Cited by 59Algal biology and biofuel productionSeaweed-derived Bioactive CompoundsAquaculture Nutrition and Growth

Fucoxanthin from marine microalgae: A promising bioactive compound for industrial production and food application

Sun, Han, Yang, Shufang, Zhao, Weiyang, Kong, Qing, Zhu, Changliang, Fu, Xiaodan, Zhang, Fang, Liu, Zhemin +3 more·2023·Critical Reviews in Food Science and Nutrition

Abstract

Fucoxanthin attracts increasing attentions due to its potential health benefits, which has been exploited in several food commodities. However, fucoxanthin available for industrial application is mainly derived from macroalgae, and is not yet sufficiently cost-effective compared with microalgae. This review focuses on the strategies to improve fucoxanthin productivity and approaches to reduce downstream costs in microalgal production. Here we comprehensively and critically discuss ways and methods to increase the cell growth rate and fucoxanthin content of marine microalgae, including strain screening, condition optimization, design of culture mode, metabolic and genetic engineering, and scale-up production of fucoxanthin. The approaches in downstream processes provide promising alternatives for fucoxanthin production from marine microalgae. Besides, this review summarizes fucoxanthin improvements in solubility and bioavailability by delivery system of emulsion, nanoparticle, and hydrogel, and discusses fucoxanthin metabolism with gut microbes. Fucoxanthin production from marine microalgae possesses numerous advantages in environmental sustainability and final profits to meet incremental global market demands of fucoxanthin. Strategies of adaptive evolution, multi-stage cultivation, and bioreactor improvements have tremendous potentials to improve economic viability of the production. Moreover, fucoxanthin is promising as the microbiota-targeted ingredient, and nanoparticles can protect fucoxanthin from external environmental factors for improving the solubility and bioavailability.

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Crossref · 10.1080/10408398.2022.2054932

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  • Advanced delivery systems including nanoemulsions, liposomes, and hydrogels improve controlled release, intestinal stability, and absorption of microalgal bioactives.

    “Advanced delivery systems, including nanoemulsions, liposomes, and hydrogels, have been shown to significantly improve the controlled release, intestinal stability, and absorption of these bioactives [26,95].”

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Authors
Sun, H., Yang, S., Zhao, W., Kong, Q., Zhu, C., Fu, X., Zhang, F., Liu, Z., Zhan, Y., Mou, H., & He, Y.
Affiliations
  • Ocean University of China (CN)
  • Shenzhen University (CN)
  • Cornell University (US)
  • Shandong Feed and Veterinary Drug Quality Center, Jinan, Shandong, China
  • Fujian Normal University (CN)
Corresponding author
  • Mou, Haijin
  • He, Yongjin
Venue
Critical Reviews in Food Science and Nutrition
Published
2022-03-23
Volume
63
Issue
26
Pages
7996-8012
ISSN
  • 1040-8398 (ISSN-L)
  • 1549-7852
OpenAlex
W4220712330
Cited by
59
References
97
Citations by year
2026: 12 · 2025: 20 · 2024: 11 · 2023: 12 · 2022: 4
FWCI
0.75
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Reviews in Food Science and Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Key Research and Development Project (2019YFD0900201)
  • Key Projects of Department of Science and Technology of Fujian Province of China (2020N0008)
Topics
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
Keywords
fucoxanthin, marine microalgae, strain screening, culture condition optimization, metabolic engineering, genetic engineering, scale-up production, downstream processing, emulsions, nanoparticles, hydrogels, bioavailability, gut microbiota, adaptive evolution, bioreactors, food applications, health benefits
MeSH terms
Food, Seaweed, Xanthophylls, Microalgae

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