Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp
Abstract
The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p<0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug.
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Anti-inflammatory activity of heparin analogues from ascidians and marine shrimps was reported.
“Anti-inflammatory activity of heparin analogues from ascidians and marine shrimps was also reported [156,157].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [156]
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Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
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A heparin mimetic isolated from a marine shrimp suppresses neovascularization
DREYFUSS, J. L., REGATIERI, C. V., LIMA, M. A., PAREDES‐GAMERO, E. J., BRITO, A. S., CHAVANTE, S. F., BELFORT JR, R., FARAH, M. E., & NADER, H. B. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.03916.x · Cited by 38 · see citing works
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- Authors
- Brito, A. S., Arimatéia, D. S., Souza, L. R., Lima, M. A., Santos, V. O., Medeiros, V. P., Ferreira, P. A., Silva, R. A., Ferreira, C. V., Justo, G. Z., Leite, E. L., Andrade, G. P. V., Oliveira, F. W., Nader, H. B., & Chavante, S. F.
- Affiliations
- Universidade Federal do Rio Grande do Norte (BR)
- Universidade Federal de São Paulo (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Corresponding author
- Chavante, Suely F.
- ORCID
- Venue
- Bioorganic & Medicinal Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 16
- Issue
- 21
- Pages
- 9588-9595
- ISSN
- 0968-0896 (ISSN-L)
- OpenAlex
- W2003277888
- Cited by
- 77
- References
- 52
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 1 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 7 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 4
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioorganic & Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- heparin-like glycosaminoglycans, anti-inflammatory activity, anticoagulant activity, Litopenaeus vannamei, shrimp, matrix metalloproteinase inhibition, MMP-9, acute inflammation, leukocyte infiltration
- MeSH terms
- Animals, Anti-Inflammatory Agents, Anticoagulants, Endothelium, Vascular, Glycosaminoglycans, Hemorrhage, Heparin, Heparan Sulfate, Inflammation, Leukocytes, Neutrophils, Peritoneal Cavity, Rabbits, Swine, Matrix Metalloproteinase 9, Penaeidae, Rats
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