Natural products with anti-aging potential: Affected targets and molecular mechanisms
Abstract
In recent years, there has been a great deal of attention toward the molecular machinery relevant to age-related progression controlled through the external intervention of polyphenols- an epigenetic-modulating diet. Natural products modulate cellular longevity through histone post-translational modification and can also induce the upregulation of autophagy, thus reducing the level of acetyl coenzyme A (AcCoA). In addition, the effect of caloric restriction (CR) on cancer-related chronic inflammation is of great significance in aging. In line with this, SIRT1 protein levels are expanded in response to calorie restriction mimetics (CRM), in this way acting as autophagy inducers relevant to cancer prevention.
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Resveratrol is a polyphenolic antioxidant with strong anti-inflammatory and antiproliferative activity.
“Grape seeds are also rich in phytoalexin resveratrol (trans-3, 4′,5-trihydroxy-stilbene), a polyphenolic antioxidant with strong anti-inflammatory and antiproliferative activity [4, 87].”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [87]
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- Authors
- Cătană, C.-S., Atanasov, A. G., & Berindan-Neagoe, I.
- Affiliations
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- University of Vienna (AT)
- Corresponding author
- Atanasov, Atanas G.
- Venue
- Biotechnology Advances
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 36
- Issue
- 6
- Pages
- 1649-1656
- ISSN
- 0734-9750 (ISSN-L)
- OpenAlex
- W2795049798
- Cited by
- 92
- References
- 45
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 8 · 2023: 8 · 2022: 10 · 2021: 11 · 2020: 13 · 2019: 19 · 2018: 5
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biotechnology Advances (publishedVersion)
- PubMed (publishedVersion)
- Funders
- POC (35/01.09.2016, ID 37_796)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- polyphenols, epigenetic modulation, histone modifications, autophagy, acetyl-CoA, caloric restriction, caloric restriction mimetics, SIRT1, chronic inflammation, cancer prevention, cell longevity
- MeSH terms
- Aging, Animals, Antioxidants, Autophagy, Biological Products, Humans, Caloric Restriction, Mice, Phytochemicals
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