Regulation of autophagy by cytosolic acetyl-coenzyme A

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Autophagy in the Pathogenesis of Disease

Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069 · see citing works

Autophagy: Renovation of Cells and Tissues

Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,467 · see citing works

Autophagy and the Integrated Stress Response

Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506 · see citing works

TFEB Links Autophagy to Lysosomal Biogenesis

Settembre, C., Di Malta, C., Polito, V. A., Arencibia, M. G., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Medina, D., Colella, P., et al. (2011) · Science · doi:10.1126/science.1204592 · Cited by 3,365 · see citing works

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300 · see citing works

In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,323 · see citing works

ATP-citrate lyase links cellular metabolism to histone acetylation

Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298 · see citing works

Induction of autophagy by spermidine promotes longevity

Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1975 · Cited by 1,680 · see citing works

Network organization of the human autophagy system

Behrends, C., Sowa, M. E., Gygi, S. P., & Harper, J. W. (2010) · Nature · doi:10.1038/nature09204 · Cited by 1,554 · see citing works

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

Lee, I. H., Cao, L., Mostoslavsky, R., Lombard, D. B., Liu, J., Bruns, N. E., Tsokos, M., Alt, F. W., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712145105 · Cited by 1,473 · see citing works

Regulation of autophagy by cytoplasmic p53

Tasdemir, E., Maiuri, M. C., Galluzzi, L., Vitale, I., Djavaheri-Mergny, M., D'Amelio, M., Criollo, A., Morselli, E., Zhu, C., Harper, F., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1730 · Cited by 1,132 · see citing works

Potential therapeutic applications of autophagy

Rubinsztein, D. C., Gestwicki, J. E., Murphy, L. O., & Klionsky, D. J. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2272 · Cited by 1,004 · see citing works

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

Donohoe, D. R., Collins, L. B., Wali, A., Bigler, R., Sun, W., & Bultman, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.033 · Cited by 993 · see citing works

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

Lan, F., Cacicedo, J. M., Ruderman, N., & Ido, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805711200 · Cited by 825 · see citing works

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

Kim, J., Kim, Y. C., Fang, C., Russell, R. C., Kim, J. H., Fan, W., Liu, R., Zhong, Q., & Guan, K. (2013) · Cell · doi:10.1016/j.cell.2012.12.016 · Cited by 806 · see citing works

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

Williams, A., Sarkar, S., Cuddon, P., Ttofi, E. K., Saiki, S., Siddiqi, F. H., Jahreiss, L., Fleming, A., Pask, D., Goldsmith, P., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.79 · Cited by 800 · see citing works

Cardiac autophagy is a maladaptive response to hemodynamic stress

Zhu, H., Tannous, P., Johnstone, J. L., Kong, Y., Shelton, J. M., Richardson, J. A., Le, V., Levine, B., Rothermel, B. A., & Hill, J. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci27523 · Cited by 765 · see citing works

HDAC6 controls autophagosome maturation essential for ubiquitin‐selective quality‐control autophagy

Lee, J., Koga, H., Kawaguchi, Y., Tang, W., Wong, E., Gao, Y., Pandey, U. B., Kaushik, S., Tresse, E., Lu, J., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2009.405 · Cited by 756 · see citing works

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

Herzig, S., Raemy, E., Montessuit, S., Veuthey, J.-L., Zamboni, N., Westermann, B., Kunji, E. R. S., & Martinou, J.-C. (2012) · Science · doi:10.1126/science.1218530 · Cited by 747 · see citing works

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor

Bowers, E. M., Yan, G., Mukherjee, C., Orry, A., Wang, L., Holbert, M. A., Crump, N. T., Hazzalin, C. A., Liszczak, G., Yuan, H., et al. (2010) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.03.006 · Cited by 666 · see citing works

Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome

Hebert, A. S., Dittenhafer-Reed, K. E., Yu, W., Bailey, D. J., Selen, E. S., Boersma, M. D., Carson, J. J., Tonelli, M., Balloon, A. J., Higbee, A. J., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.024 · Cited by 636 · see citing works

FOXO3A directs a protective autophagy program in haematopoietic stem cells

Warr, M. R., Binnewies, M., Flach, J., Reynaud, D., Garg, T., Malhotra, R., Debnath, J., & Passegué, E. (2013) · Nature · doi:10.1038/nature11895 · Cited by 625 · see citing works

Encyclopedia of biological chemistry

(2013) · Choice Reviews Online · doi:10.5860/choice.51-0034 · Cited by 558 · see citing works

A two-way street: reciprocal regulation of metabolism and signalling

Wellen, K. E., & Thompson, C. B. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3305 · Cited by 528 · see citing works

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

Morselli, E., Mariño, G., Bennetzen, M. V., Eisenberg, T., Megalou, E. V., Schroeder, S., Cabrera, S., Bénit, P., Rustin, P., Criollo, A., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201008167 · Cited by 495 · see citing works

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stressPreprint

Zaugg, K., Yao, Y., Reilly, P. T., Kannan, K., Kiarash, R., Mason, J. M., Huang, P., Sawyer, S. K., Fuerth, B. J., Faubert, B., et al. (2011) · Genes & Development · doi:10.1101/gad.1987211 · Cited by 493 · see citing works

Regulation of the p300 HAT domain via a novel activation loop

Thompson, P. R., Wang, D., Wang, L., Fulco, M., Pediconi, N., Zhang, D., An, W., Ge, Q., Roeder, R. G., Wong, J., et al. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb740 · Cited by 423 · see citing works

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

Lin, S.-Y., Li, T. Y., Liu, Q., Zhang, C., Li, X., Chen, Y., Zhang, S.-M., Lian, G., Liu, Q., Ruan, K., et al. (2012) · Science · doi:10.1126/science.1217032 · Cited by 365 · see citing works

Regulation of Autophagy by the p300 Acetyltransferase

Lee, I. H., & Finkel, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807135200 · Cited by 276 · see citing works

Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer

Roche, T. E., & Hiromasa, Y. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6380-z · Cited by 265 · see citing works

Nicotinamide-induced Mitophagy

Jang, S., Kang, H. T., & Hwang, E. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.363747 · Cited by 259 · see citing works

Function and Molecular Mechanism of Acetylation in Autophagy Regulation

Yi, C., Ma, M., Ran, L., Zheng, J., Tong, J., Zhu, J., Ma, C., Sun, Y., Zhang, S., Feng, W., et al. (2012) · Science · doi:10.1126/science.1216990 · Cited by 258 · see citing works

The Role of the Carnitine System in Human Metabolism

Foster, D. W. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1320.001 · Cited by 228 · see citing works

Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo

Zachar, Z., Marecek, J. F., Maturo, C., Gupta, S., Stuart, S. D., Howell, K. H., Schauble, A., Lem, J., Piramzadian, A., Karnik, S., et al. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0785-8 · Cited by 217 · see citing works

Starvation-induced Hyperacetylation of Tubulin Is Required for the Stimulation of Autophagy by Nutrient Deprivation

Geeraert, C., Ratier, A., Pfisterer, S. G., Perdiz, D., Cantaloube, I., Rouault, A., Pattingre, S., Proikas‐Cezanne, T., Codogno, P., & Poüs, C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.091553 · Cited by 204 · see citing works

Regulation of Transcription by AMP-activated Protein Kinase

Yang, W., Hong, Y. H., Shen, X.-Q., Frankowski, C., Camp, H. S., & Leff, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100316200 · Cited by 199 · see citing works

Autophagy is essential for mouse sense of balance

Mariño, G., Fernández, Á. F., Cabrera, S., Lundberg, Y. W., Cabanillas, R., Rodríguez, F. J., Salvador-Montoliu, N., Vega, J. A., Germanà, A., Fueyo, A., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42601 · Cited by 191 · see citing works

The emerging role of acetylation in the regulation of autophagy

Bánréti, Á., Sass, M., & Graba, Y. (2013) · Autophagy · doi:10.4161/auto.23908 · Cited by 179 · see citing works

HMB supplementation: clinical and athletic performance-related effects and mechanisms of action

Zanchi, N. E., Gerlinger‐Romero, F., Guimarães‐Ferreira, L., Filho, M. A. D. S., Felitti, V., Lira, F. S., Seelaender, M. C. L., & Lancha, A. H. (2010) · Amino Acids · doi:10.1007/s00726-010-0678-0 · Cited by 151 · see citing works

Circadian acetylome reveals regulation of mitochondrial metabolic pathways

Masri, S., Patel, V. R., Eckel‐Mahan, K. L., Peleg, S., Forné, I., Ladurner, A. G., Baldi, P., Imhof, A., & Sassone‐Corsi, P. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217632110 · Cited by 149 · see citing works

The Use ofGarciniaExtract (Hydroxycitric Acid) as a Weight loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials

Onakpoya, I., Hung, S. K., Perry, R. E., Wider, B., & Ernst, E. (2010) · Journal of Obesity · doi:10.1155/2011/509038 · Cited by 143 · see citing works

Pharmacokinetics, safety, and effects on exercise performance of l-arginine α-ketoglutarate in trained adult men

Campbell, B., Roberts, M., Kerksick, C., Wilborn, C., Marcello, B., Taylor, L., Nassar, E., Leutholtz, B., Bowden, R., Rasmussen, C., et al. (2006) · Nutrition · doi:10.1016/j.nut.2006.06.003 · Cited by 128 · see citing works

Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins

Pietrocola, F., Mariño, G., Lissa, D., Vacchelli, E., Malik, S. A., Niso‐Santano, M., Zamzami, N., Galluzzi, L., Maiuri, M. C., & Kroemer, G. (2012) · Cell Cycle · doi:10.4161/cc.22027 · Cited by 97 · see citing works

Autophagy

Lin, T.-C., Chen, Y., Kensicki, E., Li, A. Y. J., Kong, M., Li, Y., Mohney, R. P., Shen, H., Stiles, B. L., Mizushima, N., et al. (2012) · Autophagy · doi:10.4161/auto.21228 · Cited by 70 · see citing works

Reversible Acetylation Regulates Salt-inducible Kinase (SIK2) and Its Function in Autophagy*

Yang, F.-C., Tan, B. C., Chen, W.-H., Lin, Y.-H., Huang, J.-Y., Chang, H.-Y., Sun, H.-Y., Hsu, P., Liou, G., Shen, J., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.431239 · Cited by 55 · see citing works

Biological significance of protein modifications in aging and calorie restriction

Nakamura, A., Kawakami, K., Kametani, F., Nakamoto, H., & Goto, S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05374.x · Cited by 43 · see citing works

Regulation of acetyl-coA carboxylase: properties of coA activation of acetyl-coA carboxylase.

Yeh, L.-A., & Kim, K. H. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.6.3351 · Cited by 28 · see citing works

[36] Hydroxycitrate

Lowenstein, J. M., & Brunengraber, H. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)72038-x · Cited by 26 · see citing works

Triggering and amplification of insulin secretion by dimethyl α-ketoglutarate, a membrane permeable α-ketoglutarate analogue

Willenborg, M., Panten, U., & Rustenbeck, I. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.02.014 · Cited by 20 · see citing works

Branched-Chain Amino Acids

Chuang, D. (2013) · Encyclopedia of Biological Chemistry · doi:10.1016/b978-0-12-378630-2.00072-4 · Cited by 11 · see citing works

The Use of Garcinia Extract (Hydroxycitric Acid) as a Weight loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials

(21833186), I. O., (21833189), S. H., (9877772), R. P., (21833192), B. W., & Ernst, E. (2011) · Figshare · Cited by 10 · see citing works

Prevalence and risk factors associated with resistance-associated mutations to etravirine in a cohort of perinatally HIV-infected children

Contreras, G., Bell, C., Bianco, G. P. D., Pérez, N., Kleinosky, M. T., Murphy, J. R., & Heresi, G. P. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkt198 · Cited by 5 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894 · see citing works

Biological Functions of Autophagy Genes: A Disease Perspective

Levine, B., & Kroemer, G. (2019) · Cell · doi:10.1016/j.cell.2018.09.048 · Cited by 2,832 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) ¹

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,622 · see citing works

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

Pietrocola, F., Galluzzi, L., Pedro, J. M. B., Madeo, F., & Kroemer, G. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.014 · Cited by 1,349 · see citing works

Mitochondrial metabolism and cancer

Porporato, P. E., Filigheddu, N., Pedro, J. M. B., Kroemer, G., & Galluzzi, L. (2017) · Cell Research · doi:10.1038/cr.2017.155 · Cited by 1,292 · see citing works

Spermidine in health and disease

Madeo, F., Eisenberg, T., Pietrocola, F., & Kroemer, G. (2018) · Science · doi:10.1126/science.aan2788 · Cited by 1,154 · see citing works

Modulation of cellular processes by histone and non-histone protein acetylation

Shvedunova, M., & Akhtar, A. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00441-y · Cited by 975 · see citing works

Acetyl-CoA and the regulation of metabolism: mechanisms and consequences

Shi, L., & Tu, B. P. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.02.003 · Cited by 903 · see citing works

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Quirós, P. M., Prado, M. A., Zamboni, N., D’Amico, D., Williams, R. W., Finley, D., Gygi, S. P., & Auwerx, J. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201702058 · Cited by 832 · see citing works

Autophagy in inflammation, infection, and immunometabolism

Deretic, V. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.018 · Cited by 862 · see citing works

Epigenetics and aging

Pal, S., & Tyler, J. K. (2016) · Science Advances · doi:10.1126/sciadv.1600584 · Cited by 860 · see citing works

Metabolic control of autophagy

Galluzzi, L., Pietrocola, F., Levine, B., & Kroemer, G. (2014) · Cell · doi:10.1016/j.cell.2014.11.006 · Cited by 855 · see citing works

Metabolic Control of Longevity

López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753 · see citing works

Metabolic control of cell death

Green, D. R., Galluzzi, L., & Kroemer, G. (2014) · Science · doi:10.1126/science.1250256 · Cited by 661 · see citing works

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Madeo, F., Carmona-Gutierrez, D., Hofer, S. J., & Kroemer, G. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.018 · Cited by 630 · see citing works

Cellular degradation systems in ferroptosis

Chen, X., Yu, C., Kang, R., Kroemer, G., & Tang, D. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-020-00728-1 · Cited by 644 · see citing works

Interventions to slow aging in humans: are we ready?

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592 · see citing works

Caloric restriction mimetics enhance anticancer immunosurveillance

Pietrocola, F., Pol, J., Vacchelli, E., Rao, S., Enot, D. P., Baracco, E. E., Levesque, S., Castoldi, F., Jacquelot, N., Yamazaki, T., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.016 · Cited by 542 · see citing works

Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation

Lee, J. V., Carrer, A., Shah, S., Snyder, N. W., Wei, S., Venneti, S., Worth, A. J., Yuan, Z.-F., Lim, H.-W., Liu, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.004 · Cited by 563 · see citing works

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

Boland, B., Yu, W. H., Corti, O., Mollereau, B., Henriques, A., Bézard, E., Pastores, G., Rubinsztein, D. C., Nixon, R. A., Duchen, M. R., et al. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.109 · Cited by 552 · see citing works

The Role of Autophagy in the Heart

Sciarretta, S., Maejima, Y., Zablocki, D., & Sadoshima, J. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021317-121427 · Cited by 547 · see citing works

Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy

Kishton, R. J., Sukumar, M., & Restifo, N. P. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.016 · Cited by 548 · see citing works

Cytosolic lipolysis and lipophagy: two sides of the same coin

Zechner, R., Madeo, F., & Kratky, D. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.76 · Cited by 550 · see citing works

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

Mews, P., Donahue, G., Drake, A. M., Luczak, V., Abel, T., & Berger, S. L. (2017) · Nature · doi:10.1038/nature22405 · Cited by 514 · see citing works

The quest to slow ageing through drug discovery

Partridge, L., Fuentealba, M., & Kennedy, B. K. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0067-7 · Cited by 468 · see citing works

Essential role for autophagy in life span extension

Madeo, F., Zimmermann, A., Maiuri, M. C., & Kroemer, G. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73946 · Cited by 464 · see citing works

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

Covarrubias, A. J., Aksoylar, H., Yu, J., Snyder, N. W., Worth, A. J., Iyer, S. S., Wang, J., Ben‐Sahra, I., Byles, V., Polynne-Stapornkul, T., et al. (2016) · eLife · doi:10.7554/elife.11612 · Cited by 454 · see citing works

Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal

Jia, J., Claude-Taupin, A., Gu, Y., Choi, S. W., Peters, R., Bissa, B., Mudd, M. H., Allers, L., Pallikkuth, S., Lidke, K. A., et al. (2020) · Developmental Cell · doi:10.1016/j.devcel.2019.10.025 · Cited by 434 · see citing works

Nutrition, inflammation and cancer

Zitvogel, L., Pietrocola, F., & Kroemer, G. (2017) · Nature Immunology · doi:10.1038/ni.3754 · Cited by 446 · see citing works

Metabolic control of epigenetics in cancer

Kinnaird, A. S., Zhao, S., Wellen, K. E., & Michelakis, E. D. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.82 · Cited by 419 · see citing works

Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

Chen, G., Kroemer, G., & Kepp, O. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00200 · Cited by 359 · see citing works

Spermidine induces autophagy by inhibiting the acetyltransferase EP300

Pietrocola, F., Lachkar, S., Enot, D. P., Niso-Santano, M., Bravo-San Pedro, J. M., Sica, V, Izzo, V, Maiuri, M. C., Madeo, F., Mariño, G., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.215 · Cited by 357 · see citing works

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

de Cabo, R., Carmona-Gutierrez, D., Bernier, M., Hall, M. N., & Madeo, F. (2014) · Cell · doi:10.1016/j.cell.2014.05.031 · Cited by 345 · see citing works

Cancer cell metabolism and antitumour immunity

Martino, M. D., Rathmell, J. C., Galluzzi, L., & Vanpouille‐Box, C. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01026-4 · Cited by 361 · see citing works

Transcriptional and epigenetic regulation of autophagy in aging

Lapierre, L. R., Kumsta, C., Sandri, M., Ballabio, A., & Hansen, M. (2015) · Autophagy · doi:10.1080/15548627.2015.1034410 · Cited by 339 · see citing works

Molecular Mechanisms of Mitochondrial Autophagy/Mitophagy in the Heart

Saito, T., & Sadoshima, J. (2015) · Circulation Research · doi:10.1161/circresaha.116.303790 · Cited by 321 · see citing works

Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy

Galluzzi, L., Bravo-San Pedro, J. M., Demaria, S., Formenti, S. C., & Kroemer, G. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.183 · Cited by 314 · see citing works

Autophagy: a druggable process that is deregulated in aging and human disease

Kroemer, G. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78652 · Cited by 318 · see citing works

Mechanisms and Dynamics of Protein Acetylation in Mitochondria

Baeza, J., Smallegan, M. J., & Denu, J. M. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.12.006 · Cited by 312 · see citing works

Acetylation in the regulation of autophagy

Xu, Y., & Wan, W. (2022) · Autophagy · doi:10.1080/15548627.2022.2062112 · Cited by 311 · see citing works

The Double-Edge Sword of Autophagy in Cancer: From Tumor Suppression to Pro-tumor Activity

Chavez-Dominguez, R., Perez-Medina, M., López-González, J. S., Galicia-Velasco, M., & Aguilar‐Cázares, D. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.578418 · Cited by 309 · see citing works

Acetyl-CoA metabolism in cancer

Guertin, D. A., & Wellen, K. E. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00543-5 · Cited by 303 · see citing works

Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles

Bonora, M., Wieckowski, M. R., Sinclair, D. A., Kroemer, G., Pinton, P., & Galluzzi, L. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0074-0 · Cited by 299 · see citing works

Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism

Lahiri, V., Hawkins, W. D., & Klionsky, D. J. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.03.003 · Cited by 286 · see citing works

Autophagy and the hallmarks of aging

Kaushik, S., Tasset, I., Arias, E., Pampliega, O., Wong, E., Martinez-Vicente, M., & Cuervo, A. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101468 · Cited by 285 · see citing works

Emerging strategies to effectively target autophagy in cancer

Rebecca, V. W., & Amaravadi, R. K. (2015) · Oncogene · doi:10.1038/onc.2015.99 · Cited by 283 · see citing works

Drosophila as a model for ageing

Piper, M. D. W., & Partridge, L. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.09.016 · Cited by 273 · see citing works

The functional roles of TCA cycle metabolites in cancer

Eniafe, J., & Jiang, S. (2021) · Oncogene · doi:10.1038/s41388-020-01639-8 · Cited by 274 · see citing works

Mitochondrial pyruvate transport: a historical perspective and future research directions

McCommis, K. S., & Finck, B. N. (2015) · Biochemical Journal · doi:10.1042/bj20141171 · Cited by 269 · see citing works

Regulation of Stem Cell Aging by Metabolism and Epigenetics

Ren, R., Ocampo, A., Liu, G., & Belmonte, J. C. I. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.019 · Cited by 269 · see citing works

Caloric restriction mimetics: towards a molecular definition

Madeo, F., Pietrocola, F., Eisenberg, T., & Kroemer, G. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4391 · Cited by 264 · see citing works

Higher spermidine intake is linked to lower mortality: a prospective population-based study

Kiechl, S. J., Pechlaner, R., Willeit, P., Notdurfter, M., Paulweber, B., Willeit, K., Werner, P., Ruckenstuhl, C., Iglseder, B., Weger, S., et al. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy102 · Cited by 251 · see citing works

Protein and amino acid restriction, aging and disease: from yeast to humans

Mirzaei, H., Suarez, J. A., & Longo, V. D. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.07.002 · Cited by 248 · see citing works

Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

Son, S. M., Park, S. J., Lee, H., Siddiqi, F. H., Lee, J. E., Menzies, F. M., & Rubinsztein, D. C. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.013 · Cited by 243 · see citing works

Glucose Transporters in Cardiac Metabolism and Hypertrophy

Shao, D., & Tian, R. (2015) · Comprehensive physiology · doi:10.1002/cphy.c150016 · Cited by 273 · see citing works

Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation

He, A., Chen, X., Tan, M., Chen, Y., Lu, D., Zhang, X., Dean, J. M., Razani, B., & Lodhi, I. J. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.05.007 · Cited by 241 · see citing works

Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth

Sun, T., Li, X., Zhang, P., Chen, W.-D., Zhang, H., Li, D., Deng, R., Qian, X.-J., Jiao, L., Ji, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms8215 · Cited by 233 · see citing works

Undercover: gene control by metabolites and metabolic enzymesPreprint

van der Knaap, J. A., & Verrijzer, C. P. (2016) · Genes & Development · doi:10.1101/gad.289140.116 · Cited by 213 · see citing works

Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans

Edwards, C., Canfield, J., Copes, N., Brito, A. G., Rehan, M. A. Y., Lipps, D., Brunquell, J., Westerheide, S. D., & Bradshaw, P. C. (2015) · BMC Genetics · doi:10.1186/s12863-015-0167-2 · Cited by 218 · see citing works

Spermidine: A physiological autophagy inducer acting as an anti-aging vitamin in humans?

Madeo, F., Bauer, M. A., Carmona-Gutierrez, D., & Kroemer, G. (2019) · Autophagy · doi:10.1080/15548627.2018.1530929 · Cited by 212 · see citing works

AMPK and autophagy in glucose/glycogen metabolism

Ha, J., Guan, K., & Kim, J. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.08.002 · Cited by 211 · see citing works

D-beta-hydroxybutyrate extends lifespan in C. elegans

Edwards, C., Canfield, J., Copes, N., Rehan, M., Lipps, D., & Bradshaw, P. C. (2014) · Aging · doi:10.18632/aging.100683 · Cited by 203 · see citing works

Mechanisms of spermidine-induced autophagy and geroprotection

Hofer, S. J., Simon, A. K., Bergmann, M., Eisenberg, T., Kroemer, G., & Madeo, F. (2022) · Nature Aging · doi:10.1038/s43587-022-00322-9 · Cited by 205 · see citing works

The multifaceted regulation of mitophagy by endogenous metabolites

Zhang, T., Liu, Q., Gao, W., Sehgal, S. A., & Wu, H. (2021) · Autophagy · doi:10.1080/15548627.2021.1975914 · Cited by 207 · see citing works

Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia

Cotter, D. G., Erçal, B., Huang, X., Leid, J. M., d’Avignon, D. A., Graham, M. J., Dietzen, D. J., Brunt, E. M., Patti, G. J., & Crawford, P. A. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76388 · Cited by 199 · see citing works

Autophagy in cellular metabolism and cancer

Jiang, X., Overholtzer, M., & Thompson, C. B. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73942 · Cited by 198 · see citing works

Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways

Zhang, J., Ng, S., Wang, J., Zhou, J., Tan, S.-H., Yang, N., Lin, Q., Xia, D., & Shen, H. (2015) · Autophagy · doi:10.1080/15548627.2015.1023981 · Cited by 195 · see citing works

Regulation of nutrient recycling via autophagy

Masclaux‐Daubresse, C., Chen, Q., & Havé, M. (2017) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2017.05.001 · Cited by 191 · see citing works

Regulation of autophagy by amino acids and MTOR-dependent signal transduction

Meijer, A., Lorin, S., Blommaart, E., & Codogno, P. (2014) · Amino Acids · doi:10.1007/s00726-014-1765-4 · Cited by 175 · see citing works

Metabolites Regulate Cell Signaling and Growth via Covalent Modification of Proteins

Figlia, G., Willnow, P., & Teleman, A. A. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.036 · Cited by 184 · see citing works

Metabolic Plasticity in Chemotherapy Resistance

Desbats, M. A., Giacomini, I., Prayer‐Galetti, T., & Montopoli, M. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00281 · Cited by 180 · see citing works

Peroxisomes as cellular adaptors to metabolic and environmental stress

He, A., Dean, J. M., & Lodhi, I. J. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.02.005 · Cited by 186 · see citing works

Metabolic Signaling to the Nucleus in Cancer

Campbell, S. L., & Wellen, K. E. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.07.015 · Cited by 182 · see citing works

Autophagy as a therapeutic target in pancreatic cancer

Piffoux, M., Eriau, E., & Cassier, P. A. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01039-5 · Cited by 182 · see citing works

Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan

Bradshaw, P. (2021) · Antioxidants · doi:10.3390/antiox10040572 · Cited by 162 · see citing works

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

Carbonneau, M., M. Gagné, L., Lalonde, M.-E., Germain, M.-A., Motorina, A., Guiot, M.-C., Secco, B., Vincent, E. E., Tumber, A., Hulea, L., et al. (2016) · Nature Communications · doi:10.1038/ncomms12700 · Cited by 180 · see citing works

Therapeutic targeting of autophagy in cardiovascular disease

Schiattarella, G. G., & Hill, J. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.019 · Cited by 180 · see citing works

The Metabolic Impact on Histone Acetylation and Transcription in Ageing

Peleg, S., Feller, C., Ladurner, A. G., & Imhof, A. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.05.008 · Cited by 178 · see citing works

mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis

Wan, W., You, Z., Xu, Y., Zhou, L., Guan, Z., Peng, C., Wong, C. C. L., Su, H., Zhou, T., Xia, H., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.09.020 · Cited by 175 · see citing works

Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics and Oncogenesis—Part 1: Acetyl-CoA, Acetogenesis and Acyl-CoA Short-Chain Synthetases

Moffett, J. R., Puthillathu, N., Vengilote, R., Jaworski, D. M., & Namboodiri, A. M. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.580167 · Cited by 182 · see citing works

The many lives of KATs — detectors, integrators and modulators of the cellular environment

Sheikh, B. N., & Akhtar, A. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0072-4 · Cited by 171 · see citing works

Unsaturated fatty acids induce non‐canonical autophagy

Niso-Santano, M., Malik, S., Pietrocola, F., Pedro, J. M. B.-S., Mariño, G., Cianfanelli, V., BenYounès, A., Troncoso, R., Markaki, M., Sica, V., et al. (2015) · EMBO Journal · doi:10.15252/embj.201489363 · Cited by 170 · see citing works

SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo

Yi, X., Guo, W., Shi, Q., Yang, Y., Zhang, W., Chen, X., Kang, P., Chen, J., Cui, T., Ma, J., et al. (2019) · Theranostics · doi:10.7150/thno.30398 · Cited by 167 · see citing works

Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction

Cheng, C.-T., Qi, Y., Wang, Y.-C., Chi, K. K., Chung, Y., Ouyang, C., Chen, Y.-R., Oh, M. E., Sheng, X., Tang, Y., et al. (2018) · Communications Biology · doi:10.1038/s42003-018-0178-4 · Cited by 163 · see citing works

VPS34 Acetylation Controls Its Lipid Kinase Activity and the Initiation of Canonical and Non-canonical Autophagy

Su, H., Yang, F., Wang, Q., Shen, Q., Huang, J., Peng, C., Zhang, Y., Wan, W., Wong, C. C. L., Sun, Q., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.07.024 · Cited by 161 · see citing works

Regulation of autophagy by protein post-translational modification

Wani, W. Y., Boyer‐Guittaut, M., Dodson, M. B., Chatham, J. C., Darley-Usmar, V. M., & Zhang, J. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.131 · Cited by 156 · see citing works

Therapeutic Targeting of Autophagy

Orogo, A. M., & Gustafsson, Å. B. (2015) · Circulation Research · doi:10.1161/circresaha.116.303791 · Cited by 153 · see citing works

Glutaminolysis and autophagy in cancer

Villar, V. H., Merhi, F., Djavaheri-Mergny, M., & Durán, R. V. (2015) · Autophagy · doi:10.1080/15548627.2015.1053680 · Cited by 143 · see citing works

Mechanisms and disease implications of sirtuin-mediated autophagic regulation

Lee, I. H. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0302-7 · Cited by 147 · see citing works

Acetylation of STX17 (syntaxin 17) controls autophagosome maturation

Shen, Q., Shi, Y. P., Liu, J., Su, H., Huang, J., Zhang, Y., Peng, C., Zhou, T., Sun, Q., Wan, W., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1752471 · Cited by 143 · see citing works

Life span extension by targeting a link between metabolism and histone acetylation in Drosophila

Peleg, S., Feller, C., Forné, I., Schiller, E., Sévin, D. C., Schauer, T., Regnard, C., Straub, T., Prestel, M., Klima, C., et al. (2016) · EMBO Reports · doi:10.15252/embr.201541132 · Cited by 135 · see citing works

Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism

Ye, C., & Tu, B. P. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.06.002 · Cited by 137 · see citing works

Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

Li, M., Chiang, Y., Lyssiotis, C. A., Teater, M. R., Hong, J. Y., Shen, H., Wang, L., Hu, J., Jing, H., Chen, Z., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.05.002 · Cited by 141 · see citing works

Autophagy and Non-Alcoholic Fatty Liver Disease

Lavallard, V., & Gual, P. (2014) · BioMed Research International · doi:10.1155/2014/120179 · Cited by 133 · see citing works

Endoplasmic reticulum stress in obesity and obesity-related disorders: An expanded view

Pagliassotti, M. J., Kim, P., Estrada, A. L., Stewart, C. M., & Gentile, C. L. (2016) · Metabolism · doi:10.1016/j.metabol.2016.05.002 · Cited by 134 · see citing works

Review: Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories

Arber, C., Li, A., Houlden, H., & Wray, S. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12242 · Cited by 136 · see citing works

High‐fat diet intake modulates maternal intestinal adaptations to pregnancy and results in placental hypoxia, as well as altered fetal gut barrier proteins and immune markers

Gohir, W., Kennedy, K. M., Wallace, J. G., Saoi, M., Bellissimo, C. J., Britz‐McKibbin, P., Petrik, J., Surette, M. G., & Sloboda, D. M. (2019) · The Journal of Physiology · doi:10.1113/jp277353 · Cited by 129 · see citing works

Extracellular 4′-phosphopantetheine is a source for intracellular coenzyme A synthesis

Srinivasan, B., Baratashvili, M., van der Zwaag, M., Kanon, B., Colombelli, C., Lambrechts, R. A., Schaap, O., Nollen, E. A. A., Podgoršek, A., Kosec, G., et al. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1906 · Cited by 127 · see citing works

Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity

Pedro, J. M. B., Sica, V., Martins, I., Pol, J. G., Loos, F., Maiuri, M. C., Durand, S., Bossut, N., Aprahamian, F., Anagnostopoulos, G., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.010 · Cited by 127 · see citing works

The Pathophysiological Role of CoA

Czumaj, A., Szrok-Jurga, S., Hebanowska, A., Turyn, J., Świerczyński, J., Śledziński, T., & Stelmańska, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239057 · Cited by 126 · see citing works

Regulation of Autophagy by Acetyl Coenzime A : From the Mechanisms to a Revised Definition of Caloric Restriction Mimetics

Pietrocola, F. (2015) · theses.fr (ABES) · doi:10.70675/42d6808dzc206z4e0fzb806z29f806b2f781 · Cited by 1 · see citing works

Acetyl-coenzyme A

Schroeder, S., Pendl, T., Zimmermann, A., Eisenberg, T., Carmona‐Gutiérrez, D., Ruckenstuhl, C., Mariño, G., Pietrocola, F., Harger, A., Magnes, C., et al. (2014) · Autophagy · doi:10.4161/auto.28919 · Cited by 51 · see citing works

A metabolic master regulator of autophagy and longevity

Schroeder, S., Pendl, T., Zimmermann, A., Eisenberg, T., Carmona‐Gutiérrez, D., Ruckenstuhl, C., Mariño, G., Pietrocola, F., Harger, A., Magnes, C., et al. (2014)

Régulation de l’autophagie par l’Acétyl Coenzyme A : des mécanismes à une nouvelle définition des mimétiques de la restriction calorique

Pietrocola, F. (2015) · theses.fr (ABES)

Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan

Eisenberg, T., Schroeder, S., Andryushkova, A., Pendl, T., Küttner, V., Bhukel, A., Mariño, G., Pietrocola, F., Harger, A., Zimmermann, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.010 · Cited by 256 · see citing works