The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
Neurobiology of Resilience: Interface Between Mind and Body
Open accessAbstract
Stress-related neuropsychiatric disorders, such as major depressive disorder and posttraumatic stress disorder, exact enormous socioeconomic and individual consequences. Resilience, the process of adaptation in the face of adversity, is an important concept that is enabling the field to understand individual differences in stress responses, with the hope of harnessing this information for the development of novel therapeutics that mimic the body's natural resilience mechanisms. This review provides an update on the current state of research of the neurobiological mechanisms of stress resilience. We focus on physiological and transcriptional adaptations of specific brain circuits, the role of cellular and humoral factors of the immune system, the gut microbiota, and changes at the interface between the brain and the periphery, the blood-brain barrier. We propose viewing resilience as a process that requires the integration of multiple central and peripheral systems and that elucidating the underlying neurobiological mechanisms will ultimately lead to novel therapeutic options.
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“These findings reveal alterations at the levels of intracellular signaling, gene expression, neurotrophic factors, neurogenesis, neuroinflammation, excitatory and inhibitory neurotransmission, and synaptic number and function, and have been described in several brain regions implicated in depression 13-22 .”
From Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model (2020) · cites this paper as [21]
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“For example, studies demonstrate that social defeat stress increases BDNF in the VTA-NAc pathway, leading to enhanced function that is thought to contribute to disruption of reward and motivation behaviors in depression 20,21 .”
From Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model (2020) · cites this paper as [21]
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Cites
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“It was soon established that resilience is a common phenomenon rather than an extraordinary process (10).”
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“If pups experience maternal-deprivation for a long period, they show higher susceptibility to subsequent stressors in adult life, HPA axis hyperactivity and altered glucocorticoid responses (34) (35).”
BackgroundStructure and function of the blood–brain barrier
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“Stress and glucocorticoid release decrease adult hippocampal neurogenesis, a process that is reversed by treatment with some but not all antidepressants (43) (44).”
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“These responses mediate the necessary acute “fight-or-flight” reaction (3) (4).”
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Cited by
Sorted by citations
Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model
Price, R. B., & Duman, R. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0615-x · Cited by 739
López-Otín, C., & Kroemer, G. (2021) · Cell · doi:10.1016/j.cell.2020.11.034 · Cited by 499
Gut microbiota and major depressive disorder: a systematic review and meta-analysis
Sanada, K., Nakajima, S., Kurokawa, S., Barceló-Soler, A., Ikuse, D., Hirata, A., Yoshizawa, A., Tomizawa, Y., Salas-Valero, M., Noda, Y., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.102 · Cited by 372
Gut microbiota–brain axis in depression: the role of neuroinflammation
Carlessi, A. S., Borba, L. A., Zugno, A. I., Quevedo, J., & Réus, G. Z. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14631 · Cited by 243
Treasure, J. L., Willmott, D., Ambwani, S., Cardi, V., Bryan, D. C., Rowlands, K., & Schmidt, U. H. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030630 · Cited by 230
“This broad stress response reduces resilience [119] and may be accompanied by reduced mesolimbic dopamine function, anhedonia, and lack of motivation [120].”
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Metadata
- Authors
- Cathomas, F., Murrough, J. W., Nestler, E. J., Han, M.-H., & Russo, S. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Russo, Scott J.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 86
- Issue
- 6
- Pages
- 410-420
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC6717018
- OpenAlex
- W2936176560
- Cited by
- 296
- References
- 151
- Citations by year
- 2026: 22 · 2025: 55 · 2024: 55 · 2023: 36 · 2022: 45 · 2021: 40 · 2020: 38 · 2019: 5
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Center for Complementary and Integrative Health (P50 AT008661-01)
- Janssen Pharmaceuticals
- National Institute of Mental Health (P50 MH096890, R01 MH090264, R01 MH104559, R56 MH115409)
- Sunovion
- Novartis
- Sage Therapeutics
- Avanir Pharmaceuticals
- Allergan Foundation
- Janssen Research and Development
- Topics
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- resilience, stress resilience, stress-related neuropsychiatric disorders, major depressive disorder, post-traumatic stress disorder, individual differences in stress response, brain circuits, immune system, gut microbiota, blood-brain barrier, neuroimmune interactions
- MeSH terms
- Gastrointestinal Microbiome, Adaptation, Psychological, Blood-Brain Barrier, Brain, Major Depressive Disorder, Humans, Immune System, Synaptic Transmission, Neurobiology, Psychophysiology, Stress Disorders, Post-Traumatic, Resilience, Psychological
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