Discovery and development of the anticancer agent salinosporamide A (NPI-0052)

THE UBIQUITIN SYSTEM

Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840

Bioactive Microbial Metabolites: A Personal View

Bérdy, J. (2005) · The Journal of Antibiotics · doi:10.1038/ja.2005.1 · Cited by 3,170

A Phase 2 Study of Bortezomib in Relapsed, Refractory Myeloma

Richardson, P. G., Barlogie, B., Berenson, J., Singhal, S., Jagannath, S., Irwin, D., Rajkumar, S. V., Srkalovic, G., Alsina, M., Alexanian, R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030288 · Cited by 2,632

Structure of 20S proteasome from yeast at 2.4Å resolution

Groll, M., Ditzel, L., Löwe, J., Stock, D., Bochtler, M., Bartunik, H. D., & Huber, R. (1997) · Nature · doi:10.1038/386463a0 · Cited by 2,265

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

Fenteany, G., Standaert, R. F., Lane, W. S., Choi, S., Corey, E. J., & Schreiber, S. L. (1995) · Science · doi:10.1126/science.7732382 · Cited by 1,583

Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

Löwe, J., Stock, D., Jap, B. K., Zwickl, P., Baumeister, W. P., & Huber, R. (1995) · Science · doi:10.1126/science.7725097 · Cited by 1,540

Proteasome inhibitors: from research tools to drug candidates

Kisselev, A. F., & Goldberg, A. L. (2001) · Chemistry & Biology · doi:10.1016/s1074-5521(01)00056-4 · Cited by 1,209

Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus Salinospora

Feling, R. H., Buchanan, G. O., Mincer, T. J., Kauffman, C. A., Jensen, P. R., & Fenical, W. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200390115 · Cited by 1,057

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

Chauhan, D., Catley, L., Li, G., Podar, K., Hideshima, T., Velankar, M., Mitsiades, C., Mitsiades, N., Yasui, H., Letai, A., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.013 · Cited by 694

Marine natural products

Faulkner, D. J. (1990) · Natural Product Reports · doi:10.1039/np9900700269 · Cited by 4,880

Taxonomy, Physiology, and Natural Products of Actinobacteria

Barka, E. A., Vatsa, P., Sanchez, L., Vaillant‐Gaveau, N., Jacquard, C., Klenk, H., Clément, C., Ouhdouch, Y., & van Wezel, G. P. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00019-15 · Cited by 2,363

Drug development from marine natural products

Molinski, T. F., Dalisay, D. S., Lievens, S. C., & Saludes, J. P. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2487 · Cited by 1,226

Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives

Chen, D., Frezza, M., Schmitt, S. M., Kanwar, J., & Dou, Q. P. (2011) · Current Cancer Drug Targets · doi:10.2174/156800911794519752 · Cited by 810

The odyssey of marine pharmaceuticals: a current pipeline perspective

Mayer, A. M. S., Glaser, K. B., Cuevas, C., Jacobs, R. S., Kem, W. R., Little, R. D., McIntosh, J. M., Newman, D. J., Potts, B. C. M., & Shuster, D. E. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.02.005 · Cited by 669

Marine Natural Products: A Source of Novel Anticancer Drugs

Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555

Biologically active γ-lactams: synthesis and natural sources

Caruano, J., Muccioli, G. G., & Robiette, R. (2016) · Organic & Biomolecular Chemistry · doi:10.1039/c6ob01349j · Cited by 442

Marine Natural Products: A New Wave of Drugs?

Montaser, R., & Luesch, H. (2011) · Future Medicinal Chemistry · doi:10.4155/fmc.11.118 · Cited by 457

Pharmaceutically active secondary metabolites of marine actinobacteria

Manivasagan, P., Venkatesan, J., Kannan, S., & Kim, S. (2013) · Microbiological Research · doi:10.1016/j.micres.2013.07.014 · Cited by 426

Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective

Kumar, A., Singh, A. K., Singh, H., Vijayan, V., Kumar, D., Naik, J., Thareja, S., Yadav, J. P., Pathak, P., Grishina, M., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16020299 · Cited by 391

A guide to successful bioprospecting: informed by actinobacterial systematics

Goodfellow, M., & Fiedler, H. (2010) · Antonie van Leeuwenhoek · doi:10.1007/s10482-010-9460-2 · Cited by 356

Co-Cultivation—A Powerful Emerging Tool for Enhancing the Chemical Diversity of Microorganisms

Marmann, A., Aly, A., Lin, W., Wang, B., & Proksch, P. (2014) · Marine Drugs · doi:10.3390/md12021043 · Cited by 355

Bio-mining the microbial treasures of the ocean: New natural products

Imhoff, J. F., Labes, A., & Wiese, J. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.03.001 · Cited by 355

Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora

Ziemert, N., Lechner, A., Wietz, M., Millán‐Aguiñaga, N., Chavarría, K. L., & Jensen, P. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1324161111 · Cited by 279

Cnidarians as a Source of New Marine Bioactive Compounds—An Overview of the Last Decade and Future Steps for Bioprospecting

Rocha, J., Peixe, L. M. S. V., Gomes, N. C. M., & Calado, R. (2011) · Marine Drugs · doi:10.3390/md9101860 · Cited by 284

Marine-sourced anti-cancer and cancer pain control agents in clinical and late preclinical development

Newman, D., & Cragg, G. (2014) · Marine Drugs · doi:10.3390/md12010255 · Cited by 250

Marizomib, a Proteasome Inhibitor for All Seasons: Preclinical Profile and a Framework for Clinical Trials

Potts, B. C. M., Albitar, M. X., Anderson, K. C., Baritaki, S., Berkers, C. R., Bonavida, B., Chandra, J., Chauhan, D., Cusack, J. C., Fenical, W., et al. (2011) · Current Cancer Drug Targets · doi:10.2174/156800911794519716 · Cited by 247

Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics

Gulder, T. A. M., & Moore, B. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201000728 · Cited by 256

Marine-Derived Pharmaceuticals - Challenges and Opportunities

Lindequist, U. (2016) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2016.181 · Cited by 248

The Essentials of Marine Biotechnology

Rotter, A., Barbier, M., Bertoni, F., Bones, A. M., Cancela, M. L., Carlsson, J., Carvalho, M. F., Cegłowska, M., Martorell, J. C., Dalay, M. C., et al. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.629629 · Cited by 239

Actinobacteria in natural products research: Progress and prospects

Jose, P. A., Maharshi, A., & Jha, B. (2021) · Microbiological Research · doi:10.1016/j.micres.2021.126708 · Cited by 223

The shikimate pathway: gateway to metabolic diversity

Shende, V. V., Bauman, K. D., & Moore, B. S. (2024) · Natural Product Reports · doi:10.1039/d3np00037k · Cited by 224

Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria

Penn, K., Jenkins, C., Nett, M., Udwary, D., Gontang, E. A., McGlinchey, R. P., Foster, B., Lapidus, A. L., Podell, S. B., Allen, E. E., et al. (2009) · The ISME Journal · doi:10.1038/ismej.2009.58 · Cited by 203

Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses

Gao, S., Naowarojna, N., Cheng, R., Liu, X., & Liu, P. (2018) · Natural Product Reports · doi:10.1039/c7np00067g · Cited by 203

Molecular Networking and Pattern-Based Genome Mining Improves Discovery of Biosynthetic Gene Clusters and their Products from Salinispora Species

Duncan, K., Crüsemann, M., Lechner, A., Sarkar, A., Li, J., Ziemert, N., Wang, M., Bandeira, N., Moore, B. S., Dorrestein, P. C., et al. (2015) · Chemistry & Biology · doi:10.1016/j.chembiol.2015.03.010 · Cited by 200

Genome mining methods to discover bioactive natural products

Bauman, K. D., Butler, K. S., Moore, B. S., & Chekan, J. R. (2021) · Natural Product Reports · doi:10.1039/d1np00032b · Cited by 201

The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery

Jensen, P. R., Moore, B. S., & Fenical, W. (2015) · Natural Product Reports · doi:10.1039/c4np00167b · Cited by 186

Mangrove rare actinobacteria: taxonomy, natural compound, and discovery of bioactivity

Azman, A. S., Othman, I., Velu, S. S., Chan, K., & Lee, L. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00856 · Cited by 181

Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction

Baritaki, S., Chapman, A. M., Yeung, K. C., Spandidos, D. A., Palladino, M. A., & Bonavida, B. (2009) · Oncogene · doi:10.1038/onc.2009.214 · Cited by 168

Drugs and Drug Candidates from Marine Sources: An Assessment of the Current “State of Play”

Newman, D. M., & Cragg, G. M. L. (2016) · Planta Medica · doi:10.1055/s-0042-101353 · Cited by 165

Highlights of marine invertebrate-derived biosynthetic products: Their biomedical potential and possible production by microbial associants

Radjasa, O. K., Vaske, Y. S. M., Navarro, G., Vervoort, H. C., Tenney, K., Linington, R. G., & Crews, P. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.07.017 · Cited by 143

“Recycling” Classical Drugs for Malaria

Teixeira, C. A. S., Vale, N., Pérez, B. C., Gomes, A., Gomes, J. R. B., & Gomes, P. A. C. (2014) · Chemical Reviews · doi:10.1021/cr500123g · Cited by 139

Chasing the treasures of the sea — bacterial marine natural products

Gulder, T. A. M., & Moore, B. S. (2009) · Current Opinion in Microbiology · doi:10.1016/j.mib.2009.05.002 · Cited by 137

A renaissance in marine pharmacology: From preclinical curiosity to clinical reality

Glaser, K. B., & Mayer, A. M. S. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.04.015 · Cited by 134

microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data

Zuffa, S., Schmid, R., Bauermeister, A., Gomes, P. W. P., Caraballo‐Rodríguez, A. M., Abiead, Y. E., Aron, A. T., Gentry, E. C., Zemlin, J., Meehan, M. J., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-023-01575-9 · Cited by 137

Production of Induced Secondary Metabolites by a Co-Culture of Sponge-Associated Actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163

Dashti, Y., Grkovic, T., Abdelmohsen, U. R., Hentschel, U., & Quinn, R. J. (2014) · Marine Drugs · doi:10.3390/md12053046 · Cited by 128

Proteasome Inhibitors: Recent Advances and New Perspectives In Medicinal Chemistry

Génin, E., Reboud‐Ravaux, M., & Vidal, J. (2010) · Current Topics in Medicinal Chemistry · doi:10.2174/156802610790725515 · Cited by 124

Anticolon Cancer Activity of Largazole, a Marine-Derived Tunable Histone Deacetylase Inhibitor

Liu, Y., Salvador, L. A., Byeon, S., Ying, Y., Kwan, J. C., Law, B. K., Hong, J., & Luesch, H. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.172387 · Cited by 124

The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges

Tundo, G. R., Sbardella, D., Santoro, A. M., Coletta, A., Oddone, F., Grasso, G., Milardi, D., Lacal, P. M., Marini, S., Purrello, R., et al. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107579 · Cited by 120

The role of Snail in prostate cancer

Smith, B., & Odero-Marah, V. (2012) · Cell Adhesion & Migration · doi:10.4161/cam.21687 · Cited by 112

Nickel(0)-Catalyzed [2 + 2 + 1] Carbonylative Cycloaddition of Imines and Alkynes or Norbornene Leading to γ-Lactams

Hoshimoto, Y., Ohata, T., Sasaoka, Y., Ohashi, M., & Ogoshi, S. (2014) · Journal of the American Chemical Society · doi:10.1021/ja509171a · Cited by 112

Bioprospecting microbial natural product libraries from the marine environment for drug discovery

Liu, X., Ashforth, E. J., Ren, B., Song, F., Dai, H., Liu, M., Wang, J., Xie, Q., & Zhang, L. (2010) · The Journal of Antibiotics · doi:10.1038/ja.2010.56 · Cited by 108

Secondary metabolite gene expression and interplay of bacterial functions in a tropical freshwater cyanobacterial bloom

Penn, K., Wang, J., Fernando, S. C., & Thompson, J. R. (2014) · The ISME Journal · doi:10.1038/ismej.2014.27 · Cited by 107

Molecules to Ecosystems: Actinomycete Natural Products In situ

Behie, S. W., Bonet, B., Zacharia, V. M., McClung, D. J., & Traxler, M. F. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02149 · Cited by 105

Ohmyungsamycins A and B: Cytotoxic and Antimicrobial Cyclic Peptides Produced by Streptomyces sp. from a Volcanic Island

Um, S., Choi, T. J., Kim, H., Kim, B., Kim, S.-H., Lee, S. K., Oh, K., Shin, J., & Oh, D. (2013) · The Journal of Organic Chemistry · doi:10.1021/jo401974g · Cited by 104

Actinobacteria of the Extremobiosphere

Bull, A. T. (2010) · Springer eBooks · doi:10.1007/978-4-431-53898-1_58 · Cited by 106

The cave microbiome as a source for drug discovery: Reality or pipe dream?

Ghosh, S. B., Kuisienė, N., & Cheeptham, N. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.11.018 · Cited by 108

Rare taxa and dark microbial matter: novel bioactive actinobacteria abound in Atacama Desert soils

Goodfellow, M., Nouioui, I., Sanderson, R., Xie, F., & Bull, A. T. (2018) · Antonie van Leeuwenhoek · doi:10.1007/s10482-018-1088-7 · Cited by 109

Sponge-Derived Kocuria and Micrococcus spp. as Sources of the New Thiazolyl Peptide Antibiotic Kocurin

Palomo, S., González, I., de la Cruz, M., Martı́n, J., Tormo, J. R., Anderson, M. A., Hill, R. T., Vicente, F., Reyes, F., & Genilloud, O. (2013) · Marine Drugs · doi:10.3390/md11041071 · Cited by 103

Bacteria as a treasure house of secondary metabolites with anticancer potential

Mohan, C. D., Rangappa, S., Nayak, S. C., Jadimurthy, R., Wang, L., Sethi, G., Garg, M., & Rangappa, K. S. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.006 · Cited by 104

Pivotal Roles of Snail Inhibition and RKIP Induction by the Proteasome Inhibitor NPI-0052 in Tumor Cell Chemoimmunosensitization

Baritaki, S., Yeung, K. C., Palladino, M. A., Berenson, J. R., & Bonavida, B. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1069 · Cited by 99

Marine-Derived Anticancer Agents: Clinical Benefits, Innovative Mechanisms, and New Targets

Pereira, R. B., Evdokimov, N. M., Lefranc, F., Valentão, P., Kornienko, A., Pereira, D. M., Andrade, P. B., & Gomes, N. G. M. (2019) · Marine Drugs · doi:10.3390/md17060329 · Cited by 100

Impact of novel microbial secondary metabolites on the pharma industry

Ramírez-Rendón, D., Passari, A. K., Ruiz‐Villafán, B., Rodrı́guez-Sanoja, R., Sánchez, S., & Demain, A. L. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-11821-5 · Cited by 98

Bioinspired Total Synthesis and Human Proteasome Inhibitory Activity of (−)-Salinosporamide A, (−)-Homosalinosporamide A, and Derivatives Obtained via Organonucleophile Promoted Bis-cyclizations

Nguyen, H. H., Ma, G., Gladysheva, T. B., Fremgen, T., & Romo, D. (2010) · The Journal of Organic Chemistry · doi:10.1021/jo101638r · Cited by 88

α,β-Unsaturated Carbonyl System of Chalcone-Based Derivatives Is Responsible for Broad Inhibition of Proteasomal Activity and Preferential Killing of Human Papilloma Virus (HPV) Positive Cervical Cancer Cells

Bazzaro, M., Anchoori, R. K., Mudiam, M. K. R., Issaenko, O. A., Kumar, S. K., Karanam, B., Lin, Z., Vogel, R. I., Gavioli, R., Destro, F., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100589p · Cited by 87

New trends in synthetic drugs and natural products targeting 20S proteasomes in cancers

Atta, H., Alzahaby, N., Hamdy, N. Μ., Emam, S. H., Sonousi, A. S. M., & Ziko, L. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106427 · Cited by 85

Anticancer Agents from Diverse Natural Sources

Khazir, J., Riley, D. L., Pilcher, L. A., De-Maayer, P., & Mir, B. A. (2014) · Natural Product Communications · doi:10.1177/1934578x1400901130 · Cited by 81

Recently Discovered Naturally Occurring Heterocyclic Organohalogen Compounds

Gribble, G. W. (2011) · Heterocycles · doi:10.3987/rev-11-sr(p)5 · Cited by 82

Challenges and triumphs to genomics-based natural product discovery

Jensen, P. R., Chavarría, K. L., Fenical, W., Moore, B. S., & Ziemert, N. (2013) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-013-1353-8 · Cited by 80

Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment

Beesoo, R., Neergheen, V. S., Bhagooli, R., & Bahorun, T. (2014) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2014.03.005 · Cited by 78

Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor

Tsukamoto, S., Yamanokuchi, R., Yoshitomi, M., Sato, K., Ikeda, T., Rotinsulu, H., Mangindaan, R. E. P., de Voogd, N. J., van Soest, R. W. M., & Yokosawa, H. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.04.029 · Cited by 77

Replacement of bortezomib with carfilzomib for multiple myeloma patients progressing from bortezomib combination therapy

Berenson, J. R., Hilger, J. D., Yellin, O., Dichmann, R., Patel‐Donnelly, D., Boccia, R. V., Bessudo, A., Stampleman, L. V., Gravenor, D. S., Eshaghian, S., et al. (2014) · Leukemia · doi:10.1038/leu.2014.27 · Cited by 78

Marine Sediment-Derived Streptomyces Bacteria from British Columbia, Canada Are a Promising Microbiota Resource for the Discovery of Antimicrobial Natural Products

Dalisay, D. S., Williams, D. E., Wang, X. L., Centko, R. M., Chen, J., & Andersen, R. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077078 · Cited by 79

Nitropyrrolins A−E, Cytotoxic Farnesyl-α-nitropyrroles from a Marine-Derived Bacterium within the Actinomycete Family Streptomycetaceae

Kwon, H. C., Espindola, A. P. D. M., Park, J.-S., Prieto‐Davó, A., Rose, M., Jensen, P. R., & Fenical, W. (2010) · Journal of Natural Products · doi:10.1021/np1006229 · Cited by 76

Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

Lawrence, H. R., Kazi, A., Luo, Y., Kendig, R. D., Ge, Y., Jain, S., Daniel, K. G., Santiago, D. N., Guida, W. C., & Sebti, S. M. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.06.038 · Cited by 76

Phase I Clinical Trial of Marizomib (NPI-0052) in Patients with Advanced Malignancies Including Multiple Myeloma: Study NPI-0052-102 Final Results

Harrison, S. J., Mainwaring, P. N., Price, T. J., Millward, M., Padrik, P., Underhill, C. R., Cannell, P., Reich, S. D., Trikha, M., & Spencer, A. G. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2616 · Cited by 76

Highlights of marine natural products having parallel scaffolds found from marine-derived bacteria, sponges, and tunicates

McCauley, E. P., Piña, I. C., Thompson, A. D., Bashir, K., Weinberg, M., Kurz, S. L., & Crews, P. (2020) · The Journal of Antibiotics · doi:10.1038/s41429-020-0330-5 · Cited by 79

New orally active proteasome inhibitors in multiple myeloma

Allegra, A., Alonci, A., Gerace, D., Russo, S., Innao, V., Calabrò, L., & Musolino, C. (2014) · Leukemia Research · doi:10.1016/j.leukres.2013.10.018 · Cited by 74

Microbial synthesis and transformation of inorganic and organic chlorine compounds

Atashgahi, S., Liebensteiner, M. G., Janssen, D. B., Smidt, H., Stams, A. J. M., & Sipkema, D. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03079 · Cited by 64

High-Throughput Screening of Natural Products for Cancer Therapy

Harvey, A. R., & Cree, I. A. (2010) · Planta Medica · doi:10.1055/s-0030-1250162 · Cited by 73

A1,3-strain enabled retention of chirality during bis-cyclization of β-ketoamides: total synthesis of (−)-salinosporamide A and (−)-homosalinosporamide A

Nguyen, H., Ma, G., & Romo, D. (2010) · Chemical Communications · doi:10.1039/c0cc00607f · Cited by 72

The Discovery of Salinosporamide K from the Marine Bacterium “Salinispora pacifica” by Genome Mining Gives Insight into Pathway Evolution

Eustáquio, A. S., Nam, S., Penn, K., Lechner, A., Wilson, M. C., Fenical, W., Jensen, P. R., & Moore, B. S. (2010) · ChemBioChem · doi:10.1002/cbic.201000564 · Cited by 72

Recent advances in the Overman rearrangement: synthesis of natural products and valuable compounds

Fernandes, R. A., Kattanguru, P., Gholap, S. P., & Chaudhari, D. A. (2017) · Organic & Biomolecular Chemistry · doi:10.1039/c6ob02625g · Cited by 67

Advances toward the Synthesis of Functionalized γ-Lactams

Rivas, F., & Ling, T. (2016) · Organic Preparations and Procedures International · doi:10.1080/00304948.2016.1165059 · Cited by 67

Enantioselective Synthesis of Pyroglutamic Acid Esters from Glycinate via Carbonyl Catalysis

Ma, J., Zhou, Q., Song, G., Song, Y., Zhao, G., Ding, K., & Zhao, B. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202017306 · Cited by 66

A metabolomics guided exploration of marine natural product chemical space

Floros, D. J., Jensen, P. R., Dorrestein, P. C., & Koyama, N. (2016) · Metabolomics · doi:10.1007/s11306-016-1087-5 · Cited by 68

New Perspectives on Innovative Drug Discovery: An Overview

Pan, S. Y., Pan, S. L., Yu, Z., Ma, D., Chen, S., Fong, W. F., Han, Y., & Ko, K. (2010) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j39w2g · Cited by 65

Generating a Generation of Proteasome Inhibitors: From Microbial Fermentation to Total Synthesis of Salinosporamide A (Marizomib) and Other Salinosporamides

Potts, B. C. M., & Lam, K. S. (2010) · Marine Drugs · doi:10.3390/md8040835 · Cited by 64

Bahamaolides A and B, Antifungal Polyene Polyol Macrolides from the Marine Actinomycete Streptomyces sp.

Kim, D.-G., Moon, K., Kim, S.-H., Park, S.-H., Park, S., Lee, S. K., Oh, K., Shin, J., & Oh, D. (2012) · Journal of Natural Products · doi:10.1021/np3001915 · Cited by 63

β-Lactams as promising anticancer agents: Molecular hybrids, structure activity relationships and potential targets

Fu, D., Zhang, Y., Chang, A., & Li, J. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112510 · Cited by 63

Exploiting nature's rich source of proteasome inhibitors as starting points in drug development

Graewert, M. A., & Groll, M. (2011) · Chemical Communications · doi:10.1039/c1cc15273d · Cited by 62

Linking species concepts to natural product discovery in the post-genomic era

Jensen, P. R. (2009) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-009-0683-z · Cited by 60

Mangrove-Associated Fungi: A Novel Source of Potential Anticancer Compounds

Deshmukh, S. K., Gupta, M., Prakash, V., & Reddy, M. S. (2018) · Journal of Fungi · doi:10.3390/jof4030101 · Cited by 55

Concise Formal Synthesis of (−)-Salinosporamide A (Marizomib) Using a Regio- and Stereoselective Epoxidation and Reductive Oxirane Ring-Opening Strategy

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Evolution of Secondary Metabolite Genes in Three Closely Related Marine Actinomycete Species

Freel, K. C., Nam, S., Fenical, W., & Jensen, P. R. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.05943-11 · Cited by 54

Marine Microbial Secondary Metabolites

Giordano, D., Coppola, D., Russo, R., Denaro, R., Giuliano, L., Lauro, F. M., di Prisco, G., & Verde, C. (2015) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2015.04.001 · Cited by 57

Mining the Cinnabaramide Biosynthetic Pathway to Generate Novel Proteasome Inhibitors

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Marizomib irreversibly inhibits proteasome to overcome compensatory hyperactivation in multiple myeloma and solid tumour patients

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Rhodolith beds in Brazil: a new potential habitat for marine bioprospection

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Probing the Specificity and Activity Profiles of the Proteasome Inhibitors Bortezomib and Delanzomib

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Novel Proteasome Inhibitors and Histone Deacetylase Inhibitors: Progress in Myeloma Therapeutics

Chhabra, S. (2017) · Pharmaceuticals · doi:10.3390/ph10020040 · Cited by 52

Identification of a fluorometabolite from Streptomyces sp. MA37: (2R3S4S)-5-fluoro-2,3,4-trihydroxypentanoic acid

Ma, L., Bartholomé, A., Tong, M. H., Qin, Z., Yu, Y., Shepherd, T., Kyeremeh, K., Deng, H., & O’Hagan, D. (2014) · Chemical Science · doi:10.1039/c4sc03540b · Cited by 51

Chiral N‐Heterocyclic Carbene‐Catalyzed Asymmetric Michael–Intramolecular Aldol‐Lactonization Cascade for Enantioselective Construction of β‐Propiolactone‐Fused Spiro[cyclopentane‐oxindoles]

Zhang, J., Li, N., Yin, S., Sun, B., Fan, W., & Wang, X. (2017) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201601259 · Cited by 51

Total Synthesis of (−)-Salinosporamide A

Satoh, N., Yokoshima, S., & Fukuyama, T. (2011) · Organic Letters · doi:10.1021/ol200886j · Cited by 50

The variable hydroxamic acid siderophore metabolome of the marine actinomycete Salinispora tropica CNB-440

Ejje, N., Soe, C. Z., Gu, J., & Codd, R. (2013) · Metallomics · doi:10.1039/c3mt00230f · Cited by 49

Salinispora pacifica sp. nov., an actinomycete from marine sediments

Ahmed, L., Jensen, P. R., Freel, K. C., Brown, R., Jones, A. L., Kim, B., & Goodfellow, M. (2013) · Antonie van Leeuwenhoek · doi:10.1007/s10482-013-9886-4 · Cited by 48

Natural product mode of action (MOA) studies: a link between natural and synthetic worlds

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Marine-Derived Anticancer Agents Targeting Apoptotic Pathways: Exploring the Depths for Novel Cancer Therapies

Dalisay, D. S., Tenebro, C. P., Sabido, E. M., Suarez, A. F. L., Paderog, M. J. V., Reyes-Salarda, R., & Saludes, J. P. (2024) · Marine Drugs · doi:10.3390/md22030114 · Cited by 53

Unique Actinomycetes from Marine Caves and Coral Reef Sediments Provide Novel PKS and NRPS Biosynthetic Gene Clusters

Hodges, T. W., Slattery, M., & Olson, J. B. (2011) · Marine Biotechnology · doi:10.1007/s10126-011-9410-7 · Cited by 47

New Pim-1 Kinase Inhibitor From the Co-culture of Two Sponge-Associated Actinomycetes

El‐Hawary, S. S., Sayed, A. M., Mohammed, R. A., Khanfar, M. A., Rateb, M. E., Mohammed, T. A.-A. A., Hajjar, D., Hassan, H. M., Gulder, T. A. M., & Abdelmohsen, U. R. (2018) · Frontiers in Chemistry · doi:10.3389/fchem.2018.00538 · Cited by 47

From Natural Product to Clinical Trials: NPI-0052 (Salinosporamide A), a Marine Actinomycete-Derived Anticancer Agent

Lam, K. S., Lloyd, G. K., Neuteboom, S., Palladino, M. A., Sethna, K. M., Spear, M. A., & Potts, B. C. M. (2009) · Royal Society of Chemistry eBooks · doi:10.1039/9781847559890-00355 · Cited by 11

Marine Microbes as a source of Antimicrobial Compounds

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Marine-derived pipeline anticancer natural products: a review of their pharmacotherapeutic potential and molecular mechanisms

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Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Macherla, V. R., Mitchell, S. S., Manam, R. R., Reed, K. A., Chao, T., Nicholson, B., Deyanat‐Yazdi, G., Mai, B., Jensen, P. R., Fenical, W., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm048995+ · Cited by 235

The marine tropical environment's potential for the discovery of bioactive chemical entities

Arias, G. S. (2008) · OpenGrey (Institut de l'Information Scientifique et Technique)