The DOI matches its Crossref record, with a small difference in title or year; 205 of the 205 references it cites were found in a registry or an index.
The role of reward circuitry and food addiction in the obesity epidemic: An update
Abstract
The increasing worldwide prevalence of obesity is partially related to the ready availability of highly palatable foods which increases the incidence of hedonic, non-homeostatic feeding. The "food addiction" hypothesis postulates that exposure to these foods alters the brain's reward circuitry, driving an addiction-like behavioural phenotype of compulsive overeating. This review highlights recent evidence that examines changes in the mesolimbic dopaminergic circuit, the primary component of the reward system, associated with exposure to highly palatable foods and obesity. The majority of obesity studies in animals have not measured addictive-like behaviours, but reports of such behaviours have been restricted to experiments using models of binge eating. Where examined, the prevalence of addiction-like behaviour in overweight and obese subjects indicates that 10-25% of the population meets the Yale Food Addiction Score criteria. There is considerable overlap in the behaviours ascribed to food addiction and binge eating disorder, and food addiction scores correlate highly with measures of binge eating. We feel that more research is required in humans to determine whether food addiction is both behaviourally and neurobiologically distinct from binge eating disorder. While the reward circuitry is clearly affected by both highly palatable foods and diet-induced obesity in a similar manner to short and long exposure to drugs of abuse, the challenge for the future is to show that these neurobiological changes are associated with addiction-like behaviour.
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“The mesolimbic dopaminergic circuit is clearly affected by both highly palatable foods and diet-induced obesity similar to exposure to drugs of abuse [92].”
From Separating the Signal from the Noise: How Psychiatric Diagnoses Can Help Discern Food Addiction from Dietary Restraint (2020) · cites this paper as [92]
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Cites
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Molecular aspects of fructose metabolism and metabolic disease
Herman, M. A., & Birnbaum, M. J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.09.010 · Cited by 315
The impact of sugar consumption on stress driven, emotional and addictive behaviors
Jacques, A., Chaaya, N., Beecher, K., Ali, S. A., Belmer, A., & Bartlett, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.021 · Cited by 271
The Burden of Carbohydrates in Health and Disease
Clemente‐Suárez, V. J., Mielgo‐Ayuso, J., Martín-Rodríguez, A., Ramos‐Campo, D. J., Redondo-Flórez, L., & Tornero-Aguilera, J. F. (2022) · Nutrients · doi:10.3390/nu14183809 · Cited by 242
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Western Diet: Implications for Brain Function and Behavior
López-Taboada, I., González‐Pardo, H., & Conejo, N. M. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.564413 · Cited by 154
Metadata
- Authors
- Leigh, S.-J., & Morris, M. J.
- Affiliations
- UNSW Sydney (AU)
- Corresponding author
- Morris, Margaret J.
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 131
- Pages
- 31-42
- ISSN
- 0301-0511 (ISSN-L)
- OpenAlex
- W2563821226
- Cited by
- 191
- References
- 205
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 10 · 2023: 26 · 2022: 32 · 2021: 28 · 2020: 21 · 2019: 20 · 2018: 17
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council of Australia to MJM
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- food addiction, obesity, reward systems, mesolimbic dopamine system, highly palatable food, binge eating, binge eating disorder, compulsive eating, Yale Food Addiction Scale, diet-induced obesity
- MeSH terms
- Food Addiction, Animals, Feeding Behavior, Female, Humans, Male, Obesity, Reward, Binge-Eating Disorder
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