. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109663 · Cited by 8 · see citing works
The Impact of Alcohol-Induced Epigenetic Modifications in the Treatment of Alcohol use Disorders
Fanfarillo, F., Ferraguti, G., Lucarelli, M., Fuso, A., Ceccanti, M., Terracina, S. A., Micangeli, G., Tarani, L., & Fiore, M. (2023) · Current Medicinal Chemistry · doi:10.2174/0109298673256937231004093143 · Cited by 7 · see citing works
Healey, K. L., Waters, R. C., Knight, S. G., Wandling, G. M., Hall, N. I., Jones, B. N., Shobande, M., Melton, J. G., Pandey, S. C., Swartzwelder, H. S., et al. (2023) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2023.111026 · Cited by 7 · see citing works
Self-citationLuo, Y., Galaj, E., & Ma, Y. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24737 · Cited by 6 · see citing works
“The behavioral consequences, especially the prolonged effects of adolescent alcohol exposure in the clinic (e.g., high risk of developing alcohol use disorder) cause substantial morbidity, but available treatments are limited (Kyzar et al., 2019; Sakharkar et al., 2019; Viner & Taylor, 2007).”
BackgroundYou, C., Krishnan, H. R., Chen, Y., Zhang, H., Drnevich, J. M., Pinna, G., Guidotti, A., Glover, E. J., Lasek, A. W., Grayson, D. R., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.07.018 · Cited by 6 · see citing works
“In addition, qPCR and chromatin immunoprecipitation (ChIP) were performed as previously described (27, 28) and more details are provided in Supplementary Materials.”
Self-citationGobbi, C., Sánchez‐Marín, L., Flores-López, M., Vera, D. M., Pavón, F. J., de Fonseca, F. R., & Serrano, A. (2024) · Biology of Sex Differences · doi:10.1186/s13293-024-00649-5 · Cited by 7 · see citing works
“For instance, alcohol use during adolescence results in a long-term reduction in Arc expression − an immediate early gene product essential for regulating neuronal function and synaptic plasticity in the amygdala with behavioral consequences − by suppressing Arc enhancer RNA expression [10].”
BackgroundBohnsack, J. P., Zhang, H., & Pandey, S. C. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02906-y · Cited by 5 · see citing works
“Arc is down-regulated in both human AUD postmortem amygdala [25] and rodent models of alcohol dependence [26, 27].”
BackgroundMethodInfluentialSelf-citationA Novel Role for the Histone Demethylase JMJD3 in Mediating Heroin-Induced Relapse-Like Behaviors
Mitra, S., Werner, C. T., Shwani, T., Lopez, A. G., Federico, D., Higdon, K. F., Li, X., Gobira, P. H., Thomas, S. A., Martin, J. A., et al. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.06.028 · Cited by 6 · see citing works
Mugantseva, E., Hyytiä, P., & Latvala, A. (2021) · Alcohol and Alcoholism · doi:10.1093/alcalc/agab063 · Cited by 6 · see citing works
“2019) or anxiety-like behaviour during adulthood (Coleman Jr. et al. 2014; Pandey et al. 2015; Kokare et al. 2017; Loxton and Canales 2017; Torcaso et al. 2017; Kyzar et al. 2019).”
BackgroundTeenage drinking and adult neuropsychiatric disorders: An epigenetic connection
Teague, C. D., & Nestler, E. J. (2022) · Science Advances · doi:10.1126/sciadv.abq5934 · Cited by 5 · see citing works
“histone modifications and the removal of permissive histone modifications are observed at the Arc SARE site ( 4 , 5 ).”
BackgroundResultDeciphering the role of siRNA in anxiety and depression
Bale, R., & Doshi, G. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176868 · Cited by 3 · see citing works
Alcohol and Brain-Derived Neurotrophic Factor (BDNF)
Martín‐González, C., González‐Arnay, E., Fernández-Rodríguez, C. M., Rodríguez, A. G., & González‐Reimers, E. (2021) · Springer eBooks · doi:10.1007/978-3-030-67928-6_182-1 · Cited by 3 · see citing works
Aarde, S. M., Bagley, J. R., & Jentsch, J. D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.25.513748 · Cited by 3 · see citing works
Sun, Z., Du, H., Zheng, X., Zhang, H., & Hu, H.-J. (2025) · BMC Medical Genomics · doi:10.1186/s12920-024-02081-5 · Cited by 2 · see citing works
“Enhancer RNA (eRNA), once dismissed as "transcriptional noise" or a "by-product" [1, 2], has garnered increased attention, with a growing number of studies unveiling its significant role.”
Self-citationImpact of Neuroimmune System Activation by Adolescent Binge Alcohol Exposure on Adult Neurobiology
Macht, V. A., de Castro, S., & Vetreno, R. P. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-81908-7_9 · Cited by 2 · see citing works
Alcohol and Brain-Derived Neurotrophic Factor (BDNF)
Martín‐González, C., González‐Arnay, E., Fernández-Rodríguez, C. M., Rodríguez, A. G., & González‐Reimers, E. (2022) · Springer eBooks · doi:10.1007/978-3-030-92392-1_182 · Cited by 2 · see citing works
Epigenetic Regulation of Enhancer RNAs in Neuropsychiatric Disease and Addiction
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Self-citationAlcohol: Epigenome Alteration and Transgenerational EffectPreprint
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Alcohol outcomes on anxiety, impulsivity and spatial memory: Possible Omega-3 amelioration effects
Cabrera, V., Abate, P., Balaszczuk, V., & Macchione, A. F. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111281 · Cited by 2 · see citing works
Malovic, E., Tandukar, J., Zhang, H., Venkareddy, L. K., Gao, R., & Pandey, S. C. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110777 · Cited by 1 · see citing works
Self-citationFunctional Consequences Paternal Preconceptual Alcohol Consumption
Hussain, S., Day, D. J., & Ellenbroek, B. A. (2025) · Current topics in behavioral neurosciences · doi:10.1007/7854_2025_601 · Cited by 1 · see citing works
Connecting the Dots: Adolescent Alcohol, Enhancer RNA, and Anxiety
Wolstenholme, J. T., & Miles, M. F. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.004 · Cited by 1 · see citing works
Narendra, S., Klengel, C., Hamzeh, B., Patel, D., Otten, J., Lardenoije, R., Newman, E. L., Miczek, K. A., Klengel, T., Ressler, K. J., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.07.459347
“In addition, few studies investigated gene networks that are targeted by voluntary alcohol drinking in the amygdala where molecular processes may underlie the development and maintenance of alcohol-drinking and seeking behaviors [22, 23].”
BackgroundEpigenetics of Environmental Exposures
Stein, R. A., Skumiał, M. A., & Graur, F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-409548-9.10662-1
Epigenetics of Brain Disorders
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Mostafi, H. E., Elhessni, A., Doumar, H., Touil, T., & Mesfioui, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910529
“For the adolescent IEI or normal saline (Ctrl) exposure, adolescent rats received intraperitoneal (i.p.) injections of either ethanol (3 g/kg, 20% w / v ) or the equivalent volume paradigm of ethanol exposure has been used by other investigators as well [67–69].”
MethodDysregulation of Central–Medial Amygdala Histone Modifiers in Preclinical Models of Ethanol Exposure
Lamb, K. A., Margetts, A. V., Volmar, C., Bourgain‐Guglielmetti, F., Wahlestedt, C., & Tuesta, L. M. (2025) · Addiction Biology · doi:10.1111/adb.70095
Mendelian randomization facilitates identification of schizophrenia risk enhancer RNAs
Ye, L., Ni, C., Chen, R., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03358-6
“As a result, most research has focused on their cis-regulatory functions [12, 13, 15, 44, 48], with only a few studies reporting on their trans-acting roles [49].”
Gobbi, C., Sánchez-Marín, L., Flores-López, M., Medina-Vera, D., Pavón-Morón, F. J., de Fonseca, F. R., & Serrano, A. (2024) · Figshare · doi:10.6084/m9.figshare.27116085
Adolescent ethanol exposure reprograms HMGB1 responsivity to adult ethanol challenge in males
Macht, V. A., Ankeny, S. E., Kelley, H. G., Park, D. S., Wei, A., Youssef, S., Walker, A. M., Campbell, K. A., Vetreno, R. P., & Crews, F. T. (2026) · Physiology & Behavior · doi:10.1016/j.physbeh.2026.115404
- Authors
- Kyzar, E. J., Zhang, H., & Pandey, S. C.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Pandey, Subhash C.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 85
- Issue
- 11
- Pages
- 904-914
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC6684056
- OpenAlex
- W2910936809
- Semantic Scholar
- 00fe3c734e5a7c5b603a763c3fb278ab0d86ca2f
- Cited by
- 75
- References
- 55
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 11 · 2023: 12 · 2022: 13 · 2021: 15 · 2020: 10 · 2019: 6
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (UO1AA-019971, U24AA-024605)
- Neurobiology of Adolescent Drinking in Adulthood (RO1AA-010005, RO1AA-021662, P50AA-022538)
- Department of Veterans Affairs (Senior Research Career Scientist
- Individual National Research Service (F30 AA024948)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- adolescent intermittent ethanol exposure, KDM6B, epigenetic reprogramming, amygdala, NELF, condensed chromatin, alcohol exposure, anxiety disorders, synaptic plasticity
- MeSH terms
- Age Factors, Amygdala, Animals, Anxiety, Cytoskeletal Proteins, Enhancer Elements, Genetic, Male, Microinjections, Nerve Tissue Proteins, Oligonucleotides, Antisense, RNA, Small Interfering, Epigenesis, Genetic, Rats, Jumonji Domain-Containing Histone Demethylases, RNA, Small Untranslated
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