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Neurobiology of Resilience: Interface Between Mind and Body
Open accessAbstract
Stress-related neuropsychiatric disorders, such as major depressive disorder and posttraumatic stress disorder, exact enormous socioeconomic and individual consequences. Resilience, the process of adaptation in the face of adversity, is an important concept that is enabling the field to understand individual differences in stress responses, with the hope of harnessing this information for the development of novel therapeutics that mimic the body's natural resilience mechanisms. This review provides an update on the current state of research of the neurobiological mechanisms of stress resilience. We focus on physiological and transcriptional adaptations of specific brain circuits, the role of cellular and humoral factors of the immune system, the gut microbiota, and changes at the interface between the brain and the periphery, the blood-brain barrier. We propose viewing resilience as a process that requires the integration of multiple central and peripheral systems and that elucidating the underlying neurobiological mechanisms will ultimately lead to novel therapeutic options.
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“These findings reveal alterations at the levels of intracellular signaling, gene expression, neurotrophic factors, neurogenesis, neuroinflammation, excitatory and inhibitory neurotransmission, and synaptic number and function, and have been described in several brain regions implicated in depression 13-22 .”
From Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model (2020) · cites this paper as [21]
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“For example, studies demonstrate that social defeat stress increases BDNF in the VTA-NAc pathway, leading to enhanced function that is thought to contribute to disruption of reward and motivation behaviors in depression 20,21 .”
From Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model (2020) · cites this paper as [21]
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BackgroundSelf-citationRole of Monocyte-Derived MicroRNA106b∼25 in Resilience to Social Stress
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Carlessi, A. S., Borba, L. A., Zugno, A. I., Quevedo, J., & Réus, G. Z. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14631 · Cited by 243
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“This broad stress response reduces resilience [119] and may be accompanied by reduced mesolimbic dopamine function, anhedonia, and lack of motivation [120].”
Background
Metadata
- Authors
- Cathomas, F., Murrough, J. W., Nestler, E. J., Han, M.-H., & Russo, S. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Russo, Scott J.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 86
- Issue
- 6
- Pages
- 410-420
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC6717018
- OpenAlex
- W2936176560
- Cited by
- 296
- References
- 151
- Citations by year
- 2026: 22 · 2025: 55 · 2024: 55 · 2023: 36 · 2022: 45 · 2021: 40 · 2020: 38 · 2019: 5
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Center for Complementary and Integrative Health (P50 AT008661-01)
- Janssen Pharmaceuticals
- National Institute of Mental Health (P50 MH096890, R01 MH090264, R01 MH104559, R56 MH115409)
- Sunovion
- Novartis
- Sage Therapeutics
- Avanir Pharmaceuticals
- Allergan Foundation
- Janssen Research and Development
- Topics
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- resilience, stress resilience, stress-related neuropsychiatric disorders, major depressive disorder, post-traumatic stress disorder, individual differences in stress response, brain circuits, immune system, gut microbiota, blood-brain barrier, neuroimmune interactions
- MeSH terms
- Gastrointestinal Microbiome, Adaptation, Psychological, Blood-Brain Barrier, Brain, Major Depressive Disorder, Humans, Immune System, Synaptic Transmission, Neurobiology, Psychophysiology, Stress Disorders, Post-Traumatic, Resilience, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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