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Gramicidin D enhances the antibacterial activity of fluoride
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A wild-type E. coli strain was employed in which a fluoride-sensing riboswitch from Pseudomonas syringae controls the expression of a lacZ reporter gene in a fluoride concentration-dependent manner.
“Specifically, we employed a previously described wild-type (WT) E. coli strain in which a fluoride-sensing riboswitch from Pseudomonas syringae controls the expression of a lacZ reporter gene in a fluoride concentration-dependent manner (Baker et al., 2012; Nelson et al., 2014).”
From Small Molecule Fluoride Toxicity Agonists (2015) · cites this paper as Nelson et al., 2014
Some previously characterized pore-forming antibacterial and antifungal compounds have been demonstrated to enhance the cytotoxic activity of fluoride.
“This speculation is supported by the fact that some previously characterized pore-forming antibacterial and antifungal compounds have been demonstrated to enhance the cytotoxic activity of fluoride (Li and Breaker, 2012; Nelson et al., 2014; Zasloff and Steinberg, 1993).”
From Small Molecule Fluoride Toxicity Agonists (2015) · cites this paper as Nelson et al., 2014
Existing molecules only modestly increase fluoride toxicity.
“However, these existing molecules only modestly increase fluoride toxicity, and no non-peptidic molecules have been identified that increase fluoride toxicity towards bacteria.”
From Small Molecule Fluoride Toxicity Agonists (2015) · cites this paper as Nelson et al., 2014
There is precedence for compounds that disrupt membrane integrity to enhance fluoride toxicity.
“There is precedence for compounds that disrupt membrane integrity to enhance fluoride toxicity (Li and Breaker, 2012; Nelson et al., 2014; Zasloff and Steinberg, 1993).”
From Small Molecule Fluoride Toxicity Agonists (2015) · cites this paper as Nelson et al., 2014
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Research works printed but not linked: 22
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Cited by
Sorted by citations
Bacterial fluoride resistance, Fluc channels, and the weak acid accumulation effect
Ji, C., Stockbridge, R. B., & Miller, C. (2014) · Journal of General Physiology · doi:10.1085/jgp.201411243 · Cited by 97
Membrane exporters of fluoride ion
McIlwain, B. C., Ruprecht, M. T., & Stockbridge, R. B. (2021) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-071520-112507 · Cited by 69
Small Molecule Fluoride Toxicity Agonists
Nelson, J. W., Plummer, M. S., Blount, K. F., Ames, T. D., & Breaker, R. R. (2015) · Chemistry & Biology · doi:10.1016/j.chembiol.2015.03.016 · Cited by 30
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Metadata
- Authors
- Nelson, J. W., Zhou, Z., & Breaker, R. R.
- Venue
- Bioorganic & Medicinal Chemistry Letters
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 24
- Issue
- 13
- Pages
- 2969-2971
- ISSN
- 0960-894X
- PMC
- PMC4048840
- Cited by
- 15
- References
- 0
- Language
- en
- Funders
- National Institutes of Health (5R01DE022340)
- Howard Hughes Medical Institute
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