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Discovery and development of the anticancer agent salinosporamide A (NPI-0052)
Open accessAbstract
The discovery of the anticancer agent salinosporamide A (NPI-0052) resulted from the exploration of new marine environments and a commitment to the potential of the ocean to yield new natural products for drug discovery and development. Driving the success of this process was the linkage of academic research together with the ability and commitment of industry to undertake drug development and provide the resources and expertise to advance the entry of salinosporamide A (NPI-0052) into human clinical trials. This paper offers a chronicle of the important events that facilitated the rapid clinical development of this exciting molecule.
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Self-citation
Metadata
- Authors
- Fenical, W., Jensen, P. R., Palladino, M. A., Lam, K. S., Lloyd, G. K., & Potts, B. C.
- Affiliations
- Scripps Institution of Oceanography (US)
- Corresponding author
- Potts, Barbara C.
- Venue
- Bioorganic & Medicinal Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 17
- Issue
- 6
- Pages
- 2175-2180
- ISSN
- 0968-0896 (ISSN-L)
- PMC
- PMC2814440
- OpenAlex
- W2016098671
- Cited by
- 291
- References
- 48
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 13 · 2023: 10 · 2022: 12 · 2021: 11 · 2020: 14 · 2019: 8 · 2018: 12 · 2017: 10 · 2016: 21 · 2015: 22 · 2014: 30 · 2013: 24 · 2012: 29
- FWCI
- 14.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Bioorganic & Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA44848, R01CA044848, R37CA044848)
- Topics
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Physical Sciences › Chemistry › Organic Chemistry › Isoquinoline Alkaloid Synthesis
- Keywords
- salinosporamide A, NPI-0052, anticancer agents, marine natural products, drug discovery, drug development, clinical trials, university-industry collaboration, marine environment
- MeSH terms
- Antineoplastic Agents, Lactones, Pyrroles, Molecular Structure, Drugs, Investigational, Drug Discovery
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