Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata
Abstract
In this study, the fruit essential oil of Cinnamomum insularimontanum was prepared by using water distillation. Followed by GC-MS analysis, the composition of fruit essential oil was characterized. The main constituents of essential oil were alpha-pinene (9.45%), camphene (1.70%), beta-pinene (4.30%), limonene (1.76%), citronellal (24.64%), citronellol (16.78%), and citral (35.89%). According to the results obtained from nitric oxide (NO) inhibitory activity assay, crude essential oil and its dominant compound (citral) presented the significant NO production inhibitory activity, IC(50) of crude essential oil and citral were 18.68 and 13.18microg/mL, respectively. Moreover, based on the results obtained from the protein expression assay, the expression of IKK, iNOS, and nuclear NF-kappaB was decreased and IkappaBalpha was increased in dose-dependent manners, it proved that the anti-inflammatory mechanism of citral was blocked via the NF-kappaB pathway, but it could not efficiently suppress the activity on COX-2. In addition, citral exhibited a potent anti-inflammatory activity in the assay of croton oil-induced mice ear edema, when the dosage was 0.1 and 0.3mg per ear, the inflammation would reduce to 22% and 83%, respectively. The results presented that the fruit essential oil of C. insularimontanum and/or citral may have a great potential to develop the anti-inflammatory medicine in the future.
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Citral inhibits TNF-α in LPS-stimulated RAW 264.7 cells.
“In other work, Lin et al. (2008) [121] revealed that citral, the main component of the fruit essential oil of Cinnamomum insularimontanum Hayata, inhibits TNF-α in RAW 264.7 cells stimulated by LPS.”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [121]
Citral prevents degradation of IκBα in LPS-induced inflammation and reduces p50 NF-κB levels in nuclear fractions.
“The authors concluded that citral could prevent the degradation of IκBα in LPS-induced inflammation and reduce the p50 NF-κB levels in nuclear fractions [121].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [121]
Cinnamomum insularimontanum fruit essential oils and citral inhibit NO production in LPS-stimulated RAW 264.7 cells; citral inhibits LPS-induced iNOS protein expression but not COX-2.
“The fruit essential oils of Cinnamomum insularimontanum Hayata and citral were revealed to possess significant inhibitory effects on NO production in LPS-stimulated RAW 264.7 cells. Citral exhibited an inhibitory activity in LPS-induced iNOS protein expression, not found for COX-2.”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [121]
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Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
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“The authors concluded that citral could prevent the degradation of IκBα in LPS-induced inflammation and reduce the p50 NF-κB levels in nuclear fractions [121].”
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- Authors
- Lin, C.-T., Chen, C.-J., Lin, T.-Y., Tung, J. C., & Wang, S.-Y.
- Affiliations
- National Chung Hsing University (TW)
- Corresponding author
- Wang, Sheng-Yang
- ORCID
- Wang, Sheng-Yang
- Venue
- Bioresource Technology
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 99
- Issue
- 18
- Pages
- 8783-8787
- ISSN
- 0960-8524 (ISSN-L)
- OpenAlex
- W2153241109
- Cited by
- 123
- References
- 23
- Citations by year
- 2025: 9 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 9 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 11 · 2013: 12 · 2012: 8
- FWCI
- 10.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioresource Technology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- fruit essential oil, citral, anti-inflammatory activity, nitric oxide inhibition, NF-κB signaling, inducible nitric oxide synthase, IκBα, cyclooxygenase-2, ear edema, essential oil composition, α-pinene, limonene
- MeSH terms
- Acyclic Monoterpenes, Animals, Anti-Inflammatory Agents, Cell Line, Edema, Fruit, Phytotherapy, Oils, Volatile, Cinnamomum, Monoterpenes, Mice
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