A heparin mimetic isolated from a marine shrimp suppresses neovascularization

The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975.

Leibowitz, H. M., Krueger, D. E., Maunder, L. R., Milton, R. C., KINI, M. M., Kahn, H. A., Nickerson, R. J., Pool, J., Colton, T., Ganley, J. P., et al. (1980) · PubMed · Cited by 1,250 · see citing works

Drusen and Disciform Macular Detachment and Degeneration

Gass, J. D. M. (1973) · Archives of Ophthalmology · doi:10.1001/archopht.1973.01000050208006 · Cited by 593 · see citing works

Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation

Nelson, R. M., Cecconi, O., Roberts, W., Aruffo, A. A., Linhardt, R. J., & Bevilacqua, M. P. (1993) · Blood · doi:10.1182/blood.v82.11.3253.3253 · Cited by 516 · see citing works

Syndecans

Tkachenko, E., Rhodes, J., & Simons, M. (2005) · Circulation Research · doi:10.1161/01.res.0000159708.71142.c8 · Cited by 457 · see citing works

The anti-inflammatory effects of heparin and related compounds

Young, E. (2007) · Thrombosis Research · doi:10.1016/j.thromres.2006.10.026 · Cited by 390 · see citing works

Three-Dimensional Structures of Acidic and Basic Fibroblast Growth Factors

Zhu, X., Komiya, H., Chirino, A. J., Faham, S., Fox, G. M., Arakawa, T., Hsu, B. T., & Rees, D. C. (1991) · Science · doi:10.1126/science.1702556 · Cited by 386 · see citing works

Angiogenesis: update 2005

Dvorak, H. F. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01361.x · Cited by 296 · see citing works

Three-dimensional structure of human basic fibroblast growth factor.

Sauer-Eriksson, A. E., Cousens, L. S., Weaver, L. H., & Matthews, B. W. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3441 · Cited by 284 · see citing works

VEGF121, a Vascular Endothelial Growth Factor (VEGF) Isoform Lacking Heparin Binding Ability, Requires Cell-surface Heparan Sulfates for Efficient Binding to the VEGF Receptors of Human Melanoma Cells

Cohen, T., Gitay-Goren, H., Sharon, R., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.19.11322 · Cited by 268 · see citing works

Heparan sulfate proteoglycans: structure, protein interactions and cell signaling

Dreyfuss, J. L., Regatieri, C. V., Jarrouge, T. R., Cavalheiro, R. P., Sampaio, L. O., & Nader, H. B. (2009) · Anais da Academia Brasileira de Ciências · doi:10.1590/s0001-37652009000300007 · Cited by 251 · see citing works

Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene

Drissi, H., Luc, Q., Shakoori, R., Lopes, S. M. C. D. S., Choi, J., Terry, A., Hu, M., Jones, S. N., Neil, J. C., Lian, J. B., et al. (2000) · Journal of Cellular Physiology · doi:10.1002/1097-4652(200009)184:3 · Cited by 251 · see citing works

Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta.

Zhang, J. D., Cousens, L. S., Barr, P. J., & Sprang, S. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3446 · Cited by 250 · see citing works

Heparin Regulates Vascular Endothelial Growth Factor165-dependent Mitogenic Activity, Tube Formation, and Its Receptor Phosphorylation of Human Endothelial Cells

Ashikari‐Hada, S., Habuchi, H., Kariya, Y., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414581200 · Cited by 183 · see citing works

Therapeutic monoclonal antibodies in ophthalmology

Rodrigues, E. B., Farah, M. E., Maia, M., Penha, F. M., Regatieri, C. V., Melo, G. B., Pinheiro, M. M., & Zanetti, C. R. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.11.005 · Cited by 173 · see citing works

Heparin sequences in the heparan sulfate chains of an endothelial cell proteoglycan.

Nader, H. B., Dietrich, C. P., Buonassisi, V., & Colburn, P. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.11.3565 · Cited by 163 · see citing works

The Development of Neovascularization of Senile Disciform Macular Degeneration

Teeters, V. W., & Bird, A. C. (1973) · American Journal of Ophthalmology · doi:10.1016/0002-9394(73)90002-0 · Cited by 147 · see citing works

Chemical modifications of heparin that diminish its anticoagulant but preserve its heparanase-inhibitory, angiostatic, anti-tumor and anti-metastatic properties

Lapierre, F., Holme, K. R., Lam, L. H., et al. (1996) · Glycobiology · doi:10.1093/glycob/6.3.355 · Cited by 137 · see citing works

Heparin inhibits the induction of three matrix metalloproteinases (stromelysin, 92-kD gelatinase, and collagenase) in primate arterial smooth muscle cells.

Kenagy, R. D., Nikkari, S. T., Welgus, H. G., et al. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117191 · Cited by 124 · see citing works

Structural features in heparin that interact with VEGF165 and modulate its biological activity

Ono, K. (1999) · Glycobiology · doi:10.1093/glycob/9.7.705 · Cited by 118 · see citing works

The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy

Dredge, K. S., Hammond, E., Davis, K., Li, C. P., Liu, L., Johnstone, K., Handley, P., Wimmer, N., Gonda, T. J., Gautam, A. M., et al. (2009) · Investigational New Drugs · doi:10.1007/s10637-009-9245-5 · Cited by 113 · see citing works

Variations in the Size and Sulfation of Heparin Modulate the Effect of Heparin on the Binding of VEGF165 to Its Receptors

Söker, S., Goldstaub, D., Svahn, C. M., et al. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2329 · Cited by 111 · see citing works

Heparin Derivatives as Angiogenesis Inhibitors

Presta, M., Leali, D., Stabile, H., Ronca, R., Camozzi, M., Coco, L., Moroni, E., Liekens, S., & Rusnati, M. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033391379 · Cited by 103 · see citing works

Endothelial capillary tube formation and cell proliferation induced by tumor cells are affected by low molecular weight heparins and unfractionated heparin

Marchetti, M., Vignoli, A., Russo, L., Balducci, D., Pagnoncelli, M., Barbui, T., & Falanga, A. (2007) · Thrombosis Research · doi:10.1016/j.thromres.2007.06.015 · Cited by 90 · see citing works

Endothelial Cells Provide Feedback Control for Vascular Remodeling Through a Mechanosensitive Autocrine TGF-β Signaling Pathway

Baker, A. B., Ettenson, D. S., Jonas, M., Nugent, M. A., Iozzo, R. V., & Edelman, E. R. (2008) · Circulation Research · doi:10.1161/circresaha.108.179465 · Cited by 87 · see citing works

Novel heparin degradation products. Isolation and characterization of novel disaccharides and oligosaccharides produced from heparin by bacterial degradation

Dietrich, C. P. (1968) · Biochemical Journal · doi:10.1042/bj1080647 · Cited by 82 · see citing works

Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp

Brito, A. S., Arimatéia, D. S., Souza, L. R., Lima, M. A., Santos, V. O., Medeiros, V. P., Ferreira, P. A., Silva, R. A., Ferreira, C. V., Justo, G. Z., et al. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.09.020 · Cited by 77 · see citing works

Development of targeted angiogenic medicine

Loges, S., Roncal, C., & Carmeliet, P. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.03203.x · Cited by 60 · see citing works

Neuroprotective Effect of Sulfhydryl Reduction in a Rat Optic Nerve Crush Model

Swanson, K. I., Schlieve, C. R., Lieven, C. J., & Levin, L. A. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0155 · Cited by 54 · see citing works

Inhibitory effect of locally administered heparin on leukocyte rolling and chemoattractant‐induced firm adhesion in rat mesenteric venules in vivo

Xie, X., Thorlacius, H., Raud, J., Hedqvist, P., & Lindbom, L. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701454 · Cited by 41 · see citing works

Angiogenesis assays : a critical appraisal of current techniques

Staton, C. A., Lewis, C. E., & Bicknell, R. (2006) · Cited by 38 · see citing works

Dual Role of Intravitreous Infliximab in Experimental Choroidal Neovascularization: Effect on the Expression of Sulfated Glycosaminoglycans

Regatieri, C. V., Dreyfuss, J. L., Melo, G. B., et al. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-3171 · Cited by 37 · see citing works

Urinary Glycosaminoglycans as Biomarker for Urothelial Injury: Is It Possible to Discriminate Damage From Recovery?

Soler, R., Bruschini, H., Martins, J. R. M., et al. (2008) · Urology · doi:10.1016/j.urology.2008.01.028 · Cited by 34 · see citing works

The Marine-Derived Oligosaccharide Sulfate (MdOS), a Novel Multiple Tyrosine Kinase Inhibitor, Combats Tumor Angiogenesis both In Vitro and In Vivo

Ma, J., Xin, X., Meng, L., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003774 · Cited by 32 · see citing works

Adhesion mechanisms involved in C5a-induced eosinophil homotypic aggregation

Teixeira, M. M., Rossi, A. G., & Hellewell, P. G. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.59.3.389 · Cited by 31 · see citing works

Matrix metalloproteinases in human choroidal neovascular membranes excised following verteporfin photodynamic therapy

Tatar, O., ADAM, A., Shinoda, K., Eckert, T., Scharioth, G. B., Klein, M., Yoeruek, E., Bartz-Schmidt, K. U., & Grisanti, S. (2007) · British Journal of Ophthalmology · doi:10.1136/bjo.2007.114769 · Cited by 29 · see citing works

Preparation of Basement Membrane Components from <scp>EHS</scp> Tumors

Kleinman, H. K. (1998) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb1002s00 · Cited by 24 · see citing works

Differences in the expression of glycosaminoglycans in human fibroblasts derived from gingival overgrowths is related to TGF-beta up-regulation

Dreyfuss, J. L., Veiga, S. S., Coulson‐Thomas, V. J., Santos, I. A., Toma, L., Coletta, R. D., & Nader, H. B. (2009) · Growth Factors · doi:10.3109/08977190903321819 · Cited by 19 · see citing works

Distinct heparin binding sites on VEGF165 and its receptors revealed by their interaction with a non sulfated glycoaminoglycan (NaPaC)

Benedetto, M. D., Starzec, A. B., Vassy, R., et al. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.01.015 · Cited by 17 · see citing works

Long-term effects for acute phase myocardial infarct VEGF165gene transfer cardiac extracellular matrix remodeling

Mataveli, F. D., Han, S. W., Nader, H. B., et al. (2009) · Growth Factors · doi:10.1080/08977190802574765 · Cited by 15 · see citing works

A method for rapid quantitation and preparation of antithrombin III-high-affinity heparin fractions

Takahashi, H. K., Nader, H. B., & Dietrich, C. P. (1981) · Analytical Biochemistry · doi:10.1016/0003-2697(81)90388-2 · Cited by 13 · see citing works

Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects

Fedorov, S., Ermakova, S., Zvyagintseva, T., & Stonik, V. (2013) · Marine Drugs · doi:10.3390/md11124876 · Cited by 189 · see citing works

Angiogenin in age-related macular degeneration.

Skeie, J. M., Zeng, S., Faidley, E. A., & Mullins, R. F. (2011) · PubMed Central · Cited by 21 · see citing works

Introduction: understanding the role of angiogenesis and antiangiogenic agents in age-related macular degeneration

Bressler, S. B. (2009) · Ophthalmology · doi:10.1016/j.ophtha.2009.06.045 · Cited by 205 · see citing works

[Celastrol in the inhibition of neovascularization].

Huang, Y., Zhou, Y.-X., Zhou, D., Xu, Q.-N., Ye, M., Sun, C., & Du, Z. (2003) · PubMed · Cited by 6 · see citing works

FGF-2-mediated FGFR1 signaling in human microvascular endothelial cells is activated by vaccarin to promote angiogenesis

Sun, H., Cai, W., Gong, L.-L., Wang, X., Zhu, X., Wan, M.-Y., Wang, P.-Y., & Qiu, L.-Y. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.08.059 · Cited by 48 · see citing works

The Experimental Study of Neovascularization Induced by Macrophage Migration Inhibitory Factor

Shi, C. (2006) · Chinese Journal of Arteriosclerosis