Cited by 297Resilience and Mental HealthStress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

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Neurobiology of Resilience: Interface Between Mind and Body

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Cathomas, Flurin, Murrough, James W., Nestler, Eric J., Han, Ming-Hu, Russo, Scott J.·2019·Biological Psychiatry

DOI 10.1016/j.biopsych.2019.04.011PMC PMC6717018

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Abstract

Stress-related neuropsychiatric disorders, such as major depressive disorder and posttraumatic stress disorder, exact enormous socioeconomic and individual consequences. Resilience, the process of adaptation in the face of adversity, is an important concept that is enabling the field to understand individual differences in stress responses, with the hope of harnessing this information for the development of novel therapeutics that mimic the body's natural resilience mechanisms. This review provides an update on the current state of research of the neurobiological mechanisms of stress resilience. We focus on physiological and transcriptional adaptations of specific brain circuits, the role of cellular and humoral factors of the immune system, the gut microbiota, and changes at the interface between the brain and the periphery, the blood-brain barrier. We propose viewing resilience as a process that requires the integration of multiple central and peripheral systems and that elucidating the underlying neurobiological mechanisms will ultimately lead to novel therapeutic options.

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Authors: Cathomas, F., Murrough, J. W., Nestler, E. J., Han, M.-H., & Russo, S. J.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Russo, Scott J.
ORCID: Cathomas, Flurin
Murrough, James W.
Nestler, Eric J.
Han, Ming-Hu
Russo, Scott J.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2019-09
Volume: 86
Issue: 6
Pages: 410-420
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2019.04.011
PMC: PMC6717018
OpenAlex: W2936176560
Cited by: 296
References: 151
Citations by year: 2026: 22 · 2025: 55 · 2024: 55 · 2023: 36 · 2022: 45 · 2021: 40 · 2020: 38 · 2019: 5
FWCI: 5.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
National Center for Complementary and Integrative Health (P50 AT008661-01)
Janssen Pharmaceuticals
National Institute of Mental Health (P50 MH096890, R01 MH090264, R01 MH104559, R56 MH115409)
Sunovion
Novartis
Sage Therapeutics
Avanir Pharmaceuticals
Allergan Foundation
Janssen Research and Development
Topics: Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: resilience, stress resilience, stress-related neuropsychiatric disorders, major depressive disorder, post-traumatic stress disorder, individual differences in stress response, brain circuits, immune system, gut microbiota, blood-brain barrier, neuroimmune interactions
MeSH terms: Gastrointestinal Microbiome, Adaptation, Psychological, Blood-Brain Barrier, Brain, Major Depressive Disorder, Humans, Immune System, Synaptic Transmission, Neurobiology, Psychophysiology, Stress Disorders, Post-Traumatic, Resilience, Psychological

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