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Cited by 457Memory and Neural MechanismsNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

The Central Amygdala as an Integrative Hub for Anxiety and Alcohol Use Disorders

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Gilpin, Nicholas W., Herman, Melissa A., Roberto, Marisa·2015·Biological Psychiatry
DOI 10.1016/j.biopsych.2014.09.008PMC PMC4398579
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Abstract

The central amygdala (CeA) plays a central role in physiologic and behavioral responses to fearful stimuli, stressful stimuli, and drug-related stimuli. The CeA receives dense inputs from cortical regions, is the major output region of the amygdala, is primarily GABAergic (inhibitory), and expresses high levels of prostress and antistress peptides. The CeA is also a constituent region of a conceptual macrostructure called the extended amygdala that is recruited during the transition to alcohol dependence. We discuss neurotransmission in the CeA as a potential integrative hub between anxiety disorders and alcohol use disorder, which are commonly co-occurring in humans. Imaging studies in humans and multidisciplinary work in animals collectively suggest that CeA structure and function are altered in individuals with anxiety disorders and alcohol use disorder, the end result of which may be disinhibition of downstream "effector" regions that regulate anxiety-related and alcohol-related behaviors.

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Crossref · 10.1016/j.biopsych.2014.09.008

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  • GABAergic projections from the central amygdala dampen hypothalamic activity, such as autonomic anxiety responses to fearful stimuli.

    “These projections dampen hypothalamic activity, such as autonomic anxiety responses to fearful stimuli (Gilpin et al., 2015; Nuss, 2015).”

    From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Gilpin et al., 2015

    In “Effector Regions Targeted by CeA Efferents” (page unavailable), the paper says the central amygdala sends dense GABAergic projections to the lateral hypothalamus, which mediates autonomic responses to fearful stimuli. It does not say those projections dampen hypothalamic activity or the autonomic responses, so the claimed effect is unsupported. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • GABAergic neurons from the central amygdala project into the hypothalamus.

    “GABAergic neurons from the central amygdala (CeA), an integration center that converts emotionally relevant sensory information into physiological and behavioral responses, project into the hypothalamus (Gilpin et al., 2015).”

    From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Gilpin et al., 2015

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Cited by

Sorted by citations

Authors
Gilpin, N. W., Herman, M. A., & Roberto, M.
Affiliations
  • Louisiana State University Health Sciences Center New Orleans (US)
  • Scripps Research Institute (US)
Corresponding author
Gilpin, Nicholas W.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2015-05
Volume
77
Issue
10
Pages
859-869
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2014.09.008
PMC
PMC4398579
OpenAlex
W2080894664
Cited by
457
References
29
Citations by year
2026: 36 · 2025: 41 · 2024: 44 · 2023: 51 · 2022: 47 · 2021: 58 · 2020: 48 · 2019: 34 · 2018: 44 · 2017: 31 · 2016: 17 · 2015: 6
FWCI
1.74
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (AA018400 (NWG), AA023305 (NWG), AA020430 (MAH), AA021491 (MR), AA017447 (MR), AA006420 (MR), AA013498 (MR), AA015566 (MR))
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
central amygdala, anxiety disorders, alcoholism, extended amygdala, co-occurring disorders, GABAergic neurotransmission, disinhibition, fear response, stress response
MeSH terms
Ethanol, Alcoholism, Animals, Anxiety, Corticotropin-Releasing Hormone, Humans, Neurons, Neuropeptide Y, Stress, Psychological, Signal Transduction, Central Amygdaloid Nucleus

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