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Cited by 77Algal biology and biofuel productionAquaculture Nutrition and GrowthPlant biochemistry and biosynthesis

Process optimization of fucoxanthin production with Tisochrysis lutea

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Gao, Fengzheng, Teles (Cabanelas, ITD), Iago, Wijffels, René H, Barbosa, Maria J·2020·Bioresource Technology
DOI 10.1016/j.biortech.2020.123894
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Abstract

. These results can be used to achieve high Pfx or fucoxanthin content during cultivation of Tisochrysis lutea.

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  • At present, fucoxanthin is mainly extracted from seaweed, but several microalgae such as T. lutea and P. tricornutum can accumulate higher concentrations.

    “At the moment, fucoxanthin is mainly extracted from seaweed, but several microalgae can accumulate higher concentrations, such as the marine brown species T. lutea and P. tricornutum (Gao et al., 2020).”

    From Perspectives of fluorescence spectroscopy for online monitoring in microalgae industry (2022) · cites this paper as Gao et al., 2020

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  1. Abu-Rezq, T.S., Al-Musallam, L., Al-Shimmari, J., Dias, P., 1999. Optimum production conditions for different high-quality marine algae. Hydrobiologia 403, 97-107. https://doi.org/10.1023/A:1003725626504. · DOI
  2. Araie, H., Nakamura, H., Toney, J.L., Haig, H.A., Plancq, J., Shiratori, T., Leavitt, P.R., Seki, O., Ishida, K.ichiro, Sawada, K., Suzuki, I., Shiraiwa, Y., 2018. Novel alkenone- producing strains of genus Isochrysis (Haptophyta) isolated from Canadian saline lakes show temperature sensitivity of alkenones and alkenoates. Org. Geochem. 121, 89-103. https://doi.org/10.1016/j.orggeochem.2018.04.008. · DOI
  3. Babuskin, S., Radhakrishnan, K., Babu, P.A.S., Sivarajan, M., Sukumar, M., 2014. Effect of photoperiod, light intensity and carbon sources on biomass and lipid productivities of Isochrysis galbana. Biotechnol. Lett. 36, 1653-1660. https://doi.org/10.1007/s10529- 014-1517-2. · DOI
  4. Barbosa, M.J., Zijffers, J.W., Nisworo, A., Vaes, W., Van Schoonhoven, J., Wijffels, R.H., 2005. Optimization of biomass, vitamins, and carotenoid yield on light energy in a flat-panel reactor using the A-stat technique. Biotechnol. Bioeng. 89, 233-242. https://doi.org/10.1002/bit.20346. · DOI · Paper page
  5. Bendif, E.M., Probert, I., Schroeder, D.C., de Vargas, C., 2013. On the description of Tisochrysis lutea gen. nov. sp. nov. and Isochrysis nuda sp. nov. in the Isochrysidales, and the transfer of Dicrateria to the Prymnesiales (Haptophyta). J. Appl. Phycol. https://doi.org/10.1007/s10811-013-0037-0. · DOI
  6. Breuer, G., Lamers, P.P., Martens, D.E., Draaisma, R.B., Wijffels, R.H., 2012. The impact of nitrogen starvation on the dynamics of triacylglycerol accumulation in nine mi- croalgae strains. Bioresour. Technol. 124, 217-226. https://doi.org/10.1016/j. biortech.2012.08.003. · DOI
  7. Che, C.A., Kim, S.H., Hong, H.J., Kityo, M.K., Sunwoo, I.Y., Jeong, G.T., Kim, S.K., 2019. Optimization of light intensity and photoperiod for Isochrysis galbana culture to im- prove the biomass and lipid production using 14-L photobioreactors with mixed light emitting diodes (LEDs) wavelength under two-phase culture system. Bioresour. Technol. 285, 121323. https://doi.org/10.1016/j.biortech.2019.121323. · DOI
  8. Delbrut, A., Albina, P., Lapierre, T., Pradelles, R., Dubreucq, E., 2018. Fucoxanthin and polyunsaturated fatty acids co-extraction by a green process. Molecules 23, 1-15. https://doi.org/10.3390/molecules23040874. · DOI
  9. Fernandes, T., Fernandes, I., Andrade, C.A.P., Cordeiro, N., 2016. Changes in fatty acid biosynthesis in marine microalgae as a response to medium nutrient availability. Algal Res. 18, 314-320. https://doi.org/10.1016/j.algal.2016.07.005. · DOI
  10. Gómez-Loredo, A., Benavides, J., Rito-Palomares, M., 2016. Growth kinetics and fucox- anthin production of Phaeodactylum tricornutum and Isochrysis galbana cultures at different light and agitation conditions. J. Appl. Phycol. 28, 849-860. https://doi. org/10.1007/s10811-015-0635-0. · DOI
  11. Grant, C., 2011. Light intensity influences on algal pigments, proteins and carbohydrates: implications for pigment-based chemotaxonomy. J. Chem. Inf. Model. 53, 1689-1699. https://doi.org/10.1017/CBO9781107415324.004. · DOI · Paper page
  12. Ippoliti, D., Gómez, C., del Mar Morales-Amaral, M., Pistocchi, R., Fernández-Sevilla, J.M., Acién, F.G., 2016. Modeling of photosynthesis and respiration rate for Isochrysis galbana (T-Iso) and its influence on the production of this strain. Bioresour. Technol. 203, 71-79. https://doi.org/10.1016/j.biortech.2015.12.050. · DOI
  13. Kaplan, D., Cohen, Z., Abeliovich, A., 1986. Optimal growth conditions for Isochrysis galbana. Biomass 9, 37-48. https://doi.org/10.1016/0144-4565(86)90011-9. · DOI
  14. Kawakami, T., Tsushima, M., Katabami, Y., Mine, M., Ishida, A., Matsuno, T., 1998. Effect of β, β-carotene, β-echinenone, astaxanthin, fucoxanthin, vitamin A and vitamin E on the biological defense of the sea urchin Pseudocentrotus depressus. J. Exp. Mar. Bio. Ecol. 226, 165-174. https://doi.org/10.1016/S0022-0981(97)00236-0. · DOI
  15. Kim, S.M., Kang, S.W., Kwon, O.N., Chung, D., Pan, C.H., 2012. Fucoxanthin as a major carotenoid in Isochrysis aff. galbana: characterization of extraction for commercial application. J. Korean Soc. Appl. Biol. Chem. 55, 477-483. https://doi.org/10.1007/ s13765-012-2108-3. · DOI · Paper page
  16. Kita, S., Fujii, R., Cogdell, R.J., Hashimoto, H., 2015. Characterization of fucoxanthin aggregates in mesopores of silica gel: electronic absorption and circular dichroism spectroscopies. J. Photochem. Photobiol. A Chem. 313, 3-8. https://doi.org/10. 1016/j.jphotochem.2015.05.009. · DOI
  17. Kurpan Nogueira, D.P., Silva, A.F., Araújo, O.Q.F., Chaloub, R.M., 2015. Impact of tem- perature and light intensity on triacylglycerol accumulation in marine microalgae. Biomass Bioenergy 72, 280-287. https://doi.org/10.1016/j.biombioe.2014.10.017. · DOI · Paper page
  18. Li, L., Zhang, L., Zhang, Z., Liu, J., 2016. Comparison of heat resistance and application potential of two lipid-rich Isochrysis galbana strains. Algal Res. 20, 1-6. https://doi. org/10.1016/j.algal.2016.09.002. · DOI
  19. Li, Y., Sun, H., Wu, T., Fu, Y., He, Y., Mao, X., Chen, F., 2019. Storage carbon metabolism of Isochrysis zhangjiangensis under different light intensities and its application for co- production of fucoxanthin and stearidonic acid. Bioresour. Technol. 282, 94-102. https://doi.org/10.1016/j.biortech.2019.02.127. · DOI
  20. Lu, X., Sun, H., Zhao, W., Cheng, K.W., Chen, F., Liu, B., 2018. A hetero-photoautotrophic two-stage cultivation process for production of fucoxanthin by the marine diatom Nitzschia laevis. Mar. Drugs 16. https://doi.org/10.3390/md16070219. · DOI
  21. Maeda, H., Fukuda, S., Izumi, H., Saga, N., 2018. Anti-oxidant and fucoxanthin contents of brown alga ishimozuku (Sphaerotrichia divaricata) from the west coast of aomori, Japan. Mar. Drugs. https://doi.org/10.3390/md16080255. · DOI · Paper page
  22. Marchetti, J., Bougaran, G., Jauffrais, T., Lefebvre, S., Rouxel, C., Saint-Jean, B., Lukomska, E., Robert, R., Cadoret, J.P., 2013. Effects of blue light on the biochemical composition and photosynthetic activity of Isochrysis sp. (T-iso). J. Appl. Phycol. 25, 109-119. https://doi.org/10.1007/s10811-012-9844-y. · DOI
  23. McClure, D.D., Luiz, A., Gerber, B., Barton, G.W., Kavanagh, J.M., 2018. An investigation into the effect of culture conditions on fucoxanthin production using the marine microalgae Phaeodactylum tricornutum. Algal Res. 29, 41-48. https://doi.org/10. 1016/j.algal.2017.11.015. · DOI · Paper page
  24. Miyashita, K., Nishikawa, S., Beppu, F., Tsukui, T., Abe, M., Hosokawa, M., 2011. The allenic carotenoid fucoxanthin, a novel marine nutraceutical from brown seaweeds. J. Sci. Food Agric. 91, 1166-1174. https://doi.org/10.1002/jsfa.4353. · DOI
  25. Petrushkina, M., Gusev, E., Sorokin, B., Zotko, N., Mamaeva, A., Filimonova, A., Kulikovskiy, M., Maltsev, Y., Yampolsky, I., Guglya, E., Vinokurov, V., Namsaraev, Z., Kuzmin, D., 2017. Fucoxanthin production by heterokont microalgae. Algal Res. https://doi.org/10.1016/j.algal.2017.03.016. · DOI
  26. Picardo, M.C., De Medeiros, J.L., de Q.F. Araújo, O., Chaloub, R.M., 2013. Effects of CO2 enrichment and nutrients supply intermittency on batch cultures of Isochrysis galbana. Bioresour. Technol. 143, 242-250. https://doi.org/10.1016/j.biortech.2013.05.113. · DOI
  27. Renaud, S.M., Thinh, L. Van, Lambrinidis, G., Parry, D.L., 2002. Effect of temperature on growth, chemical composition and fatty acid composition of tropical Australian mi- croalgae grown in batch cultures. Aquaculture 211, 195-214. https://doi.org/10. 1016/S0044-8486(01)00875-4. · DOI · Paper page
  28. Roleda, M.Y., Slocombe, S.P., Leakey, R.J.G., Day, J.G., Bell, E.M., Stanley, M.S., 2013. Effects of temperature and nutrient regimes on biomass and lipid production by six oleaginous microalgae in batch culture employing a two-phase cultivation strategy. Bioresour. Technol. 129, 439-449. https://doi.org/10.1016/j.biortech.2012.11.043. · DOI · Paper page
  29. Saoudi-Helis, L., Dubacq, J.P., Marty, Y., Samain, J.F., Gudin, C., 1994. Influence of growth rate on pigment and lipid composition of the microalga Isochrysis aff. galbana clone T.iso. J. Appl. Phycol. 6, 315-322. https://doi.org/10.1007/BF02181945. · DOI
  30. Skau, L.F., Andersen, T., Thrane, J.E., Hessen, D.O., 2017. Growth, stoichiometry and cell size; temperature and nutrient responses in haptophytes. PeerJ. https://doi.org/10. 7717/peerj.3743. · DOI
  31. Su, J., Ye, M., Lou, Y., Yang, Z., Sun, T., Zhang, R., Xu, J., Zhou, C., Yan, X., 2017. Low- molecular-mass organic acid and lipid responses of Isochrysis galbana Parke to high temperature stress during the entire growth stage. Algal Res. 26, 93-103. https://doi. org/10.1016/j.algal.2017.06.011. · DOI
  32. Sukenik, A., Zmora, O., Carmeli, Y., 1993. Biochemical quality of marine unicellular algae with special emphasis on lipid composition. II. Nannochloropsis sp. Aquaculture 117, 313-326. https://doi.org/10.1016/0044-8486(93)90328-V. · DOI
  33. Sun, Z., Wang, X., Liu, J., 2019. Screening of Isochrysis strains for simultaneous produc- tion of docosahexaenoic acid and fucoxanthin. Algal Res. 41, 101545. https://doi. org/10.1016/J.ALGAL.2019.101545. · DOI
  34. Terasaki, M., Narayan, B., Kamogawa, H., Nomura, M., Stephen, N.M., Kawagoe, C., Hosokawa, M., Miyashita, K., 2012. Carotenoid profile of edible japanese seaweeds: an improved hplc method for separation of major carotenoids. J. Aquat. Food Prod. Technol. 21, 468-479. https://doi.org/10.1080/10498850.2011.610025. · DOI
  35. Urikura, I., Sugawara, T., Hirata, T., 2011. Protective effect of fucoxanthin against UVB- induced skin photoaging in hairless mice. Biosci. Biotechnol. Biochem. 75, 757-760. https://doi.org/10.1271/bbb.110040. · DOI
  36. Verma, P., Kumar, M., Mishra, G., Sahoo, D., 2017. Multivariate analysis of fatty acid and biochemical constitutes of seaweeds to characterize their potential as bioresource for biofuel and fine chemicals. Bioresour. Technol. 226, 132-144. https://doi.org/10. 1016/j.biortech.2016.11.044. · DOI
  37. Wang, W., Yu, L.J., Xu, C., Tomizaki, T., Zhao, S., Umena, Y., Chen, X., Qin, X., Xin, Y., Suga, M., Han, G., Kuang, T., Shen, J.R., 2019. Structural basis for blue-green light harvesting and energy dissipation in diatoms. Science 80-, 363. https://doi.org/10. 1126/science.aav0365. · DOI

Cited by

Sorted by citations

Authors
Gao, F., Teles (Cabanelas, I., Wijffels, R. H., & Barbosa, M. J.
Affiliations
  • Wageningen University & Research (NL)
  • Nord University (NO)
Corresponding author
Gao, Fengzheng
ORCID
Venue
Bioresource Technology
Publisher
Elsevier BV
Published
2020-11
Volume
315
Pages
123894
ISSN
0960-8524 (ISSN-L)
DOI
10.1016/j.biortech.2020.123894
OpenAlex
W3043852270
Cited by
77
References
2
Citations by year
2026: 10 · 2025: 7 · 2024: 17 · 2023: 11 · 2022: 15 · 2021: 13 · 2020: 4
FWCI
2.08
Type
journal article
Language
en
Open access
Licence
Locations
  • Bioresource Technology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (submittedVersion, cc-by-nc-nd)
  • NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc-nd)
  • Data Archiving and Networked Services (DANS) (submittedVersion, cc-by-nc-nd)
Funders
Horizon 2020
Topics
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Keywords
Tisochrysis lutea, microalgae cultivation, process optimization, carotenoid production, microalgae
MeSH terms
Xanthophylls, Haptophyta

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