Cited by 92Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model OrganismsPhytochemicals and Antioxidant Activities

Natural products with anti-aging potential: Affected targets and molecular mechanisms

Cătană, Cristina-Sorina, Atanasov, Atanas G., Berindan-Neagoe, Ioana·2018·Biotechnology Advances

Abstract

In recent years, there has been a great deal of attention toward the molecular machinery relevant to age-related progression controlled through the external intervention of polyphenols- an epigenetic-modulating diet. Natural products modulate cellular longevity through histone post-translational modification and can also induce the upregulation of autophagy, thus reducing the level of acetyl coenzyme A (AcCoA). In addition, the effect of caloric restriction (CR) on cancer-related chronic inflammation is of great significance in aging. In line with this, SIRT1 protein levels are expanded in response to calorie restriction mimetics (CRM), in this way acting as autophagy inducers relevant to cancer prevention.

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Crossref · 10.1016/j.biotechadv.2018.03.012

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  • Resveratrol is a polyphenolic antioxidant with strong anti-inflammatory and antiproliferative activity.

    “Grape seeds are also rich in phytoalexin resveratrol (trans-3, 4′,5-trihydroxy-stilbene), a polyphenolic antioxidant with strong anti-inflammatory and antiproliferative activity [4, 87].”

    From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [87]

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Authors
Cătană, C.-S., Atanasov, A. G., & Berindan-Neagoe, I.
Affiliations
  • Iuliu Hațieganu University of Medicine and Pharmacy (RO)
  • University of Vienna (AT)
Corresponding author
Atanasov, Atanas G.
Venue
Biotechnology Advances
Publisher
Elsevier BV
Published
2018-11
Volume
36
Issue
6
Pages
1649-1656
ISSN
0734-9750 (ISSN-L)
OpenAlex
W2795049798
Cited by
92
References
45
Citations by year
2026: 7 · 2025: 11 · 2024: 8 · 2023: 8 · 2022: 10 · 2021: 11 · 2020: 13 · 2019: 19 · 2018: 5
FWCI
1.35
Type
journal article
Language
en
Open access
closed
Locations
  • Biotechnology Advances (publishedVersion)
  • PubMed (publishedVersion)
Funders
POC (35/01.09.2016, ID 37_796)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
polyphenols, epigenetic modulation, histone modifications, autophagy, acetyl-CoA, caloric restriction, caloric restriction mimetics, SIRT1, chronic inflammation, cancer prevention, cell longevity
MeSH terms
Aging, Animals, Antioxidants, Autophagy, Biological Products, Humans, Caloric Restriction, Mice, Phytochemicals

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