The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Pathology and physiopathology of adenomyosis
Abstract
Adenomyosis is defined by the presence of endometrial mucosa within the myometrium. This probably occurs by invagination of the basalis endometrium into the myometrium. The process of invagination and intramyometrial spreading may be facilitated by the non-cyclic, anti-apoptotic activity of the basalis associated with relative hyper-oestrogenic states. Most cases of adenomyosis are discovered in multiparous women during the 'transitional' years (40-50 years), and the condition is associated with menorrhagia, dysmenorrhoea, endometrial polyps and leiomyomata uteri. Endometrioid adenocarcinoma is often associated with adenomyosis, is frequently of early stage and low histological grade, is hormone-sensitive, and has an excellent prognosis. Extension of malignant growth into foci of adenomyosis has no adverse effect on prognosis. Definite diagnosis and treatment of adenomyosis are obtained by hysterectomy. Although adenomyotic endometrial glands are hormone-sensitive, exogenous progestogenic agents are ineffective for the treatment of adenomyosis. Anti-oestrogenic danazol and gonadotrophin-releasing hormone (GnRH) analogues induce suppression of adenomyosis, but their use must be of short duration. Surgical extirpation, therefore, is the best therapeutic option.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Adenomyosis, defined as the presence of endometrial glands and stroma infiltrated deep and haphazardly into the myometrium [1], is a common gynecologic disorder with poorly understood pathogenesis and pathophysiology [2,3,4].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [2]
Citations
Cites
Amant, F. C., Moerman, P., Neven, P., Timmerman, D., Limbergen, E. V., & Vergote, I. B. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67063-8 · Cited by 1,639
The elusive adenomyosis of the uterus—revisited
Bird, C. C., McElin, T. W., & Manalo-Estrella, P. (1972) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(72)90781-8 · Cited by 531
Pathophysiology of adenomyosis
Ferenczy, A. S. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.4.312 · Cited by 512
Bazot, M., Cortez, A., Daraï, É., Rouger, J., Chopier, J., Antoine, J.-M., & Uzan, S. (2001) · Human Reproduction · doi:10.1093/humrep/16.11.2427 · Cited by 501
Azziz, R. (1989) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(21)00148-0 · Cited by 316
Cytokeratins of normal epithelia and some neoplasms of the female genital tract.
Moll, R., Levy, R., Czernobilsky, B., Hohlweg-Majert, P., Dallenbach-Hellweg, G., & Franke, W. W. (1983) · PubMed · Cited by 229
Adenomyosis: symptoms, histology, and pregnancy terminations
Levgur, M. (2000) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(99)00659-6 · Cited by 209
Uterine adenomyosis in the infertility clinic
Devlieger, R. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg010 · Cited by 206
Cyclic bcl-2 gene expression in human uterine endometrium during menstrual cycle
OTSUKI, P. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91051-0 · Cited by 187
Confirmation of the preoperative diagnoses for hysterectomy
Lee, N. C., Dicker, R. C., RUBIN, G. L., & Ory, H. W. (1984) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(84)90366-1 · Cited by 172
Research works printed but not linked: 1
- Lewinski, 1931, Beitrag zur Frage der adenomiosis, Zentralblatt fur Gynakologie, 55, 2163
Cited by
Sorted by citations
Physiology of the Endometrium and Regulation of Menstruation
Critchley, H., Maybin, J. A., Armstrong, G. M., & Williams, A. R. W. (2020) · Physiological Reviews · doi:10.1152/physrev.00031.2019 · Cited by 582
Diagnosing adenomyosis: an integrated clinical and imaging approach
Chapron, C., Vannuccini, S., Santulli, P., Abrão, M. S., Carmona, F., Fraser, I. S., Gordts, S., Guo, S., Just, P., Noël, J., et al. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmz049 · Cited by 439
Pathogenesis of uterine adenomyosis, invagination or metaplasia?
García-Solares, J., Donnez, J., Donnez, O., & Dolmans, M.-M. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.12.030 · Cited by 339
Pathogenesis of adenomyosis, an update on molecular mechanisms
Vannuccini, S., Tosti, C., Carmona, F., Huang, S. J., Chapron, C., Guo, S.-W., & Petraglia, F. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.06.016 · Cited by 326
“Invasion from the endometrium According to the current theory, adenomyosis develops through downgrowth and invagination of the endometrium basalis into the myometrium through an altered or absent junctional zone (JZ) (Bergeron et al., 2006; Parrott et al., 2001).”
Adenomyosis: A Clinical Review of a Challenging Gynecologic Condition
Struble, J., Reid, S., & Bedaiwy, M. A. (2015) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2015.09.018 · Cited by 323
Four subtypes of adenomyosis assessed by magnetic resonance imaging and their specification
Kishi, Y., Suginami, H., 蔵盛, 理., Yabuta, M., Suginami, R., & Taniguchi, F. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.06.027 · Cited by 301
Adenomyosis: Mechanisms and Pathogenesis
Zhai, J., Vannuccini, S., Petraglia, F., & Giudice, L. C. (2020) · Seminars in Reproductive Medicine · doi:10.1055/s-0040-1716687 · Cited by 331
Chapron, C., Tosti, C., Marcellin, L., Bourdon, M., Lafay-Pillet, M.-C., Millischer, A.-E., Streuli, I., Borghese, B., Petraglia, F., & Santulli, P. (2017) · Human Reproduction · doi:10.1093/humrep/dex088 · Cited by 294
The Impact of Adenomyosis on Women's Fertility
Harada, T., Khine, Y. M., Kaponis, A. I., Nikellis, T., Decavalas, G., & Taniguchi, F. (2016) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000346 · Cited by 258
Uterus-sparing operative treatment for adenomyosis
Grimbizis, G., Mikos, T., & Tarlatzis, B. C. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.10.025 · Cited by 224
Uterine adenomyosis and adenomyoma: the surgical approach
Osada, H. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.01.032 · Cited by 219
Adenomyosis: Review of the Literature
Garcia, L., & Isaacson, K. (2011) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2011.04.004 · Cited by 203
Adenomyosis pathogenesis: insights from next-generation sequencing
Bulun, S. E., Yıldız, Ş., Adli, M., & Wei, J. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmab017 · Cited by 216
“Treatments that diminish ovarian production of estradiol, such as GnRH analogs and aromatase inhibitors, suppress adenomyosis whereas tamoxifen, which acts as an estradiol agonist in the uterus, aggravates adenomyosis (Ugwumadu et al., 1993; Cohen et al., 1995; Bergeron et al., 2006; Kimura et al., 2007).”
BackgroundLiu, X., Shen, M., Qi, Q., Zhang, H., & Guo, S.-W. (2016) · Human Reproduction · doi:10.1093/humrep/dew018 · Cited by 190
“Treatment of adenomyosis is challenging, with hysterectomy being the treatment of choice (Bergeron et al., 2006).”
BackgroundTransvaginal Ultrasound for the Diagnosis of Adenomyosis: Systematic Review and Meta-Analysis
Andres, M. P., Borrelli, G. M., Ribeiro, J., Baracat, E. C., Abrão, M. S., & Kho, R. M. (2017) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2017.08.653 · Cited by 187
Immunological changes associated with adenomyosis: a systematic review
Bourdon, M., Santulli, P., Jeljeli, M. M., Vannuccini, S., Marcellin, L., Doridot, L., Petraglia, F., Batteux, F., & Chapron, C. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa038 · Cited by 195
The Pathogenesis of Adenomyosis vis-à-vis Endometriosis
Guo, S.-W. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020485 · Cited by 165
Campo, S., Campo, V., & Benagiano, G. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2011.10.003 · Cited by 158
“Bergeron et al. (2006) mention three pathogenetic theories formulated to explain the formation of adenomyosis: the first two involve an origin from the invagination of the deepest portion (basalis) of the endometrium between bundles of smooth muscle fibre of the myometrium or along the intramyometrial lymphatic system.”
BackgroundHarmsen, M. J., Wong, C. F. C., Mijatovic, V., Griffioen, A. W., Groenman, F. A., Hehenkamp, W. J. K., & Huirne, J. A. F. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz024 · Cited by 146
“Adenomyosis is a common gynecological disorder, predominantly occurring in premenopausal women (Bergeron, 2006; Cohen et al., 1995).”
BackgroundPark, C. W., Choi, M. H., Yang, K. M., & Song, I. O. (2016) · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · doi:10.5653/cerm.2016.43.3.169 · Cited by 137
“Adenomyosis is histologically defined as the presence of ectopic endometrial islets deep in the myometrium surrounded by a reactive hypertrophic myometrium [8].”
BackgroundExacoustós, C., Morosetti, G., Conway, F., Camilli, S., Martire, F. G., Lazzeri, L., Piccione, E., & Zupi, E. (2019) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2019.09.788 · Cited by 135
Guo, S.-W., Mao, X., Ma, Q., & Liu, X. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.08.038 · Cited by 131
“1 / JANUARY 2013 A denomyosis is a common gynecologic disorder with a poorly understood pathogenesis (1).”
BackgroundShen, M., Liu, X., Zhang, H., & Guo, S.-W. (2015) · Human Reproduction · doi:10.1093/humrep/dev314 · Cited by 124
Nie, J., Liu, X., & Guo, S. (2010) · Reproductive Sciences · doi:10.1177/1933719110377118 · Cited by 120
“Adenomyosis is a common, benign, gynecological condition characterized by the invasion of endometrial glands and stromal deep and haphazardly into the myometrium and has a poorly understood pathogenesis.(1) The presenting symptoms include a soft and diffusely enlarged uterus with menorrhagia, dysmenorrhea, and subfert…”
BackgroundInfluentialConservative Surgery for Adenomyosis and Results: A Systematic Review
Younes, G., & Tulandi, T. (2017) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2017.07.014 · Cited by 116
“Adenomyosis is a common benign disorder characterized by ectopic endometrial glands 45 and stroma within the myometrium (1-4).”
BackgroundAdenomyosis: An update regarding its diagnosis and clinical features
Bourdon, M., Santulli, P., Marcellin, L., Maignien, C., Maitrot‐Mantelet, L., Bordonné, C., Plu‐Bureau, G., & Chapron, C. (2021) · Journal of Gynecology Obstetrics and Human Reproduction · doi:10.1016/j.jogoh.2021.102228 · Cited by 119
Association between ultrasound features of adenomyosis and severity of menstrual pain
Naftalin, J., Hoo, W., Nunes, N., Holland, T., Mavrelos, D., & Jurkovic, D. (2015) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.15798 · Cited by 113
Clinical profiles of 710 premenopausal women with adenomyosis who underwent hysterectomy
Li, X., Liu, X., & Guo, S. (2013) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12211 · Cited by 104
“Adenomyosis, characterized by the presence of endometrial glands and stroma deep within the myometrium, is a fairly common gynecologic disorder with a poorly understood pathogenesis.(1) Its presenting symptoms in women with symptomatic adenomyosis include menorrhagia, dysmenorrhea, and subfertility.”
BackgroundThe Role of Hysteroscopy in the Diagnosis and Treatment of Adenomyosis
Sardo, A. D. S., Calagna, G., Santangelo, F., Zizolfi, B., Tanos, V., Perino, A., & Wilde, R. L. D. (2017) · BioMed Research International · doi:10.1155/2017/2518396 · Cited by 102
“The exact mechanisms of how adenomyosis develops are still unknown, but the current trend in thought is that adenomyosis or adenomyoma originate from the deep part of the endometrium that invaginates between the bundles of smooth muscle fibers of the myometrium itself, mainly after uterine traumatic events [5, 6].”
BackgroundPathophysiology of Heavy Menstrual Bleeding
Hapangama, D. K., & Bulmer, J. N. (2015) · Women s Health · doi:10.2217/whe.15.81 · Cited by 108
Adenomyosis and Infertility—Review of Medical and Surgical Approaches
Szubert, M., Koziróg, E., Olszak, O., Krygier-Kurz, K., Kaźmierczak, J., & Wilczyński, J. R. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18031235 · Cited by 99
“, is an invasion of the basal endometrium into the myometrium through an altered or absent JZ (junctional zone—the area representing the internal myometrium) [9].”
BackgroundEffective ablation therapy of adenomyosis with ultrasound‐guided high‐intensity focused ultrasound
Zhang, X., Li, K., Xie, B., He, M., He, J., & Zhang, L. (2013) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2013.08.022 · Cited by 97
“Adenomyosis is a common benign disease among women of reproductive age [1,2].”
BackgroundHigh-intensity focused ultrasound (HIFU) for adenomyosis: Two-year follow-up results
Shui, L., Mao, S., Wu, Q., Huang, G., Wang, J., Zhang, R., Li, K., He, J., & Zhang, L. (2015) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2015.05.024 · Cited by 95
Diagnostic findings in adenomyosis: a pictorial review on the major concerns.
Graziano, A., Monte, G. L., Piva, I., Caserta, D., Kärner, M., Engl, B., & Marci, R. (2015) · PubMed · Cited by 87
A pilot study on the off-label use of valproic acid to treat adenomyosis
Liu, X., & Guo, S. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.11.009 · Cited by 87
Campo, S., Campo, V., & Benagiano, G. (2011) · Obstetrics and Gynecology International · doi:10.1155/2012/786132 · Cited by 83
“Two separate pathogenetic theories have been advanced to explain its formation: an origin from the invagination of the deepest portion of the endometrial mucosa between bundles of smooth muscle fibres of the myometrium, or along the intramyometrial lymphatic system; a metaplastic process initiating from ectopic intram…”
BackgroundImmunoreactivity of progesterone receptor isoform B, nuclear factor κB, and IκBα in adenomyosis
Nie, J., Lü, Y., Liu, X., & Guo, S. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.01.084 · Cited by 82
“Treatment of adenomyosis has been a challenge, with hysterectomy being the treatment of choice (1).”
BackgroundMedical treatment for adenomyosis and/or adenomyoma
Tsui, K., Lee, W.-L., Chen, C.-Y., Sheu, B., Yen, M., Chang, T., & Wang, P. (2014) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2014.04.024 · Cited by 78
A Lifelong Impact on Endometriosis: Pathophysiology and Pharmacological Treatment
Chen, L.-H., Lo, W.-C., Huang, H.-Y., & Wu, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087503 · Cited by 94
“Endometriosis of uterus is characterized by a junctional zone disease, resulting from altered endometrial basalis cells invading the uterine myometrium through disruption of the endometrial-myometrial interface (EMI), subsequently establishing ectopic endometriotic lesions [21,22].”
BackgroundNie, J., Liu, X., & Guo, S. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.11.035 · Cited by 77
Dessouky, R., Gamil, S. A., Nada, M. G., Mousa, R., & Libda, Y. I. (2019) · Insights into Imaging · doi:10.1186/s13244-019-0732-8 · Cited by 76
An update on the pharmacological management of adenomyosis
Streuli, I., Dubuisson, J. B., Santulli, P., de Ziegler, D., Batteux, F., & Chapron, C. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.953055 · Cited by 75
“Histologically, adenomyosis is defined as the ectopic presence of endometrial islets deep in the myometrium surrounded by reactive hypertrophic myometrium [1].”
BackgroundLi, B., Chen, M., Liu, X., & Guo, S. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.04.028 · Cited by 78
Transvaginal Elastosonography as an Imaging Technique for Diagnosing Adenomyosis
Liu, X., Ding, D., Ren, Y., & Guo, S. (2018) · Reproductive Sciences · doi:10.1177/1933719117750752 · Cited by 78
Pathogenesis of Human Adenomyosis: Current Understanding and Its Association with Infertility
Khan, K. N., Fujishita, A., & Mori, T. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11144057 · Cited by 77
“Two fundamental differences between endometriosis and adenomyosis are thought to be the origin of endometrium (functionalis or basalis) and anatomic site of the lesions (outside or inside of the uterus, respectively) [1,2].”
BackgroundInfluentialKhan, K. N., Fujishita, A., Koshiba, A., Kuroboshi, H., Mori, T., Ogi, H., Itoh, K., Nakashima, M., & Kitawaki, J. (2019) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2019.03.210 · Cited by 71
Khan, K. N., Kitajima, M., Hiraki, K., Fujishita, A., Nakashima, M., & Masuzaki, H. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.124891 · Cited by 68
Liu, X., Nie, J., & Guo, S. (2010) · Human Reproduction · doi:10.1093/humrep/deq311 · Cited by 68
“Although the disease is hormonesensitive (Kitawaki, 2006), progestogenic agents are not very effective, and gonadotropin-releasing hormone (GnRH) agonists induce suppression of adenomyosis yet their use is restricted by short duration (Bergeron et al., 2006).”
BackgroundInfluentialComplications and outcomes of pregnant women with adenomyosis in Japan
Tamura, H., Kishi, H., Kitade, M., Asai‐Sato, M., Tanaka, A., Murakami, T., Minegishi, T., & Sugino, N. (2017) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12050 · Cited by 69
Tellum, T., Matic, G. V., Dormagen, J. B., Nygaard, S., Viktil, E., Qvigstad, E., & Lieng, M. (2019) · European Radiology · doi:10.1007/s00330-019-06308-3 · Cited by 69
Valproic Acid as a Therapy for Adenomyosis: A Comparative Case Series
Liu, X., Yuan, L., & Guo, S. (2010) · Reproductive Sciences · doi:10.1177/1933719110373807 · Cited by 67
“Although the disease is hormone-sensitive, progestogenic agents are not very effective, and gonadotropin-releasing hormone (GnRH) agonists induce suppression of adenomyosis, yet their use is restricted by short duration.(2) In addition, the symptoms quickly reappear after discontinuation of GnRH agonists therapy.”
BackgroundMao, X., Wang, Y., Carter, A. V., Zhen, X., & Guo, S. (2011) · Reproductive Sciences · doi:10.1177/1933719111404610 · Cited by 63
“Adenomyosis is a common gynecologic disorder with a poorly understood pathogenesis.(1) The presenting symptoms include a soft and diffusely enlarged uterus, menorrhagia, dysmenorrhea, and subfertility,(2) with dysmenorrhea being the second most prevalent symptom after menorrhagia, and arguably the most debilitating.”
BackgroundMesenchymal Tumors of the Uterus
Zaloudek, C. J., Hendrickson, M. R., & Soslow, R. A. (2010) · Springer eBooks · doi:10.1007/978-1-4419-0489-8_10 · Cited by 59
Yen, C., Huang, S.-T. J., Lee, C., Wang, H., & Liao, S. (2017) · Reproductive Sciences · doi:10.1177/1933719117691141 · Cited by 57
“Locally increased aromatase and estrogen sulphatase activities in adenomyosis(31,60,61) can induce estrogen production and make a relatively high estrogen concentrations, which are necessary for the development and maintenance of the ectopic growth of endometrial tissue.(2,32,60,61) Estrogen-associated epithelial–mese…”
BackgroundDecreased expression of NR4A nuclear receptors in adenomyosis impairs endometrial decidualization
Jiang, Y., Jiang, R., Cheng, X., Zhang, Q., Hu, Y., Zhang, H., Cao, Y., Zhang, M., Wang, J., Ding, L., et al. (2016) · Molecular Human Reproduction · doi:10.1093/molehr/gaw042 · Cited by 53
“Uterine adenomyosis is a pathological condition characterized by the presence of endometrial glands and stroma within the myometrium (Bergeron et al., 2006).”
BackgroundValproic acid alleviates generalized hyperalgesia in mice with induced adenomyosis
Liu, X., & Guo, S. (2011) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2011.01655.x · Cited by 52
“Defined as the presence of heterotopic endometrial glands and stroma in the myometrium, adenomyosis is a common gynecological disorder with a poorly understood pathogenesis.(1) The presenting symptoms include a soft and diffusely enlarged uterus, dysmenorrhea, abnormal uterine bleeding, and subfertility,(2) with dysme…”
BackgroundHormonal treatments for adenomyosis
Fedele, L., Bianchi, S., & Frontino, G. (2007) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2007.07.006 · Cited by 50
Tsui, K.-H., Lee, F.-K., Seow, K., Chang, W.-C., Wang, J.-W., Chen, S., Chao, H., Yen, M.-S., & Wang, P. (2015) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2015.05.003 · Cited by 49
Molecular characterization of human adenomyosis
Hevér, A., Roth, R. B., Hevezi, P. A., Lee, J., Willhite, D., White, E. C., Marin, E. M., Herrera, R. M. B., Acosta, H., Acosta, A. J., et al. (2006) · Molecular Human Reproduction · doi:10.1093/molehr/gal076 · Cited by 49
“It is also known that about 50% of adenomyosis patients have co-existing uterine fibroid(s) (Bergeron et al., 2006), and this may also have an effect on the gene expression results.”
BackgroundFocal adenomyosis of the outer myometrium and deep infiltrating endometriosis severity
Marcellin, L., Santulli, P., Bourdon, M., Maignien, C., Campin, L., Lafay-Pillet, M.-C., Millischer, A., Bordonné, C., Borghese, B., Dousset, B. E., et al. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.05.003 · Cited by 53
Implantation Failure in Endometriosis Patients: Etiopathogenesis
Boucher, A., Brichant, G., Gridelet, V., Nisolle, M., Ravet, S., Timmermans, M., & Henry, L. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11185366 · Cited by 46
“The invasion of the myometrium by endometrial tissue through an altered or absent JZ and positive feedback via TIAR (tissue injuries and repair) mechanism was often proposed [65,66], as well as the de novo theory, involving endometrial tissue development from embryonic mullerian remnants or adult stem cells present in…”
BackgroundFeng, Y., Hu, L., Chen, W., Zhang, R., Wang, X., & Chen, J. (2016) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2016.11.022 · Cited by 46
Yang, Z., Cao, Y., Hu, L., & Wang, Z. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.03.017 · Cited by 46
Prevalence of adenomyosis in endometrial cancer patients: a systematic review and meta-analysis
Raffone, A., Seracchioli, R., Raimondo, D., Maletta, M., Travaglino, A., Raimondo, I., Giaquinto, I., Orsini, B., Insabato, L., Pellicano, M., et al. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05840-8 · Cited by 44
“First, the hyper-estrogenic state favors the spread into the myometrium of adenomyosis and, similarly, can promote endometrial cell proliferation and the development of estrogen-related endometrial cancer [2, 14].”
BackgroundStreuli, I., Santulli, P., Chouzenoux, S., Chapron, C., & Batteux, F. (2015) · Reproductive Sciences · doi:10.1177/1933719115589410 · Cited by 43
“According to the most widely accepted theory, ectopic endometrial implants originate from the basal layer of the endometrium with an invagination of endometrial cells between smooth muscle cell bundles or along lymphatic vessels.(1) Metaplasia of Müllerian remnants within the myometrium has also been suggested.”
BackgroundAdenomyosis: What the Patient Needs
Alabiso, G., ALIO, L., Arena, S., di Prun, A. B., Bergamini, V., Berlanda, N., Busacca, M., Candiani, M., Centini, G., Cello, A. D., et al. (2016) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2015.12.017 · Cited by 43
Valentini, A. L., Speca, S., Gui, B., Soglia, B. G., Miccò, M., & Bonomo, L. (2011) · La radiologia medica · doi:10.1007/s11547-011-0714-5 · Cited by 43
An update on uterine artery embolization for uterine leiomyomata and adenomyosis of the uterus
Kröncke, T. J. (2022) · British Journal of Radiology · doi:10.1259/bjr.20220121 · Cited by 43
The Asian Society of Endometriosis and Adenomyosis guidelines for managing adenomyosis
Harada, T., Taniguchi, F., Guo, S., Choi, Y. M., Biberoglu, K. O., Tsai, S. S., Alborzi, S., Al‐Jefout, M., Chalermchockcharoenkit, A., Sison-Aguilar, A. G., et al. (2023) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12535 · Cited by 44
Adenomyosis and accompanying gynecological pathologies
Genç, M., Genç, B., & Cengiz, H. (2014) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-014-3498-8 · Cited by 44
“All specimens were reviewed by the same two pathologists, and adenomyosis was diagnosed based on histological characteristics [8].”
MethodQuestion Mark Sign and Transvaginal Ultrasound Uterine Tenderness for the Diagnosis of Adenomyosis
Zannoni, L., Ambrosio, M., Raimondo, D., Arena, A., Forno, S. D., Borghese, G., Paradisi, R., & Seracchioli, R. (2020) · Journal of Ultrasound in Medicine · doi:10.1002/jum.15237 · Cited by 42
“Another strength was the comparison between US and the histologic examination, which is considered the reference standard for the diagnosis of adenomyosis.(5) It is noteworthy that all endometriotic nodules that were suspected by TVUS were confirmed histologically.”
BackgroundMethodFroeling, V., Scheurig‐Muenkler, C., Hamm, B., & Kröncke, T. J. (2011) · CardioVascular and Interventional Radiology · doi:10.1007/s00270-011-0254-3 · Cited by 42
Tan, J., Yong, P. J., & Bedaiwy, M. A. (2019) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000555 · Cited by 42
“Gonadotropin-releasing hormone antagonists Gonadotropin-releasing hormone (GnRH)-antagonists such as elagolix competitively bind to GnRH receptors and prevent activation by endogenous GnRH activity, and unlike GnRH analogues [22], permit modulation of the degree of estradiol suppression [73].”
BackgroundAberrant Immunoreactivity of Deoxyribonucleic Acid Methyltransferases in Adenomyosis
Liu, X., & Guo, S. (2012) · Gynecologic and Obstetric Investigation · doi:10.1159/000337718 · Cited by 41
Elevated Immunoreactivity against Class I Histone Deacetylases in Adenomyosis
Liu, X., Nie, J., & Guo, S. (2012) · Gynecologic and Obstetric Investigation · doi:10.1159/000336409 · Cited by 41
Uterine-sparing surgery for adenomyosis and/or adenomyoma
Horng, H., Chen, C.-H., Chen, C.-Y., Tsui, K.-H., Liu, W., Wang, P., Chang, W.-H., Huang, B., Sun, H., Chang, T.-C., et al. (2014) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2014.01.001 · Cited by 40
“5 mm deep in the myometrium or more than one microscopic field at 10 magnification from the endometriumemyometrium junction [5].”
BackgroundStephens, V. R., Rumph, J. T., Ameli, S., Bruner‐Tran, K. L., & Osteen, K. G. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.807685 · Cited by 42
“One theory hypothesizes that adenomyosis emerges from the invagination of the basalis region of the endometrial mucosa into the myometrium as a result of disturbances to the endometrial junctional zone, a steroid-dependent region situated between the endometrium and myometrium (Brosens et al., 1995; Bergeron et al., 2…”
BackgroundThe Multifaceted Role of Autophagy in Endometrium Homeostasis and Disease
Popli, P., Sun, A. J., & Kommagani, R. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00587-2 · Cited by 46
Clinical outcomes of infertility treatment for women with adenomyosis in Japan
Tamura, H., Kishi, H., Kitade, M., Asai‐Sato, M., Tanaka, A., Murakami, T., Minegishi, T., & Sugino, N. (2017) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12036 · Cited by 41
Hao, M., Liu, X., & Guo, S. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.07.023 · Cited by 40
“Despite its prevalence, it is often regarded as an enigmatic disease with poorly understood pathogenesis and pathophysiology (Bergeron et al., 2006; Garcia-Solares et al., 2018; Vannuccini et al., 2017; Vannuccini et al., 2019).”
BackgroundMeenakshi, M., & McCluggage, W. G. (2010) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e3181b7018d · Cited by 39
“The mechanisms underlying the development of adenomyosis are poorly understood (7,8).”
BackgroundAdenomyosis and Adolescence: A Challenging Diagnosis and Complex Management
Martire, F. G., d’Abate, C., Schettini, G., Cimino, G., Ginetti, A., Colombi, I., Cannoni, A., Centini, G., Zupi, E., & Lazzeri, L. (2024) · Diagnostics · doi:10.3390/diagnostics14212344 · Cited by 38
Expression of GRIM-19 in adenomyosis and its possible role in pathogenesis
Wang, J., Deng, X., Yang, Y., Yang, X., Kong, B., & Lan, C. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.12.019 · Cited by 40
Accuracy of findings in the diagnosis of uterine adenomyosis on ultrasound
Sam, M., Raubenheimer, M., Manolea, F., Aguilar, H. N., Mathew, R. P., Patel, V. H., & Low, G. (2019) · Abdominal Radiology · doi:10.1007/s00261-019-02231-9 · Cited by 37
The prevalence of adenomyosis in an infertile population: a cross-sectional study
Hashim, H. A., Elaraby, S., Foda, A. A., & Rakhawy, M. E. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.02.011 · Cited by 37
Adenomyosis and infertility: the role of the junctional zone
Barbanti, C., Centini, G., Lazzeri, L., Habib, N., Labanca, L., Zupi, E., Afors, K., & Starace, A. C. (2021) · Gynecological Endocrinology · doi:10.1080/09513590.2021.1878131 · Cited by 38
“In adenomyosis it is possible to detect an increased intrauterine pressure, suggesting common biochemical pathways between both diseases [56,57].”
BackgroundSenturk, L. M., & İmamoğlu, M. (2015) · Women s Health · doi:10.2217/whe.15.60 · Cited by 37
Influences of Uterine Adenomyosis on Muscle Invasion and Prognosis of Endometrioid Adenocarcinoma
Taneichi, A., Fujiwara, H., Takahashi, Y., Takei, Y., 町田, 静., Saga, Y., Takahashi, S., & Suzuki, M. (2014) · International Journal of Gynecological Cancer · doi:10.1097/igc.0000000000000243 · Cited by 35
“On the other hand, incidences of uterine adenomyosis are also on the rise and similar to type I endometrial cancer, which is an estrogen-dependent disease.(8) Postoperative pathological examinations of endometrial cancer patients frequently reveal the coexistence of uterine adenomyosis.”
BackgroundInfluentialThe disturbance of TH17-Treg cell balance in adenomyosis
Gui, T., Chen, C., Zhang, Z., Tang, W., Qian, R., Ma, X., Cao, P., & Wan, G. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.10.050 · Cited by 36
The impact of adenomyosis on IVF outcomes: a prospective cohort study
Higgins, C., Fernandes, H., Costa, F. D. S., Martins, W. P., Vollenhoven, B. J., & Healey, M. (2021) · Human Reproduction Open · doi:10.1093/hropen/hoab015 · Cited by 35
“While there are no internationally agreed diagnostic criteria for adenomyosis on either ultrasound or MRI (Kunz et al., 2005; Bergeron et al., 2006; Benagiano et al., 2009; Wang et al., 2009; Maheshwari et al., 2012; Chapron et al., 2020), the Morphological Uterus Sonographic Assessment (MUSA)…”
BackgroundOccurrence of chronic endometritis in different types of human adenomyosis
Khan, K. N., Fujishita, A., Ogawa, K., Koshiba, A., Mori, T., Itoh, K., Nakashima, M., & Kitawaki, J. (2021) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12421 · Cited by 34
Laparoscopic excision of uterine adenomyomas
Grimbizis, G., Mikos, T., Zepiridis, L. I., Theodoridis, T., Miliaras, D., Tarlatzis, B. C., & Bontis, J. N. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.04.063 · Cited by 35
Pharmacological Treatment for Symptomatic Adenomyosis: A Systematic Review
Benetti‐Pinto, C. L., de Mira, T. A. A., Yela, D. A., Juliato, C. R. T., & Brito, L. G. O. (2019) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.1055/s-0039-1695737 · Cited by 34
Role of Hormones in Common Benign Uterine Lesions: Endometrial Polyps, Leiomyomas, and Adenomyosis
Kossaï, M., & Penault-Llorca, F. M. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-38474-6_3 · Cited by 41
Wu, H., Chang, H., & Leung, P. C. K. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100876 · Cited by 37
Gizzo, S., Patrelli, T. S., Dall’Asta, A., Gangi, S. D., Giordano, G., Migliavacca, C., Monica, M., Merisio, C., Nardelli, G. B., Quaranta, M., et al. (2015) · Oncology Letters · doi:10.3892/ol.2015.4032 · Cited by 33
Treatment options and reproductive outcome for adenomyosis-associated infertility
Soave, I., Wenger, J., Pluchino, N., & Marci, R. (2017) · Current Medical Research and Opinion · doi:10.1080/03007995.2017.1393404 · Cited by 33
Sztachelska, M., Ponikwicka‐Tyszko, D., Martínez-Rodrigo, L., Bernaczyk, P., Palak, E., Półchłopek, W., Bielawski, T., & Wołczyński, S. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11154407 · Cited by 36
“According to the most popular invagination [2] theory, adenomyosis is a result of the invasion of endometrial tissues through the damaged junctional zone between the endometrial layer and myometrium.”
BackgroundChen, Y., Zhu, B., Zhang, H., Liu, X., & Guo, S. (2013) · Reproductive Sciences · doi:10.1177/1933719113488455 · Cited by 32
Adenomyosis and its impact on women fertility.
Garavaglia, E., Serafini, A., Inversetti, A., Stefano, F., Tandoi, I., Corti, L., & Candiani, M. (2015) · PubMed Central · Cited by 32
Metadata
- Authors
- Bergeron, C., Amant, F., & Ferenczy, A.
- Affiliations
- Processus d'Activation Sélective par Transfert d'Énergie Uni-électronique ou Radiatif (FR)
- Jewish General Hospital (CA)
- Corresponding author
- Bergeron, Christine
- ORCID
- Bergeron, Christine
- Venue
- Best Practice & Research Clinical Obstetrics & Gynaecology
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 20
- Issue
- 4
- Pages
- 511-521
- ISSN
- 1521-6934 (ISSN-L)
- OpenAlex
- W2038354928
- Cited by
- 359
- References
- 54
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 19 · 2023: 33 · 2022: 25 · 2021: 36 · 2020: 35 · 2019: 26 · 2018: 19 · 2017: 20 · 2016: 19 · 2015: 27 · 2014: 18 · 2013: 10 · 2012: 11
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Obstetrics & Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- adenomyosis, anti-apoptotic effects, hyperoestrogenism, menorrhagia, dysmenorrhea, endometrial polyps, uterine fibroids, endometrioid carcinoma, hysterectomy, danazol, GnRH analogues, progestogens, surgical treatment
- MeSH terms
- Adult, Danazol, Endometrial Hyperplasia, Endometriosis, Estrogen Antagonists, Female, Humans, Hysterectomy, Leiomyoma, Gonadotropin-Releasing Hormone, Middle Aged, Polyps, Uterine Diseases, Uterine Neoplasms, Endometrial Neoplasms, Carcinoma, Endometrioid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
