The contribution of brain reward circuits to the obesity epidemic

Stice, Eric; Figlewicz, Dianne P.; Gosnell, Blake A.; Levine, Allen S.; Pratt, Wayne E.

doi:10.1016/j.neubiorev.2012.12.001

Cited by 274Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorEating Disorders and Behaviors

The contribution of brain reward circuits to the obesity epidemic

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Stice, Eric, Figlewicz, Dianne P., Gosnell, Blake A., Levine, Allen S., Pratt, Wayne E.·2013·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2012.12.001PMC PMC3604128

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Abstract

One of the defining characteristics of the research of Ann E. Kelley was her recognition that the neuroscience underlying basic learning and motivation processes also shed significant light upon mechanisms underlying drug addiction and maladaptive eating patterns. In this review, we examine the parallels that exist in the neural pathways that process both food and drug reward, as determined by recent studies in animal models and human neuroimaging experiments. We discuss contemporary research that suggests that hyperphagia leading to obesity is associated with substantial neurochemical changes in the brain. These findings verify the relevance of reward pathways for promoting consumption of palatable, calorically dense foods, and lead to the important question of whether changes in reward circuitry in response to intake of such foods serve a causal role in the development and maintenance of some cases of obesity. Finally, we discuss the potential value for future studies at the intersection of the obesity epidemic and the neuroscience of motivation, as well as the potential concerns that arise from viewing excessive food intake as an "addiction". We suggest that it might be more useful to focus on overeating that results in frank obesity, and multiple health, interpersonal, and occupational negative consequences as a form of food "abuse".

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Neuroimaging studies have identified some of the brain mechanisms associated with obesity and food addiction, demonstrating alterations in the core reward network (e.g. nucleus accumbens) and the extended reward network (i.e. emotion regulation, executive control, salience and somatosensory networks).
“Neuroimaging studies have identified some of the brain mechanisms associated with obesity and food addiction 39, 40, demonstrating alterations in the core reward network (e.g. nucleus accumbens) and the extended reward network (i.e. emotion regulation, executive control, salience and somatosensory networks) 41, 42, 43.”
From History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity (2019) · cites this paper as [42]

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Depression and obesity: evidence of shared biological mechanisms
Milaneschi, Y., Simmons, W. K., van Rossum, E. F. C., & Penninx, B. W. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0017-5 · Cited by 1,073 · see citing works
Neurobiology of food intake in health and disease
Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3745 · Cited by 748 · see citing works
The Prevalence of Food Addiction as Assessed by the Yale Food Addiction Scale: A Systematic Review
Pursey, K., Stanwell, P., Gearhardt, A. N., Collins, C. E., & Burrows, T. L. (2014) · Nutrients · doi:10.3390/nu6104552 · Cited by 548 · see citing works
“Eating addiction”, rather than “food addiction”, better captures addictive-like eating behavior
Hebebrand, J., Albayrak, Ö., Adan, R. A. H., Antel, J., Diéguez, C., de Jong, J. W., Leng, G., Menzies, J. R. W., Mercer, J. G., Murphy, M., et al. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.016 · Cited by 526 · see citing works
Obesity as a Disease
Upadhyay, J., Farr, O. M., Perakakis, N., Ghaly, W., & Mantzoros, C. S. (2017) · Medical Clinics of North America · doi:10.1016/j.mcna.2017.08.004 · Cited by 403 · see citing works
The neurobiological basis of binge-eating disorder
KESSLER, R. M., Hutson, P. H., Herman, B. K., & Potenza, M. N. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.01.013 · Cited by 362 · see citing works
Psychiatric disorders and obesity: A review of association studies
Rajan, T., & Menon, V (2017) · Journal of Postgraduate Medicine · doi:10.4103/jpgm.jpgm_712_16 · Cited by 346 · see citing works
Emotion, motivation, decision-making, the orbitofrontal cortex, anterior cingulate cortex, and the amygdala
Rolls, E. T. (2023) · Brain Structure and Function · doi:10.1007/s00429-023-02644-9 · Cited by 324 · see citing works
Increased Prefrontal and Parahippocampal Activation with Reduced Dorsolateral Prefrontal and Insular Cortex Activation to Food Images in Obesity: A Meta-Analysis of fMRI Studies
Brooks, S. J., Cedernaes, J., & Schiöth, H. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060393 · Cited by 269 · see citing works
Hormonal and neural mechanisms of food reward, eating behaviour and obesity
Murray, S. M., Tulloch, A. J., Gold, M. S., & Avena, N. M. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.91 · Cited by 267 · see citing works
Food reward system: current perspectives and future research needs
Alonso‐Alonso, M., Woods, S. C., Pelchat, M. L., Grigson, P. S., Stice, E. M., Farooqi, I. S., Khoo, C. S., Mattes, R. D., & Beauchamp, G. K. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv002 · Cited by 267 · see citing works
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Homeostasis Meets Motivation in the Battle to Control Food Intake
Ferrario, C. R., Labouèbe, G., Liu, S., Nieh, E. H., Routh, V. H., Xu, S., & O’Connor, E. C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2338-16.2016 · Cited by 213 · see citing works
The Smell of Healthy Choices: Cross-Modal Sensory Compensation Effects of Ambient Scent on Food Purchases
Biswas, D., & Szocs, C. (2019) · Journal of Marketing Research · doi:10.1177/0022243718820585 · Cited by 200 · see citing works
Central nervous system regulation of eating: Insights from human brain imaging
Farr, O. M., Li, C. R., & Mantzoros, C. S. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.002 · Cited by 191 · see citing works
The role of reward circuitry and food addiction in the obesity epidemic: An update
Leigh, S.-J., & Morris, M. J. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2016.12.013 · Cited by 191 · see citing works
Individual Differences in Cue-Induced Motivation and Striatal Systems in Rats Susceptible to Diet-Induced Obesity
Robinson, M. J. F., Burghardt, P. R., Patterson, C. M., Nobile, C. W., Akil, H., Watson, S. J., Berridge, K. C., & Ferrario, C. R. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.71 · Cited by 185 · see citing works
Intranasal Insulin Enhanced Resting-State Functional Connectivity of Hippocampal Regions in Type 2 Diabetes
Zhang, H., Hao, Y., Manor, B., Novak, P., Milberg, W., Zhang, J., Fang, J., & Novak, V. (2015) · Diabetes · doi:10.2337/db14-1000 · Cited by 176 · see citing works
The Neurobiology of “Food Addiction” and Its Implications for Obesity Treatment and Policy
Carter, A., Hendrikse, J. J., Lee, N., Yücel, M., Verdejo‐García, A., Andrews, Z. B., & Hall, W. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050909 · Cited by 176 · see citing works
Food addiction and obesity: unnecessary medicalization of hedonic overeating
Finlayson, G. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.61 · Cited by 175 · see citing works
Neural vulnerability factors for obesity
Stice, E. M., & Burger, K. S. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.12.002 · Cited by 155 · see citing works
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Predicting sugar consumption: Application of an integrated dual-process, dual-phase model
Hagger, M. S., Trost, N., Keech, J. J., Chan, D. K. C., & Hamilton, K. (2017) · Appetite · doi:10.1016/j.appet.2017.04.032 · Cited by 153 · see citing works
Eating ‘Junk-Food’ Produces Rapid and Long-Lasting Increases in NAc CP-AMPA Receptors: Implications for Enhanced Cue-Induced Motivation and Food Addiction
Oginsky, M. F., Goforth, P. B., Nobile, C. W., Lopez‐Santiago, L. F., & Ferrario, C. R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.111 · Cited by 148 · see citing works
Profiling motives behind hedonic eating. Preliminary validation of the Palatable Eating Motives Scale
Burgess, E. E., Turan, B., Lokken, K., Morse, A., & Boggiano, M. M. (2013) · Appetite · doi:10.1016/j.appet.2013.09.016 · Cited by 147 · see citing works
Reward-related decision making in eating and weight disorders: A systematic review and meta-analysis of the evidence from neuropsychological studies
Wu, M., Brockmeyer, T., Hartmann, M., Skunde, M., Herzog, W., & Friederich, H. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.11.017 · Cited by 132 · see citing works
Pilot test of a novel food response and attention training treatment for obesity: Brain imaging data suggest actions shape valuation
Stice, E. M., Yokum, S., Veling, H., Kemps, E., & Lawrence, N. (2017) · Behaviour Research and Therapy · doi:10.1016/j.brat.2017.04.007 · Cited by 117 · see citing works
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Cognitive and autonomic determinants of energy homeostasis in obesity
Richard, D. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.103 · Cited by 108 · see citing works
Emotional Eating, Binge Eating and Animal Models of Binge-Type Eating Disorders
Turton, R., Chami, R., & Treasure, J. L. (2017) · Current Obesity Reports · doi:10.1007/s13679-017-0265-8 · Cited by 100 · see citing works
Hedonic hunger and binge eating among women with eating disorders
Witt, A. A., & Lowe, M. R. (2013) · International Journal of Eating Disorders · doi:10.1002/eat.22171 · Cited by 96 · see citing works
Converging Relationships of Obesity and Hyperuricemia with Special Reference to Metabolic Disorders and Plausible Therapeutic Implications
Gong, M., Wen, S., Nguyen, T., Wang, C., Jin, J., & Zhou, L. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s232377 · Cited by 94 · see citing works
Enhanced cocaine-induced locomotor sensitization and intrinsic excitability of NAc medium spiny neurons in adult but not in adolescent rats susceptible to diet-induced obesity
Oginsky, M. F., Maust, J. D., Corthell, J. T., & Ferrario, C. R. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4157-x · Cited by 85 · see citing works
Overlapping neurobehavioral circuits in ADHD, obesity, and binge eating: evidence from neuroimaging research
Seymour, K. E., Reinblatt, S. P., Benson, L., & Carnell, S. (2015) · CNS Spectrums · doi:10.1017/s1092852915000383 · Cited by 85 · see citing works
The Role of the Gut Microbiota in the Gut–Brain Axis in Obesity: Mechanisms and Future Implications
van Son, J., Koekkoek, L. L., la Fleur, S. E., Serlie, M. J. M., & Nieuwdorp, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062993 · Cited by 82 · see citing works
Neuroendocrine regulation of appetitive ingestive behavior
Keen‐Rhinehart, E., Ondek, K., & Schneider, J. E. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00213 · Cited by 82 · see citing works
Extended exposure to a palatable cafeteria diet alters gene expression in brain regions implicated in reward, and withdrawal from this diet alters gene expression in brain regions associated with stress
Martire, S. I., Maniam, J., South, T., Holmes, N. M., Westbrook, R. F., & Morris, M. J. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.027 · Cited by 80 · see citing works
Striatal Reward Activity and Antipsychotic-Associated Weight Change in Patients With Schizophrenia Undergoing Initial Treatment
Nielsen, M. Ø., Rostrup, E., Wulff, S., Glenthoj, B. Y., & Ebdrup, B. H. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.2582 · Cited by 76 · see citing works
Emerging Roles of Estrogen-Related Receptors in the Brain: Potential Interactions with Estrogen Signaling
Saito, K., & Cui, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041091 · Cited by 76 · see citing works
Towards a comprehensive theory of obesity and a healthy diet: The causal role of oxidative stress in food addiction and obesity
Tobore, T. O. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112560 · Cited by 73 · see citing works
Food Addiction and Its Impact on Weight-Based Stigma and the Treatment of Obese Individuals in the U.S. and Australia
Lee, N., Hall, W., Lucke, J. C., Forlini, C., & Carter, A. (2014) · Nutrients · doi:10.3390/nu6115312 · Cited by 73 · see citing works
Reward for food odors: an fMRI study of liking and wanting as a function of metabolic state and BMI
Jiang, T., Soussignan, R., Schaal, B., & Royet, J. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu086 · Cited by 70 · see citing works
Untitled work
Navas (2017) · doi:10.1002/hbm.23407 · Cited by 71 · see citing works
Reconsidering the classification of sweet taste liker phenotypes: A methodological review
Iatridi, V., Hayes, J. E., & Yeomans, M. R. (2018) · Food Quality and Preference · doi:10.1016/j.foodqual.2018.09.001 · Cited by 65 · see citing works
Nutrition labels influence value computation of food products in the ventromedial prefrontal cortex
Enax, L., Hu, Y., Trautner, P., & Weber, B. (2015) · Obesity · doi:10.1002/oby.21027 · Cited by 66 · see citing works
Food packaging cues influence taste perception and increase effort provision for a recommended snack product in children
Enax, L., Weber, B., Ahlers, M., Kaiser, U., Diethelm, K., Holtkamp, D., Faupel, U., Holzmüller, H. H., & Kersting, M. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00882 · Cited by 65 · see citing works
Attentional bias to food-related visual cues: is there a role in obesity?
Doolan, K. J., Breslin, G., Hanna, D., & Gallagher, A. M. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s002966511400144x · Cited by 63 · see citing works
Enhanced incentive motivation in obesity-prone rats is mediated by NAc core CP-AMPARs
Derman, R. C., & Ferrario, C. R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.039 · Cited by 59 · see citing works
Integration of reward signalling and appetite regulating peptide systems in the control of food‐cue responses
Reichelt, A. C., Westbrook, R. F., & Morris, M. J. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13321 · Cited by 62 · see citing works
A Systematic Review of Obesity and Binge Eating Associated Impairment of the Cognitive Inhibition System
Saruco, E., & Pleger, B. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.609012 · Cited by 62 · see citing works
Obesity and dissociable forms of impulsivity in young adults
Chamberlain, S. R., Derbyshire, K. L., Leppink, E. W., & Grant, J. E. (2015) · CNS Spectrums · doi:10.1017/s1092852914000625 · Cited by 60 · see citing works
Synaptic Plasticity in the Nucleus Accumbens: Lessons Learned from Experience
Turner, B. D., Kashima, D. T., Manz, K. M., Grueter, C. A., & Grueter, B. A. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00420 · Cited by 59 · see citing works
Effects of the estrous cycle and ovarian hormones on cue-triggered motivation and intrinsic excitability of medium spiny neurons in the Nucleus Accumbens core of female rats
Alonso‐Caraballo, Y., & Ferrario, C. R. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.104583 · Cited by 56 · see citing works
Gut microbes and food reward: From the gut to the brain
d’Oplinter, A. D. W., Huwart, S. J. P., Cani, P. D., & Everard, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.947240 · Cited by 55 · see citing works
Deep Brain Stimulation for Obesity: A Review and Future Directions
Formolo, D. A., Gaspar, J. M., Melo, H. M., Eichwald, T., Zepeda, R. J., Latini, A., Okun, M. S., & Walz, R. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00323 · Cited by 56 · see citing works
Excessive Consumption of Sugar: an Insatiable Drive for Reward
Olszewski, P. K., Wood, E. L., Klockars, A., & Levine, A. S. (2019) · Current Nutrition Reports · doi:10.1007/s13668-019-0270-5 · Cited by 54 · see citing works
Self-citation
The impact of cafeteria diet feeding on physiology and anxiety-related behaviour in male and female Sprague–Dawley rats of different ages
Warneke, W., Klaus, S., Fink, H., Langley‐Evans, S. C., & Voigt, J. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.016 · Cited by 52 · see citing works
Dietary sugars: their detection by the gut–brain axis and their peripheral and central effects in health and diseases
Ochoa, M., Lallès, J. P., Malbert, C., & Val‐Laillet, D. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0776-y · Cited by 52 · see citing works
Insulin receptor activation in the nucleus accumbens reflects nutritive value of a recently ingested meal
Woods, C. A., Guttman, Z. R., Huang, D., Kolaric, R., Rabinowitsch, A. I., Jones, K. T., de Vaca, S. C., Sclafani, A. J., & Carr, K. D. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.03.013 · Cited by 52 · see citing works
Food Addiction and Obesity
Ferrario, C. R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.221 · Cited by 52 · see citing works
Hedonic Eating: Sex Differences and Characterization of Orexin Activation and Signaling
Buczek, L., Migliaccio, J., & Petrovich, G. D. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.04.008 · Cited by 52 · see citing works
Prevalence of obesity and overweight among Chinese children with attention deficit hyperactivity disorder: a survey in Zhejiang Province, China
Yang, R., Mao, S., Zhang, S., Li, R., & Zhao, Z. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-133 · Cited by 49 · see citing works
Brain on Fire: Incentive Salience, Hedonic Hot Spots, Dopamine, Obesity, and Other Hunger Games
Cameron, J. D., Chaput, J., Sjödin, A. M., & Goldfield, G. S. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064855 · Cited by 48 · see citing works
Running from Disease: Molecular Mechanisms Associating Dopamine and Leptin Signaling in the Brain with Physical Inactivity, Obesity, and Type 2 Diabetes
Ruegsegger, G. N., & Booth, F. W. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00109 · Cited by 46 · see citing works
Weight loss induced by deep transcranial magnetic stimulation in obesity: A randomized, double-blind, sham-controlled study
Ferrulli, A., Macrì, C., Terruzzi, I., Massarini, S., Ambrogi, F., Adamo, M., Milani, V., & Luzi, L. (2019) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13741 · Cited by 45 · see citing works
Pre-existing differences in motivation for food and sensitivity to cocaine-induced locomotion in obesity-prone rats
Vollbrecht, P. J., Nobile, C. W., Chadderdon, A. M., Jutkiewicz, E. M., & Ferrario, C. R. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.09.022 · Cited by 45 · see citing works
Effects of palatable cafeteria diet on cognitive and noncognitive behaviors and brain neurotrophins’ levels in mice
Leffa, D. D., Valvassori, S. S., Varela, R. B., Lopes-Borges, J., Daumann, F., Longaretti, L. M., Dajori, A. L. F., Quevedo, J., & de Andrade, V. M. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9682-0 · Cited by 45 · see citing works
History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity
Osadchiy, V., Mayer, E. A., Bhatt, R., Labus, J. S., Gao, L., Kilpatrick, L. A., Liu, C., Tillisch, K., Naliboff, B., Chang, L., et al. (2019) · Obesity Science & Practice · doi:10.1002/osp4.362 · Cited by 44 · see citing works
Overweight Adolescents and Life Events in Childhood
Lumeng, J. C., Wendorf, K. A., Pesch, M. H., Appugliese, D. P., Kaciroti, N., CORWYN, R. F., & Bradley, R. H. (2013) · PEDIATRICS · doi:10.1542/peds.2013-1111 · Cited by 42 · see citing works
Food for Thought: Hormonal, Experiential, and Neural Influences on Feeding and Obesity
Karatsoreos, I. N., Thaler, J. P., Borgland, S. L., Champagne, F. A., Hurd, Y. L., & Hill, M. N. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3452-13.2013 · Cited by 41 · see citing works
Maternal Adiposity Influences Neonatal Brain Functional Connectivity
Salzwedel, A., Gao, W., Andres, A., Badger, T. M., Glasier, C. M., Ramakrishnaiah, R. H., Rowell, A. C., & Ou, X. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00514 · Cited by 41 · see citing works
Chrysin mitigated obesity by regulating energy intake and expenditure in rats
Pai, S. A., Martis, E. A. F., Munshi, R., Gursahani, M., Mestry, S. N., & Juvekar, A. R. (2019) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2019.09.002 · Cited by 41 · see citing works
Brain regulation of hunger and motivation: The case for integrating homeostatic and hedonic concepts and its implications for obesity and addiction
Morales, I. (2022) · Appetite · doi:10.1016/j.appet.2022.106146 · Cited by 39 · see citing works
Biological substrates of addiction
Joffe, M. E., Grueter, C. A., & Grueter, B. A. (2014) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1273 · Cited by 39 · see citing works
Anomalous basal ganglia connectivity and obsessive–compulsive behaviour in patients with Prader Willi syndrome
Pujol, J., Blanco‐Hinojo, L., Esteba‐Castillo, S., Caixàs, A., Harrison, B. J., Bueno, M., Deus, J., Rigla, M., Macià, D., Llorente‐Onaindia, J., et al. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140338 · Cited by 38 · see citing works
Interactions between insulin and diet on striatal dopamine uptake kinetics in rodent brain slices
Patel, J. C., Stouffer, M. A., Mancini, M., Nicholson, C., Carr, K. D., & Rice, M. E. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13958 · Cited by 38 · see citing works
Dynamic fMRI networks predict success in a behavioral weight loss program among older adults
Mokhtari, F., Rejeski, W. J., Zhu, Y., Guorong Wu, A., Simpson, S. L., Burdette, J. H., & Laurienti, P. J. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.02.025 · Cited by 36 · see citing works
Mood and restrained eating moderate food-associated response inhibition in obese individuals with binge eating disorder
Loeber, S., Rustemeier, M., Paslakis, G., Pietrowsky, R., Müller, A., & Herpertz, S. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.03.081 · Cited by 36 · see citing works
Moderate intensity treadmill exercise alters food preference via dopaminergic plasticity of ventral tegmental area-nucleus accumbens in obese mice
Chen, W., Wang, H., Shang, N. N., Liu, J., Li, J., Tang, D. H., & Li, Q. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.01.055 · Cited by 36 · see citing works
Food-Related Odors Activate Dopaminergic Brain Areas
Sorokowska, A., Schoen, K., Hummel, C., Han, P., Warr, J., & Hummel, T. R. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00625 · Cited by 35 · see citing works
Independent functional connectivity networks underpin food and monetary reward sensitivity in excess weight
Verdejo‐Román, J., Fornito, A., Soriano‐Mas, C., Vilar‐López, R., & Verdejo‐García, A. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.11.011 · Cited by 36 · see citing works
Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake
Ramos‐Lopez, O., Riezu‐Boj, J. I., Milagro, F. I., Martinez, J. A., & MENA Project (2018) · Brain and Behavior · doi:10.1002/brb3.1017 · Cited by 33 · see citing works
Bidirectional relationships between appetitive behaviours and body mass index in childhood: a cross-lagged analysis in the Generation XXI birth cohort
Costa, A., Severo, M., Vilela, S., Fildes, A., & Oliveira, A. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02238-9 · Cited by 33 · see citing works
Sex specific effects of “junk-food” diet on calcium permeable AMPA receptors and silent synapses in the nucleus accumbens core
Alonso‐Caraballo, Y., Fetterly, T. L., Jorgensen, E. T., Nieto, A. M., Brown, T. E., & Ferrario, C. R. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0781-1 · Cited by 33 · see citing works
Obesity and gambling: neurocognitive and clinical associations
Grant, J. E., Derbyshire, K. L., Leppink, E. W., & Chamberlain, S. R. (2014) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12353 · Cited by 32 · see citing works
Darwinian Hedonism and the Epidemic of Unhealthy Behavior
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047 · Cited by 32 · see citing works
Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin
Begg, D. P., May-Zhang, A. A., Mul, J. D., Liu, M., D’Alessio, D. A., Seeley, R. J., & Woods, S. C. (2015) · Diabetes · doi:10.2337/db14-1364 · Cited by 31 · see citing works
Eating behavior modulates the sensitivity to the central effects of GLP-1 receptor agonist treatment: a secondary analysis of a randomized trial
van Ruiten, C. C., ten Kulve, J. S., van Bloemendaal, L., Nieuwdorp, M., Veltman, D. J., & IJzerman, R. G. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105667 · Cited by 31 · see citing works
Dopaminergic Pathways in Obesity-Associated Inflammation
Leite, F., & Ribeiro, L. V. P. T. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09863-0 · Cited by 31 · see citing works
Why did I eat that? Contributions of individual differences in incentive motivation and nucleus accumbens plasticity to obesity
Ferrario, C. R. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113114 · Cited by 30 · see citing works
The Co-occurrence of Pediatric Obesity and ADHD: an Understanding of Shared Pathophysiology and Implications for Collaborative Management
O’Hara, V. M., Curran, J. L., & Browne, N. T. (2020) · Current Obesity Reports · doi:10.1007/s13679-020-00410-0 · Cited by 29 · see citing works
Effects of Dapagliflozin and Combination Therapy With Exenatide on Food-Cue Induced Brain Activation in Patients With Type 2 Diabetes
van Ruiten, C. C., Veltman, D. J., Schrantee, A., van Bloemendaal, L., Barkhof, F., Kramer, M. H. H., Nieuwdorp, M., & IJzerman, R. G. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac043 · Cited by 33 · see citing works
Mechanism and treatments of antipsychotic-induced weight gain
Ye, W., Xing, J., Yu, Z., Hu, X., & Yan, Z. (2023) · International Journal of Obesity · doi:10.1038/s41366-023-01291-8 · Cited by 30 · see citing works
Central mechanisms in sympathetic nervous dysregulation in obesity
Patel, M., Braun, J., Lambert, G. W., Kameneva, T., Keatch, C., & Lambert, É. (2023) · Journal of Neurophysiology · doi:10.1152/jn.00254.2023 · Cited by 33 · see citing works
Why Negative Feelings are Important when Assessing Well-Being
Grinde, B. (2015) · Journal of Happiness Studies · doi:10.1007/s10902-015-9667-z · Cited by 29 · see citing works
Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status — The HUNT Study
Kvaløy, K., Holmen, J., Hveem, K., & Holmen, T. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139632 · Cited by 31 · see citing works
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Authors: Stice, E., Figlewicz, D. P., Gosnell, B. A., Levine, A. S., & Pratt, W. E.
Affiliations: Oregon Research Institute (US)
VA Puget Sound Health Care System (US)
University of Minnesota (US)
Wake Forest University (US)
Corresponding author: Pratt, Wayne E.
ORCID: Stice, Eric
Levine, Allen S.
Pratt, Wayne E.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2013-11
Volume: 37
Issue: 9
Pages: 2047-2058
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2012.12.001
PMC: PMC3604128
OpenAlex: W2076709716
Cited by: 274
References: 166
Citations by year: 2026: 2 · 2025: 10 · 2024: 8 · 2023: 20 · 2022: 22 · 2021: 21 · 2020: 14 · 2019: 56 · 2018: 14 · 2017: 20 · 2016: 29 · 2015: 26 · 2014: 21 · 2013: 11
FWCI: 2.13
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (R1MH064560A, DK080760, DK092468, DK40963)
NIH/NIDA (R01DA021280)
NIH/NIDDK (P30DK50456)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords: brain reward circuits, obesity, food reward, drug reward, hyperphagia, motivation, food addiction, palatable food intake, neurochemical changes
MeSH terms: Animals, Brain, Humans, Motivation, Neural Pathways, Obesity, Reward, Behavior, Addictive

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The contribution of brain reward circuits to the obesity epidemic

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