Incentive motivation is associated with striatal dopamine asymmetry
Open accessAbstract
Dopamine plays an important role in modulating incentive motivation, expressed behaviorally as approach behavior. EEG studies report association between approach behavior and asymmetric pattern of activation in anterior cortical regions (as measured by the inverse of EEG alpha power). Therefore, individual differences in incentive motivation may reflect asymmetries in dopaminergic systems. We examined this hypothesis by studying the relationship between self-reported degree of incentive motivation, and asymmetry of D2 receptor availability in healthy volunteers. Nineteen healthy participants were studied with positron emission tomography (PET) and [11C]raclopride to assess the availability of dopamine D2 receptors in left and right striatum. Incentive motivation was assessed by the Achievement scale of the Multidimensional Personality Questionnaire. The Achievement score was negatively correlated with the Asymmetry Index ([R-L]/[R+L]) of D2 receptor availability (r=-.721, p=.001), suggesting that greater positive incentive motivation is associated with higher receptor availability in the left relative to the right hemisphere.
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In healthy controls, greater scores on trait measures of motivation were associated with higher left relative to right striatal D2/D3 receptor availability.
“Using the Achievement scale we had previously documented in healthy controls an association with asymmetry in striatal measures of D2/D3 receptor availability such that greater scores on trait measures of motivation were associated with higher left relative to right receptor availability 31 .”
From Motivation Deficit in ADHD is Associated with Dysfunction of the Dopamine Reward Pathway (2011) · cites this paper as [31]
Higher D2 receptor availability in the left striatum is associated with greater positive incentive motivation in healthy controls.
“Similarly, Tomer et al. (Tomer et al., 2008) showed that higher D2 receptor availability in the left striatum is associated with greater positive incentive motivation in healthy controls.”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Tomer et al., 2008
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- Authors
- Tomer, R., Goldstein, R. Z., Wang, G.-J., Wong, C., & Volkow, N. D.
- Affiliations
- University of Haifa (IL)
- Brookhaven National Laboratory (US)
- National Institute on Drug Abuse (US)
- Corresponding author
- Tomer, Rachel
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 77
- Issue
- 1
- Pages
- 98-101
- ISSN
- 0301-0511 (ISSN-L)
- PMC
- PMC2413324
- OpenAlex
- W2095697295
- Cited by
- 93
- References
- 22
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 5 · 2018: 9 · 2017: 4 · 2016: 11 · 2015: 9 · 2014: 11 · 2013: 8 · 2012: 6
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA009481)
- National Institute on Drug Abuse (R01DA023579, K23DA015517, R01DA006891)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- incentive motivation, dopamine, striatum, hemispheric lateralization, approach behavior, achievement motivation, [11C]raclopride, individual differences
- MeSH terms
- Adult, Aged, Dopamine, Female, Humans, Image Processing, Computer-Assisted, Individuality, Functional Laterality, Male, Middle Aged, Motivation, Synaptic Transmission, Parkinson Disease, Neostriatum, Receptors, Dopamine D2, Dopamine Antagonists, Raclopride, Positron-Emission Tomography, Dopamine Plasma Membrane Transport Proteins, Receptors, Dopamine D3
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