Anti-inflammatory effects of essential oil isolated from the buds of Cleistocalyx operculatus (Roxb.) Merr and Perry
Abstract
Cleistocalyx operculatus (Roxb.) Merr and Perry buds (Myrtaceae) are widely used in folk medicine for the treatment of gastric ailments as well as an antiseptic agent in China, Vietnam and some other tropical countries. However, to be clinically useful, more scientific data are needed. In the present study, we investigated the in vitro and in vivo anti-inflammatory activities of the essential oil of the C. operculatus buds (EO-CO). In the applied tests, EO-CO significantly inhibited lipopolysaccharide (LPS)-induced secretion of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), in RAW 264.7 cells, a mouse macrophage-like cell line. Also the mRNA expression of TNF-alpha and IL-1beta was suppressed by treatment with EO-CO in LPS-stimulated RAW 264.7 cells. Moreover, reporter gene analysis revealed that the EO-CO significantly blocked LPS-induced transcriptional activation of NF-kappaB in RAW 264.7 cells. Nuclear translocation of p65 subunit was also suppressed by EO-CO treatment. In addition, EO-CO inhibited phorbol ester-induced increase in ear swelling and skin water content in BALB/c mice. These results suggest that EO-CO might exert an anti-inflammatory effect by suppressing the expression of pro-inflammatory cytokines which is mediated, at least in part, by blocking NF-kappaB activation.
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Interleukin-1β and tumor necrosis factor-α are important pro-inflammatory cytokines with a relevant role in inflammatory disorders.
“Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are two important pro-inflammatory cytokines with a relevant role in the inflammatory disorders.”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [103]
Cheistocalyx operculatus essential oil significantly inhibits LPS-induced secretion of IL-1β and TNF-α cytokines in RAW 264.7 mouse macrophage-like cells.
“The essential oil of Cheistocalyx operculatus, which chemical composition was not determined, significantly inhibited lipopolysaccharide (LPS)-induced secretion of IL-1β and TNF-α cytokines in RAW 264.7 cells, a mouse macrophage-like cell line [103].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [103]
The major source of TNF-α is cells of monocyte/macrophage lineage, although T lymphocytes, neutrophils, and mast cells also produce it.
“The major source of TNF-α is the cells of monocyte/macrophage lineage although T lymphocytes, neutrophils and mast cells also produce this pro-inflammatory cytokine.”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [103]
The inhibitory effect of some essential oils on pro-inflammatory cytokine production seems to be mediated by suppressing gene expression of these cytokines, mainly at the transcriptional level.
“The inhibitory effect of some of the essential oils on the production of pro-inflammatory cytokines reported in this chapter seems to be mediated by suppressing gene expression of these cytokines. Such was described by some authors because they found that the essential oils studied significantly suppressed the protein and mRNA expression of the cytokines in stimulated cells, assuming therefore,”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [103]
IL-1β is produced by a variety of cell types including monocytes, macrophages, fibroblasts, and endothelial cells.
“IL-1β is produced by a variety of cells types, including monocytes, macrophages, fibroblasts and endothelial cells [103].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [103]
Cleistocalyx operculatus oil suppresses mRNA expression of TNF-a and IL-1b and blocks LPS-induced transcriptional activation of NF-κB and nuclear translocation of p65 subunit in RAW 264.7 cells.
“Cleistocalyx operculatus (Roxb.) Merr and Perry oil not only significantly inhibited LPS-induced secretion of pro-inflammatory cytokines, TNF-α and IL-1b, in RAW 264.7 cells, as reported above, but also suppressed the mRNA expression of TNF-a and IL-1b as well as blocked LPS-induced transcriptional activation of NF-κB and nuclear translocation of p65 subunit [103].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [103]
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- Authors
- Dung, N. T., Bajpai, V. K., Yoon, J. I., & Kang, S. C.
- Affiliations
- Daegu University (KR)
- Corresponding author
- Kang, Sun Chul
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 47
- Issue
- 2
- Pages
- 449-453
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W2021929819
- Cited by
- 60
- References
- 22
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 4 · 2016: 7 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 6
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- Cleistocalyx operculatus, essential oils, anti-inflammatory activity, inflammatory cytokines, TNF-α, IL-1β, NF-κB activation, p65 nuclear translocation, lipopolysaccharide, RAW 264.7 macrophages, ear swelling, Myrtaceae
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Line, Cell Survival, Drugs, Chinese Herbal, Ear, External, Edema, Female, Macrophages, Mice, Inbred BALB C, Plant Oils, RNA, Messenger, Tumor Necrosis Factor-alpha, Gene Expression, Cytokines, NF-kappa B, Myrtaceae, Mice, Interleukin-1beta
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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