Cited by 359Endometriosis Research and TreatmentUterine Myomas and TreatmentsGynecological conditions and treatments

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Pathology and physiopathology of adenomyosis

Bergeron, Christine, Amant, Frederic, Ferenczy, Alex·2006·Best Practice & Research Clinical Obstetrics & Gynaecology

DOI 10.1016/j.bpobgyn.2006.01.016

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Abstract

Adenomyosis is defined by the presence of endometrial mucosa within the myometrium. This probably occurs by invagination of the basalis endometrium into the myometrium. The process of invagination and intramyometrial spreading may be facilitated by the non-cyclic, anti-apoptotic activity of the basalis associated with relative hyper-oestrogenic states. Most cases of adenomyosis are discovered in multiparous women during the 'transitional' years (40-50 years), and the condition is associated with menorrhagia, dysmenorrhoea, endometrial polyps and leiomyomata uteri. Endometrioid adenocarcinoma is often associated with adenomyosis, is frequently of early stage and low histological grade, is hormone-sensitive, and has an excellent prognosis. Extension of malignant growth into foci of adenomyosis has no adverse effect on prognosis. Definite diagnosis and treatment of adenomyosis are obtained by hysterectomy. Although adenomyotic endometrial glands are hormone-sensitive, exogenous progestogenic agents are ineffective for the treatment of adenomyosis. Anti-oestrogenic danazol and gonadotrophin-releasing hormone (GnRH) analogues induce suppression of adenomyosis, but their use must be of short duration. Surgical extirpation, therefore, is the best therapeutic option.

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Lewinski, 1931, Beitrag zur Frage der adenomiosis, Zentralblatt fur Gynakologie, 55, 2163

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Physiology of the Endometrium and Regulation of Menstruation
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“Invasion from the endometrium According to the current theory, adenomyosis develops through downgrowth and invagination of the endometrium basalis into the myometrium through an altered or absent junctional zone (JZ) (Bergeron et al., 2006; Parrott et al., 2001).”
Adenomyosis: A Clinical Review of a Challenging Gynecologic Condition
Struble, J., Reid, S., & Bedaiwy, M. A. (2015) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2015.09.018 · Cited by 323

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Authors: Bergeron, C., Amant, F., & Ferenczy, A.
Affiliations: Processus d'Activation Sélective par Transfert d'Énergie Uni-électronique ou Radiatif (FR)
Jewish General Hospital (CA)
Corresponding author: Bergeron, Christine
ORCID: Bergeron, Christine
Venue: Best Practice & Research Clinical Obstetrics & Gynaecology
Publisher: Elsevier BV
Published: 2006-08
Volume: 20
Issue: 4
Pages: 511-521
ISSN: 1521-6934 (ISSN-L)
DOI: 10.1016/j.bpobgyn.2006.01.016
OpenAlex: W2038354928
Cited by: 359
References: 54
Citations by year: 2026: 13 · 2025: 16 · 2024: 19 · 2023: 33 · 2022: 25 · 2021: 36 · 2020: 35 · 2019: 26 · 2018: 19 · 2017: 20 · 2016: 19 · 2015: 27 · 2014: 18 · 2013: 10 · 2012: 11
FWCI: 0.59
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Best Practice & Research Clinical Obstetrics & Gynaecology (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords: adenomyosis, anti-apoptotic effects, hyperoestrogenism, menorrhagia, dysmenorrhea, endometrial polyps, uterine fibroids, endometrioid carcinoma, hysterectomy, danazol, GnRH analogues, progestogens, surgical treatment
MeSH terms: Adult, Danazol, Endometrial Hyperplasia, Endometriosis, Estrogen Antagonists, Female, Humans, Hysterectomy, Leiomyoma, Gonadotropin-Releasing Hormone, Middle Aged, Polyps, Uterine Diseases, Uterine Neoplasms, Endometrial Neoplasms, Carcinoma, Endometrioid

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Pathology and physiopathology of adenomyosis

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