Cytotoxic, apoptotic and antioxidant activity of the essential oil of Amomum tsao-ko
Abstract
The antioxidant activity, cytotoxicity and mechanism of induction of HepG2 cell death of essential oil from Amomum tsao-ko were determined. The essential oil was cytotoxic to HepG2, Hela, Bel-7402, SGC-7901 and PC-3 cell lines. The lowest IC(50) of 31.80+/-1.18microg/ml was measured for HepG2 carcinoma cell lines. The IC(50) for normal human cell lines (HUVEC and HL-7702) was 163.91+/-5.11-272.41+/-0.97microg/ml. Analyses by flow cytometry, Hoechst 33258 staining and agarose gel electrophoresis indicated that the essential oil induced apoptosis. The essential oil has weak antioxidant activity as measured by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical assay, thiobarbituric acid (TBA) test and ferric reducing antioxidant power (FRAP) assay. The data suggest that the essential oil of A. tsao-ko could be a potential medicinal resource.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Amomum tsao-ko essential oil had weak antioxidant activity in the TBARS method, attributed to its low phenolic content.
“They found weak antioxidant activity, as expected by the authors, due to the low phenolic content of the oils.”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [56]
Amomum tsao-ko oil had low antioxidant activity by TBARS, weak DPPH scavenging, and low ferric reducing power, mainly due to low phenolic content.
“Amomum tsao-ko oil with low antioxidant activity measured through the TBARS method [70], as reported above, also had weak ability for scavenging DPPH free radicals and low ferric reducing power, mainly due to the low phenolic content of the oils [56].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [56]
Cites
Biological effects of essential oils—A review
Bakkali, F., Averbeck, S., Averbeck, D., & Idaomar, M. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.106 · Cited by 7,929 · see citing works
Cai, Y., Luo, Q., Sun, M., & Corke, H. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.09.047 · Cited by 2,823 · see citing works
Mechanisms of membrane toxicity of hydrocarbons
Sikkema, J., de Bont, J. A., & Poolman, B. (1995) · Microbiological Reviews · doi:10.1128/mr.59.2.201-222.1995 · Cited by 2,685 · see citing works
Edris, A. E. (2007) · Phytotherapy Research · doi:10.1002/ptr.2072 · Cited by 1,264 · see citing works
Afanas'ev, I. B., Dcrozhko, A. I., Brodskii, A. V., Kostyuk, V. A., & Potapovitch, A. I. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90410-3 · Cited by 982 · see citing works
Iridoid Glucosides with Free Radical Scavenging Properties from Fagraea blumei
Cuendet, M., Hostettmann, K., Potterat, O., & Dyatmiko, W. (1997) · Helvetica Chimica Acta · doi:10.1002/hlca.19970800411 · Cited by 803 · see citing works
Olive-oil consumption and health: the possible role of antioxidants
Owen, R. W., Giacosa, A., Hull, W. E., Haubner, R., Würtele, G., Spiegelhalder, B., & Bartsch, H. (2000) · The Lancet Oncology · doi:10.1016/s1470-2045(00)00015-2 · Cited by 616 · see citing works
Plumb, J. A., Milroy, R., & Kaye, S. B. (1989) · PubMed · Cited by 584 · see citing works
Luximon‐Ramma, A., Bahorun, T., Soobrattee, M. A., & Aruoma, O. I. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0201172 · Cited by 477 · see citing works
Yoo, C.-B., Han, K.-T., Cho, K.-S., et al. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.11.018 · Cited by 262 · see citing works
Inhibition of pancreatic cancer growth by the dietary isoprenoids farnesol and geraniol
Burke, Y. D., Stark, M. J., Roach, S. L., Sen, S. E., & Crowell, P. L. (1997) · Lipids · doi:10.1007/s11745-997-0019-y · Cited by 239 · see citing works
Total antioxidant power in some species of Labiatae (Adaptation of FRAP method)
Szőllősi, R., & Varga, I. (2002) · Acta Biologica Szegediensis · Cited by 222 · see citing works
Carnésecchi, S., Schneider, Y., Céraline, J., et al. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29368-x · Cited by 190 · see citing works
Vickers, A. J. (2002) · Cancer Investigation · doi:10.1081/cnv-120005926 · Cited by 168 · see citing works
Chemopreventive Effects of Dietary Flaxseed on Colon Tumor Development
Bommareddy, A., Arasada, B. L., Mathees, D. P., et al. (2006) · Nutrition and Cancer · doi:10.1207/s15327914nc5402_8 · Cited by 115 · see citing works
Yu, S. G., Hildebrandt, L. A., & Elson, C. E. (1995) · Journal of Nutrition · doi:10.1093/jn/125.11.2763 · Cited by 105 · see citing works
Constituents of Amomum tsao‐ko and their radical scavenging and antioxidant activities
Martin, T. S., Kikuzaki, H., Hisamoto, M., et al. (2000) · Journal of the American Oil Chemists Society · doi:10.1007/s11746-000-0107-4 · Cited by 97 · see citing works
Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents
Yu, J. J., Liu, H., Lei, J., et al. (2007) · Phytotherapy Research · doi:10.1002/ptr.2062 · Cited by 86 · see citing works
Shoff, S. M., Grummer, M. A., Yatvin, M. B., et al. (1991) · PubMed · Cited by 84 · see citing works
Chemical composition and antimicrobial activity of the essential oil of Amomum tsao‐ko
Yang, Y., Yan, R., Cai, X., et al. (2008) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.3321 · Cited by 75 · see citing works
Self-citationHou, J., Sun, T., Hu, J., et al. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.07.060 · Cited by 74 · see citing works
Isotsaokoin, an Antifungal Agent from Amomum tsao-ko
Moon, S., Lee, J., & Cho, S. (2004) · Journal of Natural Products · doi:10.1021/np030464l · Cited by 56 · see citing works
Chemopreventive effects of dietary mustard oil on colon tumor development
Dwivedi, C., Muller, L. A., Goetz-Parten, D. E., et al. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00211-8 · Cited by 51 · see citing works
Composition, cytotoxicity and antimicrobial activity of essential oil from Dictamnus dasycarpus
LEI, J., YU, J., Yu, H., et al. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.09.050 · Cited by 46 · see citing works
Tsaokoarylone, a Cytotoxic Diarylheptanoid from Amomum tsao-ko Fruits
Moon, S. (2005) · Bulletin of the Korean Chemical Society · doi:10.5012/bkcs.2005.26.3.447 · Cited by 41 · see citing works
G1-phase specific apoptosis in liver carcinoma cell line induced by copper-1,10-phenanthroline
Zhou, H., Zheng, C., Zou, G., et al. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00176-5 · Cited by 31 · see citing works
Bicyclononane Aldehydes and Antiproliferative Constituents fromAmomum tsao-ko
Yang, X., Küenzi, P., Plitzko, I., et al. (2009) · Planta Medica · doi:10.1055/s-0029-1185320 · Cited by 27 · see citing works
[Pharmacological comparison between volatile oil and water extract].
Qiu, S., Shou, D., Chen, L., et al. (1999) · PubMed · Cited by 7 · see citing works
Effects of Volatile Oil of Fructus Tsaoko on the Percutaneous Permeation of Rutondine in Vitro
Bai, Y.-C. (2006) · Yunnan Journal of Traditional Chinese Medicine and Materia Medica · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
Miguel, M. G. (2010) · Molecules · doi:10.3390/molecules15129252 · Cited by 933 · see citing works
“Some of the authors that had evaluated the ability of essential oils to prevent lipid peroxidation by the TBARS method, also had evaluated the capacity for scavenging free radicals, using the DPPH assay [44, 54, [51] [52] [53] 56, 57] .”
MethodInfluential
- Authors
- Yang, Y., Yue, Y., Runwei, Y., & Guolin, Z.
- Affiliations
- Guilin Medical University (CN)
- Wuhan University (CN)
- Corresponding author
- Guolin, Zou
- ORCID
- Yue, Yang
- Venue
- Bioresource Technology
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 101
- Issue
- 11
- Pages
- 4205-4211
- ISSN
- 0960-8524 (ISSN-L)
- OpenAlex
- W2045410662
- Cited by
- 120
- References
- 29
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 13 · 2023: 15 · 2022: 10 · 2021: 9 · 2020: 13 · 2019: 6 · 2018: 5 · 2017: 8 · 2016: 3 · 2015: 9 · 2014: 7 · 2013: 3 · 2012: 4
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioresource Technology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Keywords
- Amomum tsao-ko, essential oils, cytotoxicity, apoptosis, antioxidant activity, HepG2 cells, liver cancer, anticancer activity, selective cytotoxicity, free radical scavenging, lipid peroxidation
- MeSH terms
- Antioxidants, Cell Line, Electrophoresis, Agar Gel, Flow Cytometry, Humans, Oils, Volatile, Apoptosis, Amomum
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
