Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus Salinospora
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Strong and selective cytotoxicity toward a variety of cancer cell lines is shown by salinosporamide A (1), which was isolated from the culture extract of a unique marine actinomycete belonging to the recently discovered genus Salinospora.
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Salinosporamide A is in phase I clinical trials.
“Salinosporamide A, a novel long-lasting proteasome inhibitor isolated from a marine bacterium Salinispora tropica [230] in phase I clinical trials, has more efficacy against a wider range of hematologic malignancies and many solid tumor models, and less cytotoxicity to normal cells (Figure 8) [101].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [230]
The paper’s results section reports in vitro cancer-cell cytotoxicity and proteasome inhibition, but does not address clinical-trial status. Searches for “phase I clinical trials” and clinical development found no passage stating that salinosporamide A was in a phase I trial. Page numbers were not available in our copy. (LLM, conf=0.75)
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Cites
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Zheng, L., Li, Y., Wu, D., Xiao, H., Zheng, S., Wang, G., & Sun, Q. (2023) · MedComm – Oncology · doi:10.1002/mog2.56 · Cited by 71 · see citing works
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- Authors
- Feling, R. H., Buchanan, G. O., Mincer, T. J., Kauffman, C. A., Jensen, P. R., & Fenical, W.
- Affiliations
- Scripps Institution of Oceanography (US)
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2003-01-20
- Volume
- 42
- Issue
- 3
- Pages
- 355-357
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2171513236
- Cited by
- 1,057
- References
- 10
- Citations by year
- 2026: 22 · 2025: 42 · 2024: 27 · 2023: 44 · 2022: 38 · 2021: 42 · 2020: 56 · 2019: 51 · 2018: 43 · 2017: 43 · 2016: 38 · 2015: 59 · 2014: 62 · 2013: 62 · 2012: 59
- FWCI
- 17.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (CA44848)
- University of California, San Diego
- National Cancer Institute (CA44848)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- salinosporamide A, proteasome inhibitors, cytotoxicity, marine bacteria, natural product isolation, anticancer agents, marine natural products
- MeSH terms
- Actinomycetales, Adenocarcinoma, Colonic Neoplasms, Cysteine Endopeptidases, Humans, Lactones, Models, Molecular, Multienzyme Complexes, Magnetic Resonance Spectroscopy, Protease Inhibitors, Pyrroles, Tumor Cells, Cultured, Molecular Structure, Crystallography, X-Ray, Inhibitory Concentration 50, Proteasome Endopeptidase Complex
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