Cited by 77Proteoglycans and glycosaminoglycans researchSeaweed-derived Bioactive CompoundsPolysaccharides Composition and Applications

Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp

Brito, Adriana S., Arimatéia, Dayse S., Souza, Lucilla R., Lima, Marcelo A., Santos, Vanessa O., Medeiros, Valquíria P., Ferreira, Paula A., Silva, Rodrigo A. +7 more·2008·Bioorganic & Medicinal Chemistry

Abstract

The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p<0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug.

Integrity signals

Registry

Crossref · 10.1016/j.bmc.2008.09.020

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52 of 52 references verified0 citation errors · 0 not checkable

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Authors
Brito, A. S., Arimatéia, D. S., Souza, L. R., Lima, M. A., Santos, V. O., Medeiros, V. P., Ferreira, P. A., Silva, R. A., Ferreira, C. V., Justo, G. Z., Leite, E. L., Andrade, G. P. V., Oliveira, F. W., Nader, H. B., & Chavante, S. F.
Affiliations
  • Universidade Federal do Rio Grande do Norte (BR)
  • Universidade Federal de São Paulo (BR)
  • Universidade Estadual de Campinas (UNICAMP) (BR)
Corresponding author
Chavante, Suely F.
Venue
Bioorganic & Medicinal Chemistry
Publisher
Elsevier BV
Published
2008-11
Volume
16
Issue
21
Pages
9588-9595
ISSN
0968-0896 (ISSN-L)
OpenAlex
W2003277888
Cited by
77
References
52
Citations by year
2026: 3 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 1 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 7 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 4
FWCI
1.46
Type
journal article
Language
en
Open access
closed
Locations
  • Bioorganic & Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
  • UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
Funders
  • Fundação de Amparo à Pesquisa do Estado de São Paulo
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Keywords
heparin-like glycosaminoglycans, anti-inflammatory activity, anticoagulant activity, Litopenaeus vannamei, shrimp, matrix metalloproteinase inhibition, MMP-9, acute inflammation, leukocyte infiltration
MeSH terms
Animals, Anti-Inflammatory Agents, Anticoagulants, Endothelium, Vascular, Glycosaminoglycans, Hemorrhage, Heparin, Heparan Sulfate, Inflammation, Leukocytes, Neutrophils, Peritoneal Cavity, Rabbits, Swine, Matrix Metalloproteinase 9, Penaeidae, Rats

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